Childhood Cancer and Blood Disorders
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
Publications
Ruxolitinib for steroid-refractory graft versus host disease in pediatric HSCT: high response rate and manageable toxicity.
PMID: 33661711
Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Year: 2021
Reference: Pediatr Hematol Oncol. 2021 May;38(4):331-345. doi: 10.1080/08880018.2020.1868637. Epub 2021 Mar 4.
Impact factor: 1.969
Publication type: Paper in international publication
Authors: Mozo, Yasmina, Bueno, David, Sisinni, Luisa, Fernandez-Arroyo, Alba, Rosich, Blanca, Martinez, Antonio Perez, Uria, Maria Luz, Heredia, Cristina Diaz de, Mestre-Duran, Carmen, Pascual, Cristina Ferreras Barbara et al.
DOI: 10.1080/08880018.2020.1868637
Opportunities and Challenges in Drug Development for Pediatric Cancers.
PMID: 33277309
Journal: Cancer Discovery
Year: 2021
Reference: Cancer Discov. 2021 Mar;11(3):545-559. doi: 10.1158/2159-8290.CD-20-0779. Epub 2020 Dec 4.
Impact factor: 39.397
Publication type: Review in international publication
Authors: Laetsch, Theodore W, DuBois, Steven G, Bender, Julia Glade, Macy, Margaret E, Moreno, Lucas et al.
DOI: 10.1158/2159-8290.CD-20-0779
Usefulness of NGS for Diagnosis of Dominant Beta-Thalassemia and Unstable Hemoglobinopathies in Five Clinical Cases.
PMID: 33613322
Journal: Frontiers in Physiology
Year: 2021
Reference: Front Physiol. 2021 Feb 5;12:628236. doi: 10.3389/fphys.2021.628236. eCollection 2021.
Impact factor: 4.566
Publication type: Paper in international publication
Authors: Rizzuto, Valeria, Koopmann, Tamara T, Blanco-Alvarez, Adoracion, Tazon-Vega, Barbara, Idrizovic, Amira, Diaz de Heredia, Cristina, Del Orbe, Rafael, Pampliega, Miriam Vara, Velasco, Pablo, Santen, Gijs W E et al.
DOI: 10.3389/fphys.2021.628236
Combined Analysis of Concordance between Liquid and Tumor Tissue Biopsies for RAS Mutations in Colorectal Cancer with a Single Metastasis Site: The METABEAM Study.
PMID: 33602686
Journal: CLINICAL CANCER RESEARCH
Year: 2021
Reference: Clin Cancer Res. 2021 May 1;27(9):2515-2522. doi: 10.1158/1078-0432.CCR-20-3677. Epub 2021 Feb 18.
Impact factor: 12.531
Publication type: Paper in international publication
Authors: Kudo, Toshihiro, Kagawa, Yoshinori, Fernandez, Elena Elez, Garcia-Foncillas, Jesus, Bando, Hideaki, Taniguchi, Hiroya, Vivancos, Ana, Akagi, Kiwamu, Garcia, Ariadna, Denda, Tadamichi et al.
DOI: 10.1158/1078-0432.CCR-20-3677
IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults.
PMID: 31738823
Journal: BLOOD
Year: 2020
Reference: Blood. 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699.
Impact factor: 17.543
Publication type: Paper in international publication
Authors: Azorin, Daniel, Ramis-Zaldivar, Joan Enric, Gonzalez-Farre, Blanca, Balague, Olga, Celis, Veronica, Nadeu, Ferran, Salmeron-Villalobos, Julia, Andres, Mara, Martin-Guerrero, Idoia, Garrido-Pontnou, Marta et al.
DOI: 10.1182/blood.2019002699
Clinical research tools in pediatric oncology: challenges and opportunities.
PMID: 31939050
Journal: CANCER AND METASTASIS REVIEWS
Year: 2020
Reference: Cancer Metastasis Rev. 2020 Mar;39(1):149-160. doi: 10.1007/s10555-020-09856-z.
Impact factor: 6.4
Publication type: Review in international publication
Authors: de Rojas, Teresa, Neven, Anouk, Towbin, Alexander J, Carceller, Fernando, Bautista, Francisco, Riedl, David, Sodergren, Samantha, Darlington, Anne-Sophie, Fernandez-Teijeiro, Ana, Moreno, Lucas et al.
DOI: 10.1007/s10555-020-09856-z
A new standard of care for patients with high-risk rhabdomyosarcoma? - Authors' reply.
PMID: 31908304
Journal: LANCET ONCOLOGY
Year: 2020
Reference: Lancet Oncol. 2020 Jan;21(1):e3. doi: 10.1016/S1470-2045(19)30812-5.
Impact factor: 33.752
Publication type: Letter or abstract
Authors: Bisogno, Gianni, Ferrari, Andrea, Melcon, Soledad Gallego, De Salvo, Gian Luca, Bergeron, Christophe, Jenney, Meriel et al.
DOI: 10.1016/S1470-2045(19)30812-5
Haploidentical transplantation in high-risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish Working Group for Bone Marrow Transplantation in Children (GETMON) and the Spanish Grupo for Hematopoietic Transplantation (GETH).
PMID: 31625177
Journal: AMERICAN JOURNAL OF HEMATOLOGY
Year: 2020
Reference: Am J Hematol. 2020 Jan;95(1):28-37. doi: 10.1002/ajh.25661. Epub 2019 Nov 5.
Impact factor: 6.973
Publication type: Paper in international publication
Authors: Diaz, Miguel Angel, de Heredia, Cristina Diaz, Perez-Martinez, Antonio, Ferreras, Cristina, Pascual, Antonia, Gonzalez-Vicent, Marta, Alonso, Laura, Badell, Isabel, Navarro, Jose Maria Fernandez, Regueiro, Alexandra et al.
DOI: 10.1002/ajh.25661
News
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.