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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Georgina Arrambide García

Georgina Arrambide García

Main researcher
Clinical Neuroimmunology
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Herena Eixarch Ahufinger

Herena Eixarch Ahufinger

Postdoctoral researcher
Clinical Neuroimmunology
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Ingrid Galán Cartaña

Ingrid Galán Cartaña

Senior researcher
Clinical Neuroimmunology
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Javier Domeño Baztán

Javier Domeño Baztán

Research technician
Clinical Neuroimmunology
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Joaquin  Justel  Pizarro

Joaquin Justel Pizarro

Research technician
Clinical Neuroimmunology
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Joaquin Castillo Justribo

Joaquin Castillo Justribo

Postdoctoral researcher
Clinical Neuroimmunology
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Georgina Arrambide García

Georgina Arrambide García

Main researcher
Clinical Neuroimmunology
Read more
Herena Eixarch Ahufinger

Herena Eixarch Ahufinger

Postdoctoral researcher
Clinical Neuroimmunology
Read more
Ingrid Galán Cartaña

Ingrid Galán Cartaña

Senior researcher
Clinical Neuroimmunology
Read more
Javier Domeño Baztán

Javier Domeño Baztán

Research technician
Clinical Neuroimmunology
Read more
Joaquin  Justel  Pizarro

Joaquin Justel Pizarro

Research technician
Clinical Neuroimmunology
Read more
Joaquin Castillo Justribo

Joaquin Castillo Justribo

Postdoctoral researcher
Clinical Neuroimmunology
Read more

Publications

The influence of MOGAD on diagnosis of multiple sclerosis using MRI.

PMID: 39227463
Journal: Nature Reviews Neurology
Year: 2024
Reference: Nat Rev Neurol. 2024 Sep 3. doi: 10.1038/s41582-024-01005-2.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Banwell, Brenda; Barkhof, Frederik; Chard, Declan; Ciccarelli, Olga; Cortese, Rosa; DeLuca, Gabriele C; Enzinger, Christian; Filippi, Massimo; Gasperini, Claudio et al.
DOI: 10.1038/s41582-024-01005-2

Cytomegalovirus immune responses are associated with lower serum NfL and disability accumulation risk at multiple sclerosis onset.

PMID: 39246021
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Sep 9:13524585241274571. doi: 10.1177/13524585241274571.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Fissolo, Nicolas; Gutierrez, Lucia; Lunemann, Jan D; Midaglia, Luciana; Montalban, Xavier; Sao Aviles, Augusto; Tintore, Mar; Wiendl, Heinz et al.
DOI: 10.1177/13524585241274571

MiRNA-based therapeutic potential in multiple sclerosis.

PMID: 39267760
Journal: Frontiers in Immunology
Year: 2024
Reference: Front Immunol. 2024 Aug 29;15:1441733. doi: 10.3389/fimmu.2024.1441733. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Malhotra, Sunny; Montalban, Xavier; Pappolla, Agustin; Zabalza, Ana et al.
DOI: 10.3389/fimmu.2024.1441733

Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials.

PMID: 39307151
Journal: LANCET NEUROLOGY
Year: 2024
Reference: Lancet Neurol. 2024 Sep 19:S1474-4422(24)00328-4. doi: 10.1016/S1474-4422(24)00328-4.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Cree, Bruce A C; Cross, Anne H; Dahlke, Frank; Gopalakrishnan, Sathej; Guehring, Hans; Hyvert, Yann; Javor, Andrija; Kappos, Ludwig et al.
DOI: 10.1016/S1474-4422(24)00328-4

A plain language summary of what clinical studies can tell us about the safety of evobrutinib - a potential treatment for multiple sclerosis.

PMID: 37345645
Journal: Neurodegenerative disease management
Year: 2023
Reference: Neurodegener Dis Manag. 2023 Jun 22. doi: 10.2217/nmt-2023-0003.
Impact factor:
Publication type: Review in international publication
Authors: Bolay, Claire Le; Genovese, Mark C; Guehring, Hans; Kao, Amy H; Montalban, Xavier; Parsons-Rich, Dana; Tomic, Davorka; Wallace, Daniel et al.
DOI: 10.2217/nmt-2023-0003

Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis.

PMID: 37447866
Journal: SENSORS
Year: 2023
Reference: Sensors (Basel). 2023 Jun 29;23(13):6017. doi: 10.3390/s23136017.
Impact factor:
Publication type: Paper in international publication
Authors: Bailon, Raquel; Buron, Mathias Due; Comi, Giancarlo; Costa, Gloria Dalla; Cummins, Nicholas; Dobson, Richard J B; Garcia, Esther; Guerrero, Ana Isabel; Hotopf, Matthew; Kontaxis, Spyridon et al.
DOI: 10.3390/s23136017

Association of Very Early Treatment Initiation With the Risk of Long-Term Disability in Patients With a First Demyelinating Event.

PMID: 37468284
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Jul 19:10.1212/WNL.0000000000207664. doi: 10.1212/WNL.0000000000207664.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Javier Villacieros; Alvarez, Javier Villacieros; Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana Soledad et al.
DOI: 10.1212/WNL.0000000000207664

The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium.

PMID: 37490262
Journal: Clinical & Translational Oncology
Year: 2023
Reference: Clin Transl Oncol. 2023 Jul 25. doi: 10.1007/s12094-023-03262-x.
Impact factor:
Publication type: Paper in international publication
Authors: Cobo, Manuel; Conde, Esther; Corral, Jesus; de Castro, Javier; Felip, Enriqueta; Garrido, Pilar; Gil-Moncayo, Francisco; Isla, Dolores; Majem, Margarita; Mezquita, Laura et al.
DOI: 10.1007/s12094-023-03262-x

The impact of the COVID-19 pandemic on physical therapy practice for people with multiple sclerosis: A multicenter survey study of the RIMS network.

PMID: 35428030
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jun;62:103799. doi: 10.1016/j.msard.2022.103799. Epub 2022 Apr 10.
Impact factor:
Publication type: Paper in international publication
Authors: Arntzen, Ellen Christin; Coote, Susan; Jonsdottir, Johanna; Kahraman, Turhan; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne; Medina, Carme Santoyo; Moumdjian, Lousin; Pedulla, Ludovico et al.
DOI: 10.1016/j.msard.2022.103799

The agenda of the global patient reported outcomes for multiple sclerosis (PROMS) initiative: Progresses and open questions.

PMID: 35367873
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 May;61:103757. doi: 10.1016/j.msard.2022.103757. Epub 2022 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Baneke, Peer; Battaglia, Mario Alberto; Bertorello, Deborah; Brichetto, Giampaolo; Coetzee, Timothy; Comi, Giancarlo; Cutter, Gary; Edan, Gilles; Giovannoni, Gavin et al.
DOI: 10.1016/j.msard.2022.103757

Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis: Benefit/risk following review of trial and post-marketing data.

PMID: 34882037
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Apr;28(5):842-846. doi: 10.1177/13524585211061335. Epub 2021 Dec 9.
Impact factor:
Publication type: Paper in international publication
Authors: Bass, Ann D; Boster, Aaron; Chan, Andrew; Coles, Alasdair J; Comi, Giancarlo; Fernandez, Oscar; Giovannoni, Gavin; Jones, Joanne L; Kubala Havrdova, Eva; LaGanke, Christopher et al.
DOI: 10.1177/13524585211061335

Can cognitive training reignite compensatory mechanisms in advanced multiple sclerosis patients? An explorative morphological network approach.

PMID: 35364228
Journal: NEUROSCIENCE
Year: 2022
Reference: Neuroscience. 2022 Jul 15;495:86-96. doi: 10.1016/j.neuroscience.2022.03.031. Epub 2022 Mar 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Juli; Arevalo, Maria Jesus; Auger, Cristina; Cuypers, Koen; Frieske, Joana; Galan, Ingrid; Garcia-Vidal, Aran; Meesen, Raf L J; Montalban, Xavier; Pareto, Deborah et al.
DOI: 10.1016/j.neuroscience.2022.03.031

Identification of patients with relapsing multiple sclerosis eligible for high-efficacy therapies.

PMID: 33966475
Journal: Neurodegenerative disease management
Year: 2021
Reference: Neurodegener Dis Manag. 2021 Jun;11(3):251-261. doi: 10.2217/nmt-2020-0049. Epub 2021 May 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aguera, Eduardo; Brieva, Luis; Costa, Lucienne; Eichau, Sara; Garcia-Merino, Juan Antonio; Martinez-Yelamos, Sergio; Meca-Lallana, Jose; Rovira, Alex; Vidal-Jordana, Angela; Zarranz, Alfredo Rodriguez-Antiguedad et al.
DOI: 10.2217/nmt-2020-0049

The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease.

PMID: 32757905
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 May;27(6):968-972. doi: 10.1177/1352458520943777. Epub 2020 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Barkhof, Frederik; Chard, Declan; Chung, Karen; DeLuca, Gabriele; Dos Passos, Giordani Rodrigues; Enzinger, Christian; Gasperini, Claudio; Geraldes, Ruth; Hagens, Marloes et al.
DOI: 10.1177/1352458520943777

Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab.

PMID: 33903203
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Apr 26;8(4). pii: 8/4/e1003. doi: 10.1212/NXI.0000000000001003. Print 2021 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Bourre, Bertrand; Brassat, David; Clavelou, Pierre; Comabella, Manuel; Defer, Gilles; deSeze, Jerome; Fissolo, Nicolas; Labauge, Pierre; Lebrun-Frenay, Christine; Martinez-Almoyna, Laurent et al.
DOI: 10.1212/NXI.0000000000001003

Deciphering Multiple Sclerosis Progression.

PMID: 33897583
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Apr 7;12:608491. doi: 10.3389/fneur.2021.608491. eCollection 2021.
Impact factor:
Publication type: Review in international publication
Authors: Berenguer-Ruiz, Leticia; Carreres-Polo, Joan; Eichau-Madueno, Sara; Ferrer-Lozano, Jaime; Forero, Lucia; Higueras, Yolanda; Meca-Lallana, Virginia; Perez-Miralles, Francisco Carlos; Tellez Lara, Nieves; Vidal-Jordana, Angela et al.
DOI: 10.3389/fneur.2021.608491

Aggressive multiple sclerosis (2): Treatment.

PMID: 32530366
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Jun 12:1352458520924595. doi: 10.1177/1352458520924595.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Arrambide, Georgina; Brundin, Lou; Derfuss, Tobias; Hemmer, Bernhard; Iacobaeus, Ellen; Tintore, Mar; Vukusic, Sandra et al.
DOI: 10.1177/1352458520924595

Aggressive multiple sclerosis (1): Towards a definition of the phenotype.

PMID: 32530385
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Jun 12:1352458520925369. doi: 10.1177/1352458520925369.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Brundin, Lou; Derfuss, Tobias; Hemmer, Bernhard; Iacobaeus, Ellen; Pia Amato, Maria; Tintore, Mar; Vukusic, Sandra et al.
DOI: 10.1177/1352458520925369

EAN guideline on palliative care of people with severe, progressive multiple sclerosis.

PMID: 32469447
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2020
Reference: Eur J Neurol. 2020 Aug;27(8):1510-1529. doi: 10.1111/ene.14248. Epub 2020 May 29.
Impact factor:
Publication type: Paper in international publication
Authors: Aleksovska, K; Battaglia, M A; Bay, J; Copetti, M; Drulovic, J; Giordano, A; Kleiter, I; Kooij, L; Kopke, S; Mens, J et al.
DOI: 10.1111/ene.14248

EAN Guideline on Palliative Care of People with Severe, Progressive Multiple Sclerosis.

PMID: 32469284
Journal: JOURNAL OF PALLIATIVE MEDICINE
Year: 2020
Reference: J Palliat Med. 2020 Nov;23(11):1426-1443. doi: 10.1089/jpm.2020.0220. Epub 2020 May 29.
Impact factor:
Publication type: Paper in international publication
Authors: Aleksovska, Katina; Battaglia, Mario A; Bay, Jette; Copetti, Massimiliano; Drulovic, Jelena; Giordano, Andrea; Kleiter, Ingo; Kooij, Liesbeth; Kopke, Sascha; Mens, John et al.
DOI: 10.1089/jpm.2020.0220

[Tools to improve efficiency in the clinical management of hypertensive patients].

PMID: 30037730
Journal: Hipertension y riesgo vascular
Year: 2019
Reference: Hipertens Riesgo Vasc. 2019 Apr - Jun;36(2):70-84. doi: 10.1016/j.hipert.2018.06.002. Epub 2018 Jul 20.
Impact factor:
Publication type: Paper in national publication
Authors: Ferrer-Vidal, D; Galgo, A; Gorriz, J L; Hidalgo-Vega, A; Martell, N; Merino, M; Muniz, O; Orozco-Beltran, D; Sabate, N et al.
DOI: 10.1016/j.hipert.2018.06.002

Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis.

PMID: 30885374
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Apr;29:157-167. doi: 10.1016/j.msard.2018.11.021. Epub 2018 Nov 20.
Impact factor:
Publication type: Paper in international publication
Authors: Comi, Giancarlo; Cook, Stuart; Galazka, Andrew; Giovannoni, Gavin; Hicking, Christine; Leist, Thomas; Montalban, Xavier; Nolting, Axel; Sylvester, Elke et al.
DOI: 10.1016/j.msard.2018.11.021

Searching for the "Active Ingredients" in Physical Rehabilitation Programs Across Europe, Necessary to Improve Mobility in People With Multiple Sclerosis: A Multicenter Study.

PMID: 30880560
Journal: NEUROREHABILITATION AND NEURAL REPAIR
Year: 2019
Reference: Neurorehabil Neural Repair. 2019 Apr;33(4):260-270. doi: 10.1177/1545968319834893. Epub 2019 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Baert, Ilse; Conyers, Helen; Dalgas, Ulrik; Elorriaga, Iratxe; Feys, Peter; Freeman, Jennifer; Gebara, Benoit; Heric-Mansrud, Adnan; Jensen, Ellen; Jones, Kari et al.
DOI: 10.1177/1545968319834893

Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials.

PMID: 29521573
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Apr;25(4):565-573. doi: 10.1177/1352458518763089. Epub 2018 Mar 9.
Impact factor:
Publication type: Paper in international publication
Authors: Andlauer, Till Fm; Arnason, Barry; Barkhof, Frederik; Buck, Dorothea; Comi, Giancarlo; Cook, Stuart; Edan, Gilles; Filippi, Massimo; Freedman, Mark S; Hartung, Hans-Peter et al.
DOI: 10.1177/1352458518763089

Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study.

PMID: 29571860
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2018
Reference: J Neurol Sci. 2018 Apr 15;387:179-186. doi: 10.1016/j.jns.2018.02.026. Epub 2018 Feb 16.
Impact factor:
Publication type: Paper in international publication
Authors: Baert, I; Bethoux, F; Bibby, B M; Dalgas, U; Feys, P; Gebara, B; Jensen, E; Kalron, A; Knuts, K; Langeskov-Christensen, M et al.
DOI: 10.1016/j.jns.2018.02.026

Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study.

PMID: 29560379
Journal: Annals of Clinical and Translational Neurology
Year: 2018
Reference: Ann Clin Transl Neurol. 2018 Jan 30;5(3):346-356. doi: 10.1002/acn3.534. eCollection 2018 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Cree, Bruce A C; Freedman, Mark S; Gandini Wheeler-Kingshott, Claudia A M; Haring, Dieter A; Hartung, Hans-Peter; Kappos, Ludwig; Li, Bingbing; Lubetzki, Catherine; Lublin, Fred D; MacManus, David G et al.
DOI: 10.1002/acn3.534

The current role of MRI in differentiating multiple sclerosis from its imaging mimics.

PMID: 29521337
Journal: Nature Reviews Neurology
Year: 2018
Reference: Nat Rev Neurol. 2018 Apr;14(4):199-213. doi: 10.1038/nrneurol.2018.14. Epub 2018 Mar 9.
Impact factor:
Publication type: Review in international publication
Authors: Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; DeLuca, Gabriele C; Enzinger, Christian; Evangelou, Nikos; Fazekas, Franz; Filippi, Massimo; Frederiksen, Jette; Gasperini, Claudio et al.
DOI: 10.1038/nrneurol.2018.14

Varicella-zoster meningovasculitis in a multiple sclerosis patient treated with natalizumab.

PMID: 28643544
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Mar;24(3):358-360. doi: 10.1177/1352458517711569. Epub 2017 Jun 23.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Fonseca, Elena; Montalban, Xavier; Mulero, Patricia; Parolin, Laura; Requena, Manuel; Rio, Jordi; Rovira, Alex; Tintore, Mar et al.
DOI: 10.1177/1352458517711569

Treatment decisions in multiple sclerosis - insights from real-world observational studies.

PMID: 28084327
Journal: Nature Reviews Neurology
Year: 2017
Reference: Nat Rev Neurol. 2017 Feb;13(2):105-118. doi: 10.1038/nrneurol.2016.188. Epub 2017 Jan 13.
Impact factor:
Publication type: Review in national publication
Authors: Butzkueven, Helmut; Hillert, Jan; Iaffaldano, Pietro; Kalincik, Tomas; Montalban, Xavier; Sormani, Maria Pia; Spelman, Tim; Tintore, Mar; Trojano, Maria et al.
DOI: 10.1038/nrneurol.2016.188

The state of multiple sclerosis: current insight into the patient/health care provider relationship, treatment challenges, and satisfaction.

PMID: 28053511
Journal: Patient Preference and Adherence
Year: 2017
Reference: Patient Prefer Adherence. 2016 Dec 22;11:33-45. doi: 10.2147/PPA.S115090. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Alexander, Maggie; Costello, Kathleen; Duddy, Martin; Jones, David E; Law, Nancy; O'Neill, Gilmore; Tintore, Mar; Uccelli, Antonio; Weissert, Robert; Wray, Sibyl et al.
DOI: 10.2147/PPA.S115090

Influence of the bacterial growth phase on the magnetic properties of magnetosomes synthesized by Magnetospirillum gryphiswaldense.

PMID: 28093197
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Year: 2017
Reference: Biochim Biophys Acta Gen Subj. 2017 Jun;1861(6):1507-1514. doi: 10.1016/j.bbagen.2017.01.012. Epub 2017 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, J; Fdez-Gubieda, M L; Fernandez Barquin, L; Garcia-Prieto, A; Marcano, L; Muela, A; Munoz, D; Orue, I et al.
DOI: 10.1016/j.bbagen.2017.01.012

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

PMID: 28289129
Journal: DEVELOPMENT
Year: 2017
Reference: Development. 2017 Apr 15;144(8):1566-1577. doi: 10.1242/dev.138248. Epub 2017 Mar 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alberch, Jordi; Canals, Josep M; Chan, Susan; Edel, Michael J; Esgleas, Miriam; Garcia-Diaz Barriga, Gerardo; Giralt, Albert; Girault, Jean-Antoine; Guardia, Ines; Herranz, Cristina et al.
DOI: 10.1242/dev.138248

Neuromyelitis optica spectrum disorders: Comparison according to the phenotype and serostatus.

PMID: 27144216
Journal: Neurology(R) neuroimmunology & neuroinflammati
Year: 2016
Reference: Neurol Neuroimmunol Neuroinflamm. 2016 Apr 14;3(3):e225. doi: 10.1212/NXI.0000000000000225. eCollection 2016 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Aladro, Yolanda; Alvarez de Arcaya, Amaya; Antiguedad, Alfredo R; Armangue, Thais; Arrambide, Georgina; Blanco, Yolanda; Calles, Carmen; Caminero, Ana; Casanova, Bonaventura; Cervello, Angeles et al.
DOI: 10.1212/NXI.0000000000000225

Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes.

PMID: 27147513
Journal: JOURNAL OF NEUROLOGY
Year: 2016
Reference: J Neurol. 2016 Jul;263(7):1349-60. doi: 10.1007/s00415-016-8147-7. Epub 2016 May 4.
Impact factor:
Publication type: Paper in international publication
Authors: Arino, Helena; Armangue, Thais; Arrambide, Georgina; Blanco, Yolanda; Dalmau, Josep; Graus, Francesc; Martinez-Hernandez, Eugenia; Midaglia, Luciana; Montalban, Xavier; Peschl, Patrick et al.
DOI: 10.1007/s00415-016-8147-7

Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica.

PMID: 27113605
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2016
Reference: J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):1005-15. doi: 10.1136/jnnp-2015-312601. Epub 2016 Apr 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Altintas, Ayse; Barington, Torben; Berki, Timea; Berthele, Achim; Bertolotto, Antonio; Comabella, Manuel; Costa, Carme; Deniz, Gunnur; Giometto, Bruno et al.
DOI: 10.1136/jnnp-2015-312601

CSF examination still has value in the diagnosis of MS - Commentary.

PMID: 27059063
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Jul;22(8):997-8. doi: 10.1177/1352458516642033. Epub 2016 Apr 8.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Tintore, Mar et al.
DOI: 10.1177/1352458516642033

Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.

PMID: 26149978
Journal: NAT REV NEUROL
Year: 2015
Reference: Nat Rev Neurol. 2015 Aug;11(8):471-82. doi: 10.1038/nrneurol.2015.106. Epub 2015 Jul 7.
Impact factor:
Publication type: Review in international publication
Authors: Auger, Cristina; Barkhof, Frederik; De Stefano, Nicola; Fazekas, Franz; Filippi, Massimo; Kappos, Ludwig; Miller, David; Montalban, Xavier; Polman, Chris; Rocca, Maria A et al.
DOI: 10.1038/nrneurol.2015.106

Review of the novelties from the 2014 ECTRIMS-ACTRIMS Joint Congress, presented at the 7th Post-ECTRIMS Meeting (II).

PMID: 26350778
Journal: REV NEUROLOGIA
Year: 2015
Reference: Rev Neurol. 2015 Sep 16;61(6):271-283.
Impact factor:
Publication type: Review in national publication
Authors: Alvarez-Cermeno, J C; Arroyo, R; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R et al.
DOI:

Long-term results from a phase 2 extension study of fingolimod at high and approved dose in relapsing multiple sclerosis.

PMID: 26338810
Journal: J NEUROL
Year: 2015
Reference: J Neurol. 2015 Dec;262(12):2627-34. doi: 10.1007/s00415-015-7834-0. Epub 2015 Sep 4.
Impact factor:
Publication type: Paper in national publication
Authors: Antel, Jack; Comi, Giancarlo; Cremer, Malika; de Vera, Ana; Kappos, Ludwig; Montalban, Xavier; O'Connor, Paul; Sfikas, Nikolaos; von Rosenstiel, Philipp et al.
DOI: 10.1007/s00415-015-7834-0

[Review of the novelties from the 2014 ECTRIMS-ACTRIMS Joint Congress, presented at the 7th Post-ECTRIMS meeting (I)].

PMID: 26308843
Journal: REV NEUROLOGIA
Year: 2015
Reference: Rev Neurol. 2015 Sep 1;61(5):215-24.
Impact factor:
Publication type: Review in national publication
Authors: Alvarez-Cermeno, J C; Arroyo, R; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R et al.
DOI:

Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.

PMID: 24009164
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Apr;20(5):577-87. doi: 10.1177/1352458513503597. Epub 2013 Sep 5.
Impact factor:
Publication type: Paper in international publication
Authors: Bertolotto, A; Comabella, M; Deisenhammer, F; Giovanonni, G; Guger, M; Hegen, H; Hoelzl, M; Khalil, M; Killestein, J; Lindberg, R et al.
DOI: 10.1177/1352458513503597

A randomized clinical trial of oral versus intravenous methylprednisolone for relapse of MS.

PMID: 24144876
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 May;20(6):717-25. doi: 10.1177/1352458513508835. Epub 2013 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: Brieva, L; Cano, A; Carmona, O; Costa, J; Giner, P; Grau-Lopez, L; Martinez-Caceres, E; Massuet, A; Montalban, X; Nos, C et al.
DOI: 10.1177/1352458513508835

Myeloid-derived suppressor cells are generated during retroviral transduction of murine bone marrow.

PMID: 23192196
Journal: CELL TRANSPLANTATION
Year: 2014
Reference: Cell Transplant. 2014 Jan;23(1):73-85. doi: 10.3727/096368912X658971. Epub 2012 Nov 27.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Casacuberta-Serra, Silvia; Eixarch, Herena; Espejo, Carmen; Gimeno, Ramon; Gomez, Alba; Lopez-Estevez1, Sergio; Mansilla, Maria Jose; Montalban, Xavier; Pereira, Sonia et al.
DOI: 10.3727/096368912X658971

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

PMID: 24328534
Journal: AUTOIMMUNITY
Year: 2014
Reference: Autoimmunity. 2014 Mar;47(2):127-33. doi: 10.3109/08916934.2013.866104. Epub 2013 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, Joaquin; Castillo, Mireia; Comabella, Manuel; Espejo, Carmen; Mansilla, Maria Jose; Martin, Roland; Montalban, Xavier; Rio, Jordi et al.
DOI: 10.3109/08916934.2013.866104

Analysis of prognostic factors associated with longitudinally extensive transverse myelitis.

PMID: 23037550
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 May;19(6):742-8. doi: 10.1177/1352458512461968. Epub 2012 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Ayuso, Teresa; Blanco, Yolanda; Castillo, Joaquin; Corral, Juan; Gabilondo, Inigo; Graus, Francesc; Guijarro, Cristina; Iniguez, Cristina; Llufriu, Sara; Mendibe, Mar et al.
DOI: 10.1177/1352458512461968

Scoring treatment response in patients with relapsing multiple sclerosis.

PMID: 23012253
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Apr;19(5):605-12. doi: 10.1177/1352458512460605. Epub 2012 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Cornelisse, P; De Stefano, N; Li, D; Montalban, X; Rio, J; Signori, A; Sormani, Mp; Stromillo, Ml; Stubinski, B; Tintore, M et al.
DOI: 10.1177/1352458512460605

TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.

PMID: 23624563
Journal: NEUROLOGY
Year: 2013
Reference: Neurology. 2013 May 28;80(22):2010-6. doi: 10.1212/WNL.0b013e318294b2d6. Epub 2013 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Agullo, Luis; Caminero, Ana B; Comabella, Manuel; Fernandez, Oscar; Izquierdo, Guillermo; Lopez-Larios, Arturo; Malhotra, Sunny; Matesanz, Fuencisla; Montalban, Xavier; Otero, Susana et al.
DOI: 10.1212/WNL.0b013e318294b2d6

MRI criteria distinguishing seropositive NMO spectrum disorder from MS.

PMID: 23486884
Journal: NEUROLOGY
Year: 2013
Reference: Neurology. 2013 Apr 2;80(14):1336. doi: 10.1212/WNL.0b013e3182887998. Epub 2013 Mar 13.
Impact factor:
Publication type: Editorail in international publication
Authors: Rovira, Alex; Tintore, Mar et al.
DOI: 10.1212/WNL.0b013e3182887998

Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response.

PMID: 22289050
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2012
Reference: Eur J Neurol. 2012 Jun;19(6):899-904. doi: 10.1111/j.1468-1331.2011.03648.x. Epub 2012 Jan 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1468-1331.2011.03648.x

Multiple sclerosis: more pieces of the immunological puzzle.

PMID: 22172612
Journal: LANCET NEUROLOGY
Year: 2012
Reference: Lancet Neurol. 2012 Jan;11(1):9-10. doi: 10.1016/S1474-4422(11)70268-X.
Impact factor:
Publication type: Editorail in international publication
Authors: Gold, Ralf; Montalban, Xavier et al.
DOI: 10.1016/S1474-4422(11)70268-X

In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain.

PMID: 21272959
Journal: NEUROBIOLOGY OF AGING
Year: 2012
Reference: Neurobiol Aging. 2012 Jul;33(7):1457-65. doi: 10.1016/j.neurobiolaging.2010.12.006. Epub 2011 Jan 26.
Impact factor: 6.189
Publication type: Paper in international publication
Authors: Abad, Sergio, Jimenez, Xavier, Figueiras, Francisca P, Popota, Foteini, Ruiz, Alba, Flotats, Nuria, Fernandez, Francisco J, Rocha, Milagros, Rovira, Mariana, Victor, Victor M et al.
DOI: 10.1016/j.neurobiolaging.2010.12.006

Which walking capacity tests to use in multiple sclerosis? A multicentre study providing the basis for a core set.

PMID: 21952098
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Mar;18(3):364-71. doi: 10.1177/1352458511420598. Epub 2011 Sep 27.
Impact factor: 4.255
Publication type: Clinical guide
Authors: Gijbels, Domien, Dalgas, Ulrik, Romberg, Anders, de Groot, Vincent, Bethoux, Francois, Vaney, Claude, Gebara, Benoit, Medina, Carme Santoyo, Maamagi, Heigo, Rasova, Kamila et al.
DOI: 10.1177/1352458511420598

Principles of a new treatment algorithm in multiple sclerosis.

PMID: 21375441
Journal: Expert review of neurotherapeutics
Year: 2011
Reference: Expert Rev Neurother. 2011 Mar;11(3):351-62.
Impact factor:
Publication type: Letter or abstract
Authors: Hartung, Hans-Peter; Montalban, Xavier; Olsson, Tomas; Sorensen, Per Soelberg; Vermersch, Patrick et al.
DOI: 10.1586/ern.11.15

A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex((R)) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.

PMID: 21362108
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2011
Reference: Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x. Epub 2011 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1468-1331.2010.03328.x

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility.

PMID: 21354972
Journal: BRAIN
Year: 2011
Reference: Brain. 2011 Mar;134(Pt 3):693-703.
Impact factor:
Publication type: Paper in international publication
Authors: Brassat, David; Bucciarelli, Florence; Clanet, Michel; Comabella, Manuel; Confavreux, Christian; Cournu-Rebeix, Isabelle; Couturier, Nicolas; Debouverie, Marc; Defer, Gilles; Edan, Gilles et al.
DOI: 10.1093/brain/awr010

[Review of the novelties presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).]

PMID: 21341224
Journal: REVISTA DE NEUROLOGIA
Year: 2011
Reference: Rev Neurol. 2011 Mar 1;52(5):289-299.
Impact factor:
Publication type: Review in national publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI:

Bimonthly assessment of magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14-month, multicentre, follow-up study.

PMID: 20086023
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Mar;16(3):325-31. Epub 2010 Jan 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458509358713

MRI criteria for MS in patients with clinically isolated syndromes.

PMID: 20054006
Journal: NEUROLOGY
Year: 2010
Reference: Neurology. 2010 Feb 2;74(5):427-34. Epub 2010 Jan 6.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1212/WNL.0b013e3181cec45c

Brainstem lesions in clinically isolated syndromes.

PMID: 21098409
Journal: NEUROLOGY
Year: 2010
Reference: Neurology. 2010 Nov 23;75(21):1933-8.
Impact factor: 8.172
Publication type: Paper in international publication
Authors: Tintore, M, Rovira, A, Arrambide, G, Mitjana, R, Rio, J, Auger, C, Nos, C, Edo, M C, Castillo, J, Horga, A et al.
DOI: 10.1212/WNL.0b013e3181feb26f

Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis.

PMID: 20236661
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2010
Reference: J Neurol Sci. 2010 May 15;292(1-2):28-35. Epub 2010 Mar 16.
Impact factor: 2.324
Publication type: Paper in international publication
Authors: Strasser-Fuchs, S, Radue, Ernst-Wilhelm, Stuart, William H, Calabresi, Peter A, Confavreux, Christian, Galetta, Steven L, Rudick, Richard A, Lublin, Fred D, Weinstock-Guttman, Bianca, Wynn, Daniel R et al.
DOI: 10.1016/j.jns.2010.02.012

Abnormal connectivity of the sensorimotor network in patients with MS: a multicenter fMRI study.

PMID: 19034902
Journal: HUMAN BRAIN MAPPING
Year: 2009
Reference: Hum Brain Mapp. 2009 Aug;30(8):2412-25.
Impact factor:
Publication type: Paper in international publication
Authors: Absinta, Martina; Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Gass, Achim; Hirsch, Jochen; Kappos, Ludwig; Korteweg, Tjimen et al.
DOI: 10.1002/hbm.20679

Plasma levels of 15d-PGJ are not altered in multiple sclerosis.

PMID: 19538219
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2009
Reference: Eur J Neurol. 2009 Nov;16(11):1197-201.
Impact factor: 2.732
Publication type: Paper in international publication
Authors: Comabella, M, Pradillo, J M, Fernandez, M, Rio, J, Lizasoain, I, Julia, E, Moro, M A, Sastre-Garriga, J, Montalban, X et al.
DOI: 10.1111/j.1468-1331.2009.02696.x

HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis.

PMID: 19349081
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2009
Reference: J Neuroimmunol. 2009 May 29;210(1-2):116-9.
Impact factor: 3.159
Publication type: Paper in international publication
Authors: Comabella, M, Fernandez-Arquero, M, Rio, J, Guinea, A, Fernandez, M, Cenit, M C, de la Concha, E G, Montalban, X et al.
DOI: 10.1016/j.jneuroim.2009.01.012

Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis.

PMID: 18945642
Journal: CLINICAL IMMUNOLOGY
Year: 2009
Reference: Clin Immunol. 2009 Feb;130(2):145-50.
Impact factor: 3.606
Publication type: Paper in international publication
Authors: Montalban, Xavier, Oksenberg, Jorge R, Julia, Eva, Comabella, Manuel, Rio, Jordi, Espejo, Carmen, Ruiz de Villa, Mamen, Al-Zayat, Hammad, Nos, Carlos, Deisenhammer, Florian et al.
DOI: 10.1016/j.clim.2008.09.010

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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