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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Llorente Blasco, Helena

Llorente Blasco, Helena

Research technician
Clinical Neuroimmunology
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Luca Bollo

Luca Bollo

Predoctoral researcher
Clinical Neuroimmunology
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Luciana Midaglia Fernandez

Luciana Midaglia Fernandez

Research technician
Clinical Neuroimmunology
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Margarita Saez López

Margarita Saez López

Administration and Management
Clinical Neuroimmunology
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Maria Gabriela Bravo Vera

Maria Gabriela Bravo Vera

Clinical Neuroimmunology
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Marquez Parra, Jose David

Marquez Parra, Jose David

Maintenance staff and general services
Clinical Neuroimmunology
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Llorente Blasco, Helena

Llorente Blasco, Helena

Research technician
Clinical Neuroimmunology
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Luca Bollo

Luca Bollo

Predoctoral researcher
Clinical Neuroimmunology
Read more
Luciana Midaglia Fernandez

Luciana Midaglia Fernandez

Research technician
Clinical Neuroimmunology
Read more
Margarita Saez López

Margarita Saez López

Administration and Management
Clinical Neuroimmunology
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Maria Gabriela Bravo Vera

Maria Gabriela Bravo Vera

Clinical Neuroimmunology
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Marquez Parra, Jose David

Marquez Parra, Jose David

Maintenance staff and general services
Clinical Neuroimmunology
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Projects

Caracterización estructural y funcional de la vía visual anterior en pacientes con esclerosis múltiple temprana (VISIONEM).

IP: Angela Vidal Jordana
Collaborators: Dulce María Moncho Rodríguez, Alex Rovira Cañellas, Manel Alberich Jordà, Neus Mongay Ochoa, Joaquin Castillo Justribo, Sergio Cabello
Funding agency: Instituto de Salud Carlos III
Funding: 48400
Reference: PI22/01589
Duration: 01/01/2023 - 31/12/2025

Caracterización de pacientes con esclerosis múltiple muy activa y evaluación del efecto de tratamientos de alta efectividad en la evolución de su enfermedad.

IP: Georgina Arrambide García
Collaborators: Jordi Rio Izquierdo, Marta Rodríguez Barranco, Joaquin Castillo Justribo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI22/01570
Duration: 01/01/2023 - 31/12/2025

Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a first demyelinating syndrome

IP: Alvaro Cobo Calvo
Collaborators: Javier Villacieros Álvarez, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI21/00282
Duration: 01/01/2022 - 31/12/2025

TRAtamiento y recuperación VISual en neuritis óptica - Estudio TRAVIS

IP: Jaume Sastre Garriga
Collaborators: Dulce María Moncho Rodríguez, Sergio Cabello, Cristina Auger Acosta, Alex Rovira Cañellas, Ana Zabalza de Torres, Joaquin Castillo Justribo
Funding agency: Instituto de Salud Carlos III
Funding: 96800
Reference: PI19/00950
Duration: 01/01/2020 - 30/06/2024

Publications

Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers.

PMID: 37686520
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Aug 24;15(17):4245. doi: 10.3390/cancers15174245.
Impact factor:
Publication type: Review in international publication
Authors: Baraibar, Iosune; Baraibar, Iosune; Elez, Elena; Elez, Elena; Rodriguez, Marta; Rodriguez, Marta; Ros, Javier; Salva, Francesc; Salva, Francesc; Saoudi, Nadia et al.
DOI: 10.3390/cancers15174245

Do the current MS clinical course descriptors need to change and if so how? A survey of the MS community.

PMID: 37691493
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Sep 11:13524585231196786. doi: 10.1177/13524585231196786.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Calabresi, Peter A; Coetzee, Timothy; Finlayson, Marcia; Hawton, Annie; Lublin, Fred D; Marrie, Ruth Ann; Moccia, Marcello; Montalban, Xavier; Panzara, Michael et al.
DOI: 10.1177/13524585231196786

Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis: results from the HEBEM study.

PMID: 37695530
Journal: JOURNAL OF NEUROLOGY
Year: 2023
Reference: J Neurol. 2023 Sep 11. doi: 10.1007/s00415-023-11973-y.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Buti, Maria; Castillo, Joaquin; Marzo, Blanca; Montalban, Xavier; Otero-Romero, Susana; Otero-Romero, Susana; Riveiro-Barciela, Mar; Riveiro-Barciela, Mar; Robles-Sanchez, Miguel-Angel et al.
DOI: 10.1007/s00415-023-11973-y

Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury.

PMID: 37702323
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2023
Reference: Clin Chem Lab Med. 2023 Sep 13. doi: 10.1515/cclm-2023-0518.
Impact factor:
Publication type: Paper in international publication
Authors: Akgun, Katja; Bar-Or, Amit; Bielekova, Bibi; Bittner, Stefan; Blennow, Kaj; Bruck, Wolfgang; Chan, Dandan; Chang, Lei; Chitnis, Tanuja; Comabella, Manuel et al.
DOI: 10.1515/cclm-2023-0518

The kappa free light chain index and oligoclonal bands have a similar role in the McDonald criteria.

PMID: 35727945
Journal: BRAIN
Year: 2022
Reference: Brain. 2022 Jun 21. pii: 6612696. doi: 10.1093/brain/awac220.
Impact factor: 13.501
Publication type: Paper in international publication
Authors: Rodriguez-Acevedo, Breogan, Ruiz-Ortiz, Mariano, Salerno, Annalaura, Tagliani, Paula, Tur, Carmen, Vidal-Jordana, Angela, Zabalza, Ana, Sastre-Garriga, Jaume, Rovira, Alex, Comabella, Manuel et al.
DOI: 10.1093/brain/awac220

Longitudinal retinal changes in MOGAD.

PMID: 35703428
Journal: ANNALS OF NEUROLOGY
Year: 2022
Reference: Ann Neurol. 2022 Jun 15. doi: 10.1002/ana.26440.
Impact factor: 10.422
Publication type: Paper in international publication
Authors: Brandt, Alexander U, Smith, Terry J, Yeaman, Michael R, Green, Ari J, Llufriu, Sara, Pittock, Sean, Flanagan, Eoin P, Bhatti, M Tariq, Rommer, Paulus S, Bsteh, Gabriel et al.
DOI: 10.1002/ana.26440

Riemannian Geometry of Functional Connectivity Matrices for Multi-Site Attention-Deficit/Hyperactivity Disorder Data Harmonization.

PMID: 35685944
Journal: Frontiers in Neuroinformatics
Year: 2022
Reference: Front Neuroinform. 2022 May 23;16:769274. doi: 10.3389/fninf.2022.769274. eCollection 2022.
Impact factor: 4.081
Publication type: Paper in international publication
Authors: Simeon, Guillem, Piella, Gemma, Camara, Oscar, Pareto, Deborah et al.
DOI: 10.3389/fninf.2022.769274

Increased Number of Passes and Double Stent Retriever Technique Induces Cumulative Injury on Arterial Wall After Mechanical Thrombectomy in a Swine Model.

PMID: 35672562
Journal: Translational Stroke Research
Year: 2022
Reference: Transl Stroke Res. 2022 Jun 8. pii: 10.1007/s12975-022-01044-1. doi: 10.1007/s12975-022-01044-1.
Impact factor: 6.829
Publication type: Paper in international publication
Authors: Tomasello, Alejandro, Ribo, Marc, Gil, Alberto, Li, Jiahui, Esteves, Marielle, Coscojuela, Pilar, de Dios, Marta, Pinana, Carlos, Requena, Manuel, Gragmegna, Laura Ludovica et al.
DOI: 10.1007/s12975-022-01044-1

Ischemic Core Overestimation on Computed Tomography Perfusion.

PMID: 33682453
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 May;52(5):1751-1760. doi: 10.1161/STROKEAHA.120.031800. Epub 2021 Mar 8.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Campos, Daniel, Rubiera, Marta, Boned, Sandra, Olive-Gadea, Marta, Requena, Manuel, Ciolli, Ludovico, Muchada, Marian, Pagola, Jorge, Deck, Matias et al.
DOI: 10.1161/STROKEAHA.120.031800

Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study.

PMID: 33401136
Journal: NeuroImage-Clinical
Year: 2021
Reference: Neuroimage Clin. 2021;29:102549. doi: 10.1016/j.nicl.2020.102549. Epub 2020 Dec 25.
Impact factor: 4.881
Publication type: Paper in international publication
Authors: Guttmann, Charles R G, Vrenken, Hugo, Uitdehaag, Bernard M J, Burggraaff, Jessica, Liu, Yao, Prieto, Juan C, Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman et al.
DOI: 10.1016/j.nicl.2020.102549

Optic nerve region in multiple sclerosis diagnosis: the utility of visual evoked potentials.

PMID: 33328323
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Jan 26;96(4):e482-e490. doi: 10.1212/WNL.0000000000011339. Epub 2020 Dec 16.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Comabella, Manuel, Vidal-Jordana, Angela, Rovira, Alex, Arrambide, Georgina, Otero-Romero, Susana, Rio, Jordi, Galan, Ingrid, Cabello, Sergio, Moncho, Dulce, Rahnama, Kimia et al.
DOI: 10.1212/WNL.0000000000011339

CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS.

PMID: 33436375
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Jan 12;8(2). pii: 8/2/e941. doi: 10.1212/NXI.0000000000000941. Print 2021 Mar.
Impact factor: 8.485
Publication type: Paper in international publication
Authors: Brito, Veronica, Fissolo, Nicolas, Matute-Blanch, Clara, Osman, Mohamoud, Costa, Carme, Pinteac, Rucsanda, Miro, Berta, Sanchez, Alex, Khalil, Michael, Borras, Eva et al.
DOI: 10.1212/NXI.0000000000000941

Angioplasty with a retrievable stent to treat vasospasm secondary to subarachnoid hemorrhage due to an aneurysm: a multicenter study of safety and efficacy.

PMID: 32622517
Journal: Radiologia
Year: 2020
Reference: Radiologia (Engl Ed). 2020 Jul 1. pii: S0033-8338(20)30072-2. doi: 10.1016/j.rx.2020.04.011.
Impact factor: 0
Publication type: Paper in national publication
Authors: Lopez-Rueda, A, Vargas, A, Pinana, C, Chirife, O, Werner, M, Aja, L, Remollo, S, Tomasello, A et al.
DOI: 10.1016/j.rx.2020.04.011

Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease-related disability.

PMID: 32602573
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2020
Reference: Eur J Neurol. 2020 Nov;27(11):2225-2232. doi: 10.1111/ene.14421. Epub 2020 Jul 28.
Impact factor: 4.516
Publication type: Paper in international publication
Authors: Vidal-Jordana, Angela, Pareto, Deborah, Cabello, Sergio, Alberich, Manel, Rio, Jordi, Tintore, Mar, Auger, Cristina, Montalban, Xavier, Rovira, Alex, Sastre-Garriga, Jaume et al.
DOI: 10.1111/ene.14421

Texture analysis in susceptibility-weighted imaging may be useful to differentiate acute from chronic multiple sclerosis lesions.

PMID: 32535736
Journal: EUROPEAN RADIOLOGY
Year: 2020
Reference: Eur Radiol. 2020 Nov;30(11):6348-6356. doi: 10.1007/s00330-020-06995-3. Epub 2020 Jun 13.
Impact factor: 4.101
Publication type: Paper in international publication
Authors: Pessini, Lucas M, Cannella, Roberto, Salvaggio, Giuseppe, de Barros, Andrea, Salerno, Annalaura, Auger, Cristina, Rovira, Alex, Caruana, Giovanni et al.
DOI: 10.1007/s00330-020-06995-3

Initial studies with [(11)C]vorozole positron emission tomography detect over-expression of intra-tumoral aromatase in breast cancer.

PMID: 31757843
Journal: JOURNAL OF NUCLEAR MEDICINE
Year: 2020
Reference: J Nucl Med. 2020 Jun;61(6):807-813. doi: 10.2967/jnumed.119.231589. Epub 2019 Nov 22.
Impact factor: 7.887
Publication type: Paper in international publication
Authors: Shroyer, Kenneth R, Franceschi, Dinko, Dhawan, Jasbeer, Tahmi, Mouna, Pareto, Deborah, Bonilla, Patrick, Airola, Krystal, Cohen, Jules, Biegon, Anat et al.
DOI: 10.2967/jnumed.119.231589

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information