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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejos

Joaquin Ruiz Altarejos

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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejos

Joaquin Ruiz Altarejos

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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Impact of stem-related tumor extracellular vesicles subsets in TNBC progression.

IP: Joaquin Seras Franzoso
Collaborators: Maria Fidel Lledò, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI23/00223
Duration: 15/01/2024 - 14/01/2028

Funciones Alternativas de la Sex Hormone-Binding Globulin: Mecanismos Moleculares y Papel en Fisiología y Fisiopatología

IP: David Martinez Selva
Collaborators: Maria Teresa Salcedo Allende, Lorena Ramos Pérez, Pablo Gabriel Medina, Pilar Costa Forner
Funding agency: Instituto de Salud Carlos III
Funding: 190000
Reference: PI23/00544
Duration: 01/01/2024 - 31/12/2026

Antimicrobianos nebulizados en receptores de trasplante pulmonar

IP: Ibai Los Arcos Bertiz
Collaborators: M Teresa Martin Gomez, Yolanda Villena Ortiz, Javier Gomis Rodriguez, Joan Gavaldà Santapau, Judith Sacanell Lacasa, Marta Zapata Ortega, Leire Sanchez Corujo
Funding agency: Instituto de Salud Carlos III
Funding: 37500
Reference: PI23/01467
Duration: 01/01/2024 - 31/12/2026

Nanoclustered Affimers for Targeted KRAS Ablation in Pancreatic Ductal Adenocarcinoma

IP: Joaquin Seras Franzoso
Collaborators: Diana Fernandes de Rafael
Funding agency: Asociación Cáncer de Páncreas
Funding: 50000
Reference: ACANPAN/PROJECTES/2023/SERAS
Duration: 05/12/2023 - 04/12/2025

Publications

Pre-Surgery Cortisol Levels as Biomarker of Evolution after Bariatric Surgery: Weight Loss and Weight Regain.

PMID: 39274358
Journal: Journal of Clinical Medicine
Year: 2024
Reference: J Clin Med. 2024 Aug 30;13(17):5146. doi: 10.3390/jcm13175146.
Impact factor:
Publication type: Paper in international publication
Authors: Biagetti, Betina; Casteras, Anna; Ciudin, Andreea; Comas, Marta; Diaz-Troyano, Noelia; Ferrer, Roser; Fidilio, Enzamaria; Flores, Vanesa; Giralt, Marina; Vilallonga, Ramon et al.
DOI: 10.3390/jcm13175146

Trypsin Partially Cleaves Apolipoprotein A-I (ApoA-I) Precursor into Mature ApoA-I Hindering the Quantification of Naturally Occurring ApoA-I Proteoforms by Liquid Chromatography in Multiple Reaction Monitoring Mode Mass Spectrometry (LC-MRM-MS).

PMID: 39304183
Journal: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Year: 2024
Reference: J Am Soc Mass Spectrom. 2024 Sep 20. doi: 10.1021/jasms.4c00155.
Impact factor:
Publication type: Paper in international publication
Authors: Ferrer-Costa, Roser; Jacobs-Cacha, Conxita; Llorens-Cebria, Carmen; Lopez-Hellin, Joan; Martinez-Diaz, Irene; Nunez-Seral, Norberto; Soler, Maria Jose; Villena-Ortiz, Yolanda et al.
DOI: 10.1021/jasms.4c00155

Impact of Omega-3 Fatty Acid Supplementation in Parenteral Nutrition on Inflammatory Markers and Clinical Outcomes in Critically Ill COVID-19 Patients: A Randomized Controlled Trial.

PMID: 39339646
Journal: Nutrients
Year: 2024
Reference: Nutrients. 2024 Sep 10;16(18):3046. doi: 10.3390/nu16183046.
Impact factor:
Publication type: Paper in international publication
Authors: Albertos, Raquel; Barquin, Raquel; Berlana, David; Cantenys-Molina, Sergi; Cea, Cristina; Diez-Poch, Monica; Ferrer-Costa, Roser; Lopez-Martinez, Rocio; Pau-Parra, Alba et al.
DOI: 10.3390/nu16183046

SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice.

PMID: 39434906
Journal: Frontiers in Pharmacology
Year: 2024
Reference: Front Pharmacol. 2024 Oct 7;15:1415879. doi: 10.3389/fphar.2024.1415879. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Allo-Urzainqui, Estibaliz; Bermejo, Sheila; Ferrer-Costa, Roser; Garcias-Ramis, Maria Magdalena; Goncalves, Francisco; Jacobs-Cacha, Conxita; Leon-Roman, Juan; Llorens-Cebria, Carmen; Martinez-Diaz, Irene; Martos-Guillami, Nerea et al.
DOI: 10.3389/fphar.2024.1415879

mTOR inhibitors a potential predisposing factor for chronic hepatitis E: Results from the prospective collaborative CHES Study (Chronic Hepatitis E Screening in patients with immune impairment and increased transaminases levels)

PMID: 36731726
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Dec;46(10):764-773. doi: 10.1016/j.gastrohep.2023.01.010. Epub 2023 Jan 31.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, Virginia Robles; Barciela, Mar Riveiro; Berastegui, Cristina; Bilbao, Itxarone; Buti, Maria; Camprecios, Joan Martinez; Castells, Lluis; Cots, Meritxell Ventura; Diez, Basilio Rodriguez; Eliz, Maria Garcia et al.
DOI: 10.1016/j.gastrohep.2023.01.010

Cancer stem cell-derived extracellular vesicles preferentially target MHC-II-macrophages and PD1+ T cells in the tumor microenvironment.

PMID: 36735677
Journal: PLoS One
Year: 2023
Reference: PLoS One. 2023 Feb 3;18(2):e0279400. doi: 10.1371/journal.pone.0279400. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Claudio, Natalie Marcia; Gonzalez-Callejo, Patricia; Guo, Zihan; Nguyen, Kayla Hoang; Oshimori, Naoki; Pucci, Ferdinando; Seras-Franzoso, Joaquim; Ziglari, Tahereh et al.
DOI: 10.1371/journal.pone.0279400

Intracellular Delivery of Anti-Kirsten Rat Sarcoma Antibodies Mediated by Polymeric Micelles Exerts Strong In Vitro and In Vivo Anti-Tumorigenic Activity in Kirsten Rat Sarcoma-Mutated Cancers.

PMID: 36795046
Journal: ACS Applied Materials & Interfaces
Year: 2023
Reference: ACS Appl Mater Interfaces. 2023 Mar 1;15(8):10398-10413. doi: 10.1021/acsami.2c19897. Epub 2023 Feb 16.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Carcavilla, Pilar; Carcavilla, Pilar; Diaz-Riascos, Zamira V; Duran-Lara, Esteban F; Fernandez, Begona; Fernandez, Begona; German-Cortes, Julia; German-Cortes, Julia et al.
DOI: 10.1021/acsami.2c19897

Aspirin Discontinuation at 24 to 28 Weeks' Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial.

PMID: 36809321
Journal: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Year: 2023
Reference: JAMA. 2023 Feb 21;329(7):542-550. doi: 10.1001/jama.2023.0691.
Impact factor:
Publication type: Paper in international publication
Authors: Alsius, Merce; Bonacina, Erika; Caamina, Sara; Carreras, Elena; de Mingo, Laura; Diaz, Sonia; Ferrer-Costa, Roser; Garcia, Esperanza; Garcia-Manau, Pablo; Lopez, Monica et al.
DOI: 10.1001/jama.2023.0691

Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain.

PMID: 36003985
Journal: Infection and Drug Resistance
Year: 2022
Reference: Infect Drug Resist. 2022 Aug 18;15:4637-4644. doi: 10.2147/IDR.S367715. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Costa, Josep; Dopico, Eva; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Martinez, Miguel J; Niubo, Jordi; Quer, Josep; Rando-Matos, Yolanda; Rando-Segura, Ariadna et al.
DOI: 10.2147/IDR.S367715

Blood-biomarkers and devices for atrial fibrillation screening: Lessons learned from the AFRICAT (Atrial Fibrillation Research In CATalonia) study.

PMID: 35998199
Journal: PLoS One
Year: 2022
Reference: PLoS One. 2022 Aug 23;17(8):e0273571. doi: 10.1371/journal.pone.0273571. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Juan; Ballesta-Ors, Juan; Bustamante, Alejandro; Clua-Espuny, Josep Lluis; Gentille-Lorente, Delicia; Giralt, Marina; Gonzalez-Loyola, Felipe; Lechuga-Duran, Inigo; Montaner, Joan; Munoz, Miguel Angel et al.
DOI: 10.1371/journal.pone.0273571

Smart and eco-friendly N-isopropylacrylamide and cellulose hydrogels as a safe dual-drug local cancer therapy approach.

PMID: 35988981
Journal: Carbohydrate Polymers
Year: 2022
Reference: Carbohydr Polym. 2022 Nov 1;295:119859. doi: 10.1016/j.carbpol.2022.119859. Epub 2022 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Duran-Lara, Esteban F; Hide, Diana; Llaguno, Monserrat; Martell, Maria; Oliva, Mireia; Rafael, Diana; Raurell, Imma; Roca-Melendres, Maria Merce et al.
DOI: 10.1016/j.carbpol.2022.119859

Identification of Myocardial Insulin Resistance by Using Liver Tests: A Simple Approach for Clinical Practice.

PMID: 35955920
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Aug 7;23(15). pii: ijms23158783. doi: 10.3390/ijms23158783.
Impact factor:
Publication type: Paper in international publication
Authors: Aguade-Bruix, Santiago; Aparicio, Carolina; Castell-Conesa, Joan; Ferrer, Roser; Giralt-Arnaiz, Marina; Gonzalez-Ballester, Miguel Angel; Herance, Jose Raul; Hernandez, Cristina; Martin-Saladich, Queralt; Pericas, Juan M et al.
DOI: 10.3390/ijms23158783

Association between circulating alpha-1 antitrypsin polymers and lung and liver disease.

PMID: 34526035
Journal: RESPIRATORY RESEARCH
Year: 2021
Reference: Respir Res. 2021 Sep 15;22(1):244. doi: 10.1186/s12931-021-01842-5.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Farago, Georgina; Gabriel-Medina, Pablo; Genesca, Joan; Loeb, Eduardo; Miranda, Elena; Miravitlles, Marc; Nunez, Alexa et al.
DOI: 10.1186/s12931-021-01842-5

MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy.

PMID: 34530925
Journal: Acta Neuropathologica Communications
Year: 2021
Reference: Acta Neuropathol Commun. 2021 Sep 16;9(1):154. doi: 10.1186/s40478-021-01257-9.
Impact factor:
Publication type: Paper in international publication
Authors: Bonaterra-Pastra, Anna; Camacho, Jessica; Castillo-Ribelles, Laura; de Kort, Anna M; Delgado, Pilar; Hernandez-Guillamon, Mar; Klijn, Catharina J M; Kuiperij, H Bea; Marazuela, Paula; Martinez-Saez, Elena et al.
DOI: 10.1186/s40478-021-01257-9

The influence of parenteral protein intake on electrolyte disturbances in premature infants.

PMID: 34507648
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Sep;95(3):139-146. doi: 10.1016/j.anpede.2020.10.001. Epub 2020 Oct 24.
Impact factor:
Publication type: Paper in national publication
Authors: Blanco-Grau, Albert; Clemente-Bautista, Susana; Garcia-Palop, Beatriz; Gomez-Ganda, Laura; Lines-Palazon, Marcos; Montoro-Ronsano, Jose Bruno; Parramon-Teixido, Carlos Javier et al.
DOI: 10.1016/j.anpede.2020.10.001

Influencia del aporte proteico parenteral en las alteraciones electrolíticas en recién nacidos prematuros

PMID: 33036923
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Barc). 2021 Sep;95(3):139-146. doi: 10.1016/j.anpedi.2020.03.022. Epub 2020 Oct 6.
Impact factor:
Publication type: Paper in national publication
Authors: Blanco-Grau, Albert; Clemente-Bautista, Susana; Garcia-Palop, Beatriz; Gomez-Ganda, Laura; Lines-Palazon, Marcos; Montoro-Ronsano, Jose Bruno; Parramon-Teixido, Carlos Javier et al.
DOI: 10.1016/j.anpedi.2020.03.022

Performance comparison of two next-generation sequencing panels to detect actionable mutations in cell-free DNA in cancer patients.

PMID: 32623849
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2020
Reference: Clin Chem Lab Med. 2020 Jul 28;58(8):1341-1348. doi: 10.1515/cclm-2019-1267.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre, Estibaliz; Alkorta-Aranburu, Gorka; Andueza, Maria P; Bielsa, Arancha; Canada-Higueras, Eva; Corral, Jesus; Ferrer-Costa, Roser; Gil-Bazo, Ignacio; Gonzalez, Alvaro; Gracia, Javier et al.
DOI: 10.1515/cclm-2019-1267

Exploring Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors for Organ Protection in COVID-19.

PMID: 32605278
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Jun 28;9(7). pii: jcm9072030. doi: 10.3390/jcm9072030.
Impact factor:
Publication type: Review in international publication
Authors: D'Marco, Luis; Fernandez-Fernandez, Beatriz; Gorriz, Jose Luis; Jacobs-Cacha, Conxita; Kanbay, Mehmet; Luis-Lima, Sergio; Ortiz, Alberto; Porrini, Esteban; Sarafidis, Pantelis; Soler, Maria Jose et al.
DOI: 10.3390/jcm9072030

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

PMID: 32558485
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2020
Reference: N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Aghemo, Alessio; Albillos, Agustin; Albrecht, Wolfgang; Aliberti, Stefano; Aneli, Serena; Angelini, Claudio; Asselta, Rosanna; Aziz, Fatima; Badalamenti, Salvatore et al.
DOI: 10.1056/NEJMoa2020283

Conservation and variability of hepatitis B core at different chronic hepatitis stages.

PMID: 32523313
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: World J Gastroenterol. 2020 May 28;26(20):2584-2598. doi: 10.3748/wjg.v26.i20.2584.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casillas, Rosario; Cortese, Maria Francesca; Esteban, Rafael; Godoy, Cristina; Gonzalez, Carolina; Gregori, Josep; Guerrero-Murillo, Mercedes; Lopez-Martinez, Rosa; Orriols, Gerard et al.
DOI: 10.3748/wjg.v26.i20.2584

Whole-genome characterization and resistance-associated substitutions in a new HCV genotype 1 subtype.

PMID: 31118701
Journal: Infection and Drug Resistance
Year: 2019
Reference: Infect Drug Resist. 2019 Apr 24;12:947-955. doi: 10.2147/IDR.S195441. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Escarda, Ana; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Macia, Maria Dolores; Quer, Josep; Rodriguez-Frias, Francisco; von Massow, Georg et al.
DOI: 10.2147/IDR.S195441

Autophagy inhibition as a promising therapeutic target for laryngeal cancer.

PMID: 31050705
Journal: CARCINOGENESIS
Year: 2019
Reference: Carcinogenesis. 2019 Dec 31;40(12):1525-1534. doi: 10.1093/carcin/bgz080.
Impact factor:
Publication type: Paper in international publication
Authors: Benavente, Sergi; Castellvi, Josep; Garcia-Mayea, Yoelsis; LLeonart, Matilde E; Lorente, Juan; Maggio, Valentina; Mir, Cristina; Munoz, Lisandra; Paciucci, Rosanna; Temprana, Jordi et al.
DOI: 10.1093/carcin/bgz080

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection.

PMID: 30983817
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2019
Reference: World J Gastroenterol. 2019 Apr 7;25(13):1566-1579. doi: 10.3748/wjg.v25.i13.1566.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casillas, Rosario; Cortese, Maria Francesca; Esteban, Rafael; Godoy, Cristina; Gonzalez, Carolina; Gonzalez-Aseguinolaza, Gloria; Gregori, Josep; Lopez-Martinez, Rosa; Quer, Josep et al.
DOI: 10.3748/wjg.v25.i13.1566

A novel DNA-binding motif in Prostate Tumor Overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.

PMID: 30922918
Journal: CANCER LETTERS
Year: 2019
Reference: Cancer Lett. 2019 Jun 28;452:158-167. doi: 10.1016/j.canlet.2019.03.019. Epub 2019 Mar 25.
Impact factor:
Publication type: Paper in international publication
Authors: Canovas, Veronica; Ciudad, Carlos J; de Torres, Ines; Felix, Alex J; Gomez, Valenti; Maggio, Valentina; Morote, Juan; Noe, Veronique; Paciucci, Rosanna; Semidey, Maria Eugenia et al.
DOI: 10.1016/j.canlet.2019.03.019

Real world evaluation of a novel lateral flow assay (AlphaKit(R) QuickScreen) for the detection of alpha-1-antitrypsin deficiency.

PMID: 30103740
Journal: RESPIRATORY RESEARCH
Year: 2018
Reference: Respir Res. 2018 Aug 13;19(1):151. doi: 10.1186/s12931-018-0826-8.
Impact factor:
Publication type: Paper in international publication
Authors: Belmonte, Irene; Greulich, Timm; Klemmer, Andreas; Miravitlles, Marc; Rodriguez-Frias, Francisco; Vogelmeier, Claus F et al.
DOI: 10.1186/s12931-018-0826-8

Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.

PMID: 30059722
Journal: ANTIVIRAL RESEARCH
Year: 2018
Reference: Antiviral Res. 2018 Oct;158:34-44. doi: 10.1016/j.antiviral.2018.07.019. Epub 2018 Jul 29.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Caballero, Andrea; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1016/j.antiviral.2018.07.019

Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment.

PMID: 29975908
Journal: COLLOIDS AND SURFACES B-BIOINTERFACES
Year: 2018
Reference: Colloids Surf B Biointerfaces. 2018 Oct 1;170:596-608. doi: 10.1016/j.colsurfb.2018.06.056. Epub 2018 Jun 26.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, I; Allard-Vannier, E; Alvarez, V A; Cacicedo, M L; Castro, G R; Chourpa, I; Diaz-Riascos, Z V; Fernandez, Y; Garcia-Aranda, N; Islan, G A et al.
DOI: 10.1016/j.colsurfb.2018.06.056

PHARMACOKINETIC STUDY OF CONVERSION BETWEEN TWO FORMULATIONS OF ONCE-DAILY EXTENDED-RELEASE TACROLIMUS IN STABLE LUNG TRANSPLANT PATIENTS.

PMID: 29965950
Journal: TRANSPLANTATION
Year: 2018
Reference: Transplantation. 2018 Oct;102(10):e439-e446. doi: 10.1097/TP.0000000000002348.
Impact factor:
Publication type: Paper in international publication
Authors: Berastegui, Cristina; Bravo, Carlos; Gomez-Olles, Susana; Lopez-Meseguer, Manuel; Monforte, Victor; Roman, Antonio; Saez-Gimenez, Berta; Sintes, Helena; Vima, Jaume et al.
DOI: 10.1097/TP.0000000000002348

Value of urinary levels of interleukin-6, epidermal growth factor, monocyte chemoattractant protein type1 and transforming growth factor beta1 in predicting the extent of fibrosis lesions in kidney biopsies of patients with IgA nephropathy.

PMID: 28946966
Journal: NEFROLOGIA
Year: 2017
Reference: Nefrologia. 2017 Sep - Oct;37(5):531-538. doi: 10.1016/j.nefro.2016.11.017.
Impact factor:
Publication type: Paper in national publication
Authors: Agraz-Pamplona, Irene; Carnicer-Caceres, Clara; Jatem Escalante, Elias; Ostos-Roldan, Elena; Ramos-Terrades, Natalia; Segarra-Medrano, Alfons; Valtierra-Carmeno, Naiara et al.
DOI: 10.1016/j.nefro.2016.11.017

Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells.

PMID: 28938627
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Jul 22;8(35):59165-59180. doi: 10.18632/oncotarget.19467. eCollection 2017 Aug 29.
Impact factor:
Publication type: Paper in international publication
Authors: Canovas, Veronica; Lleonart, Matilde; Maggio, Valentina; Marin, Mercedes; Mellado, Begona; Morote, Juan; Olivan, Mireia; Paciucci, Rosanna; Planas, Jacques; Punal, Yolanda et al.
DOI: 10.18632/oncotarget.19467

Laboratory Diagnosis by Genotyping.

PMID: 28752445
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2017
Reference: Methods Mol Biol. 2017;1639:45-60. doi: 10.1007/978-1-4939-7163-3_5.
Impact factor:
Publication type: Paper in international publication
Authors: Belmonte, Irene; Montoto, Luciana; Rodriguez-Frias, Francisco et al.
DOI: 10.1007/978-1-4939-7163-3_5

Spanish Registry of Patients With Alpha-1 Antitrypsin Deficiency: Database Evaluation and Population Analysis.

PMID: 27323654
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2017
Reference: Arch Bronconeumol. 2017 Jan;53(1):13-18. doi: 10.1016/j.arbres.2016.05.003. Epub 2016 Jun 17.
Impact factor:
Publication type: Paper in national publication
Authors: Blanco, Ignacio; Bustamante, Ana; Cadenas, Sergio; Casas, Francisco; Curi, Sergio; Dasi, Francisco; Escribano, Amparo; Esquinas, Cristina; Hernandez, Jose M; Herrero, Ines et al.
DOI: 10.1016/j.arbres.2016.05.003

Cortisol awakening response in adults with attention deficit hyperactivity disorder: Subtype differences and association with the emotional lability.

PMID: 27084305
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
Year: 2016
Reference: Eur Neuropsychopharmacol. 2016 Jul;26(7):1140-9. doi: 10.1016/j.euroneuro.2016.03.014. Epub 2016 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Casas, M; Corominas-Roso, M; Corrales, M; Ferrer, R; Palomar, G; Ramos-Quiroga, J A; Richarte, V; Valero, S et al.
DOI: 10.1016/j.euroneuro.2016.03.014

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.

PMID: 27078873
Journal: Biofabrication
Year: 2016
Reference: Biofabrication. 2016 Apr 14;8(2):025001. doi: 10.1088/1758-5090/8/2/025001.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Conchillo-Sole, Oscar; Daura, Xavier; Fernandez, Yolanda; Ferrer-Miralles, Neus; Foradada, Laia; Pesarrodona, Mireia; Rinas, Ursula; Roldan, Monica; Sanchez-Chardi, Alejandro et al.
DOI: 10.1088/1758-5090/8/2/025001

Viral quasispecies complexity measures.

PMID: 27060566
Journal: VIROLOGY
Year: 2016
Reference: Virology. 2016 Jun;493:227-37. doi: 10.1016/j.virol.2016.03.017. Epub 2016 Apr 6.
Impact factor:
Publication type: Paper in international publication
Authors: Domingo, Esteban; Esteban, Juan I; Gregori, Josep; Perales, Celia; Quer, Josep; Rodriguez-Frias, Francisco et al.
DOI: 10.1016/j.virol.2016.03.017

A leaky splicing mutation in NFU1 is associated with a particular biochemical phenotype. Consequences for the diagnosis.

PMID: 26688339
Journal: MITOCHONDRION
Year: 2016
Reference: Mitochondrion. 2016 Jan;26:72-80. doi: 10.1016/j.mito.2015.12.004. Epub 2015 Dec 11.
Impact factor:
Publication type: Paper in international publication
Authors: Alston, Charlotte L; Arias, Angela; Arranz, Jose Antonio; Briones, Paz; Bujan, Nuria; Del Toro, Mireia; Ferrer-Cortes, Xenia; Garcia-Cazorla, Angels; Garcia-Villoria, Judit; Jou, Cristina et al.
DOI: 10.1016/j.mito.2015.12.004

Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells.

PMID: 26238079
Journal: NANOMEDICINE-UK
Year: 2015
Reference: Nanomedicine. 2015 Nov;11(8):1883-92. doi: 10.1016/j.nano.2015.07.009. Epub 2015 Jul 31.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Arango, Diego; Arranja, Alexandra; de Sousa Rafael, Diana Fernandes; Fernandez, Yolanda; Fort, Nuria Bergada; Gener, Petra; Gouveia, Luis Pleno; Ortega, Joan Sayos; Prieto, Rafael Minana et al.
DOI: 10.1016/j.nano.2015.07.009

Morbidly "Healthy" Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia.

PMID: 25515498
Journal: OBES SURG
Year: 2015
Reference: Obes Surg. 2015 Aug;25(8):1380-91. doi: 10.1007/s11695-014-1528-z.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Balibrea, Jose Maria; Caubet, Enric; Ferrer, Roser; Fort, Jose Manuel; Gonzalez, Oscar; Lecube, Albert; Oller, Laura; Pardina, Eva; Peinado-Onsurbe, Julia et al.
DOI: 10.1007/s11695-014-1528-z

Behavior of total and free serum testosterone as a predictor for the risk of prostate cancer and its aggressiveness.

PMID: 25944770
Journal: ACTAS UROL ESP
Year: 2015
Reference: Actas Urol Esp. 2015 Nov;39(9):573-81. doi: 10.1016/j.acuro.2015.03.004. Epub 2015 May 2.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, A; de Torres, I M; Ferrer, R; Morote, J; Planas, J; Regis, L et al.
DOI: 10.1016/j.acuro.2015.03.004

Tenofovir discontinuation after long-term viral suppression in HBeAg negative chronic hepatitis B. Can HBsAg levels be useful?

PMID: 26071338
Journal: J CLIN VIROL
Year: 2015
Reference: J Clin Virol. 2015 Jul;68:61-8. doi: 10.1016/j.jcv.2015.05.002. Epub 2015 May 8.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casillas, Rosario; Esteban, Rafael; Homs, Maria; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Salcedo, Maria Teresa; Tabernero, David et al.
DOI: 10.1016/j.jcv.2015.05.002

SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations.

PMID: 25331979
Journal: Molecular Cancer
Year: 2014
Reference: Mol Cancer. 2014 Oct 21;13:237. doi: 10.1186/1476-4598-13-237.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Aguilera, Kristina Y; Alcaraz, Antonio; Bermudo, Raquel; Brekken, Rolf; Canovas, Veronica; Celia-Terrassa, Toni; Fernandez, Pedro L; Fernandez, Yolanda; Marin-Aguilera, Mercedes et al.
DOI: 10.1186/1476-4598-13-237

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles.

PMID: 25019161
Journal: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Year: 2014
Reference: Int J Pharm. 2014 Oct 1;473(1-2):286-95. doi: 10.1016/j.ijpharm.2014.07.016. Epub 2014 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Ferrer-Miralles, Neus; Gener, Petra; Pesarrodona, Mireia; Ratera, Imma; Schwartz, Simo Jr; Tatkiewicz, Witold; Unzueta, Ugutz; Vazquez, Esther; Veciana, Jaume et al.
DOI: 10.1016/j.ijpharm.2014.07.016

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

PMID: 24684754
Journal: Molecular Cancer
Year: 2014
Reference: Mol Cancer. 2014 Mar 31;13:74. doi: 10.1186/1476-4598-13-74.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alana, Lide; Bigas, Anna; Canovas, Veronica; Corominas, Montserrat; de Torres, Ines; Espinosa, Lluis; Fernandez, Pedro L; Fernandez, Yolanda; Paciucci, Rosanna et al.
DOI: 10.1186/1476-4598-13-74

A randomized controlled study of CPAP effect on plasma aldosterone concentration in patients with resistant hypertension and obstructive sleep apnea.

PMID: 24879492
Journal: JOURNAL OF HYPERTENSION
Year: 2014
Reference: J Hypertens. 2014 Aug;32(8):1650-7. doi: 10.1097/HJH.0000000000000238.
Impact factor:
Publication type: Paper in international publication
Authors: Espinel, Eugenia; Ferrer, Roser; Lloberes, Patricia; Martinez-Garcia, Miguel-Angel; Ramon, Maria-Antonia; Romero, Odile; Sampol, Gabriel; Segarra, Alfons; Tovar, Jose-Luis et al.
DOI: 10.1097/HJH.0000000000000238

A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model.

PMID: 23523552
Journal: ANTIVIRAL RESEARCH
Year: 2013
Reference: Antiviral Res. 2013 May;98(2):273-83. doi: 10.1016/j.antiviral.2013.03.007. Epub 2013 Mar 20.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Camos, Silvia; Casillas, Rosario; Esteban, Rafael; Gregori, Josep; Homs, Maria; Quer, Josep; Ramirez, Clara; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1016/j.antiviral.2013.03.007

Oxidative stress and cancer: an overview.

PMID: 23123177
Journal: AGEING RESEARCH REVIEWS
Year: 2013
Reference: Ageing Res Rev. 2013 Jan;12(1):376-90. doi: 10.1016/j.arr.2012.10.004. Epub 2012 Oct 31.
Impact factor:
Publication type: Review in international publication
Authors: Kondoh, Hiroshi; Lleonart, Matilde E; Moline, Teresa; Paciucci, Rosanna; Somoza, Rosa; Sosa, Venus et al.
DOI: 10.1016/j.arr.2012.10.004

Soluble CD40 ligand in morbidly obese patients: effect of body mass index on recovery to normal levels after gastric bypass surgery.

PMID: 23426590
Journal: ARCHIVES OF SURGERY
Year: 2013
Reference: JAMA Surg. 2013 Feb;148(2):151-6. doi: 10.1001/jamasurgery.2013.419.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan A; Balada, Eva; Casals, Isidre; Catalan, Roberto; Ferrer, Roser; Fort, Jose M; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Rivero, Joaquin et al.
DOI: 10.1001/jamasurgery.2013.419

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform.

PMID: 23394132
Journal: Nanomedicine
Year: 2013
Reference: Nanomedicine (Lond). 2013 Sep;8(9):1397-413. doi: 10.2217/nnm.12.174. Epub 2013 Feb 8.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Fernandez, Yolanda; Gomes-da-Silva, Ligia C; Moreira, Joao N; Pedroso de Lima, Maria C; Ramalho, Jose S; Schwartz, Simo; Simoes, Sergio et al.
DOI: 10.2217/nnm.12.174

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells.

PMID: 22505459
Journal: JOURNAL OF CLINICAL INVESTIGATION
Year: 2012
Reference: J Clin Invest. 2012 May 1;122(5):1849-68. doi: 10.1172/JCI59218. Epub 2012 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1172/JCI59218

[Quantification of hepatitis B virus HBsAg: clinical implications.]

PMID: 21719049
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 Apr 28;138(11):483-8. Epub 2011 Jun 29.
Impact factor:
Publication type: Review in national publication
Authors: Buti Ferret, Maria; Esteban Mur, Rafael; Rodríguez Frias, Francisco et al.
DOI: 10.1016/j.medcli.2011.04.024

Generation and characterization of orthotopic murine models for endometrial cancer.

PMID: 22198674
Journal: CLINICAL & EXPERIMENTAL METASTASIS
Year: 2012
Reference: Clin Exp Metastasis. 2012 Mar;29(3):217-27. Epub 2011 Dec 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s10585-011-9444-2

[Hepatitis E: Molecular virology, epidemiology and pathogenesis.]

PMID: 22386306
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2012
Reference: Enferm Infecc Microbiol Clin. 2012 Dec;30(10):624-34. doi: 10.1016/j.eimc.2012.01.014. Epub 2012 Mar 3.
Impact factor:
Publication type: Review in national publication
Authors: ; ; et al.
DOI: 10.1016/j.eimc.2012.01.014

PTOV1 is overexpressed in human high-grade malignant tumors.

PMID: 21181414
Journal: VIRCHOWS ARCHIV
Year: 2011
Reference: Virchows Arch. 2011 Mar;458(3):323-30. Epub 2010 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00428-010-1018-1

HBV core region variability: effect of antiviral treatments on main epitopic regions.

PMID: 21311107
Journal: ANTIVIRAL THERAPY
Year: 2011
Reference: Antivir Ther. 2011;16(1):37-49.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Rafael; Fernandez-Fernandez, Pilar; Homs, Maria; Jardi, Rosendo; Quer, Josep; Rodriguez-Frias, Francisco; Schaper, Melanie; Tabernero, David et al.
DOI: 10.3851/IMP1701

Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells.

PMID: 19145631
Journal: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Year: 2009
Reference: J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):510-20.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Hindie, Mathilde; Kandhaya-Pillai, Renuka; Miro-Mur, Francesc; Schwartz, Simo Jr; Tobajas, Vanessa et al.
DOI: 10.1002/jbm.b.31312

Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo.

PMID: 19124560
Journal: FASEB JOURNAL
Year: 2009
Reference: FASEB J. 2009 May;23(5):1366-75.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Duch, Alba; Fillat, Cristina; Huch, Meritxell; Jose, Anabel; McLean, W H Irwin; Pujal, Judit; Real, Francisco X; Rodolosse, Annie; Sanchez-Palazon, Luis et al.
DOI: 10.1096/fj.08-115576

Successful use of entecavir for a severe case of reactivation of hepatitis B virus following polychemotherapy containing rituximab.

PMID: 19836097
Journal: JOURNAL OF HEPATOLOGY
Year: 2009
Reference: J Hepatol. 2009 Dec;51(6):1091-6.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.jhep.2009.07.012

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

PMID: 19738063
Journal: CANCER RESEARCH
Year: 2009
Reference: Cancer Res. 2009 Sep 15;69(18):7430-8.
Impact factor:
Publication type: Paper in international publication
Authors: Arango, Diego; Castano, Julio; Ceron, Julian; Dopeso, Higinio; Esteves, Marielle; Hernandez-Losa, Javier; Lagares-Tena, Laura; Landolfi, Stefania; Mariadason, John M; Mateo-Lozano, Silvia et al.
DOI: 10.1158/0008-5472.CAN-09-0706

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