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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Camiña Rodríguez, Gabriel Ig

Camiña Rodríguez, Gabriel Ig

Administration and Management
Clinical Neuroimmunology
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Castro D la Visitación, Marta

Castro D la Visitación, Marta

Research technician
Clinical Neuroimmunology
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Delon La Puma

Delon La Puma

Research technician
Clinical Neuroimmunology
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Diana Francesco

Diana Francesco

Predoctoral researcher
Clinical Neuroimmunology
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Elisa Marín Ordovás

Elisa Marín Ordovás

Predoctoral researcher
Clinical Neuroimmunology
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Fernàndez Garberi, Caterina

Fernàndez Garberi, Caterina

Administration and Management
Clinical Neuroimmunology
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Camiña Rodríguez, Gabriel Ig

Camiña Rodríguez, Gabriel Ig

Administration and Management
Clinical Neuroimmunology
Read more
Castro D la Visitación, Marta

Castro D la Visitación, Marta

Research technician
Clinical Neuroimmunology
Read more
Delon La Puma

Delon La Puma

Research technician
Clinical Neuroimmunology
Read more
Diana Francesco

Diana Francesco

Predoctoral researcher
Clinical Neuroimmunology
Read more
Elisa Marín Ordovás

Elisa Marín Ordovás

Predoctoral researcher
Clinical Neuroimmunology
Read more
Fernàndez Garberi, Caterina

Fernàndez Garberi, Caterina

Administration and Management
Clinical Neuroimmunology
Read more

Projects

SGR-Cat 2021: Neuroimmunologia Clínica

IP: Xavier Montalban Gairín
Collaborators: Ana Isabel Guerrero Perez, Carlos Nos Llopis, Sunny Malhotra Sareen, José Ant. Graells Salvador, Jaume Sastre Garriga, Jordi Rio Izquierdo, Ingrid Galán Cartaña, Rosalia Horno Ocaña, Manuel Comabella Lopez, Andrea Serrano Mascarós, Margarida Capell Maymo, Samuel Sánchez Pous, Elisenda Anglada Clofent, Montserrat Aroca Alsina, Sergio Cabello, Carmen Tur Gomez, Gabriel Ig Camiña Rodríguez, Herena Eixarch Ahufinger, Carme Santoyo Medina, Oriol Nualart Mundo, Mar Tintore Subirana, M Jesus Arevalo Navines, Edwin Roger Meza Murillo, Augusto Cesar Sao Aviles, Miguel Angel Robles Sanchez, Dunia Muñoz Valdivielso, Carmen Espejo Ruiz, SGR-Cat 2021: Neuroimmunologia Clínica, Gaizka Loyola Sanmillan, Mireia Resina Salles, Angela Vidal Jordana, Lucía Gutiérrez Ruiz, Ana Zabalza de Torres, Sergio Vergara Ruiz, Javier Villacieros Álvarez, Rafael Garcia Merida, Maria Arantza Dema Etxezarreta, Luciana Midaglia Fernandez, Alvaro Cobo Calvo, Neus Mongay Ochoa, Joaquin Castillo Justribo, Milagros Fraga Pereira, Breogan Rodriguez Acevedo, Andres Miguez Gonzalez, Mireia Castillo Juarez, Rucsanda Pinteac, Nicolás Miguel Fissolo
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00782
Duration: 01/01/2022 - 30/06/2025

Rio Hortega

IP: Manuel Comabella Lopez
Collaborators: Ana Zabalza de Torres, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM22/00237
Duration: 10/03/2023 - 09/03/2025

Neuroimmunologia clínica

IP: Mar Tintore Subirana
Collaborators: Miriam Izquierdo Sans, Andreu Vilaseca Jolonch
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM22/00247
Duration: 01/03/2023 - 28/02/2025

Convocatoria Juan Rodés (Preliminar: Enfermedades neurológicas mediadas por anticuerpos antineuronales)

IP: Mar Tintore Subirana
Collaborators: Genoveva Arqueros Sánchez, Xavier Montalban Gairín, Helena Ariño Rodríguez, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 180000
Reference: JR22/00071
Duration: 20/02/2023 - 19/02/2026

Publications

Uncovering alternative diagnoses in patients with clinical syndromes suggestive of multiple sclerosis: A transversal study from the prospective Barcelona CIS cohort.

PMID: 39907218
Journal: Multiple Sclerosis Journal
Year: 2025
Reference: Mult Scler. 2025 Feb 5:13524585251314749. doi: 10.1177/13524585251314749.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, M feminine Jesus; Arino, Helena; Arrambide, Georgina; Auger, Cristina; Bollo, Luca; Carbonell-Mirabent, Pere; Carvajal, Rene; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel et al.
DOI: 10.1177/13524585251314749

Novel Approaches to Treatment of Immune-Mediated Chronic Intestinal Pseudo-Obstruction.

PMID: 39908479
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2025
Reference: Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200369. doi: 10.1212/NXI.0000000000200369. Epub 2025 Feb 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis; Arino, Helena; Armangue, Thais; Arranz, Paula; Borruel, Natalia; Fernandez-Forcelledo, Jose Luis; Fonseca, Elianet Gisell; Gomez Lorente, Maria Amelia; Graus, Francesc; Llaurado, Arnau et al.
DOI: 10.1212/NXI.0000000000200369

Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies.

PMID: 39925147
Journal: Multiple Sclerosis Journal
Year: 2025
Reference: Mult Scler. 2025 Feb 10:13524585251316471. doi: 10.1177/13524585251316471.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Fernandez, Victoria; Galan, Ingrid; Marrodan, Mariano; Midaglia, Luciana; Mongay-Ochoa, Neus et al.
DOI: 10.1177/13524585251316471

Giancarlo COMI (1947-2024).

PMID: 39931971
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2025
Reference: Eur J Neurol. 2025 Feb;32(2):e70078. doi: 10.1111/ene.70078.
Impact factor:
Publication type: Paper in international publication
Authors: Edan, Gilles; Hartung, Hans-Peter; Montalban, Xavier et al.
DOI: 10.1111/ene.70078

Radial Versus Femoral Access for Mechanical Thrombectomy in Patients With Stroke: A Noninferiority Randomized Clinical Trial.

PMID: 38527149
Journal: STROKE
Year: 2024
Reference: Stroke. 2024 Apr;55(4):840-848. doi: 10.1161/STROKEAHA.124.046360. Epub 2024 Feb 1.
Impact factor:
Publication type: Paper in international publication
Authors: Carmona, Tomas; de Dios, Marta; Diana, Francesco; Garcia-Tornel, Alvaro; Gramegna, Laura Ludovica; Hernandez, David; Juega, Jesus; Molina, Carlos; Muchada, Marian; Olive-Gadea, Marta et al.
DOI: 10.1161/STROKEAHA.124.046360

Prediction of disease activity and treatment failure in relapsing-remitting MS patients initiating daily oral DMTs.

PMID: 38551315
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Mar 29:13524585241240653. doi: 10.1177/13524585241240653.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Bollo, Luca; Braga, Nathane; Carbonell-Mirabent, Pere; Carvajal, Rene; Castillo-Justribo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid et al.
DOI: 10.1177/13524585241240653

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.

PMID: 38564056
Journal: JOURNAL OF NEUROLOGY
Year: 2024
Reference: J Neurol. 2024 Apr 2. doi: 10.1007/s00415-024-12289-1.
Impact factor:
Publication type: Paper in international publication
Authors: Ahsan, Nusrat; Arroyo, Hugo A; Azevedo, Christina J; Brenton, J Nicholas; Cabre, Philippe; Carra-Dalliere, Clarisse; Casez, Olivier; de Seze, Jerome; Durand-Dubief, Francoise; Gombolay, Grace et al.
DOI: 10.1007/s00415-024-12289-1

Clusterin deficiency is associated with a lack of response to teriflunomide in multiple sclerosis.

PMID: 38591764
Journal: Clinical and Translational Medicine
Year: 2024
Reference: Clin Transl Med. 2024 Apr;14(4):e1654. doi: 10.1002/ctm2.1654.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Comabella, Manuel; Fernandez Velasco, Jose Ignacio; Fissolo, Nicolas; Goicoechea, Carlos; Malhotra, Sunny; Martinez-Vicente, Marta; Miguez, Andres; Monreal, Enric; Montalban, Xavier; Montpeyo, Marta et al.
DOI: 10.1002/ctm2.1654

Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis.

PMID: 36469103
Journal: JOURNAL OF NEUROLOGY
Year: 2023
Reference: J Neurol. 2023 Mar;270(3):1624-1636. doi: 10.1007/s00415-022-11494-0. Epub 2022 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Bernasconi, Corrado; Craveiro, Licinio; Dondelinger, Frank; Gaetano, Laura; Ganzetti, Marco; Graves, Jennifer S; Hauser, Stephen L; Holm, Sven P; Lindemann, Michael; Lipsmeier, Florian et al.
DOI: 10.1007/s00415-022-11494-0

Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis.

PMID: 36453167
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Feb;29(2):169-181. doi: 10.1177/13524585221134213. Epub 2022 Dec 1.
Impact factor:
Publication type: Review in international publication
Authors: Arrambide, Georgina; Berek, Klaus; Deisenhammer, Florian; Gnanapavan, Sharmilee; Hegen, Harald; Kaplan, Batia; Khalil, Michael; Saadeh, Ruba; Teunissen, Charlotte; Tumani, Hayrettin et al.
DOI: 10.1177/13524585221134213

Present and future of the diagnostic work-up of multiple sclerosis: the imaging perspective.

PMID: 36427168
Journal: JOURNAL OF NEUROLOGY
Year: 2023
Reference: J Neurol. 2023 Mar;270(3):1286-1299. doi: 10.1007/s00415-022-11488-y. Epub 2022 Nov 24.
Impact factor:
Publication type: Review in international publication
Authors: Arnold, Douglas L; Barkhof, Frederik; Filippi, Massimo; Harrison, Daniel M; Maggi, Pietro; Mainero, Caterina; Montalban, Xavier; Preziosa, Paolo; Rocca, Maria A; Sechi, Elia et al.
DOI: 10.1007/s00415-022-11488-y

Associations of sNfL with clinico-radiological measures in a large MS population.

PMID: 36427295
Journal: Annals of Clinical and Translational Neurology
Year: 2023
Reference: Ann Clin Transl Neurol. 2023 Jan;10(1):84-97. doi: 10.1002/acn3.51704. Epub 2022 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Akgun, Katja; Arrambide, Georgina; Bermel, Robert A; Calabresi, Peter A; Canissario, Ryan; Comabella, Manuel; Fisher, Elizabeth; Fitzgerald, Kathryn C; Hersh, Carrie M; Hyland, Megan H et al.
DOI: 10.1002/acn3.51704

Consensus on early detection of disease progression in patients with multiple sclerosis.

PMID: 35968319
Journal: Frontiers in Neurology
Year: 2022
Reference: Front Neurol. 2022 Jul 28;13:931014. doi: 10.3389/fneur.2022.931014. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Ara, Jose Ramon; Calles, Carmen; Casanova, Bonaventura; Costa-Frossard, Lucienne; Duran, Carmen; Eichau, Sara; Garcia-Merino, Antonio; Hernandez, Miguel Angel; Izquierdo, Guillermo; Meca-Lallana, Jose E et al.
DOI: 10.3389/fneur.2022.931014

Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial.

PMID: 35946107
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Oct;28(12):1913-1926. doi: 10.1177/13524585221114441. Epub 2022 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Binks, Sophie; Chan, Dennis; Chataway, Jeremy; Doshi, Anisha; Eshaghi, Arman; Heslegrave, Amanda; Tur, Carmen; Wellington, Henny; Williams, Thomas; Zetterberg, Henrik et al.
DOI: 10.1177/13524585221114441

Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-beta.

PMID: 35917745
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Oct;66:104072. doi: 10.1016/j.msard.2022.104072. Epub 2022 Jul 25.
Impact factor:
Publication type: Letter whit IF
Authors: Alonso, Ricardo; Alroughani, Raed; Arrambide, Georgina; Bebo, Bruce; Bergmann, Arnfin; Boz, Cavit; Braune, Stefan; Butzkueven, Helmut; Chertcoff, Anibal; Comi, Giancarlo et al.
DOI: 10.1016/j.msard.2022.104072

Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis.

PMID: 35902536
Journal: Neurotherapeutics
Year: 2022
Reference: Neurotherapeutics. 2022 Sep;19(5):1617-1633. doi: 10.1007/s13311-022-01279-8. Epub 2022 Jul 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Calvo-Barreiro, Laura; Chillon, Miguel; Edo, Angel; Eixarch, Herena; Espejo, Carmen et al.
DOI: 10.1007/s13311-022-01279-8

Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.

PMID: 34610987
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Nov 9;97(19):e1870-e1885. doi: 10.1212/WNL.0000000000012753. Epub 2021 Oct 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Ricardo N; Alroughani, Raed; Ardeshirdavanai, Amin; Arrambide, Georgina; Bauer, Johana; Bergmann, Arnfin B; Braune, Stefan; Brum, Doralina; Butzkueven, Helmut; Chertcoff, Anibal Sebastian et al.
DOI: 10.1212/WNL.0000000000012753

Developing a Digital Solution for Remote Assessment in Multiple Sclerosis: From Concept to Software as a Medical Device.

PMID: 34573267
Journal: Brain Sciences
Year: 2021
Reference: Brain Sci. 2021 Sep 21;11(9). pii: brainsci11091247. doi: 10.3390/brainsci11091247.
Impact factor:
Publication type: Review in international publication
Authors: Butler, Lesley M; Butzkueven, Helmut; Capezzuto, Luca; Costantino, Cristina; Davies, Geraint; Lindemann, Michael; Midaglia, Luciana; Montalban, Xavier; Shin, Robert K; van der Walt, Anneke et al.
DOI: 10.3390/brainsci11091247

Retinal Optical Coherence Tomography in Neuromyelitis Optica.

PMID: 34526385
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Sep 15;8(6). pii: 8/6/e1068. doi: 10.1212/NXI.0000000000001068. Print 2021 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Altintas, Ayse; Asgari, Nasrin; Ashtari, Fereshteh; Bereuter, Charlotte; Bichuetti, Denis; Brandt, Alexander U; Calvo, Alvaro Cobo; Chien, Claudia et al.
DOI: 10.1212/NXI.0000000000001068

COVID-19 in MS patients: susceptibility, severity risk factors and serological response.

PMID: 33340215
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2021
Reference: Eur J Neurol. 2021 Oct;28(10):3384-3395. doi: 10.1111/ene.14690. Epub 2021 Jan 9.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana; Montalban, Xavier; Nos, Carlos et al.
DOI: 10.1111/ene.14690

The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

PMID: 31610739
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Nov;26(13):1658-1669. doi: 10.1177/1352458519877810. Epub 2019 Oct 15.
Impact factor:
Publication type: Paper in international publication
Authors: Anglada, Elisenda; Arevalo, Maria Jesus; Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Comabella, Manuel; de Barros, Andrea; Espejo, Carmen; Galan, Ingrid et al.
DOI: 10.1177/1352458519877810

Shorter infusion time of ocrelizumab: Results from the randomized, double-blind ENSEMBLE PLUS substudy in patients with relapsing-remitting multiple sclerosis.

PMID: 33039944
Journal: Multiple Sclerosis and Related Disorders
Year: 2020
Reference: Mult Scler Relat Disord. 2020 Nov;46:102492. doi: 10.1016/j.msard.2020.102492. Epub 2020 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Berger, T; Bermel, R A; Brochet, B; Buffels, R; Carroll, W M; Freedman, M S; Garas, M; Hartung, H-P; Holmøy, T; Kadner, K et al.
DOI: 10.1016/j.msard.2020.102492

The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States.

PMID: 31368393
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Oct;26(11):1329-1339. doi: 10.1177/1352458519863764. Epub 2019 Aug 1.
Impact factor:
Publication type: Paper in international publication
Authors: Amezcua, L; Beecham, A H; Beecham, G W; Burchard, E G; Calabresi, P A; Chinea, A; Comabella, M; Conti, D V; De Jager, P; Delgado, S R et al.
DOI: 10.1177/1352458519863764

Effet de l'Evobrutinib, inhibiteur de la tyrosine kinase de Bruton, sur les taux de cellules immunitaires et d'immunoglobulines sur 48 semaines dans le cadre d'une etude de phase 2 sur la sclerose en plaques recurrente.

PMID: 32906528
Journal: REVUE NEUROLOGIQUE
Year: 2020
Reference: Rev Neurol (Paris). 2020 Sep;176S:S81. doi: 10.1016/j.neurol.2020.01.242.
Impact factor:
Publication type: Paper in international publication
Authors: Dangond, Fernando; Grenningloh, Roland; Martin, Emily; Montalban, Xavier; Shaw, Jamie; Vermersch, Patrick; Weber, Martin S et al.
DOI: 10.1016/j.neurol.2020.01.242

Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study.

PMID: 31523449
Journal: Multiple sclerosis journal - experimental, transla
Year: 2019
Reference: Mult Scler J Exp Transl Clin. 2019 Sep 5;5(3):2055217319871582. doi: 10.1177/2055217319871582. eCollection 2019 Jul-Sep.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Alroughani, Raed; Balcer, Laura J; Balk, Lisanne J; Behbehani, Raed; Brandt, Alexander U; Coric, Danko; Havla, Joachim; Knier, Benjamin et al.
DOI: 10.1177/2055217319871582

MRI-based prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis using SVM and lesion geometry.

PMID: 30155789
Journal: Brain Imaging and Behavior
Year: 2019
Reference: Brain Imaging Behav. 2019 Oct;13(5):1361-1374. doi: 10.1007/s11682-018-9942-9.
Impact factor:
Publication type: Paper in international publication
Authors: Amann, Michael; Barkhof, Frederik; Bendfeldt, Kerstin; Borgwardt, Stefan; Edan, Gilles; Freedman, Mark S; Gaetano, Laura; Hartung, Hans-Peter; Kappos, Ludwig; Kloppel, Stefan et al.
DOI: 10.1007/s11682-018-9942-9

Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial.

PMID: 31492652
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Nov;18(11):1021-1033. doi: 10.1016/S1474-4422(19)30238-8. Epub 2019 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Cohen, Jeffrey A; Comi, Giancarlo; Cree, Bruce A C; Hartung, Hans-Peter; Huang, Vivian; Kappos, Ludwig; Kubala Havrdova, Eva; Minton, Neil et al.
DOI: 10.1016/S1474-4422(19)30238-8

Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.

PMID: 31492651
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Nov;18(11):1009-1020. doi: 10.1016/S1474-4422(19)30239-X. Epub 2019 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Cohen, Jeffrey A; Comi, Giancarlo; Cree, Bruce A C; Ding, Ning; Hartung, Hans-Peter; Kappos, Ludwig; Kubala Havrdova, Eva; Minton, Neil et al.
DOI: 10.1016/S1474-4422(19)30239-X

Multiple sclerosis: clinical aspects.

PMID: 30300239
Journal: CURRENT OPINION IN NEUROLOGY
Year: 2018
Reference: Curr Opin Neurol. 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622.
Impact factor:
Publication type: Review in international publication
Authors: Montalban, Xavier; Oh, Jiwon; Vidal-Jordana, Angela et al.
DOI: 10.1097/WCO.0000000000000622

GDP-l-fucose synthase is a CD4(+) T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis.

PMID: 30305453
Journal: Science Translational Medicine
Year: 2018
Reference: Sci Transl Med. 2018 Oct 10;10(462). pii: 10/462/eaat4301. doi: 10.1126/scitranslmed.aat4301.
Impact factor:
Publication type: Paper in international publication
Authors: Cruciani, Carolina; Eixarch, Herena; Espejo, Carmen; Faigle, Wolfgang; Lutterotti, Andreas; Martin, Roland; Pinilla, Clemencia; Planas, Raquel; Santos, Radleigh; Schaeren-Wiemers, Nicole et al.
DOI: 10.1126/scitranslmed.aat4301

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.

PMID: 29117789
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Oct;24(11):1507-1510. doi: 10.1177/1352458517739137. Epub 2017 Nov 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Clarelli, Ferdinando; Comabella, Manuel; Comi, Giancarlo; Esposito, Federica; Lechner-Scott, Jeannette; Malhotra, Sunny; Martinelli-Boneschi, Filippo; Midaglia, Luciana; Montalban, Xavier et al.
DOI: 10.1177/1352458517739137

SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts.

PMID: 28847219
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Oct;24(11):1485-1498. doi: 10.1177/1352458517726657. Epub 2017 Aug 29.
Impact factor:
Publication type: Paper in international publication
Authors: Bove, Riley; Chitnis, Tanuja; Cree, Bruce Ac; Hauser, Stephen L; Kappos, Ludwig; Khoury, Samia J; Montalban, Xavier; Naegelin, Yvonne; Tintore, Mar; Uitdehaag, Bernard Mj et al.
DOI: 10.1177/1352458517726657

Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis.

PMID: 29051512
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Oct 19;7(1):13544. doi: 10.1038/s41598-017-12881-8.
Impact factor:
Publication type: Paper in international publication
Authors: Arcas-Garcia, Andrea; Comabella, Manuel; Comas-Casellas, Emma; Ejarque-Ortiz, Aroa; Magallon-Lorenz, Miriam; Malhotra, Sunny; Martin, Margarita; Martinez-Barriocanal, Agueda; Montalban, Xavier; Negro-Demontel, Maria Luciana et al.
DOI: 10.1038/s41598-017-12881-8

Progressive MS trials: Lessons learned.

PMID: 29041872
Journal: Multiple Sclerosis Journal
Year: 2017
Reference: Mult Scler. 2017 Oct;23(12):1583-1592. doi: 10.1177/1352458517729460.
Impact factor:
Publication type: Review in international publication
Authors: Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1177/1352458517729460

Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines.

PMID: 29034884
Journal: Stem Cell Research
Year: 2017
Reference: Stem Cell Res. 2017 Oct;24:155-159. doi: 10.1016/j.scr.2017.06.001. Epub 2017 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Aran, B; Comabella, M; Costa, C; Duarri, A; Kuebler, B; Malhotra, S; Marti, M; Miquel-Serra, L; Montalban, X; Munoz, Y et al.
DOI: 10.1016/j.scr.2017.06.001

Radiologically isolated syndrome in children: Clinical and radiologic outcomes.

PMID: 28959703
Journal: Neurology(R) neuroimmunology & neuroinflammati
Year: 2017
Reference: Neurol Neuroimmunol Neuroinflamm. 2017 Sep 25;4(6):e395. doi: 10.1212/NXI.0000000000000395. eCollection 2017 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Brassat, David; Carra Dalliere, Clarisse; de Seze, Jerome; Du, Wei; Durand Dubief, Francoise; Kantarci, Orhun; Langille, Megan; Lebrun, Christine; Makhani, Naila; Narula, Sona et al.
DOI: 10.1212/NXI.0000000000000395

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.

PMID: 27764667
Journal: NEURON
Year: 2016
Reference: Neuron. 2016 Oct 19;92(2):333-335. doi: 10.1016/j.neuron.2016.09.052.
Impact factor:
Publication type: Paper in international publication
Authors: Antel, Jack; Ban, Maria; Baranzini, Sergio; Barcellos, Lisa; Barizzone, Nadia; Beecham, Ashley; Berge, Tone; Bernardinelli, Luisa; Booth, David; Bos, Steffan et al.
DOI: 10.1016/j.neuron.2016.09.052

Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test.

PMID: 26216790
Journal: NEUROREHABILITATION AND NEURAL REPAIR
Year: 2016
Reference: Neurorehabil Neural Repair. 2016 May;30(4):373-83. doi: 10.1177/1545968315597070. Epub 2015 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Baert, Ilse; Bethoux, Francois; Dalgas, Ulrik; Dolezalova, Vendula; Feys, Peter; Gebara, Benoit; Jensen, Ellen; Knuts, Kathy; Leone, Carmela; Maamagi, Heigo et al.
DOI: 10.1177/1545968315597070

Longitudinal fMRI studies: Exploring brain plasticity and repair in MS.

PMID: 26683590
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Mar;22(3):269-78. doi: 10.1177/1352458515619781. Epub 2015 Dec 18.
Impact factor:
Publication type: Review in national publication
Authors: Audoin, Bertrand; De Luca, John; Enzinger, Christian; Filippi, Massimo; Pinter, Daniela; Rocca, Maria A; Sastre-Garriga, Jaume et al.
DOI: 10.1177/1352458515619781

Power estimation for non-standardized multisite studies.

PMID: 27039700
Journal: NEUROIMAGE
Year: 2016
Reference: Neuroimage. 2016 Jul 1;134:281-94. doi: 10.1016/j.neuroimage.2016.03.051. Epub 2016 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Amann, Michael; Bakshi, Rohit; Beyer, Mona K; Bischof, Antje; Carriero, Alessandro; Comabella, Manuel; Cournu-Rebeix, Isabelle; Crane, Jason C; D'Alfonso, Sandra; Demaerel, Philippe et al.
DOI: 10.1016/j.neuroimage.2016.03.051

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.

PMID: 24468824
Journal: MOL PSYCHIATR
Year: 2015
Reference: Mol Psychiatry. 2015 Feb;20(2):207-14. doi: 10.1038/mp.2013.195. Epub 2014 Jan 28.
Impact factor:
Publication type: Paper in international publication
Authors: Andreassen, O A; Barcellos, Lisa; Bettella, F; Booth, David; Comabella, Manuel; Compston, Alastair; D'Alfonso, Sandra; Dale, A M; De Jager, Philip; Desikan, R S et al.
DOI: 10.1038/mp.2013.195

Onset-adjusted incidence of multiple sclerosis in the Girona province (Spain): Evidence of increasing risk in the south of Europe.

PMID: 26671104
Journal: J NEUROL SCI
Year: 2015
Reference: J Neurol Sci. 2015 Dec 15;359(1-2):146-50. doi: 10.1016/j.jns.2015.10.042. Epub 2015 Oct 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bufill, E; Carmona, O; Llufriu, S; Montalban, X; Otero-Romero, S; Pericot, I; Perkal, H; Ramio-Torrenta, Ll; Robles, R; Saiz, A et al.
DOI: 10.1016/j.jns.2015.10.042

Clinicopathological Correlations and Concomitant Pathologies in Rapidly Progressive Dementia: A Brain Bank Series.

PMID: 26523804
Journal: NEURODEGENER DIS
Year: 2015
Reference: Neurodegener Dis. 2015;15(6):350-60. doi: 10.1159/000439251. Epub 2015 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Andreu, Eulalia; Arino, Sergio; Atienza, Antonio; Batlle, Jordi; Berlanga, Begona; Bisbe, Vicenta; Blesa, Rafael; Boada, Merce; Bosch, Josep; Brieva, Luis et al.
DOI: 10.1159/000439251

Quantifying brain tissue volume in multiple sclerosis with automated lesion segmentation and filling.

PMID: 26740917
Journal: NEUROIMAGE-CLIN
Year: 2015
Reference: Neuroimage Clin. 2015 Oct 28;9:640-7. doi: 10.1016/j.nicl.2015.10.012. eCollection 2015.
Impact factor:
Publication type: Paper in international publication
Authors: Llado, Xavier; Montalban, Xavier; Oliver, Arnau; Pareto, Deborah; Ramio-Torrenta, Lluis; Roura, Eloy; Rovira, Alex; Sastre-Garriga, Jaume; Valverde, Sergi; Vilanova, Joan C et al.
DOI: 10.1016/j.nicl.2015.10.012

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

PMID: 24793898
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2014
Reference: J Neuroimmunol. 2014 Jul 15;272(1-2):51-5. doi: 10.1016/j.jneuroim.2014.04.007. Epub 2014 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Marta F; Comabella, Manuel; Comella, Joan X; Martin, Isabel; Montalban, Xavier; Moreno, Montserrat; Moubarak, Rana; Negrotto, Laura; Perez-Boza, Jennifer; Rio, Jordi et al.
DOI: 10.1016/j.jneuroim.2014.04.007

HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-beta therapy in multiple sclerosis.

PMID: 24748646
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2014
Reference: J Med Genet. 2014 Jun;51(6):395-400. doi: 10.1136/jmedgenet-2014-102348. Epub 2014 Apr 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lafuente, Roberto; Arroyo, Rafael; Cenit, M Carmen; Comabella, Manuel; Fernandez, Oscar; Fernandez-Arquero, Miguel; Leyva, Laura; Montalban, Xavier; Nunez, Concepcion; Oliver-Martos, Begona et al.
DOI: 10.1136/jmedgenet-2014-102348

Multiple sclerosis registries in Europe - results of a systematic survey.

PMID: 24777278
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Oct;20(11):1523-32. doi: 10.1177/1352458514528760. Epub 2014 Apr 28.
Impact factor:
Publication type: Paper in international publication
Authors: Battaglia, Mario A; Boyko, Alexey; Buckow, Karoline; Confavreux, Christian; Ellenberger, David; Eskic, Danica; Flachenecker, Peter; Ford, David; Friede, Tim; Fuge, Jan et al.
DOI: 10.1177/1352458514528760

Adherence in multiple sclerosis (ADAMS): Classification, relevance, and research needs. A meeting report.

PMID: 24756569
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Nov;20(13):1795-1798. Epub 2014 Apr 22.
Impact factor:
Publication type: Review in international publication
Authors: Asano, Miho; Bissell, Paul; Bruce, Jared; Clyne, Wendy; Eliasson, Lina; Feys, Peter; Hausmann, Bettina; Heesen, Christoph; Imonen-Charalambous, Kaisa; Kopke, Sascha et al.
DOI: 10.1177/1352458514531348

Consensus Statement on medication use in multiple sclerosis by the Spanish Society of Neurology's study group for demyelinating diseases.

PMID: 23643683
Journal: NEUROLOGIA
Year: 2013
Reference: Neurologia. 2013 Jul-Aug;28(6):375-8. doi: 10.1016/j.nrl.2013.01.009. Epub 2013 May 3.
Impact factor:
Publication type: Review in national publication
Authors: Arbizu, T; de Andres, C; Fernandez, O; Garcia-Merino, A; Montalban, X; Oreja-Guevara, C; Rodriguez-Antiguedad, A et al.
DOI: 10.1016/j.nrl.2013.01.009

Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis.

PMID: 23263472
Journal: JOURNAL OF NEUROLOGY
Year: 2013
Reference: J Neurol. 2013 Oct;260(10):2458-71. doi: 10.1007/s00415-012-6762-5. Epub 2012 Dec 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ashburner, J; Barkhof, F; Barkhof, F; Battaglini, M; Ciccarelli, O; de Stefano, N; de Stefano, N; Enzinger, C; Fazekas, F; Filippi, M et al.
DOI: 10.1007/s00415-012-6762-5

Therapeutic decisions in multiple sclerosis: moving beyond efficacy.

PMID: 23921521
Journal: JAMA neurology
Year: 2013
Reference: JAMA Neurol. 2013 Oct;70(10):1315-24.
Impact factor:
Publication type: Letter or abstract
Authors: Bruck, Wolfgang; Gold, Raff; Lund, Brett T; Oreja-Guevara, Celia; Prat, Alexandre; Spencer, Collin M; Steinman, Lawrence; Tintore, Mar; Vollmer, Timothy L; Weber, Martin S et al.
DOI: 10.1001/jamaneurol.2013.3510

Lysosomal diseases Reply

PMID: 23562309
Journal: MEDICINA CLINICA
Year: 2013
Reference: Med Clin (Barc). 2013 Jun 18;140(12):571. doi: 10.1016/j.medcli.2013.02.007. Epub 2013 Apr 4.
Impact factor:
Publication type: Letter whit IF
Authors: Comabella, Manuel; Costa, Carme; Montalban, Xavier et al.
DOI: 10.1016/j.medcli.2013.02.007

Subcutaneous alemtuzumab for multiple sclerosis.

PMID: 22882217
Journal: Expert Review of Clinical Immunology
Year: 2012
Reference: Expert Rev Clin Immunol. 2012 Jul;8(5):423-6.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1586/eci.12.30

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes.

PMID: 22194214
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Jul;18(7):959-65. Epub 2011 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458511432741

Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.

PMID: 22183936
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Jul;18(7):983-90. Epub 2011 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458511433063

[Disease modifying drugs in multiple sclerosis and pregnancy.]

PMID: 22743277
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 Sep 22;139(7):316-8. doi: 10.1016/j.medcli.2012.04.021. Epub 2012 Jun 27.
Impact factor:
Publication type: Editorial in national publication
Authors: ; ; et al.
DOI: 10.1016/j.medcli.2012.04.021

Implication of the toll-like receptor 4 pathway in the response to interferon-beta in multiple sclerosis.

PMID: 22028223
Journal: ANNALS OF NEUROLOGY
Year: 2011
Reference: Ann Neurol. 2011 Oct;70(4):634-45. doi: 10.1002/ana.22511.
Impact factor:
Publication type: Paper in international publication
Authors: Angeles Moro, Maria; Bustamante, Marta F; Carmen Edo, Mari; Comabella, Manuel; Costa, Carme; Espejo, Carmen; Fissolo, Nicolas; Lizasoain, Ignacio; Mansilla, Maria Jose; Montalban, Xavier et al.
DOI: 10.1002/ana.22511

Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis.

PMID: 21992960
Journal: CLINICAL IMMUNOLOGY
Year: 2011
Reference: Clin Immunol. 2011 Dec;141(3):348-56. Epub 2011 Sep 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.clim.2011.09.006

MR brain iron mapping in MS: A potential neurodegenerative marker or just another technique?

PMID: 21975201
Journal: NEUROLOGY
Year: 2011
Reference: Neurology. 2011 Nov 1;77(18):1660-1. Epub 2011 Oct 5.
Impact factor:
Publication type: Editorail in international publication
Authors: ; et al.
DOI: 10.1212/WNL.0b013e318236f120

Search for Specific Biomarkers of IFNbeta Bioactivity in Patients with Multiple Sclerosis.

PMID: 21886806
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(8):e23634. Epub 2011 Aug 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Marta F; Comabella, Manuel; Deisenhammer, Florian; Fissolo, Nicolas; Malhotra, Sunny; Montalban, Xavier; Nonell, Lara; Nurtdinov, Ramil N; Perez-Miralles, Francisco; Rio, Jordi et al.
DOI: 10.1371/journal.pone.0023634

Spanish Neurology Society consensus document on the use of drugs in multiple sclerosis: escalating therapy.

PMID: 20738958
Journal: NEUROLOGIA
Year: 2010
Reference: Neurologia. 2010 Jul;25(6):378-390.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; et al.
DOI:

Targeting dendritic cells to treat multiple sclerosis.

PMID: 20717105
Journal: Nature Reviews Neurology
Year: 2010
Reference: Nat Rev Neurol. 2010 Sep;6(9):499-507. Epub 2010 Aug 17.
Impact factor:
Publication type: Review in international publication
Authors: Comabella, Manuel; Lunemann, Jan D; Montalban, Xavier; Munz, Christian et al.
DOI: 10.1038/nrneurol.2010.112

[Demyelinating lesions as incidental findings in magnetic resonance imaging: a study of 11 cases with clinico-radiological follow-up and a review of the literature]

PMID: 20645263
Journal: REVISTA DE NEUROLOGIA
Year: 2010
Reference: Rev Neurol. 2010 Aug;51(3):129-34.
Impact factor:
Publication type: Paper in national publication
Authors: Auger-Acosta, Cristina; Castillo, Joaquin; Edo, Mari Carmen; Horga-Hernandez, Alejandro; Mitjana, Raquel; Montalban, Xavier; Rio-Izquierdo, Jordi; Rovira, Alex; Sierra-Marcos, Alba; Tintore, Mar et al.
DOI:

[Clinical spectrum associated with aquaporin-4 antibodies (NMO-IgG)].

PMID: 20388455
Journal: NEUROLOGIA
Year: 2010
Reference: Neurologia. 2010 Jan-Feb;25(1):5-12.
Impact factor:
Publication type: Paper in national publication
Authors: Alana, M; Alarcia, R; Ara, J R; Arbizu, T; Arnal Garcia, C; Arroyo, R; Bartolome, M; Batlle, J; Bestue, M; Blanco, Y et al.
DOI:

HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis.

PMID: 19349081
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2009
Reference: J Neuroimmunol. 2009 May 29;210(1-2):116-9.
Impact factor:
Publication type: Paper in international publication
Authors: Cenit, M C; Comabella, M; de la Concha, E G; Fernandez, M; Fernandez-Arquero, M; Guinea, A; Montalban, X; Rio, J et al.
DOI: 10.1016/j.jneuroim.2009.01.012

Role of MRI criteria and OB for diagnosing multiple sclerosis in patients presenting with clinically isolated syndromes.

PMID: 19324977
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Apr;15(4):407-8.
Impact factor:
Publication type: Editorail in international publication
Authors: Sastre-Garriga, J; Tintore, M et al.
DOI: 10.1177/1352458509104581

[Diffuse astrocytoma presenting as an optic-spinal syndrome]

PMID: 19319816
Journal: REVISTA DE NEUROLOGIA
Year: 2009
Reference: Rev Neurol. 2009 Apr 1-15;48(7):354-6.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, J; Martinez, E; Montalban, X; Parees, I; Rovira, A et al.
DOI:

Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis.

PMID: 18945642
Journal: CLINICAL IMMUNOLOGY
Year: 2009
Reference: Clin Immunol. 2009 Feb;130(2):145-50.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Zayat, Hammad; Baranzini, Sergio E; Comabella, Manuel; Deisenhammer, Florian; Espejo, Carmen; Julia, Eva; Lopez, Cristina; Montalban, Xavier; Nonell, Lara; Nos, Carlos et al.
DOI: 10.1016/j.clim.2008.09.010

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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