Skip to main content

Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Gloria López Comellas

Gloria López Comellas

Research technician
Clinical Neuroimmunology
Read more
Granda Soto, Alejandro

Granda Soto, Alejandro

Administration and Management
Clinical Neuroimmunology
Read more
Imane Boutitah Benyaich

Imane Boutitah Benyaich

Predoctoral researcher
Clinical Neuroimmunology
Read more
Júlia Comulada Ferrer

Júlia Comulada Ferrer

Research technician
Clinical Neuroimmunology
Read more
Llorente Blasco, Helena

Llorente Blasco, Helena

Research technician
Clinical Neuroimmunology
Read more
Luca Bollo

Luca Bollo

Predoctoral researcher
Clinical Neuroimmunology
Read more
Gloria López Comellas

Gloria López Comellas

Research technician
Clinical Neuroimmunology
Read more
Granda Soto, Alejandro

Granda Soto, Alejandro

Administration and Management
Clinical Neuroimmunology
Read more
Imane Boutitah Benyaich

Imane Boutitah Benyaich

Predoctoral researcher
Clinical Neuroimmunology
Read more
Júlia Comulada Ferrer

Júlia Comulada Ferrer

Research technician
Clinical Neuroimmunology
Read more
Llorente Blasco, Helena

Llorente Blasco, Helena

Research technician
Clinical Neuroimmunology
Read more
Luca Bollo

Luca Bollo

Predoctoral researcher
Clinical Neuroimmunology
Read more

Projects

Valorización de una terapia antígeno-específica para el tratamiento disruptivo de la diabetes tipo 1; esclerosis múltiple, miastenia gravis, enfermedad celíaca y artritis reumatoide.

IP: Carmen Espejo Ruiz
Collaborators: Sara Marsal Barril, Herena Eixarch Ahufinger, Helena Borrell Paños, Maria America Lopez Lasanta
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 217313.9
Reference: CPP2021-008475
Duration: 10/02/2022 - 31/12/2025

Ministerio de Ciencia

ResEM Project - Desarrollo de un modelo global de reserva funcional y estructural del sistema nervioso central en esclerosis múltiple

IP: Jaume Sastre Garriga
Collaborators: Cristina Auger Acosta, Carme Santoyo Medina, Manel Alberich Jordà, M Jesus Arevalo Navines, Xavier Montalban Gairín, Lucía Gutiérrez Ruiz, Neus Mongay Ochoa
Funding agency: Instituto de Salud Carlos III
Funding: 157300
Reference: PI22/00750
Duration: 01/01/2023 - 31/12/2025

Caracterización de la DIScapacidad y la COgnición en sujetos con Esclerosis múltiple a partir de secuencias de Resonancia magnética convencional (DISCOvER).

IP: Deborah Pareto Onghena
Collaborators: Ingrid Galán Cartaña, Herena Eixarch Ahufinger, M Jesus Arevalo Navines, Andrea De Barros Figueredo, Neus Mongay Ochoa, Giorgio Colangelo
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI22/01709
Duration: 01/01/2023 - 31/12/2025

Caracterización estructural y funcional de la vía visual anterior en pacientes con esclerosis múltiple temprana (VISIONEM).

IP: Angela Vidal Jordana
Collaborators: Dulce María Moncho Rodríguez, Alex Rovira Cañellas, Manel Alberich Jordà, Neus Mongay Ochoa, Joaquin Castillo Justribo, Sergio Cabello
Funding agency: Instituto de Salud Carlos III
Funding: 48400
Reference: PI22/01589
Duration: 01/01/2023 - 31/12/2025

Publications

Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study.

PMID: 39939136
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2025
Reference: J Neurol Neurosurg Psychiatry. 2025 Feb 12:jnnp-2024-335137. doi: 10.1136/jnnp-2024-335137.
Impact factor:
Publication type: Paper in international publication
Authors: Alcala, Carmen; Alonso Torres, Ana Maria; Alvarez Bravo, Gary; Arrambide, Georgin; Audoin, Bertrand; Auger, Cristina; Ayrignac, Xavier; Benyahya, Lakhdar; Bernard-Valnet, Raphael; Bourre, Bertrand et al.
DOI: 10.1136/jnnp-2024-335137

Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.

PMID: 39963134
Journal: Frontiers in Immunology
Year: 2025
Reference: Front Immunol. 2025 Feb 3;16:1512189. doi: 10.3389/fimmu.2025.1512189. eCollection 2025.
Impact factor:
Publication type: Paper in international publication
Authors: Achiron, Anat; Barkhof, Frederik; Chan, Andrew; Chudecka, Anita; De Stefano, Nicola; Derfuss, Tobias; Gardner, Lidia; Hodgkinson, Suzanne; Jin, Hulin; Kloetgen, Andreas et al.
DOI: 10.3389/fimmu.2025.1512189

Evaluation of magnetic resonance spectroscopy total sodium concentration measures, and associations with microstructure and physical impairment in cervical myelopathy.

PMID: 40016502
Journal: Scientific Reports
Year: 2025
Reference: Sci Rep. 2025 Feb 27;15(1):7014. doi: 10.1038/s41598-025-91658-w.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Ahmad, Selma; Bianchi, Alessia; Choi, David; Grussu, Francesco; Kanber, Baris; Panicker, Jalesh N; Prados, Ferran; Russo, Antonino; Russo, Vittorio; Solanky, Bhavana S et al.
DOI: 10.1038/s41598-025-91658-w

To Kill Time: A Bold Step Toward Simplifying Multiple Sclerosis Diagnosis.

PMID: 40036710
Journal: NEUROLOGY
Year: 2025
Reference: Neurology. 2025 Apr 8;104(7):e213416. doi: 10.1212/WNL.0000000000213416. Epub 2025 Mar 4.
Impact factor:
Publication type: Editorail in international publication
Authors: Ontaneda, Daniel; Vidal-Jordana, Angela et al.
DOI: 10.1212/WNL.0000000000213416

Vaccine Safety and Immunogenicity in Patients With Multiple Sclerosis Treated With Natalizumab.

PMID: 38607624
Journal: JAMA Network Open
Year: 2024
Reference: JAMA Netw Open. 2024 Apr 1;7(4):e246345. doi: 10.1001/jamanetworkopen.2024.6345.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Borras-Bermejo, Blanca; Braga, Nathane; Carbonell-Mirabent, Pere; Carvajal, Rene; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Esperalba, Juliana; Galan, Ingrid et al.
DOI: 10.1001/jamanetworkopen.2024.6345

Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis.

PMID: 38648580
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 May 14;102(9):e209357. doi: 10.1212/WNL.0000000000209357. Epub 2024 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: Altincatal, Arman; Avila, Robin L; Belviso, Nicholas; Cree, Bruce A C; de Moor, Carl; de Seze, Jerome; Engle, Robert; Fisher, Elizabeth; Fox, Robert J; Gold, Ralf et al.
DOI: 10.1212/WNL.0000000000209357

ENSEMBLE PLUS: final results of shorter ocrelizumab infusion from a randomized controlled trial.

PMID: 38649522
Journal: JOURNAL OF NEUROLOGY
Year: 2024
Reference: J Neurol. 2024 Apr 22. doi: 10.1007/s00415-024-12326-z.
Impact factor:
Publication type: Paper in international publication
Authors: Berger, Thomas; Bermel, Robert A; Brochet, Bruno; Buffels, Regine; Carroll, William M; Freedman, Mark S; Garas, Monika; Hartung, Hans-Peter; Holmoy, Trygve; Kadner, Karen et al.
DOI: 10.1007/s00415-024-12326-z

Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease.

PMID: 38646958
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Apr 22:13524585241240420. doi: 10.1177/13524585241240420.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bianchi, Alessia; Brownlee, Wallace; Ciccarelli, Olga; Cortese, Rosa; De Angelis, Floriana; Hacohen, Yael; Jacob, Anu; Kanber, Baris; Magnollay, Lise et al.
DOI: 10.1177/13524585241240420

Increased cytomegalovirus immune responses at disease onset are protective in the long-term prognosis of patients with multiple sclerosis.

PMID: 36344261
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Mar;94(3):173-180. doi: 10.1136/jnnp-2022-330205. Epub 2022 Nov 7.
Impact factor:
Publication type: Paper in international publication
Authors: Carbonell-Mirabent, Pere; Comabella, Manuel; Fissolo, Nicolas; Lunemann, Jan D; Malhotra, Sunny; Montalban, Xavier; Rovira, Alex; Sao Aviles, Augusto; Tintore, Mar et al.
DOI: 10.1136/jnnp-2022-330205

Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging.

PMID: 36192175
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Jan 17;100(3):e308-e323. doi: 10.1212/WNL.0000000000201465. Epub 2022 Oct 3.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bianchi, Alessia; Brownlee, Wallace; Carrasco, Ferran Prados; Ciccarelli, Olga; Cortese, Rosa; De Angelis, Floriana; De La Paz, Isabel; Grussu, Francesco; Hacohen, Yael et al.
DOI: 10.1212/WNL.0000000000201465

Spinal cord reserve in multiple sclerosis.

PMID: 36690430
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Jul;94(7):502-510. doi: 10.1136/jnnp-2022-330613. Epub 2023 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Auger, Cristina; Carbonell-Mirabent, Pere; Garcia-Vidal, Aran; Montalban, Xavier; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1136/jnnp-2022-330613

What is a clinically isolated syndrome in the 21st century?

PMID: 36703290
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Apr;29(4-5):641-642. doi: 10.1177/13524585221149888. Epub 2023 Jan 26.
Impact factor:
Publication type: Letter or abstract
Authors: Arrambide, Georgina et al.
DOI: 10.1177/13524585221149888

Case Report: Leishmaniasis in a 33-Year-Old Man with Multiple Sclerosis.

PMID: 35895413
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2022
Reference: Am J Trop Med Hyg. 2022 Jul 5;107(2):339-41. doi: 10.4269/ajtmh.22-0117.
Impact factor:
Publication type: Letter or abstract
Authors: Aznar, Maria Luisa; Bosch-Nicolau, Pau; Espinosa-Pereiro, Juan; Guerra-Amor, Alvaro; Lopez-Gonzalez, Ane; Molina, Israel; Rodriguez-Acevedo, Breogan; Salvador, Fernando; Sanchez-Montalva, Adrian; Sulleiro, Elena et al.
DOI: 10.4269/ajtmh.22-0117

Blood-Based Biomarkers to Search for Atrial Fibrillation in High-Risk Asymptomatic Individuals and Cryptogenic Stroke Patients.

PMID: 35859587
Journal: Frontiers in Cardiovascular Medicine
Year: 2022
Reference: Front Cardiovasc Med. 2022 Jul 4;9:908053. doi: 10.3389/fcvm.2022.908053. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Juan; Angel Munoz, Miguel; Arenillas, Juan F; Ballesta-Ors, Juan; Bustamante, Alejandro; Cabezas, Juan Antonio; Clua-Espuny, Josep Lluis; De Lera Alfonso, Mercedes; de Torres, Reyes; Francisco-Pascual, Jaume et al.
DOI: 10.3389/fcvm.2022.908053

Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)-a systematic review protocol.

PMID: 35778721
Journal: Systematic Reviews
Year: 2022
Reference: Syst Rev. 2022 Jul 1;11(1):134. doi: 10.1186/s13643-022-01997-2.
Impact factor:
Publication type: Paper in international publication
Authors: Chard, Declan; Fittipaldo, Andrea V; Friede, Tim; Heesen, Christoph; Kopke, Sascha; Lehnert, Thomas; Rahn, Anne C; Rio, Jordi; Rover, Christian et al.
DOI: 10.1186/s13643-022-01997-2

Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial.

PMID: 35765217
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Oct;28(12):1944-1962. doi: 10.1177/13524585221102584. Epub 2022 Jun 28.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Cheng, Chun-Yen; Cohen, Jeffrey A; Comi, Giancarlo; Cree, Bruce Ac; Hartung, Hans-Peter; Havrdova, Eva K; Kappos, Ludwig; Minton, Neil et al.
DOI: 10.1177/13524585221102584

Effect of Changes in MS Diagnostic Criteria Over 25 Years on Time to Treatment and Prognosis in Patients With Clinically Isolated Syndrome.

PMID: 34521693
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Oct 26;97(17):e1641-e1652. doi: 10.1212/WNL.0000000000012726. Epub 2021 Sep 14.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria Jesus; Arrambide, Georgina; Auger, Cristina; Carbonell, Pere; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana; Montalban, Xavier et al.
DOI: 10.1212/WNL.0000000000012726

[Clinical monitoring of multiple sclerosis patients by means of digital technology, a field in the midst of a revolution].

PMID: 34515334
Journal: REVISTA DE NEUROLOGIA
Year: 2021
Reference: Rev Neurol. 2021 Sep 1;73(6):210-218. doi: 10.33588/rn.7306.2021136.
Impact factor:
Publication type: Review in national publication
Authors: Midaglia, L; Montalban, X; Sastre-Garriga, J et al.
DOI: 10.33588/rn.7306.2021136

CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis.

PMID: 34497102
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Sep 8;8(6). pii: 8/6/e1082. doi: 10.1212/NXI.0000000000001082. Print 2021 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Yolanda; Borras, Eva; Comabella, Manuel; Costa-Frossard, Lucienne; Fissolo, Nicolas; Garcia-Merino, Juan Antonio; Llufriu, Sara; Martinez-Yelamos, Sergio; Montalban, Xavier; Pinteac, Rucsanda et al.
DOI: 10.1212/NXI.0000000000001082

Safety of Ocrelizumab in Patients With Relapsing and Primary Progressive Multiple Sclerosis.

PMID: 34475123
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Oct 19;97(16):e1546-e1559. doi: 10.1212/WNL.0000000000012700. Epub 2021 Sep 2.
Impact factor:
Publication type: Paper in international publication
Authors: Chognot, Cathy; Craveiro, Licinio; Hauser, Stephen L; Hughes, Richard; Kappos, Ludwig; Koendgen, Harold; Montalban, Xavier; Pasquarelli, Noemi; Pradhan, Ashish; Prajapati, Kalpesh et al.
DOI: 10.1212/WNL.0000000000012700

How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process.

PMID: 32900255
Journal: Gut Microbes
Year: 2020
Reference: Gut Microbes. 2020 Nov 9;12(1):1813532. doi: 10.1080/19490976.2020.1813532.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Graciela; Calvo-Barreiro, Laura; Carrillo-Salinas, Francisco J; Espejo, Carmen; Estevez, Hector; Feliu, Ana; Guaza, Carmen; Luque-Garcia, Jose L; Mecha, Miriam; Mestre, Leyre et al.
DOI: 10.1080/19490976.2020.1813532

Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.

PMID: 32881954
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Sep 3;15(9):e0238301. doi: 10.1371/journal.pone.0238301. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Blondel, Sandrine; Cavagna, Sylvie; Cobo-Calvo, Alvaro; Ghersi-Egea, Jean-Francois; Giraudon, Pascale; Marignier, Romain; Richard, Chloe; Ruiz, Anne; Strazielle, Nathalie et al.
DOI: 10.1371/journal.pone.0238301

Using smartphones and wearable devices to monitor behavioural changes during COVID-19.

PMID: 32877352
Journal: JOURNAL OF MEDICAL INTERNET RESEARCH
Year: 2020
Reference: J Med Internet Res. 2020 Sep 25;22(9):e19992. doi: 10.2196/19992.
Impact factor:
Publication type: Paper in international publication
Authors: Buron, Mathias; Comi, Giancarlo; Conde, Pauline; Cummins, Nicholas; Dalla Costa, Gloria; Dobson, Richard Jb; Folarin, Amos A; Guerrero Perez, Ana Isabel; Haro, Josep Maria; Hotopf, Matthew et al.
DOI: 10.2196/19992

Diagnosis of multiple sclerosis: what is changing?

PMID: 31703169
Journal: Expert Review of Neurotherapeutics
Year: 2020
Reference: Expert Rev Neurother. 2020 Aug;20(8):743-746. doi: 10.1080/14737175.2020.1691530. Epub 2019 Nov 11.
Impact factor:
Publication type: Editorail in international publication
Authors: Arrambide, Georgina; Tintore, Mar et al.
DOI: 10.1080/14737175.2020.1691530

Special Issue: Rehabilitation in MS

PMID: 31469353
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Sep;25(10):1335-1336. doi: 10.1177/1352458519851212.
Impact factor:
Publication type: Editorail in international publication
Authors: Feys, Peter; Sastre-Garriga, Jaume et al.
DOI: 10.1177/1352458519851212

Adherence and Satisfaction of Smartphone- and Smartwatch-Based Remote Active Testing and Passive Monitoring in People With Multiple Sclerosis: Nonrandomized Interventional Feasibility Study.

PMID: 31471961
Journal: JOURNAL OF MEDICAL INTERNET RESEARCH
Year: 2019
Reference: J Med Internet Res. 2019 Aug 30;21(8):e14863. doi: 10.2196/14863.
Impact factor:
Publication type: Paper in international publication
Authors: Baker, Michael; Belachew, Shibeshih; Bernasconi, Corrado; Gossens, Christian; Graves, Jennifer; Hauser, Stephen L; Julian, Laura; Lindemann, Michael; Lipsmeier, Florian; Midaglia, Luciana et al.
DOI: 10.2196/14863

Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

PMID: 31424490
Journal: JAMA Neurology
Year: 2019
Reference: JAMA Neurol. 2019 Dec 1;76(12):1446-1456. doi: 10.1001/jamaneurol.2019.2478.
Impact factor:
Publication type: Paper in international publication
Authors: Calabrese, Massimiliano; Clarke, Margareta A; De Stefano, Nicola; Enzinger, Christian; Evangelou, Nikos; Giorgio, Antonio; Kappos, Ludwig; Meier, Dominik; Montalban, Xavier; Paul, Friedemann et al.
DOI: 10.1001/jamaneurol.2019.2478

Efficacy and safety of ozanimod in multiple sclerosis: Dose-blinded extension of a randomized phase II study.

PMID: 30043658
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Aug;25(9):1255-1262. doi: 10.1177/1352458518789884. Epub 2018 Jul 25.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Cohen, Jeffrey A; Comi, Giancarlo; Cree, Bruce Ac; Frohna, Paul; Hartung, Hans-Peter; Havrdova, Eva K; Huang, Vivian; Kappos, Ludwig et al.
DOI: 10.1177/1352458518789884

The hippocampus in multiple sclerosis.

PMID: 30264730
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Oct;17(10):918-926. doi: 10.1016/S1474-4422(18)30309-0. Epub 2018 Sep 18.
Impact factor:
Publication type: Review in national publication
Authors: Barkhof, Frederik; Barkhof, Frederik; Ciccarelli, Olga; De Luca, John; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Filippi, Massimo; Frederiksen, Jette L; Frisen, Jonas et al.
DOI: 10.1016/S1474-4422(18)30309-0

Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.

PMID: 30217166
Journal: Journal of Neuroinflammation
Year: 2018
Reference: J Neuroinflammation. 2018 Sep 14;15(1):265. doi: 10.1186/s12974-018-1307-1.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Arroyo, Rafael; Comabella, Manuel; Costa, Carme; Dessa Sadovnick, A; Espino-Paisan, Laura; Fissolo, Nicolas; Garcia-Merino, Juan Antonio; Gil-Varea, Elia; Malhotra, Sunny et al.
DOI: 10.1186/s12974-018-1307-1

Neurofilaments as biomarkers in neurological disorders.

PMID: 30171200
Journal: Nature Reviews Neurology
Year: 2018
Reference: Nat Rev Neurol. 2018 Oct;14(10):577-589. doi: 10.1038/s41582-018-0058-z.
Impact factor:
Publication type: Review in international publication
Authors: Barro, Christian; Blennow, Kaj; Comabella, Manuel; Fazekas, Franz; Gattringer, Thomas; Kappos, Ludwig; Khalil, Michael; Kuhle, Jens; Otto, Markus; Petzold, Axel et al.
DOI: 10.1038/s41582-018-0058-z

Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial.

PMID: 30155979
Journal: ANNALS OF NEUROLOGY
Year: 2018
Reference: Ann Neurol. 2018 Oct;84(4):527-536. doi: 10.1002/ana.25313.
Impact factor:
Publication type: Paper in international publication
Authors: Belachew, Shibeshih; Bernasconi, Corrado; Chin, Peter; Deol-Bhullar, Gurpreet; Garren, Hideki; Giovannoni, Gavin; Hauser, Stephen L; Kappos, Ludwig; Montalban, Xavier; Vermersch, Patrick et al.
DOI: 10.1002/ana.25313

Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients.

PMID: 28916537
Journal: NEUROLOGY
Year: 2017
Reference: Neurology. 2017 Oct 10;89(15):1584-1593. doi: 10.1212/WNL.0000000000004485. Epub 2017 Sep 15.
Impact factor:
Publication type: Paper in international publication
Authors: Adams, Alison; Amarante, Diogo; Chen, Yi; Cree, Bruce A C; De Seze, Jerome; Dong, Qunming; Evans, Karleyton; Fox, Robert; Gold, Ralf; Hartung, Hans-Peter et al.
DOI: 10.1212/WNL.0000000000004485

Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study.

PMID: 28899746
Journal: NEUROIMAGE
Year: 2017
Reference: Neuroimage. 2017 Dec;163:106-114. doi: 10.1016/j.neuroimage.2017.09.011. Epub 2017 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Ciccarelli, Olga; Cover, Keith S; Damangir, Soheil; de Sitter, Alexandra; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette; Frisoni, Giovanni B; Kappos, Ludwig et al.
DOI: 10.1016/j.neuroimage.2017.09.011

Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education.

PMID: 28871238
Journal: Frontiers in Neurology
Year: 2017
Reference: Front Neurol. 2017 Aug 21;8:430. doi: 10.3389/fneur.2017.00430. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Mamdani, Muhammad; Maurino, Jorge; Montalban, Xavier; Ruff, Christian C; Saposnik, Gustavo; Sempere, Angel P; Terzaghi, Maria A; Tobler, Philippe N et al.
DOI: 10.3389/fneur.2017.00430

Reply: MMP-9 as a biomarker of PML development in MS patients receiving Natalizumab.

PMID: 28869673
Journal: ANNALS OF NEUROLOGY
Year: 2017
Reference: Ann Neurol. 2017 Oct;82(4):647-648. doi: 10.1002/ana.25039. Epub 2017 Oct 4.
Impact factor:
Publication type: Letter or abstract
Authors: Brassat, David; Comabella, Manuel; Fissolo, Nicolas; Pignolet, Beatrice et al.
DOI: 10.1002/ana.25039

Power estimation for non-standardized multisite studies.

PMID: 27039700
Journal: NEUROIMAGE
Year: 2016
Reference: Neuroimage. 2016 Jul 1;134:281-94. doi: 10.1016/j.neuroimage.2016.03.051. Epub 2016 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Amann, Michael; Bakshi, Rohit; Beyer, Mona K; Bischof, Antje; Carriero, Alessandro; Comabella, Manuel; Cournu-Rebeix, Isabelle; Crane, Jason C; D'Alfonso, Sandra; Demaerel, Philippe et al.
DOI: 10.1016/j.neuroimage.2016.03.051

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome.

PMID: 25716934
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2016
Reference: J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):126-9. doi: 10.1136/jnnp-2014-309690. Epub 2015 Feb 25.
Impact factor:
Publication type: Paper in international publication
Authors: Adiutori, Rocco; Adiutori, Rocco; Altintas, Ayse; Alvarez-Cermeno, Jose C; Annibali, Viviana; Avsar, Timucin; Barizzone, Nadia; Bergamaschi, Roberto; Bestwick, Jonathan P; Bianchi, Lucia et al.
DOI: 10.1136/jnnp-2014-309690

Comparing outcomes from clinical studies of oral disease-modifying therapies (dimethyl fumarate, fingolimod, and teriflunomide) in relapsing MS: Assessing absolute differences using a number needed to treat analysis.

PMID: 27919491
Journal: Multiple Sclerosis and Related Disorders
Year: 2016
Reference: Mult Scler Relat Disord. 2016 Nov;10:204-212. doi: 10.1016/j.msard.2016.10.010. Epub 2016 Nov 3.
Impact factor:
Publication type: Paper in international publication
Authors: Dive-Pouletty, Catherine; Freedman, Mark S; Hass, Steven; Leist, Thomas P; Miller, Aaron E; Montalban, Xavier; Thangavelu, Karthinathan et al.
DOI: 10.1016/j.msard.2016.10.010

Symptom tracking: from clinically isolated syndrome to advanced multiple sclerosis.

PMID: 27874490
Journal: Neurodegenerative disease management
Year: 2016
Reference: Neurodegener Dis Manag. 2016 Dec;6(6s):27-29.
Impact factor:
Publication type: Paper in international publication
Authors: Tintore, Mar et al.
DOI: 10.2217/nmt-2016-0052

Molecular dynamics and intracellular signaling of the TNF-R1 with the R92Q mutation.

PMID: 26616867
Journal: J NEUROIMMUNOL
Year: 2015
Reference: J Neuroimmunol. 2015 Dec 15;289:12-20. doi: 10.1016/j.jneuroim.2015.10.003. Epub 2015 Oct 22.
Impact factor:
Publication type: Paper in international publication
Authors: Agullo, Luis; Comabella, Manuel; Fissolo, Nicolas; Malhotra, Sunny; Montalban, Xavier et al.
DOI: 10.1016/j.jneuroim.2015.10.003

Interferon-beta affects mitochondrial activity in CD4+ lymphocytes: Implications for mechanism of action in multiple sclerosis.

PMID: 25480861
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Sep;21(10):1262-70. doi: 10.1177/1352458514561909. Epub 2014 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Akkad, Denis A; Arning, Larissa; Baranzini, Sergio E; Chan, Andrew; Comabella, Manuel; Duscha, Alexander; Faissner, Simon; Gold, Ralf; Haghikia, Aiden; Malhotra, Sunny et al.
DOI: 10.1177/1352458514561909

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta.

PMID: 26531701
Journal: J NEUROIMMUNOL
Year: 2015
Reference: J Neuroimmunol. 2015 Nov 15;288:98-101. doi: 10.1016/j.jneuroim.2015.09.007. Epub 2015 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Comabella, Manuel; Montalban, Xavier; Negrotto, Laura; Rio, Jordi; Tintore, Mar et al.
DOI: 10.1016/j.jneuroim.2015.09.007

Genome-wide significant association with seven novel multiple sclerosis risk loci.

PMID: 26475045
Journal: J MED GENET
Year: 2015
Reference: J Med Genet. 2015 Dec;52(12):848-55. doi: 10.1136/jmedgenet-2015-103442. Epub 2015 Oct 16.
Impact factor:
Publication type: Paper in international publication
Authors: Akkad, Denis A; Aktas, Orhan; Alcina, Antonio; Alloza, Iraide; Antiguedad, Alfredo; Arroyo, Rafa; Astobiza, Ianire; Bertram, Lars; Binder, Harald; Blaschke, Paul et al.
DOI: 10.1136/jmedgenet-2015-103442

Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECTION): a multicentre, randomised, double-blind extension trial.

PMID: 24656609
Journal: LANCET NEUROLOGY
Year: 2014
Reference: Lancet Neurol. 2014 May;13(5):472-81. doi: 10.1016/S1474-4422(14)70039-0. Epub 2014 Mar 19.
Impact factor:
Publication type: Clinical Trials
Authors: Agarwal, R; Amaravadi, Lakshmi; Ambler, Z; Angstwurm, K; Bajenaru, O; Belova, A; Bereczki, D; Boiko, A; Buchakchyys'ka, N; Clemens, B et al.
DOI: 10.1016/S1474-4422(14)70039-0

Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis.

PMID: 24794503
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2014
Reference: J Neuroimmunol. 2014 Jun 15;271(1-2):56-9. doi: 10.1016/j.jneuroim.2014.04.001. Epub 2014 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Castillo, Joaquin; Comabella, Manuel; Fissolo, Nicolas; Montalban, Xavier; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jneuroim.2014.04.001

Predictive markers of disease evolution after a CIS in everyday practice.

PMID: 24881867
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2014
Reference: J Neurol Sci. 2014 Aug 15;343(1-2):8-14. doi: 10.1016/j.jns.2014.05.023. Epub 2014 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Sastre-Garriga, Jaume et al.
DOI: 10.1016/j.jns.2014.05.023

Defining the clinical course of multiple sclerosis: the 2013 revisions.

PMID: 24871874
Journal: NEUROLOGY
Year: 2014
Reference: Neurology. 2014 Jul 15;83(3):278-86. doi: 10.1212/WNL.0000000000000560. Epub 2014 May 28.
Impact factor:
Publication type: Review in international publication
Authors: Balcer, Laura J; Banwell, Brenda; Barkhof, Frederik; Bebo, Bruce Jr; Calabresi, Peter A; Clanet, Michel; Cohen, Jeffrey A; Comi, Giancarlo; Cutter, Gary R; Fox, Robert J et al.
DOI: 10.1212/WNL.0000000000000560

Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis.

PMID: 23620065
Journal: JOURNAL OF NEUROLOGY
Year: 2013
Reference: J Neurol. 2013 Aug;260(8):2016-22. doi: 10.1007/s00415-013-6918-y. Epub 2013 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Enzinger, Christian; Fazekas, Franz; Fillipp, Massimo; Flores, Jose; Frederiksen, Jette; Gama, Hugo; Gass, Achim; Miller, David H; Montalban, Xavier et al.
DOI: 10.1007/s00415-013-6918-y

A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.

PMID: 23696811
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 May 16;8(5):e63300. doi: 10.1371/journal.pone.0063300. Print 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Roby; Alfredsson, Lars; Annibali, Viviana; Ardlie, Kristin; Aubin, Cristin; Baker, Amie; Baker, Katharine; Ban, Maria; Band, Gavin; Baranzini, Sergio E et al.
DOI: 10.1371/journal.pone.0063300

CSF oligoclonal bands are important in the diagnosis of multiple sclerosis, unreasonably downplayed by the McDonald criteria 2010: No.

PMID: 23658236
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 May;19(6):717-8. doi: 10.1177/1352458513477713.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1177/1352458513477713

Clinical impact of early brain atrophy in clinically isolated syndromes.

PMID: 23652215
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Dec;19(14):1878-86. doi: 10.1177/1352458513488231. Epub 2013 May 7.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, G; Auger, C; Castillo, J; Edo, M C; Horga, A; Huerga, E; Montalban, X; Nos, C; Perez-Miralles, F; Perkal, H et al.
DOI: 10.1177/1352458513488231

Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and upregulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis.

PMID: 22727044
Journal: Journal of Neuroinflammation
Year: 2012
Reference: J Neuroinflammation. 2012 Jun 22;9:139. doi: 10.1186/1742-2094-9-139.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/1742-2094-9-139

New technologies for biomarker discovery in multiple sclerosis.

PMID: 22726889
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2012
Reference: J Neuroimmunol. 2012 Jul 15;248(1-2):1.
Impact factor:
Publication type: Editorail in international publication
Authors: Comabella, Manuel; Racke, Michael K et al.
DOI: 10.1016/j.jneuroim.2012.05.018

Review of the novelties presented at the 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).

PMID: 22673950
Journal: REVISTA DE NEUROLOGIA
Year: 2012
Reference: Rev Neurol. 2012 Jun 16;54(12):734-749.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI:

Heat Shock Protein 70: Roles in Multiple Sclerosis.

PMID: 22669475
Journal: MOLECULAR MEDICINE
Year: 2012
Reference: Mol Med. 2012 Sep 7;18:1018-28. doi: 10.2119/molmed.2012.00119.
Impact factor:
Publication type: Review in international publication
Authors: ; ; et al.
DOI: 10.2119/molmed.2012.00119

IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis.

PMID: 21889215
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2011
Reference: J Neuroimmunol. 2011 Oct 28;239(1-2):101-4. Epub 2011 Sep 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jneuroim.2011.08.004

The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study.

PMID: 21552549
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011 Apr 28;6(4):e18813.
Impact factor:
Publication type: Paper in international publication
Authors: Alfredsson, Lars; Aubin, Cristin; Bach Sondergaard, Helle; Bergamaschi, Laura; Boonen, Steven; Bustamante, Marta F; Celius, Elisabeth G; Cepok, Sabine; Comabella, Manuel; Compston, Alastair et al.
DOI: 10.1371/journal.pone.0018813

Interferon {beta}-1b-neutralizing antibodies 5 years after clinically isolated syndrome.

PMID: 21849647
Journal: NEUROLOGY
Year: 2011
Reference: Neurology. 2011 Aug 30;77(9):835-43. Epub 2011 Aug 17.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1212/WNL.0b013e31822c90d7

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

PMID: 21833088
Journal: NATURE
Year: 2011
Reference: Nature. 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature10251.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Roby; Alfredsson, Lars; Ardlie, Kristin; Aubin, Cristin; Baker, Amie; Baker, Katharine; Ban, Maria; Band, Gavin; Baranzini, Sergio E; Barcellos, Lisa F et al.
DOI: 10.1038/nature10251

Gender-Associated Differences of Perforin Polymorphisms in the Susceptibility to Multiple Sclerosis.

PMID: 20921521
Journal: JOURNAL OF IMMUNOLOGY
Year: 2010
Reference: J Immunol. 2010 Nov 1;185(9):5392-404. Epub 2010 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.4049/jimmunol.1000102

Single-nucleotide polymorphisms in response to interferon-Beta therapy in multiple sclerosis.

PMID: 20836710
Journal: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Year: 2010
Reference: J Interferon Cytokine Res. 2010 Oct;30(10):727-32.
Impact factor:
Publication type: Review in international publication
Authors: Comabella, Manuel; Vandenbroeck, Koen et al.
DOI: 10.1089/jir.2010.0085

[Recommendations for using and interpreting magnetic resonance imaging in multiple sclerosis]

PMID: 20609303
Journal: NEUROLOGIA
Year: 2010
Reference: Neurologia. 2010 May;25(4):248-65.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Cermeno, J C; Izquierdo, G; Prieto, J M; Rovira, A; Tintore, M et al.
DOI:

Considerations on discontinuing natalizumab for the treatment of multiple sclerosis.

PMID: 20818795
Journal: ANNALS OF NEUROLOGY
Year: 2010
Reference: Ann Neurol. 2010 Sep;68(3):409-11.
Impact factor:
Publication type: Letter or abstract
Authors: Berger, Joseph R; Centonze, Diego; Comi, Giancarlo; Confavreux, Christian; Cutter, Gary; Giovannoni, Gavin; Gold, Ralf; Hartung, Hans-Peter; Lublin, Fred; Miravalle, Augusto et al.
DOI: 10.1002/ana.22083

Tolerance induction in experimental autoimmune encephalomyelitis using non-myeloablative hematopoietic gene therapy with autoantigen.

PMID: 19277013
Journal: MOLECULAR THERAPY
Year: 2009
Reference: Mol Ther. 2009 May;17(5):897-905.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Castillo, Mireia; Eixarch, Herena; Espejo, Carmen; Gimeno, Ramon; Gomez, Alba; Mansilla, Maria Jose; Mildner, Alexander; Montalban, Xavier; Prinz, Marco et al.
DOI: 10.1038/mt.2009.42

[Needlestick injuries in health care workers: analysis of non preventable risk factors through standard precautions]

PMID: 19248874
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Feb 28;132(7):251-8.
Impact factor:
Publication type: Paper in national publication
Authors: Bastida, Teresa; Campins, Magda; de la Prada, Miriam; Espuga, Meritxell; Gasco, Ampar; Hermosilla, Eduardo; Lopez Clemente, Victoria; Maria Bayas, Jose; Otero, Susana; Pena, Pilar et al.
DOI: 10.1016/j.medcli.2008.06.016

Plasma chitotriosidase activity in multiple sclerosis.

PMID: 19176289
Journal: CLINICAL IMMUNOLOGY
Year: 2009
Reference: Clin Immunol. 2009 May;131(2):216-22.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, M; Dominguez, C; Espejo, C; Martin-Gallan, P; Montalban, X; Rio, J; Vilarrasa, N; Vilches, A et al.
DOI: 10.1016/j.clim.2008.12.004

Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study.

PMID: 19122034
Journal: NEUROLOGY
Year: 2009
Reference: Neurology. 2009 Jan 6;72(1):73-9.
Impact factor:
Publication type: Paper in international publication
Authors: Antel, J; Comi, G; de Vera, A; Kappos, L; Montalban, X; O'Connor, P; Pohlmann, H; Radue, E W et al.
DOI: 10.1212/01.wnl.0000338569.32367.3d

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information