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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.

PMID: 35210032
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 Mar 1;79(8):772-785. doi: 10.1016/j.jacc.2021.11.056.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Kim, Won-Keun, Castillo, Juan Carlos, Alperi, Alberto, Tchetche, Didier, Bartorelli, Antonio L, Kapadia, Samir, Stortecky, Stefan, Amat-Santos, Ignacio, Wijeysundera, Harindra C, Lisko, John et al.
DOI: 10.1016/j.jacc.2021.11.056

Gender differences in outcome in patients with diabetes mellitus.

PMID: 32458331
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2022
Reference: J Nucl Cardiol. 2022 Feb;29(1):72-82. doi: 10.1007/s12350-020-02195-0. Epub 2020 May 26.
Impact factor: 5.952
Publication type: Paper in international publication
Authors: Pizzi, Maria Nazarena, Roque, Albert, Candell-Riera, Jaume, Cuellar-Calabria, Hug, Aguade-Bruix, Santiago, Romero-Farina, Guillermo et al.
DOI: 10.1007/s12350-020-02195-0

QTc interval prolongation in patients infected with SARS-CoV-2 and treated with antiviral drugs.

PMID: 35193834
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Mar;96(3):213-220. doi: 10.1016/j.anpede.2021.04.006. Epub 2022 Feb 19.
Impact factor: 1.5
Publication type: Paper in international publication
Authors: Esmel-Vilomara, Roger, Dolader, Paola, Sabate-Rotes, Anna, Soriano-Arandes, Antoni, Gran, Ferran, Roses-Noguer, Ferran et al.
DOI: 10.1016/j.anpede.2021.04.006

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration.

PMID: 35177855
Journal: NATURE MEDICINE
Year: 2022
Reference: Nat Med. 2022 Feb;28(2):283-294. doi: 10.1038/s41591-022-01682-w. Epub 2022 Feb 17.
Impact factor: 53.44
Publication type: Paper in international publication
Authors: Ruiz-Majoral, Alejandro, Coste du Fou, Guenola, Leviatan Ben-Arye, Shani, Govani, Liana, Yehuda, Sharon, Bachar Abramovitch, Shirley, Amon, Ron, Reuven, Eliran Moshe, Atiya-Nasagi, Yafit, Yu, Hai et al.
DOI: 10.1038/s41591-022-01682-w

Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells.

PMID: 34001233
Journal: Cell and Bioscience
Year: 2021
Reference: Cell Biosci. 2021 May 17;11(1):89. doi: 10.1186/s13578-021-00605-5.
Impact factor: 7.133
Publication type: Paper in international publication
Authors: Moliner, P, Ferreiro, J L, Garay, A, Jimenez-Marrero, S, Yun, S, Sosa, S G, Alcoberro, L, Gonzalez-Costello, J, Garcia-Romero, E, Yanez-Bisbe, L et al.
DOI: 10.1186/s13578-021-00605-5

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.

PMID: 33976159
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 May 11;12(1):2628. doi: 10.1038/s41467-021-22933-3.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Muino-Mosquera, Laura, de la Fuente-Alonso, Andrea, Toral, Marta, Alfayate, Alvaro, Ruiz-Rodriguez, Maria Jesus, Bonzon-Kulichenko, Elena, Teixido-Tura, Gisela, Martinez-Martinez, Sara, Mendez-Olivares, Maria Jose, Lopez-Maderuelo, Dolores et al.
DOI: 10.1038/s41467-021-22933-3

Transesophageal echocardiography during pectus excavatum correction in children: What happens to the heart?

PMID: 32660778
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2021
Reference: J Pediatr Surg. 2021 May;56(5):988-994. doi: 10.1016/j.jpedsurg.2020.06.009. Epub 2020 Jun 12.
Impact factor: 2.545
Publication type: Paper in international publication
Authors: Gine, Carlos, Garcia Martinez, Laura, Villaverde, Ivan, Lopez, Manuel, Giralt, Gemma, Lain, Ana et al.
DOI: 10.1016/j.jpedsurg.2020.06.009

Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure.

PMID: 33978673
Journal: JAMA Cardiology
Year: 2021
Reference: JAMA Cardiol. 2021 Aug 1;6(8):891-901. doi: 10.1001/jamacardio.2021.1106.
Impact factor: 14.676
Publication type: Paper in international publication
Authors: Ortiz-Genga, Martin, Ruiz, Itziar Solla, Nielson, Soren Kristian, Rasmussen, Torsten Bloch, Robles Mezcua, Ainhoa, Alvarez-Rubio, Jorge, Eiskjaer, Hans, Gautel, Mathias, Garcia-Pinilla, Jose M, Ripoll-Vera, Tomas et al.
DOI: 10.1001/jamacardio.2021.1106

Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes.

PMID: 31929543
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Jan 13;15(1):e0226606. doi: 10.1371/journal.pone.0226606. eCollection 2020.
Impact factor: 2.74
Publication type: Paper in international publication
Authors: Ahn, Tae Hoon, Leschke, Matthias, Pansieri, Michel, Sebagh, Laurent, Krackhardt, Florian, Waliszewski, Matthias, Wan Ahmad, Wan Azman, Kocka, Viktor, Tousek, Petr, Janek, Bronislav et al.
DOI: 10.1371/journal.pone.0226606

Management of Heart Failure with Reduced Ejection Fraction after ESC 2016 Heart Failure Guidelines: The Linx Registry.

PMID: 31916413
Journal: ESC Heart Failure
Year: 2020
Reference: ESC Heart Fail. 2020 Feb;7(1):25-35. doi: 10.1002/ehf2.12567. Epub 2020 Jan 9.
Impact factor: 3.902
Publication type: Paper in international publication
Authors: de Frutos, Fernando, Mirabet, Sonia, Ortega-Paz, Luis, Buera, Irene, Darnes, Sara, Andres, Bernardo, Adelino, Raquel, Bascompte, Ramon, Perez-Rodon, Jordi, Aparicio, Xavier et al.
DOI: 10.1002/ehf2.12567

Ultra-early continuous cardiac monitoring improves atrial fibrillation detection and prognosis of patients with cryptogenic stroke.

PMID: 31424609
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2020
Reference: Eur J Neurol. 2020 Feb;27(2):244-250. doi: 10.1111/ene.14061. Epub 2019 Sep 18.
Impact factor: 4.516
Publication type: Paper in international publication
Authors: Cuadrado-Godia, Elisa, Benito, Begona, Ois, Angel, Valles, Ermengol, Rodriguez-Campello, Ana, Giralt-Steinhauer, Eva, Cabrera, Sandra, Alcalde, Oscar, Jimenez-Lopez, Jesus, Jimenez-Conde, Jordi et al.
DOI: 10.1111/ene.14061

Morpho-metabolic post-surgical patterns of non-infected prosthetic heart valves by [18F]FDG PET/CTA: "normality" is a possible diagnosis.

PMID: 31539031
Journal: European Heart Journal-Cardiovascular Imaging
Year: 2020
Reference: Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):24-33. doi: 10.1093/ehjci/jez222.
Impact factor: 4.841
Publication type: Paper in international publication
Authors: Fernandez-Hidalgo, Nuria, Permanyer, Eduard, Cuellar-Calabria, Hug, Romero-Farina, Guillermo, Rios, Remedios, Almirante, Benito, Castell-Conesa, Joan, Escobar, Manuel, Ferreira-Gonzalez, Ignacio, Tornos, Pilar et al.
DOI: 10.1093/ehjci/jez222

Blog

News

The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.