Skip to main content

Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Segura Dávila, Karen

Segura Dávila, Karen

Administration and Management
Clinical Neuroimmunology
Read more
Sergio Aguilar Alegre

Sergio Aguilar Alegre

Research technician
Clinical Neuroimmunology
Read more
Soriano Baliarda, Ricard

Soriano Baliarda, Ricard

Research assistant
Clinical Neuroimmunology
Read more
Ustrell Garrido, Cristina

Ustrell Garrido, Cristina

Research technician
Clinical Neuroimmunology
Read more
Victoria Carla Fernández Rodríguez

Victoria Carla Fernández Rodríguez

Predoctoral researcher
Clinical Neuroimmunology
Read more
Agustin Papolla

Agustin Papolla

Predoctoral researcher
Clinical Neuroimmunology
Read more
Segura Dávila, Karen

Segura Dávila, Karen

Administration and Management
Clinical Neuroimmunology
Read more
Sergio Aguilar Alegre

Sergio Aguilar Alegre

Research technician
Clinical Neuroimmunology
Read more
Soriano Baliarda, Ricard

Soriano Baliarda, Ricard

Research assistant
Clinical Neuroimmunology
Read more
Ustrell Garrido, Cristina

Ustrell Garrido, Cristina

Research technician
Clinical Neuroimmunology
Read more
Victoria Carla Fernández Rodríguez

Victoria Carla Fernández Rodríguez

Predoctoral researcher
Clinical Neuroimmunology
Read more
Agustin Papolla

Agustin Papolla

Predoctoral researcher
Clinical Neuroimmunology
Read more

Projects

Human induced pluripotent stem cell-based chimeric mice to study astrocyte pathology and neuroprotective strategies in multiple sclerosis patients

IP: Manuel Comabella Lopez
Collaborators: Andres Miguez Gonzalez, Rucsanda Pinteac, Rucsanda Pinteac
Funding agency: Instituto de Salud Carlos III
Funding: 286770
Reference: PI21/01611
Duration: 01/01/2022 - 30/06/2025

Publications

Optic Nerve Imaging in Multiple Sclerosis and Related Disorders.

PMID: 38942524
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2024
Reference: Neuroimaging Clin N Am. 2024 Aug;34(3):399-420. doi: 10.1016/j.nic.2024.03.005. Epub 2024 May 23.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Rovira, Alex; Sastre-Garriga, Jaume; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.nic.2024.03.005

Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.

PMID: 38958756
Journal: JOURNAL OF NEUROLOGY
Year: 2024
Reference: J Neurol. 2024 Jul 3. doi: 10.1007/s00415-024-12452-8.
Impact factor:
Publication type: Paper in international publication
Authors: Abboud, Hesham; Arnett, Simon; Arrambide, Georgina; Asgari, Nasrin; Banwell, Brenda L; Broadley, Simon A; Chew, Sin Hong; Dujmovic Basuroski, Irena; Fujihara, Kazuo; Hor, Jyh Yung et al.
DOI: 10.1007/s00415-024-12452-8

The global patient-reported outcomes for multiple sclerosis initiative: bridging the gap between clinical research and care - updates at the 2023 plenary event.

PMID: 38974689
Journal: Frontiers in Neurology
Year: 2024
Reference: Front Neurol. 2024 Jun 20;15:1407257. doi: 10.3389/fneur.2024.1407257. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Baneke, Peer; Battaglia, Mario Alberto; Block, Valerie; Brichetto, Giampaolo; Capezzuto, Luca; Carment, Loic; Coetzee, Timothy; Comi, Giancarlo; Cortesi, Paolo Angelo; Cutter, Gary et al.
DOI: 10.3389/fneur.2024.1407257

Value of Optic Nerve MRI in Multiple Sclerosis Clinical Management: A MAGNIMS Position Paper and Future Perspectives.

PMID: 39018513
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Aug 13;103(3):e209677. doi: 10.1212/WNL.0000000000209677. Epub 2024 Jul 17.
Impact factor:
Publication type: Paper in international publication
Authors: Ciccarelli, Olga; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette; Granziera, Cristina; Montalban, Xavier; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1212/WNL.0000000000209677

Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study.

PMID: 37222709
Journal: STROKE
Year: 2023
Reference: Stroke. 2023 May 24. doi: 10.1161/STROKEAHA.123.042674.
Impact factor:
Publication type: Paper in international publication
Authors: Abdalkader, Mohamad; Abdelhamid, Hend; Asdaghi, Negar; Berberich, Anne; Clark, Judith; Cunha, Bruno; Dabus, Guilherme; Desai, Shashvat M; Deuschl, Cornelius; Diana, Francesco et al.
DOI: 10.1161/STROKEAHA.123.042674

Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study.

PMID: 37890617
Journal: Actas dermo-sifiliograficas
Year: 2023
Reference: Actas Dermosifiliogr. 2023 Oct 25:S0001-7310(23)00847-5. doi: 10.1016/j.ad.2023.10.016.
Impact factor:
Publication type: Paper in international publication
Authors: Ara-Martin, M; Arias-Santiago, S; Barone, Paolo; Botella-Estrada, R; Canueto, J; Carrascosa-Carrillo, J M; Carretero-Hernandez, G; Coto-Segura, P; De Bernardo, Maddalena; de Eusebio-Murillo, E et al.
DOI: 10.1016/j.ad.2023.10.016

Family planning considerations in people with multiple sclerosis.

PMID: 36931808
Journal: LANCET NEUROLOGY
Year: 2023
Reference: Lancet Neurol. 2023 Apr;22(4):350-366. doi: 10.1016/S1474-4422(22)00426-4.
Impact factor:
Publication type: Review in international publication
Authors: Abdelnasser, Azza; Alroughani, Raed; Amato, Maria Pia; Bove, Riley; Ciplea, Andrea I; Dobson, Ruth; Fragoso, Yara; Hellwig, Kerstin; Houtchens, Maria; Jokubaitis, Vilija G et al.
DOI: 10.1016/S1474-4422(22)00426-4

Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI.

PMID: 36940621
Journal: NeuroImage-Clinical
Year: 2023
Reference: Neuroimage Clin. 2023;38:103376. doi: 10.1016/j.nicl.2023.103376. Epub 2023 Mar 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Cobo-Calvo, Alvaro; Coll, Llucia; Coll, Llucia; Comabella, Manuel; Galan, Ingrid et al.
DOI: 10.1016/j.nicl.2023.103376

Assessment of 2D conventional and synthetic MRI in multiple sclerosis.

PMID: 35583667
Journal: NEURORADIOLOGY
Year: 2022
Reference: Neuroradiology. 2022 Dec;64(12):2315-2322. doi: 10.1007/s00234-022-02973-2. Epub 2022 May 18.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Julio; Andrino, Ana; Arrambide, Georgina; Auger, Cristina; Aymerich, Francesc Xavier; Barros, Andrea; Clarke, Margareta A; Corral, Juan Francisco; Mora, Juan; Rovira, Alex et al.
DOI: 10.1007/s00234-022-02973-2

Two years of COVID-19 in the MS community: What have we learnt so far?

PMID: 35549532
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jun;28(7):1005-1008. doi: 10.1177/13524585221099844. Epub 2022 May 13.
Impact factor:
Publication type: Editorail in international publication
Authors: Montalban, Xavier; Thompson, Alan J; Zabalza, Ana et al.
DOI: 10.1177/13524585221099844

Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage.

PMID: 35538884
Journal: Clinical and Translational Medicine
Year: 2022
Reference: Clin Transl Med. 2022 May;12(5):e837. doi: 10.1002/ctm2.837.
Impact factor:
Publication type: Letter whit IF
Authors: Alberch, Jordi; Borras, Eva; Brito, Veronica; Calvo-Barreiro, Laura; Comabella, Manuel; Costa-Frossard, Lucienne; Fernandez-Garcia, Sara; Fitzgerald, Denise C; Garcia-Diaz Barriga, Gerardo; Guzman de la Fuente, Alerie et al.
DOI: 10.1002/ctm2.837

Disease modifying therapy switching in relapsing multiple sclerosis: A Delphi consensus of the demyelinating expert group of the Spanish society of neurology.

PMID: 35512501
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jul;63:103805. doi: 10.1016/j.msard.2022.103805. Epub 2022 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Aguera, Eduardo; Ara, Jose Ramon; Bilbao, Mar Mendibe; Blanco, Yolanda; Brieva, Luis; Castillo-Trivino, Tamara; Costa-Frossard, Lucienne; Estruch, Bonaventura Casanova; Garcia, Carmen Arnal; Gines, Maria Luisa Martinez et al.
DOI: 10.1016/j.msard.2022.103805

Immunosenescence in multiple sclerosis: The identification of new therapeutic targets.

PMID: 34237417
Journal: AUTOIMMUNITY REVIEWS
Year: 2021
Reference: Autoimmun Rev. 2021 Sep;20(9):102893. doi: 10.1016/j.autrev.2021.102893. Epub 2021 Jul 5.
Impact factor:
Publication type: Review in international publication
Authors: Dema, Maria; Eixarch, Herena; Espejo, Carmen; Montalban, Xavier; Villar, Luisa M et al.
DOI: 10.1016/j.autrev.2021.102893

Prognostic impact of total metabolic tumor volume in large B-cell lymphoma patients receiving CAR T-cell therapy.

PMID: 34236497
Journal: ANNALS OF HEMATOLOGY
Year: 2021
Reference: Ann Hematol. 2021 Sep;100(9):2303-2310. doi: 10.1007/s00277-021-04560-6. Epub 2021 Jul 8.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Barba, Pere; Bobillo, Sabela; Bosch, Francesc; Carpio, Cecilia; Catala, Eva; Diaz-Lagares, Candido; Iacoboni, Gloria; Jimenez, Moraima; Marin-Niebla, Ana et al.
DOI: 10.1007/s00277-021-04560-6

Targeting inflammasomes to treat neurological diseases.

PMID: 34219266
Journal: ANNALS OF NEUROLOGY
Year: 2021
Reference: Ann Neurol. 2021 Aug;90(2):177-188. doi: 10.1002/ana.26158. Epub 2021 Jul 17.
Impact factor:
Publication type: Review in international publication
Authors: Comabella, Manuel; Lunemann, Jan D; Malhotra, Sunny; Montalban, Xavier; Shinohara, Mari L et al.
DOI: 10.1002/ana.26158

SARS-CoV-2 Infection in Multiple Sclerosis: Results of the Spanish Neurology Society Registry.

PMID: 34168057
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 Jun 24;8(5). pii: 8/5/e1024. doi: 10.1212/NXI.0000000000001024. Print 2021 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez de Arcaya, Amaya; Arnal-Garcia, Carmen; Arrambide, Georgina; Ayuso-Blanco, Teresa; Ayuso-Peralta, Lucia; Balseiro-Gomez, Jose Jesus; Caminero-Rodriguez, Ana Belen; Castellanos-Pinedo, Fernando; Castillo-Trivino, Tamara; Cerdan-Santacruz, Debora Maria et al.
DOI: 10.1212/NXI.0000000000001024

Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.

PMID: 32681355
Journal: Neurotherapeutics
Year: 2020
Reference: Neurotherapeutics. 2020 Oct;17(4):1988-2003. doi: 10.1007/s13311-020-00885-8.
Impact factor:
Publication type: Paper in international publication
Authors: Calvo-Barreiro, Laura; Castillo, Mireia; Costa, Carme; Del Rio, Jose Antonio; Eixarch, Herena; Espejo, Carmen; Gil, Vanessa; Montalban, Xavier; Reverter-Vives, Gemma et al.
DOI: 10.1007/s13311-020-00885-8

Serum neurofilament light as a biomarker in progressive multiple sclerosis.

PMID: 32675076
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Sep 8;95(10):436-444. doi: 10.1212/WNL.0000000000010346. Epub 2020 Jul 16.
Impact factor:
Publication type: Review in international publication
Authors: Allegretta, Mark; Arnold, Douglas L; Carroll, William; Comabella, Manuel; Fox, Robert J; Furlan, Roberto; Harp, Christopher; Kapoor, Raju; Kuhle, Jens; Leppert, David et al.
DOI: 10.1212/WNL.0000000000010346

Sex effects across the lifespan in women with multiple sclerosis.

PMID: 32655689
Journal: Therapeutic Advances in Neurological Disorders
Year: 2020
Reference: Ther Adv Neurol Disord. 2020 Jul 1;13:1756286420936166. doi: 10.1177/1756286420936166. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Altintas, Ayse; Amato, Maria Pia; Bernard, Jacqueline; Bonavita, Simona; Bove, Riley; Cavalla, Paola; Clerico, Marinella; Corona, Teresa; Dobson, Ruth; Doshi, Anisha et al.
DOI: 10.1177/1756286420936166

A randomized, placebo-controlled phase 2 trial of laquinimod in primary progressive multiple sclerosis.

PMID: 32651286
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Aug 25;95(8):e1027-e1040. doi: 10.1212/WNL.0000000000010284. Epub 2020 Jul 10.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Cree, Bruce A C; Giovannoni, Gavin; Hartung, Hans-Peter; Knappertz, Volker; Krieger, Stephen; Li, Thomas; Lublin, Fred; Montalban, Xavier; Sormani, Maria Pia et al.
DOI: 10.1212/WNL.0000000000010284

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.

PMID: 31110181
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 May 20;10(1):2236. doi: 10.1038/s41467-019-09773-y.
Impact factor:
Publication type: Paper in international publication
Authors: Andlauer, Till F M; Baranzini, Sergio E; Barcellos, Lisa F; Beecham, Ashley; Berge, Tone; Bernardinelli, Luisa; Booth, David R; Bos, Steffan D; Briggs, Farren; Caillier, Stacy J et al.
DOI: 10.1038/s41467-019-09773-y

Oligoclonal bands do not represent dissemination in time in the 2017 revisions to the McDonald criteria.

PMID: 31094275
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Oct;25(12):1690-1691. doi: 10.1177/1352458519846103. Epub 2019 May 16.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Montalban, Xavier; Tintore, Mar et al.
DOI: 10.1177/1352458519846103

Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis.

PMID: 31075187
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2019
Reference: N Engl J Med. 2019 Jun 20;380(25):2406-2417. doi: 10.1056/NEJMoa1901981. Epub 2019 May 10.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Dangond, Fernando; Martin, Emily C; Montalban, Xavier; Piasecka-Stryczynska, Karolina; Staikov, Ivan; Syed, Sana; Weber, Martin S; Willmer, Jonathan; Wolinsky, Jerry S et al.
DOI: 10.1056/NEJMoa1901981

CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.

PMID: 31072955
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2019
Reference: J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):1027-1038. doi: 10.1136/jnnp-2018-318957. Epub 2019 May 9.
Impact factor:
Publication type: Paper in international publication
Authors: Ahle, Guido; Allou, Thibaut; Arquizan, Caroline; Audoin, Bertrand; Ayrignac, Xavier; Bejot, Yannick; Camdessanche, Jean-Philippe; Castelnovo, Giovanni; Chamfleur, Nicolas Menjot de; Desbordes, Patrice et al.
DOI: 10.1136/jnnp-2018-318957

Monocyte NOTCH2 expression predicts IFN-beta immunogenicity in multiple sclerosis patients.

PMID: 29875313
Journal: JCI Insight
Year: 2018
Reference: JCI Insight. 2018 Jun 7;3(11). pii: 99274. doi: 10.1172/jci.insight.99274. eCollection 2018 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Adriani, Marsilio; Bocskei, Zsolt; Broet, Philippe; Creeke, Paul; Deisenhammer, Florian; Donnes, Pierre; Fissolo, Nicolas; Fogdell-Hahn, Anna; Hassler, Signe; Hemmer, Bernhard et al.
DOI: 10.1172/jci.insight.99274

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of CHI3L1 and NF-L.

PMID: 29797629
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2018
Reference: Eur J Neurol. 2018 Sep;25(9):1189-1191. doi: 10.1111/ene.13687. Epub 2018 Jun 22.
Impact factor:
Publication type: Paper in international publication
Authors: Buxo, M; Coll, C; Comabella, M; Gich, J; Matute-Blanch, C; Montalban, X; Munoz-San Martin, M; Perkal, H; Quintana, E; Ramio-Torrenta, L L et al.
DOI: 10.1111/ene.13687

Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations.

PMID: 28445084
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 May;24(6):721-727. doi: 10.1177/1352458517707070. Epub 2017 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Huerga, Elena; Mitjana, Raquel; Montalban, Xavier; Otero-Romero, Susana; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1177/1352458517707070

Ocrelizumab: a new milestone in multiple sclerosis therapy.

PMID: 29774057
Journal: Therapeutic Advances in Neurological Disorders
Year: 2018
Reference: Ther Adv Neurol Disord. 2018 May 10;11:1756286418773025. doi: 10.1177/1756286418773025. eCollection 2018.
Impact factor:
Publication type: Review in international publication
Authors: Midaglia, Luciana; Montalban, Xavier; Mulero, Patricia et al.
DOI: 10.1177/1756286418773025

Ocrelizumab in Primary Progressive and Relapsing Multiple Sclerosis.

PMID: 28445663
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2017
Reference: N Engl J Med. 2017 Apr 27;376(17):1694. doi: 10.1056/NEJMc1702076.
Impact factor:
Publication type: Paper in international publication
Authors: Belachew, Shibeshih; Montalban, Xavier; Wolinsky, Jerry S et al.
DOI:

Brain Atrophy in Multiple Sclerosis: Clinical Relevance and Technical Aspects.

PMID: 28391787
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2017
Reference: Neuroimaging Clin N Am. 2017 May;27(2):289-300. doi: 10.1016/j.nic.2017.01.002. Epub 2017 Feb 20.
Impact factor:
Publication type: Review in national publication
Authors: Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume et al.
DOI: 10.1016/j.nic.2017.01.002

MR Imaging in Monitoring and Predicting Treatment Response in Multiple Sclerosis.

PMID: 28391786
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2017
Reference: Neuroimaging Clin N Am. 2017 May;27(2):277-287. doi: 10.1016/j.nic.2017.01.001. Epub 2017 Feb 14.
Impact factor:
Publication type: Review in national publication
Authors: Auger, Cristina; Rio, Jordi; Rovira, Alex et al.
DOI: 10.1016/j.nic.2017.01.001

Multiple Sclerosis: Epidemiologic, Clinical, and Therapeutic Aspects.

PMID: 28391781
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2017
Reference: Neuroimaging Clin N Am. 2017 May;27(2):195-204. doi: 10.1016/j.nic.2016.12.001.
Impact factor:
Publication type: Review in international publication
Authors: Montalban, Xavier; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.nic.2016.12.001

The clinical perspective: How to personalise treatment in MS and how may biomarkers including imaging contribute to this?

PMID: 27465613
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Aug;22(2 Suppl):18-33. doi: 10.1177/1352458516650739.
Impact factor:
Publication type: Paper in international publication
Authors: Berger, Thomas; Chard, Declan; Comabella, Manuel; Gold, Ralf; Lukas, Carsten; Meesen, Bianca; Palace, Jacqueline; Rovira, Alex; Trojano, Maria; Vermersch, Patrick et al.
DOI: 10.1177/1352458516650739

Multiple sclerosis: Dimethyl fumarate is coming of age.

PMID: 27448183
Journal: Nature Reviews Neurology
Year: 2016
Reference: Nat Rev Neurol. 2016 Aug;12(8):436-7. doi: 10.1038/nrneurol.2016.106. Epub 2016 Jul 22.
Impact factor:
Publication type: Review in international publication
Authors: Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1038/nrneurol.2016.106

Safety and efficacy of daclizumab in relapsing-remitting multiple sclerosis: 3-year results from the SELECTED open-label extension study.

PMID: 27461166
Journal: BMC Neurology
Year: 2016
Reference: BMC Neurol. 2016 Jul 26;16:117. doi: 10.1186/s12883-016-0635-y.
Impact factor:
Publication type: Paper in international publication
Authors: Cohan, Stanley; Elkins, Jacob; Giovannoni, Gavin; Gold, Ralf; Greenberg, Steven J; Havrdova, Eva; Montalban, Xavier; Ozen, Gulden; Radue, Ernst-Wilhelm; Selmaj, Krzysztof et al.
DOI: 10.1186/s12883-016-0635-y

Safety and Efficacy of Siponimod (BAF312) in Patients With Relapsing-Remitting Multiple Sclerosis: Dose-Blinded, Randomized Extension of the Phase 2 BOLD Study.

PMID: 27380540
Journal: JAMA Neurology
Year: 2016
Reference: JAMA Neurol. 2016 Sep 1;73(9):1089-98. doi: 10.1001/jamaneurol.2016.1451.
Impact factor:
Publication type: Paper in international publication
Authors: Arnould, Sophie; Freedman, Mark S; Hartung, Hans-Peter; Hemmer, Bernhard; Hunter, Brian; Kappos, Ludwig; Li, David K B; Montalban, Xavier; Rieckmann, Peter; Selmaj, Krzysztof et al.
DOI: 10.1001/jamaneurol.2016.1451

Should we systematically test patients with clinically isolated syndrome for auto-antibodies?

PMID: 25778697
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Dec;21(14):1802-10. doi: 10.1177/1352458515575338. Epub 2015 Mar 16.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Comabella, Manuel; Galan, Ingrid; Mitjana, Raquel; Montalban, Xavier; Negrotto, Laura; Nos, Carlos; Palavra, Filipe et al.
DOI: 10.1177/1352458515575338

ATON: results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis.

PMID: 25758472
Journal: J NEUROL SCI
Year: 2015
Reference: J Neurol Sci. 2015 Apr 15;351(1-2):174-8. doi: 10.1016/j.jns.2015.02.019. Epub 2015 Feb 17.
Impact factor:
Publication type: Clinical Trials
Authors: Arbizu, Txomin; Bennett, Jeffrey; Bennett, Jeffrey; Bennett, Jeffrey L; Coret, Francisco; Freedman, Mark; Freudensprung, Ulrich; Hemmer, Bernhard; Izquierdo, Guillermo; Jefferson, Thomas et al.
DOI: 10.1016/j.jns.2015.02.019

MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis.

PMID: 25748099
Journal: LANCET NEUROL
Year: 2015
Reference: Lancet Neurol. 2015 Apr;14(4):443-54. doi: 10.1016/S1474-4422(14)70294-7. Epub 2015 Mar 4.
Impact factor:
Publication type: Review in international publication
Authors: Agosta, Federica; Barkhof, F; Barkhof, Frederik; Bischof, Antje; Brooks, Jonathan C W; Chard, Declan; Ciccarelli, O; Ciccarelli, Olga; de Stefano, N; Eisele, Philipp et al.
DOI: 10.1016/S1474-4422(14)70294-7

A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: a cognitive rehabilitation programme for patients with multiple sclerosis.

PMID: 25716880
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Sep;21(10):1332-43. doi: 10.1177/1352458515572405. Epub 2015 Feb 25.
Impact factor:
Publication type: Paper in international publication
Authors: Freixanet, Jordi; Garcia, Rafael; Genis, David; Gich, Jordi; Montalban, Xavier; Ramio-Torrenta, Lluis; Silva, Yolanda; Vilanova, Joan Carles et al.
DOI: 10.1177/1352458515572405

Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.

PMID: 25129256
Journal: AMERICAN JOURNAL OF PATHOLOGY
Year: 2014
Reference: Am J Pathol. 2014 Sep;184(9):2420-9. doi: 10.1016/j.ajpath.2014.05.021. Epub 2014 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Cepok-Kauffeld, Sabine; Comabella, Manuel; Hemmer, Bernhard; Holmdahl, Rikard; Ibrahim, Saleh M; Lemcke, Susanne; Moller, Steffen; Montalban, Xavier; Muller, Susen; Nandakumar, Kutty Selva et al.
DOI: 10.1016/j.ajpath.2014.05.021

Molecular mechanism underlying the impact of vitamin D on disease activity of MS.

PMID: 25285313
Journal: Annals of clinical and translational neurology
Year: 2014
Reference: Ann Clin Transl Neurol. 2014 Aug;1(8):605-17. doi: 10.1002/acn3.91. Epub 2014 Aug 22.
Impact factor:
Publication type: Letter or abstract
Authors: Ascherio, Alberto; Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Hartung, Hans P; Kappos, Ludwig; Kochert, Karl; Miller, David H; Montalban, Xavier; Munger, Kassandra L et al.
DOI: 10.1002/acn3.91

N-Acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis.

PMID: 25228004
Journal: JOURNAL OF NEUROLOGY
Year: 2014
Reference: J Neurol. 2014 Dec;261(12):2338-43. doi: 10.1007/s00415-014-7507-4. Epub 2014 Sep 17.
Impact factor:
Publication type: Paper in international publication
Authors: Bellini, Tiziana; Blankenstein, Marinus A; Comabella, Manuel; Killestein, Joep; Koel-Simmelink, Marleen J A; Korth, Carsten; Montalban, Xavier; Ottis, Philipp; Roos, Birthe; Rovira, Alex et al.
DOI: 10.1007/s00415-014-7507-4

Diagnosis and trials of clinically isolated syndrome.

PMID: 25192850
Journal: LANCET NEUROLOGY
Year: 2014
Reference: Lancet Neurol. 2014 Oct;13(10):962-3. doi: 10.1016/S1474-4422(14)70202-9. Epub 2014 Sep 2.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Sastre-Garriga, Jaume et al.
DOI: 10.1016/S1474-4422(14)70202-9

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).

PMID: 24008938
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Sep 16;57(6):269-281.
Impact factor:
Publication type: Paper in national publication
Authors: Arnal-Garcia, C; Arroyo-Gonzalez, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; de Las Heras, V; Fernandez, O; Garcia-Merino, J A; Grupo Post-Ectrims, Grupo Post-Ectrims et al.
DOI:

Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial.

PMID: 23562009
Journal: LANCET
Year: 2013
Reference: Lancet. 2013 Jun 22;381(9884):2167-75. doi: 10.1016/S0140-6736(12)62190-4. Epub 2013 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, R; Ambler, Z; Angstwurm, K; Bajenaru, O; Bates, D; Belova, A; Bereczki, D; Boiko, A; Buchakchyys'ka, N; Chan, A et al.
DOI: 10.1016/S0140-6736(12)62190-4

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).

PMID: 23975528
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Sep 1;57(5):217-229.
Impact factor:
Publication type: Review in national publication
Authors: Arnal-Garcia, C; Arroyo-Gonzalez, R; Brieva, Ll; Calles-Hernandez, M C; Casanova-Estruch, B; Comabella, M; de Las Heras, V; Fernandez, O; Garcia-Merino, J A; Grupo Post-Ectrims, Grupo Post-Ectrims et al.
DOI:

Serum biomarker gMS-Classifier2: predicting conversion to clinically definite multiple sclerosis.

PMID: 23555846
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013;8(3):e59953. doi: 10.1371/journal.pone.0059953. Epub 2013 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Dotan, Nir; Dukler, Avinoam; Espejo, Carmen; Fire, Ella; Montalban, Xavier; Rovira, Alex; Spector, Larissa; Tintore, Mar; Yarden, Jennifer et al.
DOI: 10.1371/journal.pone.0059953

Value of NMO-IgG determination at the time of presentation as CIS.

PMID: 22551725
Journal: NEUROLOGY
Year: 2012
Reference: Neurology. 2012 May 15;78(20):1608-11. doi: 10.1212/WNL.0b013e3182563b32. Epub 2012 May 2.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1212/WNL.0b013e3182563b32

[Optical coherence tomography in multiple sclerosis].

PMID: 22532220
Journal: REVISTA DE NEUROLOGIA
Year: 2012
Reference: Rev Neurol. 2012 May 1;54(9):556-63.
Impact factor:
Publication type: Letter or abstract
Authors: Montalban, X; Sastre-Garriga, J; Vidal-Jordana, A et al.
DOI:

Effects of interferon beta-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis.

PMID: 22492127
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Oct;18(10):1466-71. Epub 2012 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458512442438

Therapeutic strategies in multiple sclerosis.

PMID: 22155340
Journal: CLINICAL IMMUNOLOGY
Year: 2012
Reference: Clin Immunol. 2012 Jan;142(1):1. doi: 10.1016/j.clim.2011.11.008. Epub 2011 Dec 2.
Impact factor:
Publication type: Editorail in international publication
Authors: ; et al.
DOI: 10.1016/j.clim.2011.11.008

[Hemichorea-hemiballism secondary to infarction in the primary motor area: an atypical form of presentation of Moya moya syndrome.]

PMID: 21484730
Journal: REVUE NEUROLOGIQUE
Year: 2011
Reference: Rev Neurol. 2011 May 1;52(9):575-576.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI:

Multiple sclerosis: current treatment algorithms.

PMID: 21499098
Journal: CURRENT OPINION IN NEUROLOGY
Year: 2011
Reference: Curr Opin Neurol. 2011 Jun;24(3):230-7.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Montalban, Xavier; Rio, Jordi et al.
DOI: 10.1097/WCO.0b013e328346bf66

Tumor necrosis factor alpha (TNF-alpha), anti-TNF-alpha and demyelination revisited: An ongoing story.

PMID: 21474190
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2011
Reference: J Neuroimmunol. 2011 May;234(1-2):1-6. Epub 2011 Apr 7.
Impact factor:
Publication type: Review in international publication
Authors: ; ; et al.
DOI: 10.1016/j.jneuroim.2011.03.004

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.

PMID: 20944657
Journal: GENES AND IMMUNITY
Year: 2011
Reference: Genes Immun. 2011 Mar;12(2):110-5. Epub 2010 Oct 14.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/gene.2010.52

B cell expression of the inhibitory Fcgamma receptor is unchanged in early MS.

PMID: 20399509
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2010
Reference: J Neuroimmunol. 2010 Jun;223(1-2):135-7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.jneuroim.2010.03.015

Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis.

PMID: 20225269
Journal: ANNALS OF NEUROLOGY
Year: 2010
Reference: Ann Neurol. 2010 Feb;67(2):159-69.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/ana.21886

Fingolimod for relapsing multiple sclerosis: an update.

PMID: 20367536
Journal: EXPERT OPINION ON PHARMACOTHERAPY
Year: 2010
Reference: Expert Opin Pharmacother. 2010 May;11(7):1183-96.
Impact factor:
Publication type: Review in national publication
Authors: ; ; et al.
DOI: 10.1517/14656561003769866

Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis.

PMID: 20363033
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2010
Reference: J Neuroimmunol. 2010 May;222(1-2):70-5. Epub 2010 Apr 2.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jneuroim.2010.03.003

A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis.

PMID: 19433658
Journal: ARCHIVES OF NEUROLOGY
Year: 2009
Reference: Arch Neurol. 2009 May;66(5):587-92.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Fredrick; Filippi, Massimo; Frederiksen, Jette L; Huerga, Elena; Langkilde, Annika; Miller, David; Miszkiel, Katherine; Montalban, Xavier; Polman, Chris; Rovaris, Marco et al.
DOI: 10.1001/archneurol.2009.49

The search for responsive clinical endpoints in primary progressive multiple sclerosis.

PMID: 19383646
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Jun;15(6):715-20.
Impact factor:
Publication type: Paper in international publication
Authors: Bosma, L V A E; Brieva, L; Khaleeli, Z; Kragt, J J; Montalban, X; Polman, C H; Thompson, A J; Tintore, M; Uitdehaag, B M J et al.
DOI: 10.1177/1352458509102626

Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis.

PMID: 19515430
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2009
Reference: J Neuroimmunol. 2009 Aug 18;213(1-2):142-7.
Impact factor:
Publication type: Paper in international publication
Authors: Camina-Tato, M; Comabella, M; Fernandez, M; Horga, A; Montalban, X; Morcillo-Suarez, C; Navarro, A et al.
DOI: 10.1016/j.jneuroim.2009.05.010

Brain volumetry counterparts of cognitive impairment in patients with multiple sclerosis.

PMID: 19157420
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2009
Reference: J Neurol Sci. 2009 Jul 15;282(1-2):120-4.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, J; Arevalo, M J; Galan, I; Gonzalez, I; Montalban, X; Renom, M; Rovira, A; Sastre-Garriga, J et al.
DOI: 10.1016/j.jns.2008.12.019

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information