About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.
With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.
In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.
IP: Marta Martínez Vicente Collaborators: José Antonio Arranz Amo, Eddie Pradas Gracia, Laura Castillo Ribelles, Clara Carnicer Cáceres, David Moreno Martinez, Jordi Riera Heredia, New nanotechnological therapy for Parkinson's disease: nose-to-brain delivery of GBA-polymer nanoconjugates (NANOGBAtoBRAIN), Pablo Castillo Sánchez Funding agency: Fundació "La Caixa" Funding: 249950 Reference: HR22-00602 Duration: 01/11/2022 - 31/10/2025
IP: - Collaborators: Roser Ferrer Costa Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 157300 Reference: PID2021-126447OB-I00 Duration: 01/09/2022 - 31/08/2025
IP: Josep Quer Sivila Collaborators: Sergi Colomer Castell, Marta Ibañez Lligoña, Lluís Viladomiu Catà, Damir Garcia Cehic, Maria Piñana Moro, Pablo Gabriel Medina, Arnau Llauradó Gayete, Carolina Campos Martinez, Alejandra Gonzalez Sánchez Funding agency: Instituto de Salud Carlos III Funding: 292820 Reference: PI22/00258 Duration: 01/01/2023 - 31/12/2025
IP: Joaquin Seras Franzoso Collaborators: Laura García Latorre, Diego Baranda Martínez-Abasca, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Belen Garcia Prats Funding agency: Instituto de Salud Carlos III Funding: 99220 Reference: PI22/01301 Duration: 01/01/2023 - 31/12/2025
PMID: 36986692 Journal: Pharmaceutics Year: 2023 Reference: Pharmaceutics. 2023 Mar 3;15(3):831. doi: 10.3390/pharmaceutics15030831. Impact factor: Publication type: Review in international publication Authors: Abasolo, Ibane; Andrade, Fernanda; German-Cortes, Julia; Rafael, Diana; Vilar-Hernandez, Mireia et al. DOI: 10.3390/pharmaceutics15030831
PMID: 37033229 Journal: Frontiers in Endocrinology Year: 2023 Reference: Front Endocrinol (Lausanne). 2023 Mar 22;14:1129213. doi: 10.3389/fendo.2023.1129213. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Aulinas, Anna; Biagetti, Betina; Blanco, Alberto; Carrato, Cristina; Casano-Sancho, Paula; Cordero, Esteban; Gil, Joan; Hostalot, Cristina; Ibanez-Dominguez, Javier; Jorda, Mireia et al. DOI: 10.3389/fendo.2023.1129213
PMID: 37242726 Journal: Pharmaceutics Year: 2023 Reference: Pharmaceutics. 2023 May 12;15(5):1484. doi: 10.3390/pharmaceutics15051484. Impact factor: Publication type: Review in international publication Authors: Arango, Diego; Clark, Simon J; Duran-Lara, Esteban F; Ferrer, Roser; Ferrer, Roser; Guerrero, Marcelo; Marican, Adolfo; Rafael, Diana; Sarmento, Bruno; Schwartz, Simo Jr et al. DOI: 10.3390/pharmaceutics15051484
PMID: 37376135 Journal: Pharmaceutics Year: 2023 Reference: Pharmaceutics. 2023 Jun 8;15(6):1686. doi: 10.3390/pharmaceutics15061686. Impact factor: Publication type: Review in international publication Authors: Abasolo, Ibane; Andrade, Fernanda; Baranda-Martinez-Abascal, Diego; Baranda-Martinez-Abascal, Diego; Carcavilla, Pilar; Diaz-Riascos, Zamira Vanessa; German-Cortes, Julia; Molto-Abad, Marc; Montero, Sara; Rafael, Diana et al. DOI: 10.3390/pharmaceutics15061686
PMID: 35625929 Journal: Biomedicines Year: 2022 Reference: Biomedicines. 2022 May 21;10(5). pii: biomedicines10051194. doi: 10.3390/biomedicines10051194. Impact factor: Publication type: Paper in international publication Authors: Buti, Maria; Caballero-Garralda, Andrea; Cortese, Maria Francesca; Ferrer-Costa, Roser; Garcia-Garcia, Selene; Gregori, Josep; Homs, Maria; Pacin-Ruiz, Beatriz; Pumarola, Tomas; Quer, Josep et al. DOI: 10.3390/biomedicines10051194
PMID: 35588100 Journal: PLoS One Year: 2022 Reference: PLoS One. 2022 May 19;17(5):e0268522. doi: 10.1371/journal.pone.0268522. eCollection 2022. Impact factor: Publication type: Paper in international publication Authors: Blanco-Grau, Albert; Brouwer, Nannette; Casis, Ernesto; Cobbaert, Christa M; den Elzen, Wendy P J; Ferrer-Costa, Roser; Martinez-Sanchez, Luisa; Noordam, Raymond; Rodriguez-Frias, Francisco; Thelen, Marc et al. DOI: 10.1371/journal.pone.0268522
PMID: 35555847 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2022 Reference: J Viral Hepat. 2022 Jul;29(7):579-583. doi: 10.1111/jvh.13686. Epub 2022 May 23. Impact factor: Publication type: Paper in international publication Authors: Barreira, Ana; Buti, Maria; Casado, Miguel Angel; Dominguez-Hernandez, Raquel; Esteban, Rafael; Martinez-Camprecios, Joan; Palom, Adriana; Rando-Segura, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco et al. DOI: 10.1111/jvh.13686
PMID: 35453934 Journal: Diagnostics Year: 2022 Reference: Diagnostics (Basel). 2022 Apr 1;12(4). pii: diagnostics12040886. doi: 10.3390/diagnostics12040886. Impact factor: Publication type: Paper in international publication Authors: Barquin-DelPino, Raquel; Castillo-Ribelles, Laura; Diaz-Troyano, Noelia; Esteban, Angels; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Hernandez-Gonzalez, Manuel; Klammer, Martin; Pumarola, Tomas; Rodriguez-Frias, Francisco et al. DOI: 10.3390/diagnostics12040886
PMID: 34200506 Journal: Journal of Fungi Year: 2021 Reference: J Fungi (Basel). 2021 Jun 7;7(6). pii: jof7060456. doi: 10.3390/jof7060456. Impact factor: Publication type: Paper in international publication Authors: Benitez Carabante, Maria Isabel; Diaz-de-Heredia, Cristina; Martin-Gomez, Maria Teresa; Mendoza-Palomar, Natalia; Renedo Miro, Berta; Soler-Palacin, Pere; Valle-T-Figueras, Jose Maria; Vima Bofarull, Jaume et al. DOI: 10.3390/jof7060456
PMID: 34181772 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2021 Reference: Aliment Pharmacol Ther. 2021 Aug;54(4):462-469. doi: 10.1111/apt.16485. Epub 2021 Jun 28. Impact factor: Publication type: Paper in international publication Authors: Barreira, Ana; Berenguer-Hayme, Marina; Buti, Maria; Carvalho-Gomes, Angela; Esteban, Rafael; Garcia-Eliz, Maria; Garcia-Samaniego, Javier; Hernandez-Evole, Helena; Isabel Gil-Garcia, Ana; Lens, Sabela et al. DOI: 10.1111/apt.16485
PMID: 34160295 Journal: Nanomedicine Year: 2021 Reference: Nanomedicine (Lond). 2021 Jul;16(17):1471-1485. doi: 10.2217/nnm-2021-0013. Epub 2021 Jun 23. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Ibane; Abu-Serie, Marwa M; Andrade, Fernanda; Camara-Sanchez, Patricia; Diaz-Riascos, Zamira V; Gener, Petra; Rafael, Diana; Schwartz, Simo Jr; Seras-Franzoso, Joaquin et al. DOI: 10.2217/nnm-2021-0013
PMID: 34069888 Journal: Journal of Clinical Medicine Year: 2021 Reference: J Clin Med. 2021 May 18;10(10). pii: jcm10102174. doi: 10.3390/jcm10102174. Impact factor: Publication type: Paper in international publication Authors: Agraz, Irene; Gabaldon, Maria-Alejandra; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Moreso, Francesc; Puig-Gay, Natalia; Sellares, Joana; Seron, Daniel; Soler, Maria Jose; Vergara, Ander et al. DOI: 10.3390/jcm10102174
PMID: 32098204 Journal: Pharmaceutics Year: 2020 Reference: Pharmaceutics. 2020 Feb 21;12(2). pii: pharmaceutics12020185. doi: 10.3390/pharmaceutics12020185. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Ibane; Andrade, Fernanda; Arango, Diego; Martinez-Trucharte, Francesc; Montero, Sara; Quesada, Manuel; Rafael, Diana; Schwartz, Simo Jr; Seras-Franzoso, Joaquin; Vilar-Hernandez, Mireia et al. DOI: 10.3390/pharmaceutics12020185
PMID: 32094085 Journal: ANALES DE PEDIATRIA Year: 2020 Reference: An Pediatr (Barc). 2020 Dec;93(6):417-419. doi: 10.1016/j.anpedi.2020.01.008. Epub 2020 Feb 21. Impact factor: Publication type: Letter whit IF Authors: Clemente Leon, Maria; Ferrer Costa, Roser; Puerto Carranza, Elsa; Pujol Borrell, Ricard; Scatti Regas, Aina et al. DOI: 10.1016/j.anpedi.2020.01.008
PMID: 32075316 Journal: Pharmaceutics Year: 2020 Reference: Pharmaceutics. 2020 Feb 15;12(2). pii: pharmaceutics12020157. doi: 10.3390/pharmaceutics12020157. Impact factor: Publication type: Paper in international publication Authors: Andrade, Fernanda; Aris, Anna; Boon, Lise; Cano-Garrido, Olivia; Garcia-Fruitos, Elena; Gifre-Renom, Laia; Martens, Erik; Martinez-Trucharte, Francesc; Opdenakker, Ghislain; Rafael, Diana et al. DOI: 10.3390/pharmaceutics12020157
PMID: 32046355 Journal: Journal of Clinical Medicine Year: 2020 Reference: J Clin Med. 2020 Feb 8;9(2). pii: jcm9020472. doi: 10.3390/jcm9020472. Impact factor: Publication type: Review in international publication Authors: Garcia-Fernandez, Nuria; Jacobs-Cacha, Conxita; Mora-Gutierrez, Jose Maria; Orbe, Josune; Soler, Maria Jose; Vergara, Ander et al. DOI: 10.3390/jcm9020472
PMID: 29198640 Journal: Clinical Genitourinary Cancer Year: 2018 Reference: Clin Genitourin Cancer. 2018 Apr;16(2):e491-e496. doi: 10.1016/j.clgc.2017.10.025. Epub 2017 Dec 2. Impact factor: Publication type: Paper in international publication Authors: Carles, Joan; Celma, Ana; Comas, Inma; Ferrer, Roser; Maldonado, Xavier; Morote, Juan; Placer, Jose; Planas, Jacques; Regis, Lucas et al. DOI: 10.1016/j.clgc.2017.10.025
PMID: 29127040 Journal: Nanomedicine-Nanotechnology Biology and Medicine Year: 2018 Reference: Nanomedicine. 2018 Feb;14(2):257-267. doi: 10.1016/j.nano.2017.10.009. Epub 2017 Nov 7. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Ibane; Albericio, Fernando; Aviles, Pablo; Calvo, Pilar; Fernandez, Yolanda; Foradada, Laia; Garcia-Aranda, Natalia; Guillen, Maria Jose; Rocas, Josep; Rocas, Pau et al. DOI: 10.1016/j.nano.2017.10.009
PMID: 28259362 Journal: Actas Urologicas Espanolas Year: 2018 Reference: Actas Urol Esp. 2018 Mar;42(2):86-93. doi: 10.1016/j.acuro.2017.01.007. Epub 2017 Mar 2. Impact factor: Publication type: Review in national publication Authors: Celma, A; Comas, I; Ferrer, R; Morote, J; Planas, J; Regis, L et al. DOI: 10.1016/j.acuro.2017.01.007
PMID: 29482911 Journal: NEUROMUSCULAR DISORDERS Year: 2018 Reference: Neuromuscul Disord. 2018 Apr;28(4):374-375. doi: 10.1016/j.nmd.2018.01.011. Epub 2018 Jan 31. Impact factor: Publication type: Letter or abstract Authors: Ariatti, Lorenzo Alessandra; Carnicer-Caceres, Clara; Carreno-Gago, Lidia; de Luna, Noemi; Garcia-Arumi, Elena; Pinos, Tomas; Russignan, Anna; Scarpelli, Mauro; Tonin, Paola; Verriello, Grazia Devigili et al. DOI: 10.1016/j.nmd.2018.01.011
PMID: 28124681 Journal: Revista Espanola de Salud Publica Year: 2017 Reference: Rev Esp Salud Publica. 2017 Jan 25;91. pii: e201701009. Impact factor: Publication type: Paper in national publication Authors: Carrascosa Lezcano, Antonio; Ferrer Costa, Roser; Garcia-Algar, Oscar; Manzano Varo, Cristina; Mur Sierra, Antonio; Ortigosa Gomez, Sandra; Yeste Fernandez, Diego et al. DOI:
PMID: 28192235 Journal: CLINICAL MICROBIOLOGY AND INFECTION Year: 2017 Reference: Clin Microbiol Infect. 2017 Oct;23(10):775.e1-775.e6. doi: 10.1016/j.cmi.2017.02.007. Epub 2017 Feb 10. Impact factor: Publication type: Paper in international publication Authors: Asensio, Miriam; Augustin, Salvador; Blasi, Maria; Buti, Maria; Carbonell, Judit; Casillas, Rosario; Castells, Lluis; Chen, Qian; Esteban, Juan Ignacio; Esteban, Rafael et al. DOI: 10.1016/j.cmi.2017.02.007
PMID: 28107169 Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Year: 2017 Reference: Clin Chem Lab Med. 2017 Aug 28;55(9):1276-1283. doi: 10.1515/cclm-2016-0842. Impact factor: Publication type: Paper in international publication Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Miravitlles, Marc; Rodriguez, Esther; Rodriguez-Frias, Francisco et al. DOI: 10.1515/cclm-2016-0842
PMID: 26003454 Journal: APPL MICROBIOL BIOT Year: 2015 Reference: Appl Microbiol Biotechnol. 2015 Sep;99(17):7079-88. doi: 10.1007/s00253-015-6684-0. Epub 2015 May 24. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Ibane; Corchero, Jose Luis; Ferrer-Miralles, Neus; Mendoza, Rosa; Rodriguez-Carmona, Escarlata; Ruiz-Canovas, Eugenia; Schwartz, Simo Jr; Villaverde, Antonio et al. DOI: 10.1007/s00253-015-6684-0
PMID: 25027067 Journal: ARCH BRONCONEUMOL Year: 2015 Reference: Arch Bronconeumol. 2015 Apr;51(4):185-92. doi: 10.1016/j.arbres.2014.05.008. Epub 2014 Jul 12. Impact factor: Publication type: Paper in national publication Authors: Blanco, Ignacio; Bustamante, Ana; Cadenas, Sergio; Casas, Francisco; Hernandez, Jose M; Lara, Beatriz; Lazaro, Lourdes; Martinez, Maria Teresa; Miravitlles, Marc; Rodriguez, Esther et al. DOI: 10.1016/j.arbres.2014.05.008
PMID: 25619882 Journal: CURR GENE THER Year: 2015 Reference: Curr Gene Ther. 2015;15(3):300-12. Impact factor: Publication type: Review in international publication Authors: Abasolo, I; Doktorovova, S; Florindo, H F; Gener, P; Rafael, D; Schwartz, S; Videira, M A et al. DOI:
PMID: 25378574 Journal: J CLIN MICROBIOL Year: 2015 Reference: J Clin Microbiol. 2015 Jan;53(1):219-26. doi: 10.1128/JCM.02093-14. Epub 2014 Nov 5. Impact factor: Publication type: Paper in international publication Authors: Allende, Helena; Alvarez-Tejado, Miguel; Belmonte, Irene; Bes, Marta; Blasi, Maria; Briones, Carlos; Buti, Maria; Caballero, Andrea; Casillas, Rosario; Castells, LLuis et al. DOI: 10.1128/JCM.02093-14
PMID: 24463862 Journal: NEFROLOGIA Year: 2014 Reference: Nefrologia. 2014;34(1):46-52. doi: 10.3265/Nefrologia.pre2013.Oct.12256. Impact factor: Publication type: Paper in national publication Authors: Agraz, Irene; Arbos, M Antonia; Carnicer, Clara; Jatem, Elias; Ostos, Helena; Quiles, M Teresa; Salcedo, M Teresa; Segarra, Alfons; Valtierra, Naiara et al. DOI: 10.3265/Nefrologia.pre2013.Oct.12256
PMID: 24552864 Journal: Annals of Hepatology Year: 2014 Reference: Ann Hepatol. 2014 Mar-Apr;13(2):219-30. Impact factor: Publication type: Paper in international publication Authors: Allende, Helena; Bes, Marta; Campos-Varela, Isabel; Castells, Lluis; Charco, Ramon; Dopazo, Cristina; Esteban, Juan Ignacio; Esteban, Rafael; Guardia, Jaime; Rodriguez-Frias, Francisco et al. DOI:
PMID: 24492423 Journal: TRANSPLANTATION Year: 2014 Reference: Transplantation. 2014 Feb 15;97(3):358-62. doi: 10.1097/01.TP.0000435699.69266.66. Impact factor: Publication type: Paper in international publication Authors: Berastegui, Cristina; Blanco, Albert; Bravo, Carlos; Camos, Silvia; Lopez-Meseguer, Manuel; Mendez, Alejandra; Monforte, Victor; Pou, Leonor; Roman, Antonio et al. DOI: 10.1097/01.TP.0000435699.69266.66
PMID: 24389655 Journal: BIOINFORMATICS Year: 2014 Reference: Bioinformatics. 2014 Apr 15;30(8):1104-1111. doi: 10.1093/bioinformatics/btt768. Epub 2014 Jan 2. Impact factor: Publication type: Paper in international publication Authors: Domingo, Esteban; Gregori, Josep; Quer, Josep; Rodriguez-Frias, Francisco; Salicru, Miquel; Sanchez, Alex et al. DOI: 10.1093/bioinformatics/btt768
Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.
Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.
Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.
