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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Publications

A wearable device perspective on the standard definitions of disability progression in multiple sclerosis.

PMID: 38084497
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Dec 12:13524585231214362. doi: 10.1177/13524585231214362.
Impact factor:
Publication type: Paper in international publication
Authors: Bailon, Raquel; Buron, Mathias; Comi, Giancarlo; Cummins, Nicholas; Dalla Costa, Gloria; Dobson, Richard; Folarin, Amos; Garcia, Esther; Guerrero, Ana Isabel; Hotopf, Matthew et al.
DOI: 10.1177/13524585231214362

270th ENMC International Workshop: Consensus for SMN2 genetic analysis in SMA patients 10-12 March, 2023, Hoofddorp, the Netherlands.

PMID: 38183850
Journal: NEUROMUSCULAR DISORDERS
Year: 2023
Reference: Neuromuscul Disord. 2023 Dec 14;34:114-122. doi: 10.1016/j.nmd.2023.12.008.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Abiusi, Emanuela; Bertini, Enrico Silvio; Costa-Roger, Mar; de Dios Lascuevas, Marta; Diana, Francesco; Frauenfelder, Giulia; Hernandez, David; Peschillo, Simone; Requena, Manuel; Ribo, Marc et al.
DOI: 10.1016/j.nmd.2023.12.008

Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis.

PMID: 35105687
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2022
Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Feb 1;9(2). pii: 9/2/e1143. doi: 10.1212/NXI.0000000000001143. Print 2022 Mar.
Impact factor: 8.485
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Zabalza, Ana; Nos, Carlos; Sastre-Garriga, Jaume; Tintore, Mar; Montalban, Xavier; Comabella, Manuel; Espejo, Carmen; Castillo, Joaquin; Otero-Romero, Susana et al.
DOI: 10.1212/NXI.0000000000001143

Neurotoxicity-associated sinus bradycardia after chimeric antigen receptor T-cell therapy.

PMID: 35139240
Journal: HEMATOLOGICAL ONCOLOGY
Year: 2022
Reference: Hematol Oncol. 2022 Feb 9. doi: 10.1002/hon.2976.
Impact factor: 5.271
Publication type: Letter or abstract
Authors: Barba, Pere; Tintore, Mar; Bosch, Francesc; Cabirta, Alba; Catala, Eva; Iacoboni, Gloria; Vidal-Jordana, Angela; Oristrell, Gerard; Carpio, Cecilia; Vilaseca, Andreu et al.
DOI: 10.1002/hon.2976

Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis.

PMID: 34836608
Journal: REVUE NEUROLOGIQUE
Year: 2022
Reference: Rev Neurol (Paris). 2022 Jan-Feb;178(1-2):121-128. doi: 10.1016/j.neurol.2021.10.003. Epub 2021 Nov 4.
Impact factor: 2.607
Publication type: Review in international publication
Authors: Zabalza, A; Mahdavi, S; Baratian, M; Sedaghat, N; Sepulveda, M; Blanco, Y; Salari, M; Akhavan Sigari, A; Etemadifar, M; Nouri, H et al.
DOI: 10.1016/j.neurol.2021.10.003

Treatment satisfaction, safety, and tolerability of cladribine tablets in patients with highly active relapsing multiple sclerosis: CLARIFY-MS study 6-month interim analysis.

PMID: 35158476
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jan;57:103385. doi: 10.1016/j.msard.2021.103385. Epub 2021 Nov 9.
Impact factor: 4.339
Publication type: Paper in international publication
Authors: Hupperts, Raymond; Langdon, Dawn; Solari, Alessandra; Piehl, Fredrik; Lechner-Scott, Jeannette; Montalban, Xavier; Selmaj, Krzysztof; Valis, Martin; Rejdak, Konrad; Havrdova, Eva K et al.
DOI: 10.1016/j.msard.2021.103385

Ischemic Core Overestimation on Computed Tomography Perfusion.

PMID: 33682453
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 May;52(5):1751-1760. doi: 10.1161/STROKEAHA.120.031800. Epub 2021 Mar 8.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Campos, Daniel, Rubiera, Marta, Boned, Sandra, Olive-Gadea, Marta, Requena, Manuel, Ciolli, Ludovico, Muchada, Marian, Pagola, Jorge, Deck, Matias et al.
DOI: 10.1161/STROKEAHA.120.031800

Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study.

PMID: 33401136
Journal: NeuroImage-Clinical
Year: 2021
Reference: Neuroimage Clin. 2021;29:102549. doi: 10.1016/j.nicl.2020.102549. Epub 2020 Dec 25.
Impact factor: 4.881
Publication type: Paper in international publication
Authors: Guttmann, Charles R G, Vrenken, Hugo, Uitdehaag, Bernard M J, Burggraaff, Jessica, Liu, Yao, Prieto, Juan C, Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman et al.
DOI: 10.1016/j.nicl.2020.102549

Optic nerve region in multiple sclerosis diagnosis: the utility of visual evoked potentials.

PMID: 33328323
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Jan 26;96(4):e482-e490. doi: 10.1212/WNL.0000000000011339. Epub 2020 Dec 16.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Comabella, Manuel, Vidal-Jordana, Angela, Rovira, Alex, Arrambide, Georgina, Otero-Romero, Susana, Rio, Jordi, Galan, Ingrid, Cabello, Sergio, Moncho, Dulce, Rahnama, Kimia et al.
DOI: 10.1212/WNL.0000000000011339

CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS.

PMID: 33436375
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Jan 12;8(2). pii: 8/2/e941. doi: 10.1212/NXI.0000000000000941. Print 2021 Mar.
Impact factor: 8.485
Publication type: Paper in international publication
Authors: Brito, Veronica, Fissolo, Nicolas, Matute-Blanch, Clara, Osman, Mohamoud, Costa, Carme, Pinteac, Rucsanda, Miro, Berta, Sanchez, Alex, Khalil, Michael, Borras, Eva et al.
DOI: 10.1212/NXI.0000000000000941

[Prevalence and impact of comorbidities in patients with multiple sclerosis].

PMID: 32700311
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 Aug 16;71(4):151-158. doi: 10.33588/rn.7104.2020095.
Impact factor: 0.562
Publication type: Review in national publication
Authors: Cardenas-Robledo, S, Otero-Romero, S, Montalban, X, Tintore, M et al.
DOI: 10.33588/rn.7104.2020095

Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.

PMID: 32681355
Journal: Neurotherapeutics
Year: 2020
Reference: Neurotherapeutics. 2020 Oct;17(4):1988-2003. doi: 10.1007/s13311-020-00885-8.
Impact factor: 6.035
Publication type: Paper in international publication
Authors: Castillo, Mireia, Eixarch, Herena, Calvo-Barreiro, Laura, Costa, Carme, Reverter-Vives, Gemma, Montalban, Xavier, Espejo, Carmen, Del Rio, Jose Antonio, Gil, Vanessa et al.
DOI: 10.1007/s13311-020-00885-8

Preliminary Experience Using a Covered Stent Graft in Patients with Acute Ischemic Stroke and Carotid Tandem Lesion.

PMID: 32676962
Journal: CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Year: 2020
Reference: Cardiovasc Intervent Radiol. 2020 Nov;43(11):1679-1686. doi: 10.1007/s00270-020-02594-3. Epub 2020 Jul 16.
Impact factor: 2.034
Publication type: Paper in international publication
Authors: Pinana, Carlos, Gramegna, Laura Ludovica, Folleco, Edgar, Requena, Manuel, Hernandez, David, Tomasello Weitz, Alejandro et al.
DOI: 10.1007/s00270-020-02594-3

Real-World Goal Setting and Use of Outcome Measures According to the International Classification of Functioning, Disability and Health: A European Survey of Physical Therapy Practice in Multiple Sclerosis.

PMID: 32630765
Journal: International Journal of Environmental Research and Public Health
Year: 2020
Reference: Int J Environ Res Public Health. 2020 Jul 2;17(13). pii: ijerph17134774. doi: 10.3390/ijerph17134774.
Impact factor: 2.849
Publication type: Paper in international publication
Authors: Rasova, Kamila, Martinkova, Patricia, Soler, Bernadita, Freeman, Jenny, Cattaneo, Davide, Jonsdottir, Johanna, Smedal, Tori, Romberg, Anders, Henze, Thomas, Santoyo-Medina, Carme et al.
DOI: 10.3390/ijerph17134774

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information