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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Samanta Mecocci

Samanta Mecocci

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Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Samanta Mecocci

Samanta Mecocci

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Projects

MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small Cell Lung Cancer

IP: Ibane Abasolo Olaortua
Collaborators: Joaquin Seras Franzoso, Fernanda Raquel Da Silva Andrade
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 333099
Reference: CPP2022-009780
Duration: 01/07/2023 - 30/06/2026

Ministerio de Ciencia

HydroTheC

IP: HydroTheC
Collaborators: Miriam Izquierdo Sans, Diana Fernandes de Rafael, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 221390.88
Reference: HYDROTEC_HE-MSCA-PF-GF2022
Duration: 01/01/2024 - 31/12/2026

Hacia un manejo clínico personalizado de pacientes oncológicos con fracaso renal agudo asociado a los immune-checkpoint inhibitors (ICIs)

IP: Maria Jose Soler Romeo
Collaborators: Oriol Bestard Matamoros, Sheila Bermejo Garcia, Concepció Jacobs Cachá, Elena Isabel Crespo Gimeno
Funding agency: Instituto de Salud Carlos III
Funding: 246840
Reference: AC22/00029
Duration: 01/01/2023 - 31/12/2025

(Standard-D) Standardization of HDV-RNA quantification: a need that can no longer be ignored.

IP: -
Collaborators: David Tabernero Caellas
Funding agency: GILEAD SCIENCES SLU
Funding: 49961.71
Reference: GLD22/00080
Duration: 28/02/2023 - 27/02/2025

Publications

HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers.

PMID: 37745192
Journal: JHEP Reports
Year: 2023
Reference: JHEP Rep. 2023 Jul 13;5(10):100842. doi: 10.1016/j.jhepr.2023.100842. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Berg, Thomas; Bes, Marta; Buti, Maria; Buti, Maria; Casillas, Rosario; Esteban, Rafael; Esteban, Rafael; Palom, Adriana; Pfefferkorn, Maria; Rando-Segura, Ariadna et al.
DOI: 10.1016/j.jhepr.2023.100842

Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy's Continued Importance in Colorectal Cancer Treatment.

PMID: 37760489
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Sep 12;15(18):4520. doi: 10.3390/cancers15184520.
Impact factor:
Publication type: Paper in international publication
Authors: Clar-Marmaneu, Helena; Garcia-Fernandez, Alba Estela; Garcia-Fernandez, Francisco Javier et al.
DOI: 10.3390/cancers15184520

Impact of time of culture specimen collection on the recovery of Neisseria gonorrhoeae after a positive nucleic acid amplification test.

PMID: 37802652
Journal: SEXUALLY TRANSMITTED INFECTIONS
Year: 2023
Reference: Sex Transm Infect. 2023 Oct 6:sextrans-2023-055899. doi: 10.1136/sextrans-2023-055899.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Alvarez-Lopez, Patricia; Arando, Maider; Arando, Maider; Blanco-Grau, Albert; Curran, Adrian; Curran, Adrian; Descalzo, Vicente; El Ouazzani, Rachid; Garcia, Jorge Nestor et al.
DOI: 10.1136/sextrans-2023-055899

Solved the enigma of pediatric severe acute hepatitis of unknown origin?

PMID: 37808908
Journal: Frontiers in Cellular and Infection Microbiology
Year: 2023
Reference: Front Cell Infect Microbiol. 2023 Sep 21;13:1175996. doi: 10.3389/fcimb.2023.1175996. eCollection 2023.
Impact factor:
Publication type: Review in international publication
Authors: Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco et al.
DOI: 10.3389/fcimb.2023.1175996

Blog

News

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.