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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

HydroTheC

IP: -
Collaborators: Miriam Izquierdo Sans, Diana Fernandes de Rafael, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 221390.88
Reference: HYDROTEC_HE-MSCA-PF-GF2022
Duration: 01/01/2024 - 31/12/2026

Hacia un manejo clínico personalizado de pacientes oncológicos con fracaso renal agudo asociado a los immune-checkpoint inhibitors (ICIs)

IP: Maria Jose Soler Romeo
Collaborators: Oriol Bestard Matamoros, Sheila Bermejo Garcia, Concepció Jacobs Cachá, Elena Isabel Crespo Gimeno
Funding agency: Instituto de Salud Carlos III
Funding: 246840
Reference: AC22/00029
Duration: 01/01/2023 - 31/12/2025

Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia (Clinical Biochemistry, Drug Delivery & Therapy, CB-DDT)

IP: -
Collaborators: José Antonio Arranz Amo, Raquel Barquin Del Pino, Laura Conesa Milian, Clara Ramírez Serra, Yolanda Villena Ortiz, Joan López Hellin, Albert Blanco Grau, Roser Ferrer Costa, Joaquin Seras Franzoso, Diego Baranda Martínez-Abasca, Laura Castillo Ribelles, Clara Carnicer Cáceres, Marina Giralt Arnaiz, Ana Gomez Garcia, Simon Schwartz Navarro, Pablo Gabriel Medina, Zamira Vanessa Diaz Riascos, Marc Miquel Moltó Abad, Laura Castellote Bellés, Daniel Bravo Nieto, Luz María Cruz Carlos, Clara Sanz Gea, Alba Estela García Fernández, Maria del Pilar Reimundo Diaz-Fierros, Belen Garcia Prats, Noelia Díaz Troyano, JAUME VIMA BOFARULL, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Maria Francesca Cortese, Sandra Mancilla Zamora
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 01173
Duration: 01/01/2022 - 30/06/2025

Nefrologia i Trasplantament Renal

IP: Oriol Bestard Matamoros
Collaborators: Marina Lopez Martinez, Francesc Moreso Mateos, Natalia Ramos Terrades, Maria Jose Soler Romeo, Joana Sellarés Roig, Pamela Dominguez Baez, Irene Agraz Pamplona, Sheila Bermejo Garcia, Mariona Juvé Torres, Irina Betsabe Torres Rodriguez, Concepció Jacobs Cachá, Elena Isabel Crespo Gimeno, Laura Donadeu Casassas, Carmen Llorens Cebriá, Manel Perelló Carrascosa, Maria Antonia Emilia Meneghini
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00883
Duration: 01/01/2022 - 30/06/2025

Publications

Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.

PMID: 36872299
Journal: BRITISH JOURNAL OF PHARMACOLOGY
Year: 2023
Reference: Br J Pharmacol. 2023 Aug;180(15):1999-2017. doi: 10.1111/bph.16065. Epub 2023 Mar 29.
Impact factor:
Publication type: Paper in international publication
Authors: Bonaterra-Pastra, Anna; Castellote, Laura; Gimenez-Llort, Lydia; Hernandez-Guillamon, Mar; Marazuela, Paula; Sole, Montse et al.
DOI: 10.1111/bph.16065

Executive summary of the position statement of the Spanish Societies SEQC(ML)/SEEN/SEEP. Recommendations for the measurement of sex steroids in clinical practice.

PMID: 36894451
Journal: Endocrinologia Diabetes y Nutricion
Year: 2023
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2023 Mar 7:S2530-0180(23)00036-7. doi: 10.1016/j.endien.2023.03.004.
Impact factor:
Publication type: Paper in international publication
Authors: Argente, Jesus; Biagetti, Betina; Casals, Gregori; Escobar-Morreale, Hector F; Ferrer Costa, Roser; Sesmilo, Gemma; Urgell Rull, Eulalia et al.
DOI: 10.1016/j.endien.2023.03.004

Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI).

PMID: 37892566
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Oct 10;12(20):6422. doi: 10.3390/jcm12206422.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alvarez-Roman, Maria Teresa; Andrade, Fernanda; Barez-Garcia, Abelardo; Bernardo-Gutierrez, Angel; Bernat-Pablo, Silvia; Bolanos-Calderon, Estefania; Butta-Coll, Nora; Caballero-Navarro, Gonzalo; Canaro Hirnyk, Mariana et al.
DOI: 10.3390/jcm12206422

Comments on: Reducing the Risks of Nuclear War-The Role of Health Professionals.

PMID: 37863196
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2023
Reference: Anaesth Crit Care Pain Med. 2023 Oct 18:101314. doi: 10.1016/j.accpm.2023.101314.
Impact factor:
Publication type: Editorail in international publication
Authors: Allaouchiche, Bernard; Arias Garcia, Andrea; Arnaiz, Marina Giralt; Bastide, Sophie; Benhamou, Dan; Biais, Matthieu; Blet, Alice; Bouvet, Lionel; Bravo Nieto, Daniel; Brissaud, Olivier et al.
DOI: 10.1016/j.accpm.2023.101314

Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study.

PMID: 35844497
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Jun 29;13:902837. doi: 10.3389/fimmu.2022.902837. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Antonio; Alvarez, Antonio; Alvarez-Sierra, Daniel; Anton, Andres; Arrese-Munoz, Iria; Bas-Minguet, Jordi; Blanco-Grau, Albert; Blanco-Grau, Albert; Bosch-Nicolau, Pau; Buzon, Maria Jose et al.
DOI: 10.3389/fimmu.2022.902837

Detailed stratified GWAS analysis for severe COVID-19 in four European populations.

PMID: 35848942
Journal: HUMAN MOLECULAR GENETICS
Year: 2022
Reference: Hum Mol Genet. 2022 Nov 28;31(23):3945-3966. doi: 10.1093/hmg/ddac158.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Afset, Jan Egil; Aghemo, Alessio; Albano, Giovanni; Albillos, Agustin; Albrecht, Wolfgang; Aliberti, Stefano; Altmuller, Janine; Ampuero, Javier; Andrade, Victor et al.
DOI: 10.1093/hmg/ddac158

When Sugar Reaches the Liver: Phenotypes of Patients with Diabetes and NAFLD.

PMID: 35743358
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Jun 8;11(12). pii: jcm11123286. doi: 10.3390/jcm11123286.
Impact factor:
Publication type: Review in international publication
Authors: Banares, Juan; Ciudin, Andreea; Ferrer, Roser; Gabriel-Medina, Pablo; Manzano-Nunez, Ramiro; Martinez Selva, David; Pericas, Juan M; Rivera-Esteban, Jesus; Rojano-Toimil, Alba et al.
DOI: 10.3390/jcm11123286

Influence of Type 2 Diabetes in the Association of PNPLA3 rs738409 and TM6SF2 rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis.

PMID: 35625751
Journal: Biomedicines
Year: 2022
Reference: Biomedicines. 2022 Apr 28;10(5). pii: biomedicines10051015. doi: 10.3390/biomedicines10051015.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Ciudin, Andreea; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Pericas, Juan M; Rivera-Esteban, Jesus; Rodriguez-Frias, Francisco; Selva, David Martinez et al.
DOI: 10.3390/biomedicines10051015

Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction.

PMID: 34368505
Journal: JACC-Basic to Translational Science
Year: 2021
Reference: JACC Basic Transl Sci. 2021 Jul 26;6(7):567-580. doi: 10.1016/j.jacbts.2021.05.004. eCollection 2021 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Aluja, David; Baneras, Jordi; Barrabes, Jose A; Beneitez, David; Benito, Begona; Buera, Irene; Castellote, Laura; Delgado-Tomas, Sara; Ferreira-Gonzalez, Ignacio; Inserte, Javier et al.
DOI: 10.1016/j.jacbts.2021.05.004

Thermo-Responsive Hydrogels for Cancer Local Therapy: Challenges and State-of-Art.

PMID: 34332061
Journal: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Year: 2021
Reference: Int J Pharm. 2021 Sep 5;606:120954. doi: 10.1016/j.ijpharm.2021.120954. Epub 2021 Jul 28.
Impact factor:
Publication type: Review in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Francisco Duran-Lara, Esteban; Martinez-Trucharte, Francesc; Martinez-Trucharte, Francesc; Merce Roca Melendres, Maria; Montero, Sara; Rafael, Diana; Schwartz, Simo Jr; Vilar-Hernandez, Mireia et al.
DOI: 10.1016/j.ijpharm.2021.120954

Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy.

PMID: 34242330
Journal: PLoS One
Year: 2021
Reference: PLoS One. 2021 Jul 9;16(7):e0254243. doi: 10.1371/journal.pone.0254243. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Costafreda, Maria Isabel; Esteban, Juan Ignacio; Gabriel-Medina, Pablo; Guerrero-Murillo, Mercedes; Llorens-Revull, Meritxell; Perales, Celia; Piriz-Ruzo, Sofia; Quer, Josep; Rico, Angie et al.
DOI: 10.1371/journal.pone.0254243

Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method.

PMID: 34219919
Journal: JOURNAL OF SUPERCRITICAL FLUIDS
Year: 2021
Reference: J Supercrit Fluids. 2021 Jul;173:105204. doi: 10.1016/j.supflu.2021.105204.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alcaina-Hernando, Marta; Corchero, Jose-Luis; Cordoba, Alba; Cristobal-Lecina, Edgar; Danino, Dganit; Falk, Andreas; Font, Albert; Garcia-Aranda, Natalia; Garcia-Fruitos, Elena et al.
DOI: 10.1016/j.supflu.2021.105204

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine.

PMID: 32295053
Journal: Nanomaterials
Year: 2020
Reference: Nanomaterials (Basel). 2020 Apr 13;10(4). pii: nano10040744. doi: 10.3390/nano10040744.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Aparicio-Gomez, Carolina; Garcia, Hermenegildo; Gutierrez-Carcedo, Patricia; Herance, Jose Raul; Navalon, Sergio; Setoain, Xavier; Simo, Rafael; Victor, Victor Manuel et al.
DOI: 10.3390/nano10040744

Zileuton loaded in polymer micelles effectively reduce breast Cancer circulating tumor cells and intratumoral Cancer stem cells

PMID: 31666201
Journal: Nanomedicine-Nanotechnology Biology and Medicine
Year: 2020
Reference: Nanomedicine. 2020 Feb;24:102106. doi: 10.1016/j.nano.2019.102106. Epub 2019 Oct 27.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Arango, Diego; Diaz-Riascos, Zamira V; Gener, Petra; Gonzalez, Patricia; Manzano, Albert; Martinez-Trucharte, Francesc; Montero, Sara; Rafael, Diana et al.
DOI: 10.1016/j.nano.2019.102106

Insights into new mechanisms and models of cancer stem cell multidrug resistance.

PMID: 31369817
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2020
Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
Impact factor:
Publication type: Review in international publication
Authors: Garcia-Mayea, Y; LLeonart, M E; Masson, F; Mir, C; Paciucci, R et al.
DOI: 10.1016/j.semcancer.2019.07.022

Unexpected long-lasting anti-HEV IgM positivity: Is HEV antigen a better serological marker for hepatitis E infection diagnosis?

PMID: 32106351
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2020
Reference: J Viral Hepat. 2020 Jul;27(7):747-753. doi: 10.1111/jvh.13285. Epub 2020 Mar 11.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Bes, Marta; Buti, Maria; Esteban, Rafael; Piron, Maria; Quer, Josep; Rando-Segura, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruzo, Sofia P et al.
DOI: 10.1111/jvh.13285

Apolipoprotein A-Ib as a biomarker of FSGS recurrence after kidney transplantation: Diagnostic performance and assessment of its prognostic value - a multi-centre cohort study.

PMID: 30411406
Journal: TRANSPLANT INTERNATIONAL
Year: 2019
Reference: Transpl Int. 2019 Mar;32(3):313-322. doi: 10.1111/tri.13372. Epub 2018 Nov 28.
Impact factor:
Publication type: Paper in international publication
Authors: Angel, Alonso; Beneyto, Isabel; Cantarell, Carmen; Crespo, Marta; Fernandez, Ana; Franco, Antonio; Gonzalez Roncero, Francisco; Guirado, Lluis; Hernandez, Domingo; Jacobs-Cacha, Conxita et al.
DOI: 10.1111/tri.13372

Seasonal variations of changes in lipid and glucidic variables after bariatric surgery.

PMID: 30351989
Journal: CHRONOBIOLOGY INTERNATIONAL
Year: 2019
Reference: Chronobiol Int. 2019 Feb;36(2):250-257. doi: 10.1080/07420528.2018.1533560. Epub 2018 Oct 23.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan A; Balibrea, Jose Maria; Cambras, Trinitat; Carmona, Julia; Caubet, Enric; Cuello, Elena; Diez-Noguera, Antoni; Ferrer, Roser; Fort, Jose Manuel; Gonzalez, Oscar et al.
DOI: 10.1080/07420528.2018.1533560

Sex hormones and their influence on chronic kidney disease.

PMID: 30320621
Journal: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Year: 2019
Reference: Curr Opin Nephrol Hypertens. 2019 Jan;28(1):1-9. doi: 10.1097/MNH.0000000000000463.
Impact factor:
Publication type: Paper in international publication
Authors: Jacobs-Cacha, Conxita; Soler, Maria Jose; Valdivielso, Jose Manuel et al.
DOI: 10.1097/MNH.0000000000000463

Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells.

PMID: 30483800
Journal: ONCOLOGY REPORTS
Year: 2019
Reference: Oncol Rep. 2019 Feb;41(2):1275-1283. doi: 10.3892/or.2018.6885. Epub 2018 Nov 26.
Impact factor:
Publication type: Paper in international publication
Authors: Castellon, E A; Contreras, H R; Herrera, D; Orellana-Serradell, O; Paciucci, R; Torres, M J; Villar, P et al.
DOI: 10.3892/or.2018.6885

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy.

PMID: 29785078
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2018
Reference: World J Gastroenterol. 2018 May 21;24(19):2095-2107. doi: 10.3748/wjg.v24.i19.2095.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casillas, Rosario; Cortese, Maria Francesca; Esteban, Rafael; Godoy, Cristina; Gonzalez, Carolina; Gregori, Josep; Lopez-Martinez, Rosa; Quer, Josep; Rando, Ariadna et al.
DOI: 10.3748/wjg.v24.i19.2095

Erratum to "A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-beta induction" [J Hepatol 67 (2017) 669-679].

PMID: 29776712
Journal: JOURNAL OF HEPATOLOGY
Year: 2018
Reference: J Hepatol. 2018 Jul;69(1):262-264. doi: 10.1016/j.jhep.2018.04.003.
Impact factor:
Publication type: Letter or abstract
Authors: Aldabe, Rafael; Buti, Maria; Di Scala, Marianna; Godoy, Cristina; Gonzalez-Aseguinolaza, Gloria; Hommel, Mirja; Ni, Yi; Olague, Cristina; Palomo, Laura; Prieto, Jesus et al.
DOI: 10.1016/j.jhep.2018.04.003

Amino acid substitutions within HLA-B*27-restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells.

PMID: 29669837
Journal: JOURNAL OF VIROLOGY
Year: 2018
Reference: J Virol. 2018 Jun 13;92(13). pii: JVI.01891-17. doi: 10.1128/JVI.01891-17. Print 2018 Jul 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alavian, Seyed Moayed; Antes, Iris; Bauer, Tanja; Budeus, Bettina; Buti, Maria; Fiedler, Melanie; Glaser, Manuel; Grabowski, Jan; Heinold, Andreas; Hoffmann, Daniel et al.
DOI: 10.1128/JVI.01891-17

AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells.

PMID: 29667444
Journal: DRUG DELIVERY
Year: 2018
Reference: Drug Deliv. 2018 Nov;25(1):961-972. doi: 10.1080/10717544.2018.1461276.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Arango, Diego; Fernandez, Yolanda; Florindo, Helena F; Gener, Petra; Hidalgo, Manuel; Montero, Sara; Rafael, Diana; Sayos, Joan et al.
DOI: 10.1080/10717544.2018.1461276

Serum Hepatitis B core-related antigen is more accurate than HBsAg to identify inactive carriers, regardless of HBV genotype.

PMID: 28288829
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2017
Reference: Clin Microbiol Infect. 2017 Nov;23(11):860-867. doi: 10.1016/j.cmi.2017.03.003. Epub 2017 Mar 11.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Buti, Maria; Casillas, Rosario; Esteban, Rafael; Homs, Maria; Nieto, Leonardo; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruiz, Alicia; Sauleda, Silvia et al.
DOI: 10.1016/j.cmi.2017.03.003

Assessment of Bone Health in Patients with Type 1 Gaucher Disease Using Impact Microindentation.

PMID: 28263001
Journal: JOURNAL OF BONE AND MINERAL RESEARCH
Year: 2017
Reference: J Bone Miner Res. 2017 Jul;32(7):1575-1581. doi: 10.1002/jbmr.3121. Epub 2017 May 11.
Impact factor:
Publication type: Paper in international publication
Authors: Cabezudo, Elena; Diez-Perez, Adolfo; Esteve, Jordi; Guerri-Fernandez, Roberto; Hernandez, Albert; Herrera, Sabina; Molto-Abad, Marc; Nogues, Xavier; Novelli, Silvana; Perez-Lopez, Jordi et al.
DOI: 10.1002/jbmr.3121

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis.

PMID: 28262839
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Mar 6;7:43702. doi: 10.1038/srep43702.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Afonso, Elsa; Andretta, Elena; Arango, Diego; Bazzocco, Sarah; Bilic, Josipa; Cacci, Karina; Carton-Garcia, Fernando; de Marcondes, Priscila Guimaraes; Del Llano, Edgar et al.
DOI: 10.1038/srep43702

Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (The GEHEP 005 study).

PMID: 28248445
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2017
Reference: J Viral Hepat. 2017 Sep;24(9):725-732. doi: 10.1111/jvh.12700. Epub 2017 Apr 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Antonio; Alados, Juan Carlos; Benitez, Laura; Bernal, Samuel; Cardenoso, Laura; Casas, Paz; Coletta, Eleda; de la Iglesia, Alberto; Del Carmen Lozano, Maria; Echevarria, Maria Julia et al.
DOI: 10.1111/jvh.12700

Self-assembly PEGylation assists SLN-Paclitaxel delivery inducing cancer cell apoptosis upon internalization.

PMID: 26853316
Journal: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Year: 2016
Reference: Int J Pharm. 2016 Mar 30;501(1-2):180-9. doi: 10.1016/j.ijpharm.2016.01.075. Epub 2016 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Arranja, Alexandra; Gener, Petra; Gouveia, Luis F; Pereira, Carolina; Rafael, Diana F; Schwartz, Simo Jr; Videira, Mafalda A et al.
DOI: 10.1016/j.ijpharm.2016.01.075

The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation.

PMID: 25927603
Journal: PLOS ONE
Year: 2015
Reference: PLoS One. 2015 Apr 30;10(4):e0123928. doi: 10.1371/journal.pone.0123928. eCollection 2015.
Impact factor:
Publication type: Paper in international publication
Authors: Ejarque-Ortiz, Aroa; Martin, Margarita; Martinez-Barriocanal, Agueda; Peluffo, Hugo; Sayos, Joan; Schwartz, Simo Jr; Sola, Carme et al.
DOI: 10.1371/journal.pone.0123928

HIGHLY EXPRESSED GENES IN RAPIDLY PROLIFERATING TUMOR CELLS AS NEW TARGETS FOR COLORECTAL CANCER TREATMENT.

PMID: 25944804
Journal: CLIN CANCER RES
Year: 2015
Reference: Clin Cancer Res. 2015 Aug 15;21(16):3695-704. doi: 10.1158/1078-0432.CCR-14-2457. Epub 2015 May 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alazzouzi, Hafid; Andretta, Elena; Arango, Diego; Bazzocco, Sarah; Bilic, Josipa; Carton-Garcia, Fernando; Chionh, Fiona; Dopeso, Higinio; Garrido, Miriam; Macaya, Irati et al.
DOI: 10.1158/1078-0432.CCR-14-2457

Strategies for the production of difficult-to-express full-length eukaryotic proteins using microbial cell factories: production of human alpha-galactosidase A.

PMID: 25616525
Journal: APPL MICROBIOL BIOT
Year: 2015
Reference: Appl Microbiol Biotechnol. 2015 Jul;99(14):5863-74. doi: 10.1007/s00253-014-6328-9. Epub 2015 Jan 24.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Accardi, Giulia; Corchero, Jose L; Ferrer-Miralles, Neus; Giuliani, Maria; Mendoza, Rosa; Parrilli, Ermenegilda; Sannino, Filomena; Schwartz, Simo Jr; Toledo-Rubio, Veronica et al.
DOI: 10.1007/s00253-014-6328-9

Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile.

PMID: 26046314
Journal: EUR J MED CHEM
Year: 2015
Reference: Eur J Med Chem. 2015 Jun 24;99:67-81. doi: 10.1016/j.ejmech.2015.05.018. Epub 2015 May 14.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Fernandez-Bolanos, Jose G; Lopez, Oscar; Merino-Montiel, Penelope; Meza-Reyes, Socorro; Montiel-Smith, Sara; Romero-Hernandez, Laura L; Schwartz, Simo Jr; Vega-Baez, Jose Luis et al.
DOI: 10.1016/j.ejmech.2015.05.018

Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1.

PMID: 23455324
Journal: ONCOGENE
Year: 2014
Reference: Oncogene. 2014 Feb 27;33(9):1124-34. doi: 10.1038/onc.2013.51. Epub 2013 Mar 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, I; Bermudo, R; Canovas, V; Castellon, E; Celia-Terrassa, T; Contreras, H; de Torres, I; Fernandez, P L; Fernandez, Y; Marques, N et al.
DOI: 10.1038/onc.2013.51

Bariatric surgery in morbidly obese patients improves the atherogenic qualitative properties of the plasma lipoproteins.

PMID: 24674904
Journal: ATHEROSCLEROSIS
Year: 2014
Reference: Atherosclerosis. 2014 May;234(1):200-5. doi: 10.1016/j.atherosclerosis.2014.02.034. Epub 2014 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Blanco-Vaca, Francisco; Ferrer, Roser; Fort, Jose Manuel; Julve, Josep; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Perez-Cuellar, Montserrat; Rossell, Joana et al.
DOI: 10.1016/j.atherosclerosis.2014.02.034

Early predictors of antiviral treatment response in liver transplant recipients with recurrent hepatitis C genotype 1.

PMID: 24620835
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Bes, M; Campos-Varela, I; Caralt, M; Castells, L; Charco, R; Esteban, J I; Esteban, R; Guardia, J; Rodriguez-Frias, F et al.
DOI: 10.1111/jvh.12246

[Value of soluble urokinase receptor serum levels in the differential diagnosis between idiopathic and secondary focal segmental glomerulosclerosis].

PMID: 24463863
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(1):53-61. doi: 10.3265/Nefrologia.pre2013.Oct.12272.
Impact factor:
Publication type: Paper in national publication
Authors: Arbos, M Antonia; Carnicer, Clara; Jatem, Elias; Ostos, Helena; Quiles, M Teresa; Salcedo, M Teresa; Segarra, Alfons; Valtierra, Naiara et al.
DOI: 10.3265/Nefrologia.pre2013.Oct.12272

A Form of Apolipoprotein A-I Is Found Specifically in Relapses of Focal Segmental Glomerulosclerosis Following Transplantation.

PMID: 23205849
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2013
Reference: Am J Transplant. 2013 Feb;13(2):493-500. doi: 10.1111/j.1600-6143.2012.04338.x. Epub 2012 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, A; Burgos, D; Cantarell, C; Fernandez, A; Fernandez-Alvarez, P; Gonzalez-Roncero, F M; Guirado, L; Jacobs-Cacha, C; Jimenez, C; Jimeno, L et al.
DOI: 10.1111/j.1600-6143.2012.04338.x

Twelve-Week Posttreatment Follow-Up to Predict Sustained Virologic Response for Recurrent Hepatitis C Infection in Liver Recipients.

PMID: 22262129
Journal: TRANSPLANTATION
Year: 2012
Reference: Transplantation. 2012 Feb 27;93(4):450-3. doi: 10.1097/TP.0b013e318240e9dd.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/TP.0b013e318240e9dd

A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

PMID: 22155090
Journal: TOXICOLOGY AND APPLIED PHARMACOLOGY
Year: 2012
Reference: Toxicol Appl Pharmacol. 2012 Jan 15;258(2):275-87. doi: 10.1016/j.taap.2011.11.007. Epub 2011 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1016/j.taap.2011.11.007

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Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.