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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Ana Isabel Guerrero Perez

Ana Isabel Guerrero Perez

Research technician
Clinical Neuroimmunology
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Ana Zabalza de Torres

Ana Zabalza de Torres

Postdoctoral researcher
Clinical Neuroimmunology
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Andrea Serrano Mascarós

Andrea Serrano Mascarós

Administration and Management
Clinical Neuroimmunology
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Andres Miguez Gonzalez

Andres Miguez Gonzalez

Postdoctoral researcher
Clinical Neuroimmunology
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Angela Vidal Jordana

Angela Vidal Jordana

Main researcher
Clinical Neuroimmunology
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Breogan Rodriguez Acevedo

Breogan Rodriguez Acevedo

Senior researcher
Clinical Neuroimmunology
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Ana Isabel Guerrero Perez

Ana Isabel Guerrero Perez

Research technician
Clinical Neuroimmunology
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Ana Zabalza de Torres

Ana Zabalza de Torres

Postdoctoral researcher
Clinical Neuroimmunology
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Andrea Serrano Mascarós

Andrea Serrano Mascarós

Administration and Management
Clinical Neuroimmunology
Read more
Andres Miguez Gonzalez

Andres Miguez Gonzalez

Postdoctoral researcher
Clinical Neuroimmunology
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Angela Vidal Jordana

Angela Vidal Jordana

Main researcher
Clinical Neuroimmunology
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Breogan Rodriguez Acevedo

Breogan Rodriguez Acevedo

Senior researcher
Clinical Neuroimmunology
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Projects

Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a first demyelinating syndrome

IP: Alvaro Cobo Calvo
Collaborators: Rosalia Horno Ocaña, Cristina Auger Acosta, Marta Rodríguez Barranco, Luciana Midaglia Fernandez, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 134915
Reference: PI20/00800
Duration: 01/01/2021 - 30/06/2025

Caracterización de patrones espaciotemporales de daño tisular cerebral en esclerosis múltiple mediante técnicas de aprendizaje profundo no supervisado

IP: Carmen Tur Gomez
Collaborators: -
Funding agency: Fundación Merck Salud
Funding: 30000
Reference: MERK/INVESTIGACION/2020/TUR
Duration: 15/06/2021 - 15/06/2024

Desvelando los mecanismos que llevan al aumento irreversible de discapacidad en esclerosis múltiple mediante resonancia magnética multi-modal cuantitativa

IP: Carmen Tur Gomez
Collaborators: Jordi Rio Izquierdo, Oscar Persiva Morenza, Elena Huerga Núñez
Funding agency: Instituto de Salud Carlos III
Funding: 150040
Reference: PI21/01860
Duration: 01/01/2022 - 31/12/2024

Rejuvenation of the immune system as a therapeutic approach for progressive multiple sclerosis.

IP: Carmen Espejo Ruiz
Collaborators: Rosalia Horno Ocaña, Herena Eixarch Ahufinger, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI21/01682
Duration: 01/01/2022 - 31/12/2024

Publications

Safety and efficacy with alemtuzumab over 13 years in relapsing-remitting multiple sclerosis: final results from the open-label TOPAZ study.

PMID: 37745914
Journal: Therapeutic Advances in Neurological Disorders
Year: 2023
Reference: Ther Adv Neurol Disord. 2023 Sep 21;16:17562864231194823. doi: 10.1177/17562864231194823. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Achiron, Anat; Chirieac, Magdalena; Coles, Alasdair J; Comi, Giancarlo; Freedman, Mark S; Giovannoni, Gavin; Montalban, Xavier; Oreja-Guevara, Celia; Pozzilli, Carlo; Rawlings, Andreea M et al.
DOI: 10.1177/17562864231194823

Association of magnetic resonance imaging phenotypes and serum biomarker levels with treatment response and long-term disease outcomes in multiple sclerosis patients.

PMID: 37754568
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 Sep 27. doi: 10.1111/ene.16077.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, Joaquin; Comabella, Manuel; Comabella, Manuel; Fissolo, Nicolas; Midaglia, Luciana; Miro, Berta; Montalban, Xavier; Rio, Jordi; Rio, Jordi; Rovira, Alex et al.
DOI: 10.1111/ene.16077

Assessing treatment response to oral drugs for multiple sclerosis in real-world setting: a MAGNIMS Study.

PMID: 37775266
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Sep 29:jnnp-2023-331920. doi: 10.1136/jnnp-2023-331920.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Araji, Sarmad; Annovazzi, Pietro Osvaldo; Barkhof, Frederik; Bisecco, Alvino; Ciccarelli, Olga; Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Enzinger, Christian; Evangelou, Nikos et al.
DOI: 10.1136/jnnp-2023-331920

Retinal Changes After Acute and Late Optic Neuritis in Aquaporin-4 Antibody Seropositive NMOSD.

PMID: 37782525
Journal: JOURNAL OF NEURO-OPHTHALMOLOGY
Year: 2023
Reference: J Neuroophthalmol. 2023 Sep 29. doi: 10.1097/WNO.0000000000001991.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Asseyer, Eva Susanna; Bereuter, Charlotte; Brandt, Alexander U; Chien, Claudia; Cobo-Calvo, Alvaro; Cobo-Calvo, Alvaro; Cook, Lawrence; Fontenelle, Mariana Andrade et al.
DOI: 10.1097/WNO.0000000000001991

Disease modifying therapy switching in relapsing multiple sclerosis: A Delphi consensus of the demyelinating expert group of the Spanish society of neurology.

PMID: 35512501
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jul;63:103805. doi: 10.1016/j.msard.2022.103805. Epub 2022 Apr 12.
Impact factor: 4.339
Publication type: Paper in international publication
Authors: Costa-Frossard, Lucienne, Gonzalez Platas, Montserrat, Pascual, Lamberto Landete, Llaneza-Gonzalez, Miguel, Gines, Maria Luisa Martinez, Matias-Guiu, Jorge, Meca-Lallana, Jose E, Bilbao, Mar Mendibe, Sempere, Angel Perez, Romero-Pinel, Lucia et al.
DOI: 10.1016/j.msard.2022.103805

Angioplasty with a stent retriever to treat vasospasm secondary to subarachnoid hemorrhage due to an aneurysm: a multicenter study of safety and efficacy.

PMID: 35504675
Journal: Radiologia
Year: 2022
Reference: Radiologia. 2022 Mar-Apr;64(2):103-109. doi: 10.1016/j.rxeng.2020.04.009.
Impact factor: 0
Publication type: Paper in international publication
Authors: Remollo, S, Lopez-Rueda, A, Vargas, A, Pinana, C, Chirife, O, Werner, M, Aja, L, Tomasello, Y A et al.
DOI: 10.1016/j.rxeng.2020.04.009

Combined technique as first approach in mechanical thrombectomy: Efficacy and safety of REACT catheter combined with stent retriever.

PMID: 35491662
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2022
Reference: Interv Neuroradiol. 2022 May 2:15910199221095798. doi: 10.1177/15910199221095798.
Impact factor: 1.61
Publication type: Paper in international publication
Authors: Requena, Manuel, Pinana, Carlos, Olive-Gadea, Marta, Hernandez, David, Boned, Sandra, De Dios, Marta, Rodrigo, Marc, Rivera, Eila, Muchada, Marian, Cuevas, Jose Luis et al.
DOI: 10.1177/15910199221095798

Serum neurofilament light chain levels predict long-term disability progression in patients with progressive multiple sclerosis.

PMID: 35487685
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2022
Reference: J Neurol Neurosurg Psychiatry. 2022 Apr 29. pii: jnnp-2022-329020. doi: 10.1136/jnnp-2022-329020.
Impact factor: 10.283
Publication type: Paper in international publication
Authors: Comabella, Manuel, Sastre-Garriga, Jaume, Carbonell-Mirabent, Pere, Fissolo, Nicolas, Tur, Carmen, Malhotra, Sunny, Pareto, Deborah, Aymerich, Francesc X, Rio, Jordi, Rovira, Alex et al.
DOI: 10.1136/jnnp-2022-329020

Value of 3T Susceptibility-Weighted Imaging in the Diagnosis of Multiple Sclerosis.

PMID: 32439639
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Jun;41(6):1001-1008. doi: 10.3174/ajnr.A6547. Epub 2020 May 21.
Impact factor: 3.381
Publication type: Paper in international publication
Authors: Tintore, M, Sastre-Garriga, J, Auger, C, Montalban, X, Evangelou, N, Rovira, A, Cappelle, S, Crescenzo, F, Alberich, M, Arrambide, G et al.
DOI: 10.3174/ajnr.A6547

12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (II).

PMID: 32436209
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 Jun 1;70(11):417-429. doi: 10.33588/rn.7011.2020122.
Impact factor: 0.562
Publication type: Review in international publication
Authors: Arroyo, R, Brieva, Ll, Calles-Hernandez, M C, Carrascal, P, Comabella, M, Costa-Frossard, L, Eichau, S, Garcia-Merino, J A, Ginestal, R, Gonzalez, I et al.
DOI: 10.33588/rn.7011.2020122

Computed Tomography Perfusion After Thrombectomy: An Immediate Surrogate Marker of Outcome After Recanalization in Acute Stroke.

PMID: 32404034
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1736-1742. doi: 10.1161/STROKEAHA.120.029212. Epub 2020 May 14.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Garcia-Tornel, Alvaro, Olive-Gadea, Marta, Campos, Daniel, Requena, Manuel, Vert, Carla, Pagola, Jorge, Rodriguez-Luna, David, Muchada, Marian, Boned, Sandra et al.
DOI: 10.1161/STROKEAHA.120.029212

Time Matters: Adjusted Analysis of the Influence of Direct Transfer to Angio-Suite Protocol in Functional Outcome.

PMID: 32390548
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1766-1771. doi: 10.1161/STROKEAHA.119.028586. Epub 2020 May 11.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Molina, Carlos A, Tomasello, Alejandro, Ribo, Marc, Hernandez, David, Rodriguez-Luna, David, Pagola, Jorge, Coscojuela, Pilar, Requena, Manuel, Olive, Marta et al.
DOI: 10.1161/STROKEAHA.119.028586

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Job offers

Research Technician.
Start date:
12/02/2022
End date:
26/02/2022
Document: Download
Clinical researcher - Clinical Neuroinmunology
Start date:
03/02/2022
End date:
17/02/2022
Document: Download
Research Nursing
Start date:
25/01/2022
End date:
02/02/2022
Document: Download

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information