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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Pérez Rubio, Ana Maria

Pérez Rubio, Ana Maria

Administration and Management
Clinical Neuroimmunology
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Pulido Salgado, Marta

Pulido Salgado, Marta

Administration and Management
Clinical Neuroimmunology
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Rafael Garcia Merida

Rafael Garcia Merida

Administration and Management
Clinical Neuroimmunology
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Ramos Hernandez, Lidia

Ramos Hernandez, Lidia

Administration and Management
Clinical Neuroimmunology
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René Yeltsin Carvajal Junco

René Yeltsin Carvajal Junco

Predoctoral researcher
Clinical Neuroimmunology
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Rucsanda Pinteac

Rucsanda Pinteac

Postdoctoral researcher
Clinical Neuroimmunology
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Pérez Rubio, Ana Maria

Pérez Rubio, Ana Maria

Administration and Management
Clinical Neuroimmunology
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Pulido Salgado, Marta

Pulido Salgado, Marta

Administration and Management
Clinical Neuroimmunology
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Rafael Garcia Merida

Rafael Garcia Merida

Administration and Management
Clinical Neuroimmunology
Read more
Ramos Hernandez, Lidia

Ramos Hernandez, Lidia

Administration and Management
Clinical Neuroimmunology
Read more
René Yeltsin Carvajal Junco

René Yeltsin Carvajal Junco

Predoctoral researcher
Clinical Neuroimmunology
Read more
Rucsanda Pinteac

Rucsanda Pinteac

Postdoctoral researcher
Clinical Neuroimmunology
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Projects

Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a first demyelinating syndrome

IP: Alvaro Cobo Calvo
Collaborators: Rosalia Horno Ocaña, Cristina Auger Acosta, Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a , Luciana Midaglia Fernandez, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 134915
Reference: PI20/00800
Duration: 01/01/2021 - 30/06/2025

Desvelando los mecanismos que llevan al aumento irreversible de discapacidad en esclerosis múltiple mediante resonancia magnética multi-modal cuantitativa

IP: Carmen Tur Gomez
Collaborators: Jordi Rio Izquierdo, Oscar Persiva Morenza, Elena Huerga Núñez
Funding agency: Instituto de Salud Carlos III
Funding: 150040
Reference: PI21/01860
Duration: 01/01/2022 - 30/06/2026

Rejuvenation of the immune system as a therapeutic approach for progressive multiple sclerosis.

IP: Carmen Espejo Ruiz
Collaborators: Rosalia Horno Ocaña, Herena Eixarch Ahufinger, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI21/01682
Duration: 01/01/2022 - 30/06/2026

Determinación de biomarcadores de lesión neuronal y astrocitaria en suero de paciente con encefalopatía hepática

IP: Macarena Simon-Talero Horga
Collaborators: Joaquin Castillo Justribo, Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 60500
Reference: PI21/00312
Duration: 01/01/2022 - 30/06/2026

Publications

Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer.

PMID: 40067927
Journal: CANCER RESEARCH
Year: 2025
Reference: Cancer Res. 2025 Mar 11. doi: 10.1158/0008-5472.CAN-24-2531.
Impact factor:
Publication type: Paper in international publication
Authors: Abdalfttah, Mohmed; Balmana, Judith; Casali, Giorgia; Clavell-Revelles, Pau; Domenech, Heura; Eixarch, Herena; Espejo, Carmen; Fasani, Roberta; Florian, Stefan; Grueso, Judit et al.
DOI: 10.1158/0008-5472.CAN-24-2531

Vaccination in multiple sclerosis: Tackling challenges and paving the way for effective immunization.

PMID: 40071952
Journal: Multiple Sclerosis Journal
Year: 2025
Reference: Mult Scler. 2025 Mar 12:13524585251318513. doi: 10.1177/13524585251318513.
Impact factor:
Publication type: Paper in international publication
Authors: Borras-Bermejo, Blanca; Carvajal, Rene; Montalban, Xavier; Otero-Romero, Susana; Saylor, Deanna; Tintore, Mar; Tur, Carmen et al.
DOI: 10.1177/13524585251318513

Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Aquaporin-4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis.

PMID: 38780377
Journal: ANNALS OF NEUROLOGY
Year: 2024
Reference: Ann Neurol. 2024 May 23. doi: 10.1002/ana.26951.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Apostolos Pereira, Samira Luisa; Arrambide, Georgina; Barkhof, Frederik; Battaglini, Marco; Bellenberg, Barbara; Bianchi, Alessia; Bodini, Benedetta; Cacciaguerra, Laura; Celius, Elisabeth G et al.
DOI: 10.1002/ana.26951

Using the Progression Independent of Relapse Activity Framework to Unveil the Pathobiological Foundations of Multiple Sclerosis.

PMID: 38889384
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Jul 9;103(1):e209444. doi: 10.1212/WNL.0000000000209444. Epub 2024 Jun 18.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Calabrese, Massimiliano; Ciccarelli, Olga; De Stefano, Nicola; Eshaghi, Arman; Filippi, Massimo; Gasperini, Claudio; Granziera, Cristina; Kappos, Ludwig; Rocca, Maria A et al.
DOI: 10.1212/WNL.0000000000209444

Association of Complement Factors With Disability Progression in Primary Progressive Multiple Sclerosis.

PMID: 38912898
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2024
Reference: Neurol Neuroimmunol Neuroinflamm. 2024 Jul;11(4):e200270. doi: 10.1212/NXI.0000000000200270. Epub 2024 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelhak, Ahmed; Alvarez-Lafuente, Roberto; Bachhuber, Franziska; Berek, Klaus; Blanco, Yolanda; Carbonell-Mirabent, Pere; Castillo-Trivino, Tamara; Comabella, Manuel; Fissolo, Nicolas; Garcia Merino, Juan Antonio et al.
DOI: 10.1212/NXI.0000000000200270

IL-6 Inhibition as a Therapeutic Target in Aged Experimental Autoimmune Encephalomyelitis.

PMID: 38928437
Journal:
Year: 2024
Reference: Int J Mol Sci. 2024 Jun 19;25(12):6732. doi: 10.3390/ijms25126732.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, Mireia; Dema, Maria; Eixarch, Herena; Espejo, Carmen; Montalban, Xavier et al.
DOI: 10.3390/ijms25126732

Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders.

PMID: 36810323
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Jul;94(7):560-566. doi: 10.1136/jnnp-2022-330608. Epub 2023 Feb 21.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Asgari, Nasrin; Ashtari, Fereshteh; Brandt, Alexander U; Chien, Claudia; Cobo-Calvo, Alvaro; Cook, Lawrence; Dcunha, Anitha; Dehghani, Alireza et al.
DOI: 10.1136/jnnp-2022-330608

Using The Virtual Brain to study the relationship between structural and functional connectivity in patients with multiple sclerosis: a multicenter study.

PMID: 36813475
Journal: CEREBRAL CORTEX
Year: 2023
Reference: Cereb Cortex. 2023 Jun 8;33(12):7322-7334. doi: 10.1093/cercor/bhad041.
Impact factor:
Publication type: Paper in international publication
Authors: Deco, Gustavo; Filippi, Massimo; Foster, Michael A; Gonzalez-Escamilla, Gabriel; Groppa, Sergiu; Harbo, Hanne F; Hogestol, Einar A; Llufriu, Sara; Marti-Juan, Gerard; Martinez-Heras, Eloy et al.
DOI: 10.1093/cercor/bhad041

Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs.

PMID: 36848127
Journal: JAMA Neurology
Year: 2023
Reference: JAMA Neurol. 2023 Apr 1;80(4):397-403. doi: 10.1001/jamaneurol.2023.0010.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Alvarez-Lafuente, Roberto; Brieva, Luis; Cabrera-Maqueda, Jose Maria; Casanova, Bonaventura; Chico-Garcia, Juan Luis; Comabella, Manuel; Costa-Frossard, Lucienne; Dominguez-Mozo, Maria Inmaculada; Eichau, Sara et al.
DOI: 10.1001/jamaneurol.2023.0010

Antithrombotic regimen in emergent carotid stenting for acute ischemic stroke due to tandem occlusion: a meta-analysis of aggregate data.

PMID: 37185107
Journal: Journal of NeuroInterventional Surgery
Year: 2023
Reference: J Neurointerv Surg. 2023 Apr 25:jnis-2023-020204. doi: 10.1136/jnis-2023-020204.
Impact factor:
Publication type: Paper in international publication
Authors: Abdalkader, Mohamad; Abud, Daniel Giansante; Aguiar de Sousa, Diana; Al-Mufti, Fawaz; Bartolini, Bruno; Beaujeux, Remy; Behme, Daniel; Berlis, Ansgar; Bracco, Sandra; Choi, Jae Young et al.
DOI: 10.1136/jnis-2023-020204

Longitudinal retinal changes in MOGAD.

PMID: 35703428
Journal: ANNALS OF NEUROLOGY
Year: 2022
Reference: Ann Neurol. 2022 Sep;92(3):476-485. doi: 10.1002/ana.26440. Epub 2022 Jul 16.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Altintas, Ayse; Aly, Lilian; Andrade, Mariana; Asgari, Nasrin; Ashtari, Fereshte; Asseyer, Eva Susanna; Ayzenberg, Ilya; Bhatti, M Tariq et al.
DOI: 10.1002/ana.26440

Sick leave and occupational burnout among nurses caring for patients with multiple sclerosis.

PMID: 35661566
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jul;63:103916. doi: 10.1016/j.msard.2022.103916. Epub 2022 May 28.
Impact factor:
Publication type: Paper in international publication
Authors: Azanza-Munarriz, Cristina; Becerril-Rios, Noelia; Bueno-Gil, Guillermo; Del Rio-Munoz, Beatriz; Goicochea-Briceno, Haydee; Horno, Rosalia; Lendinez-Mesa, Alejandro; Maurino, Jorge; Medrano, Nicolas; Rodriguez-Antiguedad, Alfredo et al.
DOI: 10.1016/j.msard.2022.103916

Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis.

PMID: 35598462
Journal: NeuroImage-Clinical
Year: 2022
Reference: Neuroimage Clin. 2022;35:103048. doi: 10.1016/j.nicl.2022.103048. Epub 2022 May 16.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Battaglini, Marco; Calvi, Alberto; Chard, Declan; Ciccarelli, Olga; Cortese, Rosa; De Riz, Milena; De Stefano, Nicola; Galimberti, Daniela; Pietroboni, Anna et al.
DOI: 10.1016/j.nicl.2022.103048

Assessment of 2D conventional and synthetic MRI in multiple sclerosis.

PMID: 35583667
Journal: NEURORADIOLOGY
Year: 2022
Reference: Neuroradiology. 2022 Dec;64(12):2315-2322. doi: 10.1007/s00234-022-02973-2. Epub 2022 May 18.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Julio; Andrino, Ana; Arrambide, Georgina; Auger, Cristina; Aymerich, Francesc Xavier; Barros, Andrea; Clarke, Margareta A; Corral, Juan Francisco; Mora, Juan; Rovira, Alex et al.
DOI: 10.1007/s00234-022-02973-2

Drug-related demyelinating syndromes: understanding risk factors, pathophysiological mechanisms and magnetic resonance imaging findings.

PMID: 34332456
Journal: Multiple Sclerosis and Related Disorders
Year: 2021
Reference: Mult Scler Relat Disord. 2021 Oct;55:103146. doi: 10.1016/j.msard.2021.103146. Epub 2021 Jul 21.
Impact factor:
Publication type: Review in international publication
Authors: Apostolos-Pereira, Samira Luisa; Boaventura, Mateus; Calich, Ana Luisa; Callegaro, Dagoberto; Godoy, Luis Filipe; Leite, Claudia da Costa; Lucato, Leandro Tavares; Rimkus, Carolina M; Rovira, Alex; Sastre-Garriga, Jaume et al.
DOI: 10.1016/j.msard.2021.103146

Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis.

PMID: 34322119
Journal: Frontiers in Immunology
Year: 2021
Reference: Front Immunol. 2021 Jul 12;12:685139. doi: 10.3389/fimmu.2021.685139. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Aladro, Yolanda; Alvarez-Cermeno, Jose Carlos; Alvarez-Lafuente, Roberto; Comabella, Manuel; Costa-Frossard, Lucienne; Dominguez-Mozo, Maria Inmaculada; Espejo, Carmen; Espino, Mercedes; Fernandez-Velasco, Jose Ignacio; Guaza, Carmen et al.
DOI: 10.3389/fimmu.2021.685139

Multiple sclerosis is associated with higher comorbidity and healthcare resource use: a population-based, case-control study in a western Mediterranean region.

PMID: 34293826
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2021
Reference: Eur J Neurol. 2021 Dec;28(12):4124-4134. doi: 10.1111/ene.15030. Epub 2021 Aug 5.
Impact factor:
Publication type: Paper in international publication
Authors: Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Montalban, Xavier; Otero-Romero, Susana; Passarell-Bacardit, Maria Angels; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1111/ene.15030

Angiogenin in the Neurogenic Subventricular Zone After Stroke.

PMID: 34234733
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Jun 21;12:662235. doi: 10.3389/fneur.2021.662235. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Costa, Carme; Gabriel-Salazar, Marina; Grayston, Alba; Lei, Ting; Medina-Gutierrez, Esperanza; Montaner, Joan; Rosell, Anna et al.
DOI: 10.3389/fneur.2021.662235

A pharmacogenetic study implicates NINJ2 in the response to Interferon-beta in multiple sclerosis.

PMID: 31221001
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1074-1082. doi: 10.1177/1352458519851428. Epub 2019 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose Carlos; Citterio, Lorena; Clarelli, Ferdinando; Comabella, Manuel; Comi, Giancarlo; de Jager, Philip; Esposito, Federica; Ferre, Laura; Guaschino, Clara; Lechner-Scott, Jeannette et al.
DOI: 10.1177/1352458519851428

The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history.

PMID: 32710096
Journal: BRAIN
Year: 2020
Reference: Brain. 2020 Sep 1;143(9):2637-2652. doi: 10.1093/brain/awaa145.
Impact factor:
Publication type: Review in international publication
Authors: Comi, Giancarlo; Hartung, Hans-Peter; Montalban, Xavier; Sellebjerg, Finn; Sorensen, Per Soelberg; Tintore, Mar et al.
DOI: 10.1093/brain/awaa145

[Prevalence and impact of comorbidities in patients with multiple sclerosis].

PMID: 32700311
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 Aug 16;71(4):151-158. doi: 10.33588/rn.7104.2020095.
Impact factor:
Publication type: Review in national publication
Authors: Cardenas-Robledo, S; Montalban, X; Otero-Romero, S; Tintore, M et al.
DOI: 10.33588/rn.7104.2020095

Five-years of ocrelizumab in relapsing multiple sclerosis: OPERA studies open-label extension.

PMID: 32690791
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Sep 29;95(13):e1854-e1867. doi: 10.1212/WNL.0000000000010376. Epub 2020 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Bar-Or, Amit; Belachew, Shibeshih; Brochet, Bruno; Hauser, Stephen L; Hubeaux, Stanislas; Kappos, Ludwig; Koendgen, Harold; Levesque, Victoria; Manfrini, Marianna et al.
DOI: 10.1212/WNL.0000000000010376

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8(+) T cell tumor-infiltration impairing anti-PD1 therapy.

PMID: 31186412
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Jun 11;10(1):2416. doi: 10.1038/s41467-019-10369-9.
Impact factor:
Publication type: Paper in international publication
Authors: Arias, Alexandra; Bonfill-Teixidor, Ester; Brana, Irene; Cuartas, Isabel; Escudero, Laura; Espejo, Carmen; Garralda, Elena; Graus, Francesc; Huber-Ruano, Isabel; Iurlaro, Raffaella et al.
DOI: 10.1038/s41467-019-10369-9

Review of the novelties presented at the 2018 ECTRIMS Congress: 11th Post-ECTRIMS Meeting (II).

PMID: 31132136
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 Jun 1;68(11):468-479. doi: 10.33588/rn.6811.2019121.
Impact factor:
Publication type: Review in international publication
Authors: Aladro, Y; Arnal-Garcia, C; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Carrascal, P; Comabella, M; Costa-Frossard, L; Fernandez, O; Garcia-Merino, J A et al.
DOI: 10.33588/rn.6811.2019121

Introducing the International Women in Multiple Sclerosis network.

PMID: 31122489
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Jun;18(6):521. doi: 10.1016/S1474-4422(19)30160-7.
Impact factor:
Publication type: Letter or abstract
Authors: Arrambide, Georgina; Costello, Fiona; Jokubaitis, Vilija G; Probstel, Anne-Katrin; Waubant, Emmanuelle et al.
DOI: 10.1016/S1474-4422(19)30160-7

Engaging across dimensions of diversity: A cross-national perspective on mHealth tools for managing relapsing remitting and progressive multiple sclerosis.

PMID: 31125754
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Jul;32:123-132. doi: 10.1016/j.msard.2019.04.020. Epub 2019 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria Jesus; Comi, Giancarlo; Curtis, Hannah; Evans, Joanne; Ferrao, Jose; Gamble, Peter; Greer, Ben; Matcham, Faith; Mulero, Patricia; Polhemus, Ashley et al.
DOI: 10.1016/j.msard.2019.04.020

Restoring Axonal Function with 4-Aminopyridine: Clinical Efficacy in Multiple Sclerosis and Beyond.

PMID: 29992409
Journal: CNS DRUGS
Year: 2018
Reference: CNS Drugs. 2018 Jul;32(7):637-651. doi: 10.1007/s40263-018-0536-2.
Impact factor:
Publication type: Review in national publication
Authors: Hartung, Hans-Peter; Leussink, Verena Isabell; Montalban, Xavier et al.
DOI: 10.1007/s40263-018-0536-2

Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI.

PMID: 29984155
Journal: NeuroImage-Clinical
Year: 2018
Reference: Neuroimage Clin. 2018 Apr 26;19:466-475. doi: 10.1016/j.nicl.2018.04.023. eCollection 2018.
Impact factor:
Publication type: Review in national publication
Authors: Amiri, Houshang; Barkhof, Frederik; Battaglini, Marco; Bendfeldt, Kerstin; Calabrese, Massimiliano; de Sitter, Alexandra; de Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Gandini Wheeler-Kingshott, Claudia A M et al.
DOI: 10.1016/j.nicl.2018.04.023

[Review of the novelties from the 2017 ECTRIMS Congress, presented at the 10th Post-ECTRIMS Meeting (II)].

PMID: 29971758
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Jul 15;67(2):50-62.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Arnal-Garcia, C; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R; Izquierdo, G et al.
DOI: 10.33588/rn.6702.2018193

[Review of the novelties from the 2017 ECTRIMS Congress, presented at the 10th Post-ECTRIMS Meeting (I)].

PMID: 29923596
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Jul 1;67(1):15-27.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Arnal-Garcia, C; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R; Izquierdo, G et al.
DOI: 10.33588/rn.6701.2018192

Neuroimmunology: B cells and variant BAFF in autoimmune disease.

PMID: 28621764
Journal: Nature Reviews Neurology
Year: 2017
Reference: Nat Rev Neurol. 2017 Aug;13(8):453-454. doi: 10.1038/nrneurol.2017.87. Epub 2017 Jun 16.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel et al.
DOI: 10.1038/nrneurol.2017.87

Consensus guidelines for lumbar puncture in patients with neurological diseases.

PMID: 28603768
Journal:
Year: 2017
Reference: Alzheimers Dement (Amst). 2017 May 18;8:111-126. doi: 10.1016/j.dadm.2017.04.007. eCollection 2017.
Impact factor:
Publication type: Clinical guide
Authors: Blennow, Kaj; Brouns, Raf; Comabella, Manuel; de Mendonca, Alexandre; Duits, Flora; Dujmovic, Irena; Engelborghs, Sebastiaan; Frolich, Lutz; Galimberti, Daniela; Gnanapavan, Sharmilee et al.
DOI: 10.1016/j.dadm.2017.04.007

Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

PMID: 28593439
Journal: Neurotherapeutics
Year: 2017
Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Castano, A Raul; Chillon, Miguel; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Hirota, Keiji; Miralles, Marta; Montalban, Xavier; Puig, Meritxell et al.
DOI: 10.1007/s13311-017-0545-8

Sodium intake and multiple sclerosis activity and progression in BENEFIT.

PMID: 28556498
Journal: ANNALS OF NEUROLOGY
Year: 2017
Reference: Ann Neurol. 2017 Jul;82(1):20-29. doi: 10.1002/ana.24965.
Impact factor:
Publication type: Paper in international publication
Authors: Ascherio, Alberto; Edan, Gilles; Fitzgerald, Kathryn C; Freedman, Mark S; Hartung, Hans P; Kappos, Ludwig; Montalban, Xavier; Munger, Kassandra L; Pohl, Christoph; Radue, Ernst-Wilhelm et al.
DOI: 10.1002/ana.24965

Myeloid-derived suppressor cells expressing a self-antigen ameliorate experimental autoimmune encephalomyelitis.

PMID: 27693617
Journal: EXPERIMENTAL NEUROLOGY
Year: 2016
Reference: Exp Neurol. 2016 Dec;286:50-60. doi: 10.1016/j.expneurol.2016.09.012. Epub 2016 Sep 28.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Casacuberta-Serra, Silvia; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Lopez-Estevez, Sergio; Mansilla, Maria Jose; Martorell, Lluis; Montalban, Xavier; Pares, Marta et al.
DOI: 10.1016/j.expneurol.2016.09.012

Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis.

PMID: 27566747
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 27;87(13):1368-74. doi: 10.1212/WNL.0000000000003144. Epub 2016 Aug 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria Jesus; Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana; Mitjana, Raquel; Montalban, Xavier; Nos, Carlos et al.
DOI: 10.1212/WNL.0000000000003144

Neurofilament light chain level is a weak risk factor for the development of MS.

PMID: 27521440
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 13;87(11):1076-84. doi: 10.1212/WNL.0000000000003085. Epub 2016 Aug 12.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Arevalo, Maria J; Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Comabella, Manuel; Disanto, Giulio; Eixarch, Herena; Espejo, Carmen; Galan, Ingrid et al.
DOI: 10.1212/WNL.0000000000003085

The 11-year long-term follow-up study from the randomized BENEFIT CIS trial.

PMID: 27511182
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 6;87(10):978-87. doi: 10.1212/WNL.0000000000003078. Epub 2016 Aug 10.
Impact factor:
Publication type: Paper in international publication
Authors: Altenkirch, H; Angstwurm, K; Anten, B; Arbizu, T; Arroyo, R; Ayuso, G Izquierdo; Barcena, J; Barkhof, F; Barkhof, F; Barkhof, F et al.
DOI: 10.1212/WNL.0000000000003078

Comment on severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody.

PMID: 25662350
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Apr;21(5):660-1. doi: 10.1177/1352458514551457. Epub 2015 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1177/1352458514551457

Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration.

PMID: 25593207
Journal: STEM CELL TRANSL MED
Year: 2015
Reference: Stem Cells Transl Med. 2015 Mar;4(3):252-60. doi: 10.5966/sctm.2014-0133. Epub 2015 Jan 15.
Impact factor:
Publication type: Review in international publication
Authors: Boster, Aaron L; Comabella, Manuel; Deleidi, Michela; Imitola, Jaime; Mahajan, Kedar; Nicholas, Jacqueline A; Orack, Joshua C; Pitt, David; Racke, Michael K; Watanabe, Fumihiro et al.
DOI: 10.5966/sctm.2014-0133

Any evident MRI T2 lesion activity should guide change of therapy in multiple sclerosis: no.

PMID: 25583834
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Feb;21(2):132-3. doi: 10.1177/1352458514565415. Epub 2015 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Rio, Jordi et al.
DOI: 10.1177/1352458514565415

Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab.

PMID: 25581547
Journal: ANN NEUROL
Year: 2015
Reference: Ann Neurol. 2015 Mar;77(3):447-57. doi: 10.1002/ana.24345. Epub 2015 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Aguera, Eduardo; Alvarez-Cermeno, Jose C; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Bar-Or, Amit; Casanova, Bonaventura; Comabella, Manuel; Coret, Francisco; Costa-Frossard, Lucienne; de Andres, Clara et al.
DOI: 10.1002/ana.24345

One step forward in the quest for evidence of the efficacy of cognitive rehabilitation in multiple sclerosis.

PMID: 24347477
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Jan;20(1):2. doi: 10.1177/1352458513510982.
Impact factor:
Publication type: Editorail in international publication
Authors: Penner, Iris-Katharina; Sastre-Garriga, Jaume et al.
DOI: 10.1177/1352458513510982

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis.

PMID: 25123034
Journal: Biomarkers in Medicine
Year: 2014
Reference: Biomark Med. 2014 Jun;8(5):653-61. doi: 10.2217/bmm.14.9.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo-Trivino, Tamara; Comabella, Manuel; Irizar, Haritz; Lopez de Munain, Adolfo; Lopez-Mato, Maria P; Munoz-Culla, Maider; Olascoaga, Javier; Osorio-Querejeta, Inaki; Otaegui, David; Prada, Alvaro et al.
DOI: 10.2217/bmm.14.9

NMO spectrum disorders: how wide is the spectrum?

PMID: 25160127
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Sep;20(10):1417-9. doi: 10.1177/1352458514546517.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Montalban, Xavier; Rovira, Alex; Tur, Carmen et al.
DOI: 10.1177/1352458514546517

Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.

PMID: 25129256
Journal: AMERICAN JOURNAL OF PATHOLOGY
Year: 2014
Reference: Am J Pathol. 2014 Sep;184(9):2420-9. doi: 10.1016/j.ajpath.2014.05.021. Epub 2014 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Cepok-Kauffeld, Sabine; Comabella, Manuel; Hemmer, Bernhard; Holmdahl, Rikard; Ibrahim, Saleh M; Lemcke, Susanne; Moller, Steffen; Montalban, Xavier; Muller, Susen; Nandakumar, Kutty Selva et al.
DOI: 10.1016/j.ajpath.2014.05.021

Amyotrophic lateral sclerosis in Catalonia: a population based study.

PMID: 23286747
Journal: Amyotrophic Lateral Sclerosis
Year: 2013
Reference: Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):278-83. doi: 10.3109/21678421.2012.749915. Epub 2013 Jan 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Ramiro; Aragones, Josep Maria; Baiges, Juan Jose; Basart, Esther; Bello, Juan; Bonaventura, Imma; Coll, Jaume; Fossas, Pilar; Gamez, Jose; Gich, Ignasi et al.
DOI: 10.3109/21678421.2012.749915

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

PMID: 24052443
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Oct 1;57(7):317-329.
Impact factor:
Publication type: Review in national publication
Authors: Arnal-Garcia, C; Arroyo-Gonzalez, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; de Las Heras, V; Fernandez, O; Garcia-Merino, J A; Grupo Post-Ectrims, Grupo Post-Ectrims et al.
DOI:

Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study.

PMID: 23764350
Journal: LANCET NEUROLOGY
Year: 2013
Reference: Lancet Neurol. 2013 Aug;12(8):756-67. doi: 10.1016/S1474-4422(13)70102-9. Epub 2013 Jun 11.
Impact factor:
Publication type: Paper in international publication
Authors: Auberson, Lixin Zhang; Dahlke, Frank; Freedman, Mark S; Hartung, Hans-Peter; Hemmer, Bernhard; Kappos, Ludwig; Li, David K B; Mercier, Francois; Montalban, Xavier; Pohlmann, Harald et al.
DOI: 10.1016/S1474-4422(13)70102-9

TRPM4 mRNA expression levels in peripheral blood mononuclear cells from multiple sclerosis patients.

PMID: 23796873
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2013
Reference: J Neuroimmunol. 2013 Aug 15;261(1-2):146-8. doi: 10.1016/j.jneuroim.2013.05.013. Epub 2013 Jun 22.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, J; Comabella, M; Malhotra, S; Merino-Zamorano, C; Montalban, X; Montaner, J; Negrotto, L; Vidal-Jordana, A et al.
DOI: 10.1016/j.jneuroim.2013.05.013

Association between pathological and MRI findings in multiple sclerosis.

PMID: 22441196
Journal: LANCET NEUROLOGY
Year: 2012
Reference: Lancet Neurol. 2012 Apr;11(4):349-60. Epub 2012 Mar 19.
Impact factor:
Publication type: Review in international publication
Authors: Barkhof, F; Barkhof, Frederik; Bruck, W; Bruck, Wolfgang; Chen, J T; Chen, Jacqueline T; Comi, G; Comi, Giancarlo; De Stefano, N; De Stefano, Nicola et al.
DOI: 10.1016/S1474-4422(12)70003-0

EBV-specific immune responses in patients with multiple sclerosis responding to IFN{beta} therapy.

PMID: 22020417
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 May;18(5):605-9. Epub 2011 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1177/1352458511426816

Olfactory dysfunction in multiple sclerosis: association with secondary progression.

PMID: 22020420
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 May;18(5):616-21. Epub 2011 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458511427156

[Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis].

PMID: 22234570
Journal: REVISTA DE NEUROLOGIA
Year: 2012
Reference: Rev Neurol. 2012 Jan 16;54(2):114-24.
Impact factor:
Publication type: Letter or abstract
Authors: Clemente, Diego; de Castro, Fernando; Espejo, Carmen; Fernandez-Fernandez, Oscar; Guaza, Carmen; Mestre, Leyre; Montalban, Xavier; Moreno, Beatriz; Suardiaz, Margarita; Villoslada, Pablo et al.
DOI:

Pharmacogenomics and Multiple Sclerosis: Moving Toward Individualized Medicine.

PMID: 21701907
Journal: Current Neurology and Neuroscience Reports
Year: 2011
Reference: Curr Neurol Neurosci Rep. 2011 Oct;11(5):484-91. doi: 10.1007/s11910-011-0211-1.
Impact factor:
Publication type: Review in international publication
Authors: ; et al.
DOI: 10.1007/s11910-011-0211-1

Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.

PMID: 21571593
Journal: LANCET NEUROLOGY
Year: 2011
Reference: Lancet Neurol. 2011 Jun;10(6):520-9. Epub 2011 May 13.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/S1474-4422(11)70099-0

Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonbeta therapy in multiple sclerosis.

PMID: 21471993
Journal: GENES AND IMMUNITY
Year: 2011
Reference: Genes Immun. 2011 Sep;12(6):466-72. doi: 10.1038/gene.2011.18. Epub 2011 Apr 7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/gene.2011.18

Monoclonal antibodies in the development of multiple sclerosis.

PMID: 21481981
Journal: NEUROLOGIA
Year: 2011
Reference: Neurologia. 2011 Nov;26(9):556-62. Epub 2011 Apr 8.
Impact factor:
Publication type: Review in national publication
Authors: ; et al.
DOI: 10.1016/j.nrl.2011.02.006

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.

PMID: 20508602
Journal: GENES AND IMMUNITY
Year: 2010
Reference: Genes Immun. 2010 Jul;11(5):439-45. Epub 2010 May 27.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/gene.2010.30

A study of right-left shunt in transient global amnesia.

PMID: 20487707
Journal: NEUROLOGIA
Year: 2010
Reference: Neurologia. 2010 Mar;25(2):83-89.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; et al.
DOI:

Progression on the Multiple Sclerosis Functional Composite in MS: what is the optimal cut-off for the three components?

PMID: 20488826
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Jul;16(7):862-7. Epub 2010 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458510370464

[Multiple sclerosis epidemiological situation update: pertinence and set-up of a population based registry of new cases in Catalonia]

PMID: 20473839
Journal: REVISTA DE NEUROLOGIA
Year: 2010
Reference: Rev Neurol. 2010 May 16;50(10):623-33.
Impact factor:
Publication type: Paper in national publication
Authors: Batlle, J; Batlle, J; Bello, J; Berlanga, B; Blanco, Y; Boltes, A; Bonaventura, I; Bonaventura, I; Brieva, Ll; Brieva, Ll et al.
DOI:

Magnetic resonance imaging predictors of conversion to multiple sclerosis in the BENEFIT study.

PMID: 19901165
Journal: ARCHIVES OF NEUROLOGY
Year: 2009
Reference: Arch Neurol. 2009 Nov;66(11):1345-52.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Hartung, Hans-Peter; Kappos, Ludwig; Lanius, Vivian; Miller, David H; Montalban, Xavier; Moraal, Bastiaan; Pohl, Christoph et al.
DOI: 10.1001/archneurol.2009.243

Differential susceptibility to apoptosis of CD4+T cells expressing CCR5 and CXCR3 in patients with MS.

PMID: 19740704
Journal: CLINICAL IMMUNOLOGY
Year: 2009
Reference: Clin Immunol. 2009 Dec;133(3):364-74.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1016/j.clim.2009.08.012

Measures in the first year of therapy predict the response to interferon beta in MS.

PMID: 19542263
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Jul;15(7):848-53.
Impact factor:
Publication type: Paper in international publication
Authors: Aymerich, X; Castillo, J; Comabella, M; Horga, A; Montalban, X; Nos, C; Rio, J; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.1177/1352458509104591

A type I interferon signature in monocytes is associated with poor response to interferon-{beta} in multiple sclerosis.

PMID: 19741051
Journal: BRAIN
Year: 2009
Reference: Brain. 2009 Dec;132(Pt 12):3353-65.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/brain/awp228

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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