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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Sunny Malhotra Sareen

Sunny Malhotra Sareen

Main researcher
Clinical Neuroimmunology
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Carmen Espejo Ruiz

Carmen Espejo Ruiz

Main researcher
Clinical Neuroimmunology
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Elisenda Anglada Clofent

Elisenda Anglada Clofent

Predoctoral researcher
Clinical Neuroimmunology
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Javier Villacieros Álvarez

Javier Villacieros Álvarez

Predoctoral researcher
Clinical Neuroimmunology
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Julia Enric Rubio Roca

Julia Enric Rubio Roca

Administration and Management
Clinical Neuroimmunology
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Sergio Vergara Ruiz

Sergio Vergara Ruiz

Administration and Management
Clinical Neuroimmunology
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Sunny Malhotra Sareen

Sunny Malhotra Sareen

Main researcher
Clinical Neuroimmunology
Read more
Carmen Espejo Ruiz

Carmen Espejo Ruiz

Main researcher
Clinical Neuroimmunology
Read more
Elisenda Anglada Clofent

Elisenda Anglada Clofent

Predoctoral researcher
Clinical Neuroimmunology
Read more
Javier Villacieros Álvarez

Javier Villacieros Álvarez

Predoctoral researcher
Clinical Neuroimmunology
Read more
Julia Enric Rubio Roca

Julia Enric Rubio Roca

Administration and Management
Clinical Neuroimmunology
Read more
Sergio Vergara Ruiz

Sergio Vergara Ruiz

Administration and Management
Clinical Neuroimmunology
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Projects

Profiling of patients with highly active multiple sclerosis and assessment of highly efficacious treatment effects on the evolution of their disease

IP: Georgina Arrambide García
Collaborators: Miriam Izquierdo Sans
Funding agency: ECTRIMS
Funding: 55000
Reference: ECTRIMS/CLINICAL-TRAININGFELLOWSHIP/2023/ARRAMBIDE
Duration: 06/10/2023 - 05/10/2024

Caracterización de las infecciones y de su impacto en pacientes con Esclerosis Múltiple en la era de los tratamientos inmunosupresores de alta eficacia

IP: Susana Otero Romero
Collaborators: Imane Boutitah Benyaich, Blanca Borras Bermejo, Anna Falcó Roget, Mar Tintore Subirana, Ana Zabalza de Torres, Jesus Trejo Zahinos, Enrique Rodríguez Zafra
Funding agency: Instituto de Salud Carlos III
Funding: 115000
Reference: PI23/01654
Duration: 01/01/2024 - 31/12/2026

Investigation of pathology-informed neuroimaging predictors of progression independent of relapse activity at the first attack of multiple sclerosis: from histopathology to routinely acquired anatomical MRI, through advanced quantitative neuroimaging and

IP: Carmen Tur Gomez
Collaborators: Carlos Domínguez Pérez, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 242500
Reference: CP23/00117
Duration: 01/01/2024 - 31/12/2028

BEHIND-MS: The role of an Epstein-Barr virus infection in the pathogenesis of multiple sclerosis

IP: Manuel Comabella Lopez
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 248720
Reference: BEHIND-MS_HE-HLTH2023
Duration: 01/12/2023 - 30/11/2028

Publications

Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial.

PMID: 38218195
Journal: LANCET INFECTIOUS DISEASES
Year: 2024
Reference: Lancet Infect Dis. 2024 Jan 10:S1473-3099(23)00629-1. doi: 10.1016/S1473-3099(23)00629-1.
Impact factor:
Publication type: Paper in international publication
Authors: Almeida, Paulo Emilio Clementino; Aznar, Maria Luisa; Bosch-Nicolau, Pau; Chamorro-Tojeiro, Sandra; Correa-Oliveira, Rodrigo; de Paula, Alfredo Mauricio Batista; Del Carmen Bangher, Maria; Eloi-Santos, Silvana Maria; Espinosa-Pereiro, Juan; Fernandez, Maria L et al.
DOI: 10.1016/S1473-3099(23)00629-1

Longitudinal stability of inter-eye differences in optical coherence tomography measures for identifying unilateral optic nerve lesions in multiple sclerosis.

PMID: 37167654
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2023
Reference: J Neurol Sci. 2023 May 3;449:120669. doi: 10.1016/j.jns.2023.120669.
Impact factor:
Publication type: Paper in international publication
Authors: Balcer, Laura J; Galetta, Steven L; Joseph, Binu; Kenney, Rachel C; Montalban, Xavier; Patil, Sachi A; Sastre-Garriga, Jaume; Tagliani, Paula; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jns.2023.120669

Transitional Care for Young People with Movement Disorders: Consensus-Based Recommendations from the MDS Task Force on Pediatrics.

PMID: 37205244
Journal: Movement Disorders Clinical Practice
Year: 2023
Reference: Mov Disord Clin Pract. 2023 Apr 4;10(5):748-755. doi: 10.1002/mdc3.13728. eCollection 2023 May.
Impact factor:
Publication type: Review in international publication
Authors: Batla, Amit; Ben-Pazi, Hilla; Cosentino, Carlos; Dale, Russell C; Ebrahimi-Fakhari, Darius; Friedman, Jennifer; Fung, Victor S C; Hoshino, Kyoko; Kurian, Manju A; Lin, Jean-Pierre et al.
DOI: 10.1002/mdc3.13728

International Delphi Consensus on the Management of AQP4-IgG+ NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab.

PMID: 37258412
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2023
Reference: Neurol Neuroimmunol Neuroinflamm. 2023 May 31;10(4):e200124. doi: 10.1212/NXI.0000000000200124. Print 2023 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Asgari, Nasrin; Bennett, Jeffrey L; Cree, Bruce Anthony Campbell; De Seze, Jerome; Fujihara, Kazuo; Hornby, Rebecca; Huda, Saif; Kim, Ho Jin; Kissani, Najib et al.
DOI: 10.1212/NXI.0000000000200124

European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs.

PMID: 37293849
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 Jun 9. doi: 10.1111/ene.15809.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Campins, Magda; Farez, Mauricio; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Lebrun-Frenay, Christine; Magyari, Melinda; Oreja-Guevara, Celia et al.
DOI: 10.1111/ene.15809

CSF chitinase 3-like 1 is associated with iron rims in patients with a first demyelinating event.

PMID: 33870790
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jan;28(1):71-81. doi: 10.1177/13524585211010082. Epub 2021 Apr 19.
Impact factor: 6.312
Publication type: Paper in international publication
Authors: Pinteac, Rucsanda; Granziera, Cristina; Sastre-Garriga, Jaume; Benkert, Pascal; Auger, Cristina; Kuhle, Jens; Montalban, Xavier; Rovira, Alex; Fissolo, Nicolas; Pareto, Deborah et al.
DOI: 10.1177/13524585211010082

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome: A MAGNIMS Study.

PMID: 34716250
Journal: NEUROLOGY
Year: 2022
Reference: Neurology. 2022 Jan 4;98(1):e1-e14. doi: 10.1212/WNL.0000000000013016. Epub 2021 Oct 29.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Filippi, Massimo; Preziosa, Paolo; Meani, Alessandro; Costa, Gloria Dalla; Mesaros, Sarlota; Drulovic, Jelena; Ivanovic, Jovana; Rovira, Alex; Tintore, Mar; Montalban, Xavier et al.
DOI: 10.1212/WNL.0000000000013016

Treatment response scoring systems to assess long-term prognosis in self-injectable DMTs relapsing-remitting multiple sclerosis patients.

PMID: 34596743
Journal: JOURNAL OF NEUROLOGY
Year: 2022
Reference: J Neurol. 2022 Jan;269(1):452-459. doi: 10.1007/s00415-021-10823-z. Epub 2021 Oct 1.
Impact factor: 4.849
Publication type: Paper in international publication
Authors: Tur, Carmen; Auger, Cristina; Sastre-Garriga, Jaume; Montalban, Xavier; Cobo, Alvaro; Nos, Carlos; Arrambide, Georgina; Castillo, Joaquim; Rio, Jordi; Gasperini, Claudio et al.
DOI: 10.1007/s00415-021-10823-z

Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay.

PMID: 34988947
Journal: ACTA NEUROLOGICA BELGICA
Year: 2022
Reference: Acta Neurol Belg. 2022 Jun;122(3):823-825. doi: 10.1007/s13760-021-01864-2. Epub 2022 Jan 6.
Impact factor: 2.396
Publication type: Letter or abstract
Authors: Lallana, Sofia; Sanchez-Tejerina, Daniel; Auger, Cristina; Callejo, Ana; Rio, Jordi; Cobo-Calvo, Alvaro et al.
DOI: 10.1007/s13760-021-01864-2

Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence.

PMID: 34607924
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Nov 23;97(21):989-999. doi: 10.1212/WNL.0000000000012884. Epub 2021 Oct 4.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Barkhof, Frederik, Vrenken, Hugo, Jenkinson, Mark, Pham, Dzung, Guttmann, Charles R G, Pareto, Deborah, Paardekooper, Michel, de Sitter, Alexandra, Rocca, Maria A, Wottschel, Viktor et al.
DOI: 10.1212/WNL.0000000000012884

Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.

PMID: 34610987
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Nov 9;97(19):e1870-e1885. doi: 10.1212/WNL.0000000000012753. Epub 2021 Oct 5.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Pirmani, Ashkan, Simpson-Yap, Steve, De Brouwer, Edward, Kalincik, Tomas, Rijke, Nick, Hillert, Jan A, Walton, Clare, Edan, Gilles, Moreau, Yves, Spelman, Tim et al.
DOI: 10.1212/WNL.0000000000012753

Monocyte-to-Lymphocyte Ratio in Clot Analysis as a Marker of Cardioembolic Stroke Etiology.

PMID: 34586594
Journal: Translational Stroke Research
Year: 2021
Reference: Transl Stroke Res. 2021 Sep 29. pii: 10.1007/s12975-021-00946-w. doi: 10.1007/s12975-021-00946-w.
Impact factor: 6.829
Publication type: Paper in international publication
Authors: Ribo, Marc, Juega, Jesus, Palacio-Garcia, Carlos, Rodriguez, Maite, Deck, Matias, Rodriguez-Luna, David, Requena, Manuel, Garcia-Tornel, Alvaro, Rodriguez-Villatoro, Noelia, Rubiera, Marta et al.
DOI: 10.1007/s12975-021-00946-w

Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.

PMID: 34556662
Journal: Scientific Data
Year: 2021
Reference: Sci Data. 2021 Sep 23;8(1):251. doi: 10.1038/s41597-021-01044-0.
Impact factor: 6.444
Publication type: Letter or abstract
Authors: Horak, Tomas, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostal, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R, Epperson, Kevin S, Freund, Patrick et al.
DOI: 10.1038/s41597-021-01044-0

New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab.

PMID: 33408681
Journal: Frontiers in Neurology
Year: 2020
Reference: Front Neurol. 2020 Dec 17;11:579438. doi: 10.3389/fneur.2020.579438. eCollection 2020.
Impact factor: 2.889
Publication type: Paper in international publication
Authors: Romero, Fernando, Laroni, Alicia, Uccelli, Antonio, Perez-Sempere, Angel, Saiz, Albert, Blanco, Yolanda, Galimberti, Daniela, Scarpini, Elio, Espejo, Carmen, Montalban, Xavier et al.
DOI: 10.3389/fneur.2020.579438

Palliative care in multiple sclerosis: European guideline.

PMID: 32513039
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1009-1011. doi: 10.1177/1352458520926467. Epub 2020 Jun 9.
Impact factor: 5.412
Publication type: Paper in international publication
Authors: Solari, Alessandra, Oliver, David, Solari, Alessandra, Giordano, Andrea, Sastre-Garriga, Jaume, Kopke, Sascha, Rahn, Anne C, Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A et al.
DOI: 10.1177/1352458520926467

Modelling multiple sclerosis using induced pluripotent stem cells.

PMID: 33130461
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2020
Reference: J Neuroimmunol. 2020 Dec 15;349:577425. doi: 10.1016/j.jneuroim.2020.577425. Epub 2020 Oct 17.
Impact factor: 3.125
Publication type: Review in international publication
Authors: Matute-Blanch, Clara, Martinez-Larrosa, Julia, Comabella, Manuel, Montalban, Xavier et al.
DOI: 10.1016/j.jneuroim.2020.577425

The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

PMID: 31610739
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Nov;26(13):1658-1669. doi: 10.1177/1352458519877810. Epub 2019 Oct 15.
Impact factor: 5.649
Publication type: Paper in international publication
Authors: Arevalo, Maria Jesus, Anglada, Elisenda, Menendez, Rebeca, Midaglia, Luciana, Galan, Ingrid, Vidal-Jordana, Angela, Castillo, Joaquin, Mulero, Patricia, Zabalza, Ana, Rodriguez-Acevedo, Breogan et al.
DOI: 10.1177/1352458519877810

Usefulness of brain perfusion CT in focal-onset status epilepticus.

PMID: 31166616
Journal: EPILEPSIA
Year: 2019
Reference: Epilepsia. 2019 Jul;60(7):1317-1324. doi: 10.1111/epi.16063. Epub 2019 Jun 5.
Impact factor: 5.562
Publication type: Paper in international publication
Authors: Gonzalez-Cuevas, Montserrat, Coscojuela, Pilar, Santamarina, Estevo, Pareto, Deborah, Quintana, Manuel, Sueiras, Maria, Guzman, Lorena, Sarria, Silvana, Salas-Puig, Xavier, Toledo, Manuel et al.
DOI: 10.1111/epi.16063

Predictors of response to endovascular treatment of posterior circulation stroke.

PMID: 31153569
Journal: EUROPEAN JOURNAL OF RADIOLOGY
Year: 2019
Reference: Eur J Radiol. 2019 Jul;116:219-224. doi: 10.1016/j.ejrad.2019.05.001. Epub 2019 May 2.
Impact factor: 2.948
Publication type: Paper in international publication
Authors: Tomasello, Alejandro, Molina, Carlos, Rovira, Alex, Rubiera, Marta, Gramegna, Laura Ludovica, Requena, Manuel, Dinia, Lavinia, Melendez, Fernando, Hernandez, David, Coscojuela, Pilar et al.
DOI: 10.1016/j.ejrad.2019.05.001

Engaging across dimensions of diversity: A cross-national perspective on mHealth tools for managing relapsing remitting and progressive multiple sclerosis.

PMID: 31125754
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Jul;32:123-132. doi: 10.1016/j.msard.2019.04.020. Epub 2019 Apr 16.
Impact factor: 2.725
Publication type: Paper in international publication
Authors: Simblett, Sara K, Evans, Joanne, Greer, Ben, Curtis, Hannah, Matcham, Faith, Radaelli, Marta, Mulero, Patricia, Arevalo, Maria Jesus, Polhemus, Ashley, Ferrao, Jose et al.
DOI: 10.1016/j.msard.2019.04.020

CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.

PMID: 31072955
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2019
Reference: J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):1027-1038. doi: 10.1136/jnnp-2018-318957. Epub 2019 May 9.
Impact factor: 8.327
Publication type: Paper in international publication
Authors: Taieb, Guillaume, Mulero, Patricia, Psimaras, Dimitri, van Oosten, Bob W, Seebach, Jorg D, Marignier, Romain, Pico, Fernando, Rigau, Valerie, Ueno, Yuji, Duflos, Claire et al.
DOI: 10.1136/jnnp-2018-318957

Ocrelizumab: a new milestone in multiple sclerosis therapy.

PMID: 29774057
Journal: Therapeutic Advances in Neurological Disorders
Year: 2018
Reference: Ther Adv Neurol Disord. 2018 May 10;11:1756286418773025. doi: 10.1177/1756286418773025. eCollection 2018.
Impact factor: 4.75
Publication type: Review in international publication
Authors: Mulero, Patricia, Midaglia, Luciana, Montalban, Xavier et al.
DOI: 10.1177/1756286418773025

Clinical commentary on "Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica".

PMID: 29671675
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Oct;24(11):1516-1517. doi: 10.1177/1352458518771259. Epub 2018 Apr 19.
Impact factor: 5.28
Publication type: Editorail in international publication
Authors: Rio, Jordi, Rodriguez-Acevedo, Breogan et al.
DOI: 10.1177/1352458518771259

[New drugs for the treatment of multiple sclerosis].

PMID: 29645067
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Apr 16;66(8):253.
Impact factor: 0.601
Publication type: Editorail in international publication
Authors: Rio, J et al.
DOI:

Physiotherapeutic interventions in multiple sclerosis across Europe: Regions and other factors that matter.

PMID: 29579644
Journal: Multiple Sclerosis and Related Disorders
Year: 2018
Reference: Mult Scler Relat Disord. 2018 May;22:59-67. doi: 10.1016/j.msard.2018.03.005. Epub 2018 Mar 14.
Impact factor: 3.199
Publication type: Paper in international publication
Authors: Rasova, Kamila, Pavlikova, Marketa, Salci, Yeliz, Martinkova, Patricia, Freeman, Jenny, Drabinova, Adela, Erosheva, Elena, Cattaneo, Davide, Jonsdottir, Johanna, Baert, Ilse et al.
DOI: 10.1016/j.msard.2018.03.005

Automated tissue segmentation of MR brain images in the presence of white matter lesions.

PMID: 27598104
Journal: MEDICAL IMAGE ANALYSIS
Year: 2017
Reference: Med Image Anal. 2017 Jan;35:446-457. doi: 10.1016/j.media.2016.08.014. Epub 2016 Aug 30.
Impact factor: 4.565
Publication type: Paper in international publication
Authors: Valverde, Sergi, Oliver, Arnau, Roura, Eloy, Gonzalez-Villa, Sandra, Pareto, Deborah, Vilanova, Joan C, Ramio-Torrenta, Lluis, Rovira, Alex, Llado, Xavier et al.
DOI: 10.1016/j.media.2016.08.014

Grey matter atrophy is associated with disability increase in natalizumab-treated patients.

PMID: 27354019
Journal: Multiple Sclerosis Journal
Year: 2017
Reference: Mult Scler. 2017 Apr;23(4):556-566. doi: 10.1177/1352458516656808. Epub 2016 Jul 11.
Impact factor: 4.671
Publication type: Paper in international publication
Authors: Ciampi, Ethel, Pareto, Deborah, Sastre-Garriga, Jaume, Vidal-Jordana, Angela, Tur, Carmen, Rio, Jordi, Tintore, Mar, Auger, Cristina, Rovira, Alex, Montalban, Xavier et al.
DOI: 10.1177/1352458516656808

Lesion topographies in multiple sclerosis diagnosis: A reappraisal.

PMID: 29101276
Journal: NEUROLOGY
Year: 2017
Reference: Neurology. 2017 Dec 5;89(23):2351-2356. doi: 10.1212/WNL.0000000000004715. Epub 2017 Nov 3.
Impact factor: 8.32
Publication type: Paper in international publication
Authors: Rio, Jordi, Castillo, Joaquin, Vidal-Jordana, Angela, Galan, Ingrid, Nos, Carlos, Comabella, Manuel, Mitjana, Raquel, Mulero, Patricia, de Barros, Andrea, Rodriguez-Acevedo, Breogan et al.
DOI: 10.1212/WNL.0000000000004715

Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

PMID: 28593439
Journal: Neurotherapeutics
Year: 2017
Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8.
Impact factor: 5.166
Publication type: Paper in international publication
Authors: Eixarch, Herena, Tejero, Marcos, Costa, Carme, Hirota, Keiji, Castano, A Raul, Puig, Meritxell, Stockinger, Gitta, Montalban, Xavier, Bosch, Assumpcio, Espejo, Carmen et al.
DOI: 10.1007/s13311-017-0545-8

Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test.

PMID: 26216790
Journal: NEUROREHABILITATION AND NEURAL REPAIR
Year: 2016
Reference: Neurorehabil Neural Repair. 2016 May;30(4):373-83. doi: 10.1177/1545968315597070. Epub 2015 Jul 27.
Impact factor: 4.035
Publication type: Paper in international publication
Authors: Feys, Peter, Leone, Carmela, Severijns, Deborah, Dolezalova, Vendula, Baert, Ilse, Dalgas, Ulrik, Romberg, Anders, Bethoux, Francois, Maamagi, Heigo, Rasova, Kamila et al.
DOI: 10.1177/1545968315597070

Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis.

PMID: 27566747
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 27;87(13):1368-74. doi: 10.1212/WNL.0000000000003144. Epub 2016 Aug 26.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Nos, Carlos, Arevalo, Maria Jesus, Vidal-Jordana, Angela, Castillo, Joaquin, Rodriguez-Acevedo, Breogan, Midaglia, Luciana, Mitjana, Raquel, Auger, Cristina, Sastre-Garriga, Jaume, Rovira, Alex et al.
DOI: 10.1212/WNL.0000000000003144

Neurofilament light chain level is a weak risk factor for the development of MS.

PMID: 27521440
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 13;87(11):1076-84. doi: 10.1212/WNL.0000000000003085. Epub 2016 Aug 12.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Kappos, Ludwig, Sastre-Garriga, Jaume, Pareto, Deborah, Simon, Eva, Comabella, Manuel, Rio, Jordi, Nos, Carlos, Tur, Carmen, Castillo, Joaquin, Disanto, Giulio et al.
DOI: 10.1212/WNL.0000000000003085

Assessing response to interferon-beta in a multicenter dataset of patients with MS.

PMID: 27306626
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Jul 12;87(2):134-40. doi: 10.1212/WNL.0000000000002830. Epub 2016 Jun 15.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Prosperini, Luca, Rocca, Maria Assunta, Rovira, Alex, Sprenger, Till, Stromillo, Maria Laura, Tedeschi, Gioacchino, Tintore, Mar, Tortorella, Carla, Trojano, Maria, Montalban, Xavier et al.
DOI: 10.1212/WNL.0000000000002830

Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women.

PMID: 25698781
Journal: JOURNAL OF NUCLEAR MEDICINE
Year: 2015
Reference: J Nucl Med. 2015 Apr;56(4):580-5. doi: 10.2967/jnumed.114.150383. Epub 2015 Feb 19.
Impact factor: 6.16
Publication type: Paper in international publication
Authors: Biegon, Anat, Alexoff, David L, Kim, Sung Won, Logan, Jean, Pareto, Deborah, Schlyer, David, Wang, Gene-Jack, Fowler, Joanna S et al.
DOI: 10.2967/jnumed.114.150383

Pixel-by-Pixel Comparison of Volume Transfer Constant and Estimates of Cerebral Blood Volume from Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast-Enhanced MR Imaging in High-Grade Gliomas.

PMID: 25634715
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2015
Reference: AJNR Am J Neuroradiol. 2015 May;36(5):871-6. doi: 10.3174/ajnr.A4231. Epub 2015 Jan 29.
Impact factor: 3.589
Publication type: Paper in international publication
Authors: Alcaide-Leon, P, Pareto, D, Martinez-Saez, E, Auger, C, Bharatha, A, Rovira, A et al.
DOI: 10.3174/ajnr.A4231

Juxtacortical Lesions and Cortical Thinning in Multiple Sclerosis.

PMID: 26450537
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2015
Reference: AJNR Am J Neuroradiol. 2015 Dec;36(12):2270-6. doi: 10.3174/ajnr.A4485. Epub 2015 Oct 8.
Impact factor: 3.589
Publication type: Paper in international publication
Authors: Pareto, D, Sastre-Garriga, J, Auger, C, Vives-Gilabert, Y, Delgado, J, Tintore, M, Montalban, X, Rovira, A et al.
DOI: 10.3174/ajnr.A4485

Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls.

PMID: 26305477
Journal: Translational Psychiatry
Year: 2015
Reference: Transl Psychiatry. 2015 Aug 25;5:e626. doi: 10.1038/tp.2015.122.
Impact factor: 5.62
Publication type: Paper in international publication
Authors: Batalla, A, Bargallo, N, Gasso, P, Molina, O, Pareto, D, Mas, S, Roca, J M, Bernardo, M, Lafuente, A, Parellada, E et al.
DOI: 10.1038/tp.2015.122

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

PMID: 24328534
Journal: AUTOIMMUNITY
Year: 2014
Reference: Autoimmunity. 2014 Mar;47(2):127-33. doi: 10.3109/08916934.2013.866104. Epub 2013 Dec 12.
Impact factor: 2.754
Publication type: Paper in international publication
Authors: Mansilla, Maria Jose, Comabella, Manuel, Rio, Jordi, Castillo, Joaquin, Castillo, Mireia, Martin, Roland, Montalban, Xavier, Espejo, Carmen et al.
DOI: 10.3109/08916934.2013.866104

Evaluating the response to glatiramer acetate in relapsing-remitting multiple sclerosis (RRMS) patients.

PMID: 24622350
Journal: MULT SCLER J
Year: 2014
Reference: Mult Scler. 2014 Oct;20(12):1602-8. doi: 10.1177/1352458514527863. Epub 2014 Mar 12.
Impact factor: 4.863
Publication type: Paper in international publication
Authors: Montalban, Xavier, Vidal, Angela, Tur, Carmen, Nos, Carlos, Rio, Jordi, Rovira, Alex, Tintore, Mar, Sastre-Garriga, Jaume, Castillo, Joaquin, Auger, Cristina et al.
DOI: 10.1177/1352458514527863

Erythrocytes labeled with [(18) F]SFB as an alternative to radioactive CO for quantification of blood volume with PET.

PMID: 23613441
Journal: Contrast Media & Molecular Imaging
Year: 2013
Reference: Contrast Media Mol Imaging. 2013 Jul-Aug;8(4):375-81. doi: 10.1002/cmmi.1533.
Impact factor: 2.872
Publication type: Paper in international publication
Authors: Gispert, Juan Domingo, Abad, Sergio, Victor, Victor M, Pareto, Deborah, Torrent, Elia, Rojas, Santiago, Herance, Jose Raul et al.
DOI: 10.1002/cmmi.1533

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography.

PMID: 23402900
Journal: NEUROBIOLOGY OF AGING
Year: 2013
Reference: Neurobiol Aging. 2013 Jul;34(7):1790-8. doi: 10.1016/j.neurobiolaging.2012.12.027. Epub 2013 Feb 10.
Impact factor: 6.166
Publication type: Paper in international publication
Authors: Rojas, Santiago, Herance, Jose Raul, Gispert, Juan Domingo, Abad, Sergio, Torrent, Elia, Jimenez, Xavier, Pareto, Deborah, Perpina, Unai, Sarroca, Sara, Rodriguez, Elisenda et al.
DOI: 10.1016/j.neurobiolaging.2012.12.027

Cellular immune responses in multiple sclerosis patients treated with interferon-beta.

PMID: 23379429
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2013
Reference: Clin Exp Immunol. 2013 Mar;171(3):243-6. doi: 10.1111/cei.12016.
Impact factor: 3.409
Publication type: Paper in international publication
Authors: Bustamante, M F, Rio, J, Castro, Z, Sanchez, A, Montalban, X, Comabella, M et al.
DOI: 10.1111/cei.12016

Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes.

PMID: 23319072
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Aug;19(9):1175-81. doi: 10.1177/1352458512473190. Epub 2013 Jan 14.
Impact factor: 4.472
Publication type: Paper in international publication
Authors: Vidal-Jordana, Angela, Sastre-Garriga, Jaume, Perez-Miralles, Francisco, Tur, Carmen, Tintore, Mar, Horga, Alejandro, Auger, Cristina, Rio, Jordi, Nos, Carlos, Edo, Mari C et al.
DOI: 10.1177/1352458512473190

EBV-specific immune responses in patients with multiple sclerosis responding to IFN{beta} therapy.

PMID: 22020417
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 May;18(5):605-9. Epub 2011 Oct 21.
Impact factor: 4.255
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1177/1352458511426816

Value of NMO-IgG determination at the time of presentation as CIS.

PMID: 22551725
Journal: NEUROLOGY
Year: 2012
Reference: Neurology. 2012 May 15;78(20):1608-11. doi: 10.1212/WNL.0b013e3182563b32. Epub 2012 May 2.
Impact factor: 8.312
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1212/WNL.0b013e3182563b32

Natalizumab discontinuation after PML risk stratification: outcome from a shared and informed decision.

PMID: 22383232
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Aug;18(8):1193-6. doi: 10.1177/1352458512439238. Epub 2012 Mar 1.
Impact factor: 4.255
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1177/1352458512439238

Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response.

PMID: 22289050
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2012
Reference: Eur J Neurol. 2012 Jun;19(6):899-904. doi: 10.1111/j.1468-1331.2011.03648.x. Epub 2012 Jan 31.
Impact factor: 3.692
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2011.03648.x

Search for Specific Biomarkers of IFNbeta Bioactivity in Patients with Multiple Sclerosis.

PMID: 21886806
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(8):e23634. Epub 2011 Aug 23.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Malhotra, Sunny, Bustamante, Marta F, Perez-Miralles, Francisco, Rio, Jordi, Ruiz de Villa, Mari Carmen, Vegas, Esteban, Nonell, Lara, Deisenhammer, Florian, Fissolo, Nicolas, Nurtdinov, Ramil N et al.
DOI: 10.1371/journal.pone.0023634

Multiple sclerosis: current treatment algorithms.

PMID: 21499098
Journal: CURRENT OPINION IN NEUROLOGY
Year: 2011
Reference: Curr Opin Neurol. 2011 Jun;24(3):230-7.
Impact factor: 5.021
Publication type: Paper in international publication
Authors: Rio, Jordi, Comabella, Manuel, Montalban, Xavier et al.
DOI: 10.1097/WCO.0b013e328346bf66

[An observational study of the effectiveness and safety of natalizumab in the treatment of multiple sclerosis.]

PMID: 21387248
Journal: REVISTA DE NEUROLOGIA
Year: 2011
Reference: Rev Neurol. 2011 Mar 16;52(6):321-330.
Impact factor: 1.218
Publication type: Paper in national publication
Authors: , , , , , , , , , et al.
DOI:

Do multimodal evoked potentials add information to MRI in clinically isolated syndromes?

PMID: 19995838
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Jan;16(1):55-61. Epub 2009 Dec 7.
Impact factor: 3.279
Publication type: Paper in international publication
Authors: Pelayo, R, Montalban, X, Minoves, T, Moncho, D, Rio, J, Nos, C, Tur, C, Castillo, J, Horga, A, Comabella, M et al.
DOI: 10.1177/1352458509352666

Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months.

PMID: 19770470
Journal: NEUROLOGY
Year: 2009
Reference: Neurology. 2009 Sep 22;73(12):949-53.
Impact factor: 7.043
Publication type: Paper in international publication
Authors: Llufriu, S, Castillo, J, Blanco, Y, Ramio-Torrenta, L, Rio, J, Valles, M, Lozano, M, Castella, M D, Calabia, J, Horga, A et al.
DOI: 10.1212/WNL.0b013e3181b879be

Measures in the first year of therapy predict the response to interferon beta in MS.

PMID: 19542263
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Jul;15(7):848-53.
Impact factor: 3.312
Publication type: Paper in international publication
Authors: Rio, J, Castillo, J, Rovira, A, Tintore, M, Sastre-Garriga, J, Horga, A, Nos, C, Comabella, M, Aymerich, X, Montalban, X et al.
DOI: 10.1177/1352458509104591

A type I interferon signature in monocytes is associated with poor response to interferon-{beta} in multiple sclerosis.

PMID: 19741051
Journal: BRAIN
Year: 2009
Reference: Brain. 2009 Dec;132(Pt 12):3353-65.
Impact factor: 9.603
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1093/brain/awp228

[Natalizumab in multiple sclerosis]

PMID: 19714558
Journal: REVISTA DE NEUROLOGIA
Year: 2009
Reference: Rev Neurol. 2009 Sep 1-15;49(5):265-9.
Impact factor: 1.083
Publication type: Review in national publication
Authors: Rio-Izquierdo, J, Montalban, X et al.
DOI:

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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