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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Clara Carnicer Cáceres

Clara Carnicer Cáceres

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Daniel Bravo Nieto

Daniel Bravo Nieto

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Clara Carnicer Cáceres

Clara Carnicer Cáceres

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Daniel Bravo Nieto

Daniel Bravo Nieto

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Projects

(HEPAST) - Estrategias de terapia genica para controlar la infeccion por los virus de la Hepatitis B y Delta basada en el estudio de las cuasiespecies virales por secuenciación masiva

IP: -
Collaborators: Roser Ferrer Costa
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 157300
Reference: PID2021-126447OB-I00
Duration: 01/09/2022 - 01/09/2025

Ministerio de Ciencia

Estudio de quasispecies por metagenómica en neuropatías asociadas a virus por secuenciación masiva de nueva generación.

IP: Josep Quer Sivila
Collaborators: Sergi Colomer Castell, Marta Ibañez Lligoña, Lluís Viladomiu Catà, Damir Garcia Cehic, Maria Piñana Moro, Pablo Gabriel Medina, Arnau Llauradó Gayete, Carolina Campos Martinez, Alejandra Gonzalez Sánchez
Funding agency: Instituto de Salud Carlos III
Funding: 292820
Reference: PI22/00258
Duration: 01/01/2023 - 31/12/2025

Impacto y valor pronóstico de vesículas extracelulares tumorales provenientes de células madre cancerígenas en tumores de mama triple negativo.

IP: Joaquin Seras Franzoso
Collaborators: Laura García Latorre, Diego Baranda Martínez-Abasca, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Belen Garcia Prats
Funding agency: Instituto de Salud Carlos III
Funding: 99220
Reference: PI22/01301
Duration: 01/01/2023 - 31/12/2025

RICORS2040 - Inflamación e inmunopatología de órganos y sistemas

IP: Maria Jose Soler Romeo
Collaborators: Francesc Moreso Mateos, Oriol Bestard Matamoros, Joana Sellarés Roig, Irina Betsabe Torres Rodriguez, Concepció Jacobs Cachá, Maria Antonia Emilia Meneghini
Funding agency: Instituto de Salud Carlos III
Funding: 105765
Reference: RD21/0005/0016
Duration: 01/01/2022 - 31/12/2024

Publications

Accuracy of a sequential algorithm based on FIB-4 and ELF to identify high-risk advanced liver fibrosis at the primary care level.

PMID: 37952070
Journal: Internal and Emergency Medicine
Year: 2023
Reference: Intern Emerg Med. 2023 Nov 11. doi: 10.1007/s11739-023-03441-2.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Augustin, Salvador; Campo, Elias; Casanueva-Eliceiry, Sebastian; Ciudin, Andreea; Correa, Juan Gonzalo; Delgado, Julio; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Gine, Eva et al.
DOI: 10.1007/s11739-023-03441-2

Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial.

PMID: 37963304
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2023
Reference: J Clin Oncol. 2023 Nov 14:JCO2300339. doi: 10.1200/JCO.23.00339.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Neeraj; Augustin, Salvador; Barnicle, Alan; Chi, Kim N; Ciudin, Andreea; de Bono, Johann S; Ferrer-Costa, Roser; Fizazi, Karim; Gabriel-Medina, Pablo; Hussain, Maha et al.
DOI: 10.1200/JCO.23.00339

Formation of an invasion-permissive matrix requires TGFbeta/SNAIL1-regulated alternative splicing of fibronectin.

PMID: 37964360
Journal: BREAST CANCER RESEARCH
Year: 2023
Reference: Breast Cancer Res. 2023 Nov 14;25(1):143. doi: 10.1186/s13058-023-01736-y.
Impact factor:
Publication type: Paper in international publication
Authors: Baulida, Josep; Benitez-Carbante, Maria Isabel; Diaz de Heredia, Cristina; Eyras, Eduardo; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Franco-Valls, Hector; Garcia de Herreros, Antonio; Grau Cerrato, Santiago; Iaconcig, Alessandra et al.
DOI: 10.1186/s13058-023-01736-y

Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica(R) IM Solution Immunoassay Analyzer.

PMID: 37996255
Journal: ANNALS OF CLINICAL BIOCHEMISTRY
Year: 2023
Reference: Ann Clin Biochem. 2023 Nov 23:45632231219387. doi: 10.1177/00045632231219387.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Monica Viegas; Blanco, Albert; Bracarense, Henrique; Braga, Paulo Estevao Franco; Comas, Immaculada; Conesa, Laura; de Miranda, Maria Carolina Correa; de Souza, Aline; Diaz-Troyano, Noelia; Ferrer, Roser et al.
DOI: 10.1177/00045632231219387

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.