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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Estudio de la quasiespecies del gen X en ARN circulante del virus de la hepatitis B (ARN-VHB): en búsqueda de nuevos factores pronósticos y dianas para terapia génica.

IP: -
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: FI19/00025
Duration: 23/01/2020 - 22/01/2024

Design of Nanoparticles for Blood-Brain-Barrier Crossing and Glioblastoma Multiforme Cancer Stem Cells Targeting (NanoGlio)

IP: Ibane Abasolo Olaortua
Collaborators: Fernanda Raquel Da Silva Andrade, Miriam Izquierdo Sans
Funding agency: Asociación Española Contra el Cáncer
Funding: 100000
Reference: INVES211530DASI
Duration: 01/09/2021 - 31/08/2025

Vehiculización de proteínas terapéuticas mediante vesículas extracelulares para el tratamiento de enfermedades huérfanas

IP: Ibane Abasolo Olaortua
Collaborators: Diego Baranda Martínez-Abasca, Miriam Izquierdo Sans
Funding agency: Ministerio de Educación, Cultura y Deporte
Funding: 59223.42
Reference: FPU20/04210
Duration: 01/12/2021 - 31/03/2025

Mejora del tratamiento de las enfermedades de depósito lisosomal mediante vehículos nanométricos optimizados

IP: Ibane Abasolo Olaortua
Collaborators: Marc Miquel Moltó Abad, Miriam Izquierdo Sans
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 90306.55
Reference: SLT017/20/000181
Duration: 05/07/2021 - 31/12/2024

Publications

Electronic health records (EHRs) in clinical research and platform trials: application of the innovative EHR-based methods developed by EU-PEARL.

PMID: 38000766
Journal: JOURNAL OF BIOMEDICAL INFORMATICS
Year: 2023
Reference: J Biomed Inform. 2023 Nov 22:104553. doi: 10.1016/j.jbi.2023.104553.
Impact factor:
Publication type: Paper in international publication
Authors: Amasi-Hartoonian, Nare; Ammour, Nadir; Begum, Amina; Blanco, Albert; Brown, Mollie; Comas, Immaculada; Conesa, Laura; Couvert, Camille; Diaz-Troyano, Noelia; Didden, Eva-Maria et al.
DOI: 10.1016/j.jbi.2023.104553

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.

PMID: 38030066
Journal:
Year: 2023
Reference: J Sport Health Sci. 2023 Nov 27:S2095-2546(23)00115-1. doi: 10.1016/j.jshs.2023.11.006.
Impact factor:
Publication type: Paper in international publication
Authors: Alejo, Lidia B; Barranco-Gil, David; Bestard, Oriol; Bustos, Asuncion; Castellote-Belles, Laura; Couzi, Lionel; Fernandez-Ruiz, Mario; Ferrer-Costa, Roser; Kaminski, Hannah; Lucia, Alejandro et al.
DOI: 10.1016/j.jshs.2023.11.006

Postoperative complications after pancreatoduodenectomy for malignancy: results from the Recurrence After Whipple's (RAW) study.

PMID: 38036696
Journal: BJS Open
Year: 2023
Reference: BJS Open. 2023 Nov 1;7(6):zrad106. doi: 10.1093/bjsopen/zrad106.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Sarrieh, Bilal A; Alejo, Lidia B; Alhaboob, Nassir; Aroori, Somaiah; Ausania, Fabio; Bari, Hassaan; Barranco-Gil, David; Bhogal, Ricky H; Bustos, Asuncion; Castellote-Belles, Laura et al.
DOI: 10.1093/bjsopen/zrad106

Prevalence and Risk Factors of MASLD and Liver Fibrosis amongst the Penitentiary Population in Catalonia: The PRISONAFLD Study.

PMID: 38068330
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Nov 24;12(23):7276. doi: 10.3390/jcm12237276.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Guerrero, Rafael A; Jimenez-Masip, Alba; Marco, Andres; Munoz-Martinez, Sergio; On Behalf Of The Prisonafld Study Group Collaborators; Pericas, Juan M; Rivera-Esteban, Jesus et al.
DOI: 10.3390/jcm12237276

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.