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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Luciana Midaglia Fernandez

Luciana Midaglia Fernandez

Research technician
Clinical Neuroimmunology
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Margarita Saez López

Margarita Saez López

Administration and Management
Clinical Neuroimmunology
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Maria Gabriela Bravo Vera

Maria Gabriela Bravo Vera

Clinical Neuroimmunology
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Marquez Parra, Jose David

Marquez Parra, Jose David

Maintenance staff and general services
Clinical Neuroimmunology
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Noelia Rojas Garnacho

Noelia Rojas Garnacho

Research technician
Clinical Neuroimmunology
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Nualart Mundo, Oriol

Nualart Mundo, Oriol

Research technician
Clinical Neuroimmunology
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Luciana Midaglia Fernandez

Luciana Midaglia Fernandez

Research technician
Clinical Neuroimmunology
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Margarita Saez López

Margarita Saez López

Administration and Management
Clinical Neuroimmunology
Read more
Maria Gabriela Bravo Vera

Maria Gabriela Bravo Vera

Clinical Neuroimmunology
Read more
Marquez Parra, Jose David

Marquez Parra, Jose David

Maintenance staff and general services
Clinical Neuroimmunology
Read more
Noelia Rojas Garnacho

Noelia Rojas Garnacho

Research technician
Clinical Neuroimmunology
Read more
Nualart Mundo, Oriol

Nualart Mundo, Oriol

Research technician
Clinical Neuroimmunology
Read more

Projects

Caracterización de pacientes con esclerosis múltiple muy activa y evaluación del efecto de tratamientos de alta efectividad en la evolución de su enfermedad.

IP: Georgina Arrambide García
Collaborators: Jordi Rio Izquierdo, Caracterización de pacientes con esclerosis múltiple muy activa y evaluación del efecto de tratamientos de alta efectividad en l, Joaquin Castillo Justribo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI22/01570
Duration: 01/01/2023 - 31/12/2025

Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a first demyelinating syndrome

IP: Alvaro Cobo Calvo
Collaborators: Javier Villacieros Álvarez, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI21/00282
Duration: 01/01/2022 - 31/12/2025

Liquid biopsy in multiple sclerosis: A non-invasive approach for disease prognosis and drug discovery...

IP: Sunny Malhotra Sareen
Collaborators: Jordi Rio Izquierdo, Ana Zabalza de Torres, Rucsanda Pinteac, Rucsanda Pinteac
Funding agency: Instituto de Salud Carlos III
Funding: 140360
Reference: PI20/01697
Duration: 01/01/2021 - 30/06/2025

Search of immune signatures associated with multiple sclerosis disease phenotypes

IP: Nicolás Miguel Fissolo
Collaborators: Luciana Midaglia Fernandez, Breogan Rodriguez Acevedo
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI20/00276
Duration: 01/01/2021 - 30/06/2025

Publications

Clinical Results of the ANAIS Study: Mechanical Thrombectomy Using the ANA Device in Combination with a Stent Retriever in Subjects with Acute Ischemic Stroke.

PMID: 40037699
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2025
Reference: AJNR Am J Neuroradiol. 2025 Mar 4;46(3):502-509. doi: 10.3174/ajnr.A8556.
Impact factor:
Publication type: Paper in international publication
Authors: Bashir, Saima; Diana, Francesco; Diaz-Perez, Jose; Dios, Marta De; Galve, Inyaki; Gramegna, Laura Ludovica; Hernandez, David; Requena, Manuel; Ribo, Marc; Rivera, Eila et al.
DOI: 10.3174/ajnr.A8556

Short-chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile.

PMID: 40033709
Journal: Annals of Clinical and Translational Neurology
Year: 2025
Reference: Ann Clin Transl Neurol. 2025 Mar 3. doi: 10.1002/acn3.52259.
Impact factor:
Publication type: Paper in international publication
Authors: Aladro, Yolanda; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Casanova-Peno, Ignacio; Comabella, Manuel; Costa-Frossard, Lucienne; Dominguez-Mozo, Maria Inmaculada; Garcia-Calvo, Estefania; Garcia-Dominguez, Jose Manuel; Garcia-Martinez, Maria Angel et al.
DOI: 10.1002/acn3.52259

Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer.

PMID: 40067927
Journal: CANCER RESEARCH
Year: 2025
Reference: Cancer Res. 2025 Mar 11. doi: 10.1158/0008-5472.CAN-24-2531.
Impact factor:
Publication type: Paper in international publication
Authors: Abdalfttah, Mohmed; Balmana, Judith; Casali, Giorgia; Clavell-Revelles, Pau; Domenech, Heura; Eixarch, Herena; Espejo, Carmen; Fasani, Roberta; Florian, Stefan; Grueso, Judit et al.
DOI: 10.1158/0008-5472.CAN-24-2531

Vaccination in multiple sclerosis: Tackling challenges and paving the way for effective immunization.

PMID: 40071952
Journal: Multiple Sclerosis Journal
Year: 2025
Reference: Mult Scler. 2025 Mar 12:13524585251318513. doi: 10.1177/13524585251318513.
Impact factor:
Publication type: Paper in international publication
Authors: Borras-Bermejo, Blanca; Carvajal, Rene; Montalban, Xavier; Otero-Romero, Susana; Saylor, Deanna; Tintore, Mar; Tur, Carmen et al.
DOI: 10.1177/13524585251318513

Modeling Robotic-Assisted Mechanical Thrombectomy Procedures with the CorPath GRX Robot: The Core-Flow Study.

PMID: 38663990
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2024
Reference: AJNR Am J Neuroradiol. 2024 Apr 25. doi: 10.3174/ajnr.A8205.
Impact factor:
Publication type: Paper in international publication
Authors: Cendrero, Judith; De Dios, Marta; Diana, Francesco; Diaz, Maria Lourdes; Esteves, Marielle; Gramegna, Laura Ludovica; Hernandez, David; Jablonska, Magda; Li, Jiahui; Losada, Cristina et al.
DOI: 10.3174/ajnr.A8205

The Contribution of Vessel Wall Magnetic Resonance Imaging to the Diagnosis of Primary and Secondary Central Nervous System Vasculitis.

PMID: 38732340
Journal: Diagnostics
Year: 2024
Reference: Diagnostics (Basel). 2024 Apr 29;14(9):927. doi: 10.3390/diagnostics14090927.
Impact factor:
Publication type: Paper in international publication
Authors: Anzalone, Nicoletta; Carrozzi, Alessandro; Chieffo, Raffaella; Cirillo, Luigi; D'Aniello, Serena; Dall'Olio, Massimo; Gentile, Mauro; Godi, Claudia; Gramegna, Laura Ludovica; Lodi, Raffaele et al.
DOI: 10.3390/diagnostics14090927

Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial.

PMID: 38730097
Journal: JOURNAL OF NEUROLOGY
Year: 2024
Reference: J Neurol. 2024 May 10. doi: 10.1007/s00415-024-12417-x.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Hartung, Hans-Peter; Kappos, Ludwig; Koelbach, Ralf; MacManus, David G; Montalban, Xavier; Wicklein, Eva-Maria et al.
DOI: 10.1007/s00415-024-12417-x

Artificial intelligence applied to MRI data to tackle key challenges in multiple sclerosis.

PMID: 38738527
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 May 13:13524585241249422. doi: 10.1177/13524585241249422.
Impact factor:
Publication type: Paper in international publication
Authors: Coll, Llucia; Collorone, Sara; Llado, Xavier; Lorenzi, Marco; Montalban, Xavier; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Tur, Carmen et al.
DOI: 10.1177/13524585241249422

Non-ADEM encephalitis in patients with myelin oligodendrocyte glycoprotein antibodies: a systematic review.

PMID: 36704861
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 May;30(5):1515-1527. doi: 10.1111/ene.15684. Epub 2023 Feb 20.
Impact factor:
Publication type: Review in international publication
Authors: Armangue, Thais; Arrambide, Georgina; Castillo, Mireia; Cobo-Calvo, Alvaro; Espejo, Carmen; Felipe-Rucian, Ana; Montalban, Xavier; Olive, Gemma; Sepulveda, Maria; Tintore, Mar et al.
DOI: 10.1111/ene.15684

Real-world evaluation of ocrelizumab in multiple sclerosis: A systematic review.

PMID: 36728340
Journal: Annals of Clinical and Translational Neurology
Year: 2023
Reference: Ann Clin Transl Neurol. 2023 Mar;10(3):302-311. doi: 10.1002/acn3.51732. Epub 2023 Feb 2.
Impact factor:
Publication type: Review in international publication
Authors: Disanto, Giulio; Kuhle, Jens; Matthews, Paul M; Montalban, Xavier; Petrie, John L; Ramagopalan, Sreeram; Sammon, Cormac; Simpson, Alex et al.
DOI: 10.1002/acn3.51732

Changes in physiotherapy services and use of technology for people with multiple sclerosis during the COVID-19 pandemic.

PMID: 36724646
Journal: Multiple Sclerosis and Related Disorders
Year: 2023
Reference: Mult Scler Relat Disord. 2023 Mar;71:104520. doi: 10.1016/j.msard.2023.104520. Epub 2023 Jan 25.
Impact factor:
Publication type: Paper in international publication
Authors: Arntzen, Ellen Christin; Coote, Susan; Grange, Erica; Jonsdottir, Johanna; Kahraman, Turhan; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne; Moumdjian, Lousin; Pedulla, Ludovico et al.
DOI: 10.1016/j.msard.2023.104520

Physical Activity in Multiple Sclerosis: Meeting the Guidelines at the Time of the COVID-19 Pandemic.

PMID: 36753458
Journal: Journal of Neurologic Physical Therapy
Year: 2023
Reference: J Neurol Phys Ther. 2023 Apr 1;47(2):112-121. doi: 10.1097/NPT.0000000000000430. Epub 2023 Jan 31.
Impact factor:
Publication type: Paper in international publication
Authors: Arntzen, Ellen Christin; Coote, Susan; Gungor, Feray; Jonsdottir, Johanna; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne; Moumdjian, Lousin; Nedeljkovic, Una; Novotna, Klara et al.
DOI: 10.1097/NPT.0000000000000430

The impact of the COVID-19 pandemic on physical activity and associated technology use in persons with multiple sclerosis: an international RIMS-SIG Mobility survey study.

PMID: 35760106
Journal: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
Year: 2022
Reference: Arch Phys Med Rehabil. 2022 Oct;103(10):2009-2015. doi: 10.1016/j.apmr.2022.06.001. Epub 2022 Jun 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arntzen, Ellen Christin; Coote, Susan; Jonsdottir, Johanna; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne; Moumdjian, Lousin; Nedeljkovic, Una; Novotna, Klara; Pedulla, Ludovico et al.
DOI: 10.1016/j.apmr.2022.06.001

Confirming a Historical Diagnosis of Multiple Sclerosis: Challenges and Recommendations.

PMID: 35747540
Journal: Neurology. Clinical practice
Year: 2022
Reference: Neurol Clin Pract. 2022 Jun;12(3):263-269. doi: 10.1212/CPJ.0000000000001149.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Brownlee, Wallace; Cohen, Jeffrey A; Cross, Anne H; Gaitan, Maria I; Lublin, Fred D; Makhani, Naila; Mowry, Ellen M; Reich, Daniel S; Rovira, Alex et al.
DOI: 10.1212/CPJ.0000000000001149

The kappa free light chain index and oligoclonal bands have a similar role in the McDonald criteria.

PMID: 35727945
Journal: BRAIN
Year: 2022
Reference: Brain. 2022 Nov 21;145(11):3931-3942. doi: 10.1093/brain/awac220.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Dieli-Crimi, Romina; Dieli-Crimi, Romina et al.
DOI: 10.1093/brain/awac220

Early Reduction of MRI Activity During 6 Months of Treatment With Cladribine Tablets for Highly Active Relapsing Multiple Sclerosis: MAGNIFY-MS.

PMID: 35701185
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2022
Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Jun 14;9(4). pii: 9/4/e1187. doi: 10.1212/NXI.0000000000001187. Print 2022 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Achiron, Anat; Barkhof, Frederik; Chan, Andrew; de Stefano, Nicola; Derfuss, Tobias; Hodgkinson, Suzanne; Keller, Birgit; Leocani, Letizia; Montalban, Xavier; Prat, Alexandre et al.
DOI: 10.1212/NXI.0000000000001187

Quantification of Cervical Cord Cross-Sectional Area: Which Acquisition, Vertebra Level, and Analysis Software? A Multicenter Repeatability Study on a Traveling Healthy Volunteer.

PMID: 34421797
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Aug 4;12:693333. doi: 10.3389/fneur.2021.693333. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bellenberg, Barbara; Brouwer, Iman; Filippi, Massimo; Gandini Wheeler-Kingshott, Claudia A M; Kappos, Ludwig; Lukas, Carsten; Pareto, Deborah; Parmar, Katrin; Prados, Ferran et al.
DOI: 10.3389/fneur.2021.693333

Myelin-oligodendrocyte glycoprotein antibody-associated disease.

PMID: 34418402
Journal: LANCET NEUROLOGY
Year: 2021
Reference: Lancet Neurol. 2021 Sep;20(9):762-772. doi: 10.1016/S1474-4422(21)00218-0.
Impact factor:
Publication type: Review in international publication
Authors: Aktas, Orhan; Alexopoulos, Harry; Amato, Maria-Pia; Asgari, Nasrin; Banwell, Brenda; Bennett, Jeffrey; Brilot, Fabienne; Capobianco, Marco; Chitnis, Tanuja; Ciccarelli, Olga et al.
DOI: 10.1016/S1474-4422(21)00218-0

Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis.

PMID: 34385365
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Aug 12;8(6). pii: 8/6/e1065. doi: 10.1212/NXI.0000000000001065. Print 2021 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Ammitzboll, Cecilie; Carrion, Belinda; Christensen, Jeppe Romme; Comabella, Manuel; Dziegiel, Morten Hanefeld; Hadi, Mahdieh; Issazadeh-Navikas, Shohreh; Liu, Yawei; Lundstrom, Jon; Montalban, Xavier et al.
DOI: 10.1212/NXI.0000000000001065

Chitinase 3-like 1 is not a target antigen in patients with multiple sclerosis.

PMID: 33327838
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 Aug;27(9):1455-1457. doi: 10.1177/1352458520980141. Epub 2020 Dec 17.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Deutschmann, Claudia; Martinez, Julia; Midaglia, Luciana; Montalban, Xavier; Roggenbuck, Dirk; Schierack, Peter et al.
DOI: 10.1177/1352458520980141

Harnessing Real-World Data to Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS).

PMID: 32849170
Journal: Frontiers in Neurology
Year: 2020
Reference: Front Neurol. 2020 Aug 7;11:632. doi: 10.3389/fneur.2020.00632. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Benzinger, Tammie L S; Bermel, Robert A; de Moor, Carl; Fisher, Elizabeth; Hersh, Carrie M; Hyland, Megan H; Izbudak, Izlem; Jones, Stephen E; Kieseier, Bernd C; Kitzler, Hagen H et al.
DOI: 10.3389/fneur.2020.00632

Multiple sclerosis management during the COVID-19 pandemic.

PMID: 32772807
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Sep;26(10):1163-1171. doi: 10.1177/1352458520948231. Epub 2020 Aug 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aravidis, Berna; Arrambide, Georgina; Bermel, Robert A; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Cohen, Jeffrey A; Douglas, Morgan; Fitzgerald, Kathryn C; Hellisz, Kelsey; Hua, Le H et al.
DOI: 10.1177/1352458520948231

CNS demyelination after initiating the tyrosine kinase inhibitor imatinib: A report of two cases.

PMID: 31845621
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1121-1124. doi: 10.1177/1352458519892914. Epub 2019 Dec 17.
Impact factor:
Publication type: Paper in international publication
Authors: Bharatha, Aditya; Lipton, Jeffrey H; Montalban, Xavier; Rotstein, Dalia L; Sawicka, Katherine et al.
DOI: 10.1177/1352458519892914

A pharmacogenetic study implicates NINJ2 in the response to Interferon-beta in multiple sclerosis.

PMID: 31221001
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1074-1082. doi: 10.1177/1352458519851428. Epub 2019 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Citterio, Lorena; Clarelli, Ferdinando; Comabella, Manuel; Comi, Giancarlo; de Jager, Philip; Esposito, Federica; Ferre, Laura; Guaschino, Clara; Lechner-Scott, Jeannette et al.
DOI: 10.1177/1352458519851428

SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes.

PMID: 31344857
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2019
Reference: Int J Mol Sci. 2019 Jul 24;20(15). pii: ijms20153615. doi: 10.3390/ijms20153615.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Egido, Jesus; Espejo, Carmen; Garcia-Ramirez, Marta; Gomez-Guerrero, Carmen; Hernandez, Cristina; Prieto, Ignacio; Sampedro, Joel; Simo, Rafael; Sola-Adell, Cristina et al.
DOI: 10.3390/ijms20153615

Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.

PMID: 31263110
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Jul 1;10(1):2956. doi: 10.1038/s41467-019-10951-1.
Impact factor:
Publication type: Letter or abstract
Authors: Andlauer, Till F M; Baranzini, Sergio E; Barcellos, Lisa F; Beecham, Ashley; Berge, Tone; Bernardinelli, Luisa; Booth, David R; Bos, Steffan D; Briggs, Farren; Caillier, Stacy J et al.
DOI: 10.1038/s41467-019-10951-1

Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis.

PMID: 31258540
Journal: Frontiers in Immunology
Year: 2019
Reference: Front Immunol. 2019 Jun 14;10:1374. doi: 10.3389/fimmu.2019.01374. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Carrillo-Salinas, Francisco Javier; Espejo, Carmen; Feliu, Ana; Guaza, Carmen; Mecha, Miriam; Mestre, Leyre; Villar, Luisa Maria et al.
DOI: 10.3389/fimmu.2019.01374

Traffic Lights Intervention Reduces Therapeutic Inertia: A Randomized Controlled Trial in Multiple Sclerosis Care.

PMID: 31259250
Journal: MDM policy & practice
Year: 2019
Reference: MDM Policy Pract. 2019 Jun 21;4(1):2381468319855642. doi: 10.1177/2381468319855642. eCollection 2019 Jan-Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Caceres, Fernando; Mamdani, Muhammad; Montalban, Xavier; Saladino, Maria Laura; Saposnik, Gustavo; Silva, Berenice; Terzaghi, Maria; Tobler, Philippe N et al.
DOI: 10.1177/2381468319855642

Myasthenia gravis following alemtuzumab therapy for multiple sclerosis.

PMID: 30143565
Journal: NEUROLOGY
Year: 2018
Reference: Neurology. 2018 Sep 25;91(13):622-624. doi: 10.1212/WNL.0000000000006251. Epub 2018 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Caronna, Edoardo; Gratacos, Margarida; Midaglia, Luciana; Montalban, Xavier; Raguer, Nuria; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1212/WNL.0000000000006251

Usability of an Educational Intervention to Overcome Therapeutic Inertia in Multiple Sclerosis Care.

PMID: 30042720
Journal: Frontiers in Neurology
Year: 2018
Reference: Front Neurol. 2018 Jul 10;9:522. doi: 10.3389/fneur.2018.00522. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Caceres, Fernando; Fruns Quintana, Manuel; Mamdani, Muhammad; Maurino, Jorge; Montalban, Xavier; Oh, Jiwon; Ruff, Christian; Saposnik, Gustavo; Terzaghi, Maria A; Tobler, Philippe N et al.
DOI: 10.3389/fneur.2018.00522

Clinical monitoring of multiple sclerosis should routinely include spinal cord imaging - Commentary.

PMID: 30033805
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Oct;24(12):1539-1540. doi: 10.1177/1352458518783362. Epub 2018 Jul 23.
Impact factor:
Publication type: Letter or abstract
Authors: Sastre-Garriga, Jaume et al.
DOI: 10.1177/1352458518783362

Cladribine tablets added to IFN-beta in active relapsing MS: The ONWARD study.

PMID: 30027104
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2018
Reference: Neurol Neuroimmunol Neuroinflamm. 2018 Jul 11;5(5):e477. doi: 10.1212/NXI.0000000000000477. eCollection 2018 Sep.
Impact factor:
Publication type: Paper in international publication
Authors: Campbell, Jackie; Cohen, Bruce A; Dangond, Fernando; Hicking, Christine; Leist, Thomas P; Montalban, Xavier; Moses, Harold et al.
DOI: 10.1212/NXI.0000000000000477

Review of the novelties from the 32nd ECTRIMS Congress, 2016, presented at the 9th Post-ECTRIMS Meeting (II).

PMID: 28675259
Journal: REVISTA DE NEUROLOGIA
Year: 2017
Reference: Rev Neurol. 2017 Jul 16;65(2):75-84.
Impact factor:
Publication type: Review in national publication
Authors: Arroyo, R; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R; Izquierdo, G et al.
DOI: 10.33588/rn.6502.2017169

MMP9 is decreased in natalizumab-treated MS patients at risk for PML.

PMID: 28681388
Journal: ANNALS OF NEUROLOGY
Year: 2017
Reference: Ann Neurol. 2017 Aug;82(2):186-195. doi: 10.1002/ana.24987. Epub 2017 Jul 22.
Impact factor:
Publication type: Paper in international publication
Authors: Almoyna, Laurent; Brassat, David; Clavelou, Pierre; Comabella, Manuel; de Seze, Jerome; Fissolo, Nicolas; Labauge, Pierre; Lebrun-Frenay, Christine; Matute-Blanch, Clara; Miro, Berta et al.
DOI: 10.1002/ana.24987

Review of the novelties from the 32nd ECTRIMS Congress, 2016, presented at the 9th Post-ECTRIMS Meeting (I).

PMID: 28650065
Journal: REVISTA DE NEUROLOGIA
Year: 2017
Reference: Rev Neurol. 2017 Jul 1;65(1):31-40.
Impact factor:
Publication type: Review in national publication
Authors: Arroyo, R; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R; Izquierdo, G et al.
DOI: 10.33588/rn.6501.2017168

Cumulative Dose of Macrocyclic Gadolinium-Based Contrast Agent Improves Detection of Enhancing Lesions in Patients with Multiple Sclerosis.

PMID: 28619842
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2017
Reference: AJNR Am J Neuroradiol. 2017 Aug;38(8):1486-1493. doi: 10.3174/ajnr.A5253. Epub 2017 Jun 15.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Corral, J F; Huerga, E; Mitjana, R; Montalban, X; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.3174/ajnr.A5253

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy.

PMID: 27815407
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Dec 6;87(23):2491-2494. doi: 10.1212/WNL.0000000000003401. Epub 2016 Nov 4.
Impact factor:
Publication type: Letter or abstract
Authors: Alexia di-Paolo; Anne, Olivier; Audoin, Bertrand; Averseng-Peaureaux, Delphine; Bensa, Caroline; Berger, Eric; Berger, Eric; Berger, Eric; Biotti, Damien; Bourre, Bertrand et al.
DOI: 10.1212/WNL.0000000000003401

Correction: Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.

PMID: 27815448
Journal: JOURNAL OF IMMUNOLOGY
Year: 2016
Reference: J Immunol. 2016 Nov 15;197(10):4177.
Impact factor:
Publication type: Paper in international publication
Authors: Alloza, Iraide; Astobiza, Ianire; Carrillo-Salinas, Francisco J; Comabella, Manuel; Feliu, Ana; Guaza, Carmen; Lopez de Lapuente, Aitzkoa; Mecha, Miriam; Mena, Jorge; Montalban, Xavier et al.
DOI: 10.4049/jimmunol.1601659

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

PMID: 27804975
Journal: Nature Communications
Year: 2016
Reference: Nat Commun. 2016 Nov 2;7:13467. doi: 10.1038/ncomms13467.
Impact factor:
Publication type: Paper in international publication
Authors: Albar, Juan Pablo; Andersen, Claus L; Boxer, Matthew B; Bramsem, Jesper B; Esteller, Manel; Heyn, Holger; Leal, Lucia; Lopez-Serra, Paula; Marcilla, Miguel; Martinez-Balibrea, Eva et al.
DOI: 10.1038/ncomms13467

Sustained reduction of MS disability: New player in comparing disease-modifying treatments.

PMID: 27733564
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Nov 8;87(19):1966-1967. doi: 10.1212/WNL.0000000000003314. Epub 2016 Oct 12.
Impact factor:
Publication type: Paper in international publication
Authors: Bielekova, Bibiana; Tintore, Mar et al.
DOI: 10.1212/WNL.0000000000003314

No association of multiple sclerosis activity and progression with EBV or tobacco use in BENEFIT.

PMID: 26453645
Journal: NEUROLOGY
Year: 2015
Reference: Neurology. 2015 Nov 10;85(19):1694-701. doi: 10.1212/WNL.0000000000002099. Epub 2015 Oct 9.
Impact factor:
Publication type: Paper in international publication
Authors: Ascherio, Alberto; Barkhof, Frederik; Edan, Gilles; Fitzgerald, Kathryn C; Freedman, Mark S; Hartung, Hans-Peter; Kappos, Ludwig; Miller, David H; Montalban, Xavier; Munger, Kassandra L et al.
DOI: 10.1212/WNL.0000000000002099

Juxtacortical Lesions and Cortical Thinning in Multiple Sclerosis.

PMID: 26450537
Journal: AM J NEURORADIOL
Year: 2015
Reference: AJNR Am J Neuroradiol. 2015 Dec;36(12):2270-6. doi: 10.3174/ajnr.A4485. Epub 2015 Oct 8.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Delgado, J; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Tintore, M; Vives-Gilabert, Y et al.
DOI: 10.3174/ajnr.A4485

Antibody dissociation rates are predictive of neutralizing antibody (NAb) course: a comparison of interferon beta-1b-treated Multiple Sclerosis (MS) patients with transient versus sustained NAbs.

PMID: 25543089
Journal: CLIN IMMUNOL
Year: 2015
Reference: Clin Immunol. 2015 Mar;157(1):91-101. doi: 10.1016/j.clim.2014.12.005. Epub 2014 Dec 24.
Impact factor:
Publication type: Clinical Trials
Authors: Edan, Gilles; Freedman, Mark S; Gibbs, Ebrima; Hartung, Hans Peter; Karim, Mohammad Ehsanul; Miller, David; Montalban, Xavier; Oger, Joel; Pleimes, Dirk; Pohl, Christoph et al.
DOI: 10.1016/j.clim.2014.12.005

Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab.

PMID: 25581547
Journal: ANN NEUROL
Year: 2015
Reference: Ann Neurol. 2015 Mar;77(3):447-57. doi: 10.1002/ana.24345. Epub 2015 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Aguera, Eduardo; Alvarez-Cermeno, Jose C; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Bar-Or, Amit; Casanova, Bonaventura; Comabella, Manuel; Coret, Francisco; Costa-Frossard, Lucienne; de Andres, Clara et al.
DOI: 10.1002/ana.24345

Predictive markers of disease evolution after a CIS in everyday practice.

PMID: 24881867
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2014
Reference: J Neurol Sci. 2014 Aug 15;343(1-2):8-14. doi: 10.1016/j.jns.2014.05.023. Epub 2014 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Sastre-Garriga, Jaume et al.
DOI: 10.1016/j.jns.2014.05.023

Defining the clinical course of multiple sclerosis: the 2013 revisions.

PMID: 24871874
Journal: NEUROLOGY
Year: 2014
Reference: Neurology. 2014 Jul 15;83(3):278-86. doi: 10.1212/WNL.0000000000000560. Epub 2014 May 28.
Impact factor:
Publication type: Review in international publication
Authors: Balcer, Laura J; Banwell, Brenda; Barkhof, Frederik; Bebo, Bruce Jr; Calabresi, Peter A; Clanet, Michel; Cohen, Jeffrey A; Comi, Giancarlo; Cutter, Gary R; Fox, Robert J et al.
DOI: 10.1212/WNL.0000000000000560

Natalizumab: risk stratification of individual patients with multiple sclerosis.

PMID: 24942634
Journal: CNS DRUGS
Year: 2014
Reference: CNS Drugs. 2014 Jul;28(7):641-8. doi: 10.1007/s40263-014-0168-0.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1007/s40263-014-0168-0

Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis.

PMID: 24909126
Journal: ANNALS OF NEUROLOGY
Year: 2014
Reference: Ann Neurol. 2014 Aug;76(2):231-40. doi: 10.1002/ana.24190. Epub 2014 Jul 2.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Avsar, Timucin; Bar-Or, Amit; Casanova, Bonaventura; Comabella, Manuel; Coret, Francisco; de Andres, Clara; Evdoshenko, Evgeniy et al.
DOI: 10.1002/ana.24190

Fingolimod versus intramuscular interferon in patient subgroups from TRANSFORMS.

PMID: 23632946
Journal: JOURNAL OF NEUROLOGY
Year: 2013
Reference: J Neurol. 2013 Aug;260(8):2023-32. doi: 10.1007/s00415-013-6932-0. Epub 2013 Apr 30.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Cohen, Jeffrey A; Comi, Giancarlo; Eckert, Benjamin; Francis, Gordon; Haring, Dieter A; Izquierdo, Guillermo; Khatri, Bhupendra; Montalban, Xavier; Pelletier, Jean et al.
DOI: 10.1007/s00415-013-6932-0

Baseline gene expression signatures in monocytes from multiple sclerosis patients treated with interferon-beta.

PMID: 23637780
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Apr 18;8(4):e60994. doi: 10.1371/journal.pone.0060994. Print 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Marta F; Comabella, Manuel; Montalban, Xavier; Nurtdinov, Ramil N; Rio, Jordi et al.
DOI: 10.1371/journal.pone.0060994

Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-beta treatment.

PMID: 23700969
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2013
Reference: Eur J Neurol. 2013 Oct;20(10):1390-7. doi: 10.1111/ene.12193. Epub 2013 May 22.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, J; Comabella, M; Malhotra, S; Montalban, X; Morcillo-Suarez, C; Moreno, M; Navarro, A; Nurtdinov, R; Rio, J; Sarro, E et al.
DOI: 10.1111/ene.12193

Localized grey matter atrophy in multiple sclerosis: a meta-analysis of voxel-based morphometry studies and associations with functional disability.

PMID: 23518268
Journal: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Year: 2013
Reference: Neurosci Biobehav Rev. 2013 Jun;37(5):819-30. doi: 10.1016/j.neubiorev.2013.03.006. Epub 2013 Mar 18.
Impact factor:
Publication type: Paper in international publication
Authors: Grau, M; Lansley, J; Mataix-Cols, D; Radua, J; Sastre-Garriga, J et al.
DOI: 10.1016/j.neubiorev.2013.03.006

Risk stratification for progressive multifocal leukoencephalopathy in patients treated with natalizumab.

PMID: 22312009
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Feb;18(2):143-52.
Impact factor:
Publication type: Review in international publication
Authors: Bertolotto, Antonio; Edan, Gilles; Giovannoni, Gavin; Gold, Ralf; Havrdova, Eva; Kappos, Ludwig; Kieseier, Bernd C; Montalban, Xavier; Olsson, Tomas; Sorensen, Per Soelberg et al.
DOI: 10.1177/1352458511435105

Transcriptomics: mRNA and alternative splicing.

PMID: 22626445
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2012
Reference: J Neuroimmunol. 2012 Jul 15;248(1-2):23-31. Epub 2012 May 22.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; et al.
DOI: 10.1016/j.jneuroim.2012.04.008

Review of the novelties presented at the 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).

PMID: 22627749
Journal: REVISTA DE NEUROLOGIA
Year: 2012
Reference: Rev Neurol. 2012 Jun 1;54(11):677-691.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI:

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis.

PMID: 21716315
Journal: GENES AND IMMUNITY
Year: 2012
Reference: Genes Immun. 2012 Jan;13(1):21-8. doi: 10.1038/gene.2011.44. Epub 2011 Jun 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alcina, A; Alloza, I; Alvarez, J; Antiguedad, A; Aransay, A; Arroyo, R; Caillier, S; Comabella, M; Fedetz, M; Fernandez, O et al.
DOI: 10.1038/gene.2011.44

Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study.

PMID: 21727148
Journal: MULTIPLE SCLEROSIS
Year: 2011
Reference: Mult Scler. 2011 Nov;17(11):1341-50. Epub 2011 Jul 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1177/1352458511411061

Using the WHOQOL-DIS to Measure Quality of Life in Persons with Physical Disabilities Caused by Neurodegenerative Disorders.

PMID: 21135535
Journal: Neurodegenerative Diseases
Year: 2011
Reference: Neurodegener Dis. 2011;8(4):178-86. Epub 2010 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1159/000321582

A functional magnetic resonance proof of concept pilot trial of cognitive rehabilitation in multiple sclerosis.

PMID: 21177323
Journal: MULTIPLE SCLEROSIS
Year: 2011
Reference: Mult Scler. 2011 Apr;17(4):457-67. Epub 2010 Dec 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458510389219

Utility of oligoclonal IgG band detection for MS diagnosis in daily clinical practice.

PMID: 21704629
Journal: JOURNAL OF IMMUNOLOGICAL METHODS
Year: 2011
Reference: J Immunol Methods. 2011 Aug 31;371(1-2):170-3. Epub 2011 Jun 17.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jim.2011.06.009

Clinical features of CIS of the brainstem/cerebellum of the kind seen in MS.

PMID: 19946780
Journal: JOURNAL OF NEUROLOGY
Year: 2010
Reference: J Neurol. 2010 May;257(5):742-6. Epub 2009 Nov 28.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, J; Comabella, M; Horga, A; Montalban, X; Nos, C; Perkal, H; Rio, J; Rovira, A; Sastre-Garriga, Jaume; Tellez, N et al.
DOI: 10.1007/s00415-009-5403-0

Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes.

PMID: 20530323
Journal: NEUROLOGY
Year: 2010
Reference: Neurology. 2010 Jun 8;74(23):1868-1876.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1212/WNL.0b013e3181e24136

EFNS guidelines on diagnosis and management of neuromyelitis optica.

PMID: 20528913
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2010
Reference: Eur J Neurol. 2010 Aug;17(8):1019-32. Epub 2010 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1468-1331.2010.03066.x

Orchestrating innate immune responses in multiple sclerosis: Molecular players.

PMID: 20537409
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2010
Reference: J Neuroimmunol. 2010 Aug 25;225(1-2):5-12.
Impact factor:
Publication type: Review in international publication
Authors: ; ; et al.
DOI: 10.1016/j.jneuroim.2010.05.014

Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months.

PMID: 19770470
Journal: NEUROLOGY
Year: 2009
Reference: Neurology. 2009 Sep 22;73(12):949-53.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Y; Calabia, J; Castella, M D; Castillo, J; Graus, F; Horga, A; Llufriu, S; Lozano, M; Montalban, X; Ramio-Torrenta, L et al.
DOI: 10.1212/WNL.0b013e3181b879be

Early onset multiple sclerosis: the role of gender.

PMID: 19683727
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2009
Reference: J Neurol Sci. 2009 Nov 15;286(1-2):31-4.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Tintore, Mar et al.
DOI: 10.1016/j.jns.2009.07.016

United Europeans for development of pharmacogenomics in multiple sclerosis network.

PMID: 19450134
Journal: PHARMACOGENOMICS
Year: 2009
Reference: Pharmacogenomics. 2009 May;10(5):885-94.
Impact factor:
Publication type: Paper in international publication
Authors: Brassat, David; Comabella, Manuel; Escorza, Sergio; Favorov, Alexander; Goertsches, Robert; Hintzen, Rogier; Infante-Duarte, Carmen; Oksenberg, Jorge R; Palacios, Ricardo; Tolosa, Eva et al.
DOI: 10.2217/pgs.09.33

Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial.

PMID: 19748319
Journal: LANCET NEUROLOGY
Year: 2009
Reference: Lancet Neurol. 2009 Nov;8(11):987-97.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bauer, Lars; Edan, Gilles; Freedman, Mark S; Hartung, Hans-Peter; Kappos, Ludwig; Lanius, Vivian; Metzig, Carola; Miller, David H; Montalban, Xavier et al.
DOI: 10.1016/S1474-4422(09)70237-6

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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