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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Alvaro Cobo Calvo

Alvaro Cobo Calvo

Main researcher
Clinical Neuroimmunology
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Ana Zabalza de Torres

Ana Zabalza de Torres

Postdoctoral researcher
Clinical Neuroimmunology
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Andrea Serrano Mascarós

Andrea Serrano Mascarós

Administration and Management
Clinical Neuroimmunology
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Angela Vidal Jordana

Angela Vidal Jordana

Main researcher
Clinical Neuroimmunology
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Breogan Rodriguez Acevedo

Breogan Rodriguez Acevedo

Senior researcher
Clinical Neuroimmunology
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Carlos Nos  Llopis

Carlos Nos Llopis

Research technician
Clinical Neuroimmunology
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Alvaro Cobo Calvo

Alvaro Cobo Calvo

Main researcher
Clinical Neuroimmunology
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Ana Zabalza de Torres

Ana Zabalza de Torres

Postdoctoral researcher
Clinical Neuroimmunology
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Andrea Serrano Mascarós

Andrea Serrano Mascarós

Administration and Management
Clinical Neuroimmunology
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Angela Vidal Jordana

Angela Vidal Jordana

Main researcher
Clinical Neuroimmunology
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Breogan Rodriguez Acevedo

Breogan Rodriguez Acevedo

Senior researcher
Clinical Neuroimmunology
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Carlos Nos  Llopis

Carlos Nos Llopis

Research technician
Clinical Neuroimmunology
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Publications

Generalizing the Results of Clinical Trials if Participants Are Not From Diverse Racial and Ethnic Groups.

PMID: 39018517
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Aug 13;103(3):e209730. doi: 10.1212/WNL.0000000000209730. Epub 2024 Jul 17.
Impact factor:
Publication type: Paper in international publication
Authors: Carvajal, Rene; Otero-Romero, Susana; Tintore, Mar; Tur, Carmen et al.
DOI: 10.1212/WNL.0000000000209730

The evolving contribution of MRI measures towards the prediction of secondary progressive multiple sclerosis.

PMID: 39038948
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2024
Reference: J Neurol Neurosurg Psychiatry. 2024 Jul 22:jnnp-2024-333917. doi: 10.1136/jnnp-2024-333917.
Impact factor:
Publication type: Paper in international publication
Authors: Ananthavarathan, Piriyankan; Barkhof, Frederik; Chard, Declan T; Chung, Karen; Ciccarelli, Olga; Haider, Lukas; Prados, Ferran; Sahi, Nitin; Trip, S Anand; Tur, Carmen et al.
DOI: 10.1136/jnnp-2024-333917

The ageing central nervous system in multiple sclerosis: the imaging perspective.

PMID: 39045667
Journal: BRAIN
Year: 2024
Reference: Brain. 2024 Jul 24:awae251. doi: 10.1093/brain/awae251.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Ciccarelli, Olga; Cossarizza, Andrea; De Stefano, Nicola; Filippi, Massimo; Gasperini, Claudio; Geraldes, Ruth; Granziera, Cristina; Haider, Lukas; Lassmann, Hans et al.
DOI: 10.1093/brain/awae251

Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network.

PMID: 39099240
Journal: Annals of Clinical and Translational Neurology
Year: 2024
Reference: Ann Clin Transl Neurol. 2024 Aug 4. doi: 10.1002/acn3.52166.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Ricardo; Asseyer, Susanna; Bereuter, Charlotte; Bialer, Omer; Bick, Atira; Carta, Sara; Chen, John J; Cohen, Leila; Cohen-Tayar, Yamit; Contentti, Edgar Carnero et al.
DOI: 10.1002/acn3.52166

Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure.

PMID: 36973075
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2023
Reference: Neurol Neuroimmunol Neuroinflamm. 2023 Mar 27;10(3):e200100. doi: 10.1212/NXI.0000000000200100. Print 2023 May.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Hurtado-Navarro, Laura; Malhotra, Sunny; Montalban, Xavier; Pappolla, Agustin; Pelegrin, Pablo; Rio, Jordi; Villar, Luisa M M et al.
DOI: 10.1212/NXI.0000000000200100

Long-term follow-up of patients with relapsing multiple sclerosis from the CLARITY/CLARITY Extension cohort of CLASSIC-MS: An ambispective study.

PMID: 37012898
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 May;29(6):719-730. doi: 10.1177/13524585231161494. Epub 2023 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Aydemir, Aida; Borsi, Laszlo; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S; Giovannoni, Gavin; Leist, Thomas; Montalban, Xavier; Rammohan, Kottil et al.
DOI: 10.1177/13524585231161494

Longitudinal stability of inter-eye differences in optical coherence tomography measures for identifying unilateral optic nerve lesions in multiple sclerosis.

PMID: 37167654
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2023
Reference: J Neurol Sci. 2023 May 3;449:120669. doi: 10.1016/j.jns.2023.120669.
Impact factor:
Publication type: Paper in international publication
Authors: Balcer, Laura J; Galetta, Steven L; Joseph, Binu; Kenney, Rachel C; Montalban, Xavier; Patil, Sachi A; Sastre-Garriga, Jaume; Tagliani, Paula; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jns.2023.120669

Neurophysiological monitoring during endovascular treatment of brain arteriovenous malformations: A meta-analysis.

PMID: 37170611
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2023
Reference: Interv Neuroradiol. 2023 May 11:15910199231175195. doi: 10.1177/15910199231175195.
Impact factor:
Publication type: Review in international publication
Authors: Abdalkader, Mohamad; Caroff, Jildaz; Cuevas, Jose Luis; Da Ros, Valerio; Diana, Francesco; Diana, Francesco; Forestier, Geraud; Hernandez, David; Hernandez, David; Lascuevas, Marta De Dios et al.
DOI: 10.1177/15910199231175195

Correction to: COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab.

PMID: 35503396
Journal: Neurology and Therapy
Year: 2022
Reference: Neurol Ther. 2022 Jun;11(2):759-762. doi: 10.1007/s40120-022-00346-8.
Impact factor:
Publication type: Letter or abstract
Authors: Cree, Bruce A C; Cross, Anne H; Davydovskaya, Maria; Delgado, Silvia; Gupta, Ayan Das; Habek, Mario; Hu, Xixi; Mancione, Linda; Montalban, Xavier; Pingili, Ratnakar et al.
DOI: 10.1007/s40120-022-00346-8

Serum neurofilament light chain levels predict long-term disability progression in patients with progressive multiple sclerosis.

PMID: 35487685
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2022
Reference: J Neurol Neurosurg Psychiatry. 2022 Apr 29:jnnp-2022-329020. doi: 10.1136/jnnp-2022-329020.
Impact factor:
Publication type: Paper in international publication
Authors: Aymerich, Francesc X; Carbonell-Mirabent, Pere; Comabella, Manuel; Fissolo, Nicolas; Malhotra, Sunny; Montalban, Xavier; Pareto, Deborah; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume et al.
DOI: 10.1136/jnnp-2022-329020

Association of No Evidence of Disease Activity With No Long-term Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-analysis.

PMID: 35473761
Journal: NEUROLOGY
Year: 2022
Reference: Neurology. 2022 Apr 26:10.1212/WNL.0000000000200549. doi: 10.1212/WNL.0000000000200549.
Impact factor:
Publication type: Review in international publication
Authors: Dababneh, Dina; Montalban, Xavier; Muccilli, Alexandra; Rotstein, Dalia; Shah, Prakesh; Solomon, Jacqueline Madeleine; Sormani, Maria Pia; Ye, Xiang Y et al.
DOI: 10.1212/WNL.0000000000200549

Multiple Sclerosis: Immunopathological heterogeneity and its implications.

PMID: 35476319
Journal: EUROPEAN JOURNAL OF IMMUNOLOGY
Year: 2022
Reference: Eur J Immunol. 2022 Jun;52(6):869-881. doi: 10.1002/eji.202149757. Epub 2022 May 6.
Impact factor:
Publication type: Review in international publication
Authors: Chan, Andrew; Comabella, Manuel; Engelhardt, Britta et al.
DOI: 10.1002/eji.202149757

The potential of serum neurofilament as biomarker for multiple sclerosis.

PMID: 34180982
Journal: BRAIN
Year: 2021
Reference: Brain. 2021 Nov 29;144(10):2954-2963. doi: 10.1093/brain/awab241.
Impact factor:
Publication type: Paper in international publication
Authors: Bittner, Stefan; Havrdova, Eva Kubala; Oh, Jiwon; Tintore, Mar; Zipp, Frauke et al.
DOI: 10.1093/brain/awab241

Adding brain volume measures into response criteria in multiple sclerosis: the Rio-4 score.

PMID: 33237430
Journal: NEURORADIOLOGY
Year: 2021
Reference: Neuroradiology. 2021 Jul;63(7):1031-1041. doi: 10.1007/s00234-020-02604-8. Epub 2020 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Montalban, Xavier; Pareto, Deborah; Perez-Miralles, Francisco Carlos; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1007/s00234-020-02604-8

2021 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis.

PMID: 34139157
Journal: LANCET NEUROLOGY
Year: 2021
Reference: Lancet Neurol. 2021 Aug;20(8):653-670. doi: 10.1016/S1474-4422(21)00095-8. Epub 2021 Jun 14.
Impact factor:
Publication type: Review in international publication
Authors: Banwell, Brenda; Banwell, Brenda; Barkhof, Frederik; Barkhof, Frederik; Ciccarelli, Olga; Ciccarelli, Olga; de Stefano, Nicola; de Stefano, Nicola; Enzinger, Christian; Enzinger, Christian et al.
DOI: 10.1016/S1474-4422(21)00095-8

13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (II).

PMID: 34109999
Journal: REVISTA DE NEUROLOGIA
Year: 2021
Reference: Rev Neurol. 2021 Jun 16;72(12):433-442. doi: 10.33588/rn.7212.2021173.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Alonso, A; Arroyo, R; Calles, C; Castillo-Trivino, T; Comabella, M; Costa-Frossard, L; Fernandez, O; Forero, L; Ginestal, R et al.
DOI: 10.33588/rn.7212.2021173

MOG-antibody-associated disease-getting the whole picture.

PMID: 31621491
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Jul;26(8):1000-1001. doi: 10.1177/1352458519882594. Epub 2019 Oct 17.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina et al.
DOI: 10.1177/1352458519882594

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

PMID: 31066634
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Jul;26(8):912-923. doi: 10.1177/1352458519845844. Epub 2019 May 8.
Impact factor:
Publication type: Paper in international publication
Authors: Altintas, A; Alvarez-Cermeno, J C; Alvarez-Lafuente, R; Bellini, T; Bridel, C; Castellazzi, M; Comabella, M; Deisenhammer, F; Drulovic, J; Dujmovic, I et al.
DOI: 10.1177/1352458519845844

Expert opinion on the use of cladribine tablets in clinical practice.

PMID: 32636933
Journal: Therapeutic Advances in Neurological Disorders
Year: 2020
Reference: Ther Adv Neurol Disord. 2020 Jun 24;13:1756286420935019. doi: 10.1177/1756286420935019. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Centonze, Diego; Giovannoni, Gavin; Montalban, Xavier; Rieckmann, Peter; Salloukh, Hashem; Selchen, Daniel; Sorensen, Per Soelberg; Vermersch, Patrick; Wiendl, Heinz; Yamout, Bassem et al.
DOI: 10.1177/1756286420935019

Real-World Goal Setting and Use of Outcome Measures According to the International Classification of Functioning, Disability and Health: A European Survey of Physical Therapy Practice in Multiple Sclerosis.

PMID: 32630765
Journal: International Journal of Environmental Research and Public Health
Year: 2020
Reference: Int J Environ Res Public Health. 2020 Jul 2;17(13). pii: ijerph17134774. doi: 10.3390/ijerph17134774.
Impact factor:
Publication type: Paper in international publication
Authors: Cattaneo, Davide; Feys, Peter; Freeman, Jenny; Henze, Thomas; Jonsdottir, Johanna; Martinkova, Patricia; Rasova, Kamila; Romberg, Anders; Santoyo-Medina, Carme; Smedal, Tori et al.
DOI: 10.3390/ijerph17134774

[Review of the novelties presented at the 2018 ECTRIMS Congress: 11th Post-ECTRIMS Meeting (I)].

PMID: 31070235
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 May 16;68(10):431-441. doi: 10.33588/rn.6810.2019120.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Arnal-Garcia, C; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Carrascal, P; Comabella, M; Costa-Frossard, L; Fernandez, O; Garcia-Merino, J A et al.
DOI: 10.33588/rn.6810.2019120

Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study.

PMID: 30447419
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2019
Reference: J Neuroimmunol. 2019 Jan 15;326:19-27. doi: 10.1016/j.jneuroim.2018.11.002. Epub 2018 Nov 7.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Auer, Michael; Bachelet, Delphine; Bertotti, Elisa; Broet, Philippe; Buck, Dorothea; Comabella, Manuel; Deisenhammer, Florian; Derfuss, Tobias; Donnellan, Naoimh et al.
DOI: 10.1016/j.jneuroim.2018.11.002

Multiple sclerosis registries in Europe - An updated mapping survey.

PMID: 30384204
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Jan;27:171-178. doi: 10.1016/j.msard.2018.09.032. Epub 2018 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Battaglia, M A; Brichetto, G; Brola, W; Butzkueven, H; Casey, R; de Giacomoni, A C; Drulovic, J; Eichstadt, K; Flachenecker, P; Glaser, A et al.
DOI: 10.1016/j.msard.2018.09.032

Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.

PMID: 30587516
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Jan 22;92(4):180-192. doi: 10.1212/WNL.0000000000006810. Epub 2018 Dec 26.
Impact factor:
Publication type: Review in international publication
Authors: Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette L; Gasperini, Claudio; Kappos, Ludwig; Montalban, Xavier; Palace, Jacqueline et al.
DOI: 10.1212/WNL.0000000000006810

Progression of regional grey matter atrophy in multiple sclerosis.

PMID: 29741648
Journal: BRAIN
Year: 2018
Reference: Brain. 2018 Jun 1;141(6):1665-1677. doi: 10.1093/brain/awy088.
Impact factor:
Publication type: Paper in international publication
Authors: Alexander, Daniel C; Barkhof, Frederik; Battaglini, Marco; Brownlee, Wallace J; Cawley, Niamh; Chard, Declan; Ciccarelli, Olga; De Angelis, Floriana; De Stefano, Nicola; Enzinger, Christian et al.
DOI: 10.1093/brain/awy088

Measurement of Whole-Brain and Gray Matter Atrophy in Multiple Sclerosis: Assessment with MR Imaging.

PMID: 29714673
Journal: RADIOLOGY
Year: 2018
Reference: Radiology. 2018 Aug;288(2):554-564. doi: 10.1148/radiol.2018172468. Epub 2018 May 1.
Impact factor:
Publication type: Paper in international publication
Authors: De Stefano, Nicola; Filippi, Massimo; Horsfield, Mark A; Pagani, Elisabetta; Palace, Jacqueline; Rocca, Maria A; Rovira, Alex; Sastre-Garriga, Jaume; Sima, Diana; Smeets, Dirk et al.
DOI: 10.1148/radiol.2018172468

Disease-modifying therapy in multiple sclerosis: Two guidelines (almost) passing in the night.

PMID: 29692224
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Apr;24(5):558-562. doi: 10.1177/1352458518767323.
Impact factor:
Publication type: Review in international publication
Authors: Marrie, Ruth Ann; Montalban, Xavier et al.
DOI: 10.1177/1352458518767323

Clinical commentary on "Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica".

PMID: 29671675
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Oct;24(11):1516-1517. doi: 10.1177/1352458518771259. Epub 2018 Apr 19.
Impact factor:
Publication type: Editorail in international publication
Authors: Rio, Jordi; Rodriguez-Acevedo, Breogan et al.
DOI: 10.1177/1352458518771259

Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status.

PMID: 28380047
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Apr 5;12(4):e0174588. doi: 10.1371/journal.pone.0174588. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Blasco-Lucas, Arnau; Casos, Kelly; Castro, Miguel A; Ferrer-Curriu, Gemma; Galinanes, Manuel; Gracia-Baena, Juan Manuel; Perez, Maria L; Permanyer, Eduard; Soler-Ferrer, Paula et al.
DOI: 10.1371/journal.pone.0174588

Commentary on "Successful pregnancy after natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis".

PMID: 28260414
Journal: Multiple Sclerosis Journal
Year: 2017
Reference: Mult Scler. 2017 Mar;23(3):486-487. doi: 10.1177/1352458516675752. Epub 2016 Nov 12.
Impact factor:
Publication type: Review in international publication
Authors: Arrambide, Georgina et al.
DOI: 10.1177/1352458516675752

Laquinimod Safety Profile: Pooled Analyses from the ALLEGRO and BRAVO Trials.

PMID: 28243182
Journal: International journal of MS care
Year: 2017
Reference: Int J MS Care. 2017 Jan-Feb;19(1):16-24. doi: 10.7224/1537-2073.2015-024.
Impact factor:
Publication type: Paper in international publication
Authors: Comi, Giancarlo; Dadon, Yuval; Gorfine, Tali; Kappos, Ludwig; Knappertz, Volker; Margalit, Maya; Montalban, Xavier; Rubinchick, Svetlana; Sasson, Nissim; Sorensen, Per Soelberg et al.
DOI: 10.7224/1537-2073.2015-024

[New areas, new challenges...]

PMID: 28229438
Journal: REVISTA DE NEUROLOGIA
Year: 2017
Reference: Rev Neurol. 2017 Mar 1;64(5):193.
Impact factor:
Publication type: Editorail in international publication
Authors: Sastre-Garriga, J et al.
DOI: 10.33588/rn.6405.2017081

Assessing response to interferon-beta in a multicenter dataset of patients with MS.

PMID: 27306626
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Jul 12;87(2):134-40. doi: 10.1212/WNL.0000000000002830. Epub 2016 Jun 15.
Impact factor:
Publication type: Paper in international publication
Authors: Calabrese, Massimiliano; Cocco, Eleonora; Comi, Giancarlo; De Stefano, Nicola; Enzingher, Christian; Fazekas, Franz; Filippi, Massimo; Gallo, Antonio; Gasperini, Claudio; Kappos, Ludwig et al.
DOI: 10.1212/WNL.0000000000002830

Improved Automatic Detection of New T2 Lesions in Multiple Sclerosis Using Deformation Fields.

PMID: 27282863
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2016
Reference: AJNR Am J Neuroradiol. 2016 Oct;37(10):1816-1823. doi: 10.3174/ajnr.A4829. Epub 2016 Jun 9.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Cabezas, M; Corral, J F; Diez, Y; Llado, M; Montalban, X; Oliver, A; Pareto, D; Rovira, A; Tintore, M et al.
DOI: 10.3174/ajnr.A4829

Review of the novelties from the 31st ECTRIMS Congress, 2015, presented at the 8th Post-ECTRIMS meeting.

PMID: 27270678
Journal: REVUE NEUROLOGIQUE
Year: 2016
Reference: Rev Neurol. 2016 Jun 16;62(12):559-569.
Impact factor:
Publication type: Review in national publication
Authors: Arnal-Garcia, C; Arroyo, R; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Comabella, M; Fernandez, O; Garcia-Merino, J A; Ginestal, R; Izquierdo, G et al.
DOI:

Short-term suboptimal response criteria for predicting long-term non-response to first-line disease modifying therapies in multiple sclerosis: A systematic review and meta-analysis.

PMID: 26810535
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2016
Reference: J Neurol Sci. 2016 Feb 15;361:158-67. doi: 10.1016/j.jns.2015.12.043. Epub 2015 Dec 29.
Impact factor:
Publication type: Review in national publication
Authors: Rio, Jordi; Ruiz-Pena, Juan Luis et al.
DOI: 10.1016/j.jns.2015.12.043

Treating relapsing-remitting multiple sclerosis: therapy effects on brain atrophy.

PMID: 26041617
Journal: J NEUROL
Year: 2015
Reference: J Neurol. 2015 Dec;262(12):2617-26. doi: 10.1007/s00415-015-7798-0. Epub 2015 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Rovira, Alex; Sastre-Garriga, Jaume; Vidal-Jordana, Angela et al.
DOI: 10.1007/s00415-015-7798-0

Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in RRMS.

PMID: 26024899
Journal: NEUROLOGY
Year: 2015
Reference: Neurology. 2015 Jul 7;85(1):29-39. doi: 10.1212/WNL.0000000000001706. Epub 2015 May 29.
Impact factor:
Publication type: Clinical Trials
Authors: Butzkueven, Helmut; Comi, Giancarlo; Dahlke, Frank; Derfuss, Tobias; Giovannoni, Gavin; Gottschalk, Rebecca; Griffiths, Sarah; Hartung, Hans-Peter; Kappos, Ludwig; Montalban, Xavier et al.
DOI: 10.1212/WNL.0000000000001706

Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion.

PMID: 26014610
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Jul;21(8):1084-6. doi: 10.1177/1352458515586090. Epub 2015 May 26.
Impact factor:
Publication type: Paper in international publication
Authors: Ciampi, Ethel; Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1177/1352458515586090

Cognitive reserve in multiple sclerosis: Protective effects of education.

PMID: 25948624
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Sep;21(10):1312-21. doi: 10.1177/1352458515581874. Epub 2015 May 6.
Impact factor:
Publication type: Paper in international publication
Authors: Bettencourt, Andreia; Cavaco, Sara; Coutinho, Ester; Da Silva, Berta Martins; Dias, Claudia C; Goncalves, Alexandra; Martins Da Silva, Ana; Montalban, Xavier; Moreira, Ines; Pinto, Claudia et al.
DOI: 10.1177/1352458515581874

Spinal cord MRI should always be performed in clinically isolated syndrome patients: No.

PMID: 25395547
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Nov;20(13):1686-7. doi: 10.1177/1352458514543812.
Impact factor:
Publication type: Paper in international publication
Authors: Rovira, Alex; Tintore, Mar et al.
DOI: 10.1177/1352458514543812

Anti-myelin antibodies play an important role in the susceptibility to develop proteolipid protein-induced experimental autoimmune encephalomyelitis.

PMID: 24188195
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2014
Reference: Clin Exp Immunol. 2014 Feb;175(2):202-7. doi: 10.1111/cei.12233.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, J C; Eixarch, H; Espejo, C; Guaza, C; Mansilla, M J; Marin, N; Mecha, M; Montalban, X; Rodriguez-Martin, E; Villar, L M et al.
DOI: 10.1111/cei.12233

Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.

PMID: 25153885
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Aug 25;9(8):e105737. doi: 10.1371/journal.pone.0105737. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Aigrot, Marie-Stephane; Castillo, Mireia; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Lubetzki, Catherine; Mansilla, M Jose; Martin, Roland; Montalban, Xavier; Tepavcevic, Vanja et al.
DOI: 10.1371/journal.pone.0105737

Regulatory lymphocytes are key factors in MHC-independent resistance to EAE.

PMID: 24868560
Journal: JOURNAL OF IMMUNOTHERAPY
Year: 2014
Reference: J Immunol Res. 2014;2014:156380. doi: 10.1155/2014/156380. Epub 2014 Apr 27.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez-Cermeno, Jose C; Eixarch, Herena; Espejo, Carmen; Guaza, Carmen; Marin, Nieves; Mecha, Miriam; Mestre, Leyre; Montalban, Xavier; Villar, Luisa M et al.
DOI: 10.1155/2014/156380

Circulating levels of soluble apoptosis-related molecules in patients with multiple sclerosis.

PMID: 23932896
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2013
Reference: J Neuroimmunol. 2013 Oct 15;263(1-2):152-4. doi: 10.1016/j.jneuroim.2013.07.013. Epub 2013 Jul 26.
Impact factor:
Publication type: Paper in international publication
Authors: Canto, Ester; Castillo, Joaquin; Comabella, Manuel; Montalban, Xavier; Moreno, Montserrat; Negrotto, Laura; Saenz-Cuesta, Matias; Vidal-Jordana, Angela et al.
DOI: 10.1016/j.jneuroim.2013.07.013

Effects of early treatment with glatiramer acetate in patients with clinically isolated syndrome.

PMID: 23234810
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Jul;19(8):1074-83. doi: 10.1177/1352458512469695. Epub 2012 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Bajenaru, Ovidiu; Carra, Adriana; Comi, Giancarlo; Elovaara, Irina; Fazekas, Franz; Filippi, Massimo; Hartung, Hans-Peter; Hillert, Jan; King, John; Komoly, Samuel et al.
DOI: 10.1177/1352458512469695

Treatment of cognitive impairment in multiple sclerosis: position paper.

PMID: 23180174
Journal: JOURNAL OF NEUROLOGY
Year: 2013
Reference: J Neurol. 2013 Jun;260(6):1452-68. doi: 10.1007/s00415-012-6678-0. Epub 2012 Nov 23.
Impact factor:
Publication type: Review in international publication
Authors: Amato, Maria Pia; Benedict, Ralph H B; Comi, Giancarlo; Deluca, John; Krupp, Lauren B; Langdon, Dawn; Montalban, Xavier; Thompson, Alan J et al.
DOI: 10.1007/s00415-012-6678-0

Possible new modifications for the McDonald 2010 criteria for the diagnosis of primary progressive multiple sclerosis.

PMID: 23818017
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Jul;19(8):993-4. doi: 10.1177/1352458513493036.
Impact factor:
Publication type: Editorail in international publication
Authors: Montalban, Xavier; Tur, Carmen et al.
DOI: 10.1177/1352458513493036

Dalfampridine in multiple sclerosis: From symptomatic treatment to immunomodulation.

PMID: 21742559
Journal: CLINICAL IMMUNOLOGY
Year: 2012
Reference: Clin Immunol. 2012 Jan;142(1):84-92. doi: 10.1016/j.clim.2011.06.004. Epub 2011 Jun 25.
Impact factor:
Publication type: Review in international publication
Authors: ; et al.
DOI: 10.1016/j.clim.2011.06.004

Immunopathogenesis of multiple sclerosis.

PMID: 21458377
Journal: CLINICAL IMMUNOLOGY
Year: 2012
Reference: Clin Immunol. 2012 Jan;142(1):2-8. doi: 10.1016/j.clim.2011.03.004. Epub 2011 Mar 12.
Impact factor:
Publication type: Review in international publication
Authors: ; et al.
DOI: 10.1016/j.clim.2011.03.004

Placebo-controlled trial of oral laquinimod for multiple sclerosis.

PMID: 22417253
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2012
Reference: N Engl J Med. 2012 Mar 15;366(11):1000-9.
Impact factor:
Publication type: Paper in international publication
Authors: Abou Zeid, N; Absinta, M; Aladro, Y; Amelina, O; Amigo Jorrin, M d C; Anderson, G; Arroyo, R; Ayotte, C; Balasa, R I; Bartos, L et al.
DOI: 10.1056/NEJMoa1104318

Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.

PMID: 22386267
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2012
Reference: J Neuroimmunol. 2012 Apr;245(1-2):98-101. doi: 10.1016/j.jneuroim.2012.02.005. Epub 2012 Mar 2.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jneuroim.2012.02.005

Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE.

PMID: 21451581
Journal: GENE THERAPY
Year: 2011
Reference: Gene Ther. 2011 Aug;18(8):795-806. doi: 10.1038/gt.2011.24. Epub 2011 Mar 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/gt.2011.24

THC and CBD oromucosal spray (Sativex((R))) in the management of spasticity associated with multiple sclerosis.

PMID: 21456949
Journal: Expert review of neurotherapeutics
Year: 2011
Reference: Expert Rev Neurother. 2011 May;11(5):627-37. Epub 2011 Apr 1.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; et al.
DOI: 10.1586/ern.11.47

Risk of multiple sclerosis in children with acute demyelination.

PMID: 21459045
Journal: LANCET NEUROLOGY
Year: 2011
Reference: Lancet Neurol. 2011 May;10(5):399-400. Epub 2011 Mar 31.
Impact factor:
Publication type: Editorail in international publication
Authors: et al.
DOI: 10.1016/S1474-4422(11)70068-0

Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI.

PMID: 21209373
Journal: NEUROLOGY
Year: 2011
Reference: Neurology. 2011 Feb 1;76(5):418-24. Epub 2011 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Agosta, F; Barkhof, F; Barkhof, F; Calabrese, M; Chard, D T; Ciccarelli, O; de Stefano, N; Fazekas, F; Filippi, M; Frederiksen, J et al.
DOI: 10.1212/WNL.0b013e31820a0cc4

Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results.

PMID: 20028707
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Feb;16(2):197-207. Epub 2009 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: Achtnichts, L; Airas, L; Almeida, M; Antel, J; Antel, J; Antel, J; Aradhye, S; Arbizu, T; Arroyo, R; Baldini, S et al.
DOI: 10.1177/1352458509357065

Short commentary on 'a consensus protocol for the standardization of cerebrospinal fluid collection and biobanking'.

PMID: 20042453
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Feb;16(2):129-32. Epub 2009 Dec 30.
Impact factor:
Publication type: Editorail in international publication
Authors: Bennett, J L; Berven, F S; Brundin, L; Comabella, M; Deisenhammer, F; Federiksen, J L; Fleming, J O; Franciotta, D; Furlan, R; Giovannoni, G et al.
DOI: 10.1177/1352458509356368

Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.

PMID: 20237129
Journal: BRAIN
Year: 2010
Reference: Brain. 2010 Apr;133(Pt 4):1082-93. Epub 2010 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/brain/awq035

Neurofilament ELISA validation.

PMID: 19857497
Journal: JOURNAL OF IMMUNOLOGICAL METHODS
Year: 2010
Reference: J Immunol Methods. 2010 Jan 31;352(1-2):23-31. Epub 2009 Oct 24.
Impact factor:
Publication type: Paper in international publication
Authors: Altintas, Ayse; Andreoni, Laura; Bartos, Ales; Berthele, Achim; Blankenstein, Marinus A; Buee, Luc; Castellazzi, Massimiliano; Cepok, Sabine; Comabella, Manuel; Constantinescu, Cris S et al.
DOI: 10.1016/j.jim.2009.09.014

Transgene expression levels determine the immunogenicity of transduced hematopoietic grafts in partially myeloablated mice.

PMID: 19707185
Journal: MOLECULAR THERAPY
Year: 2009
Reference: Mol Ther. 2009 Nov;17(11):1904-9.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Eixarch, Herena; Espejo, Carmen; George, Monica; Gimeno, Ramon; Gomez, Alba; Kadar, Elisabeth; Martinez, Nuria; Petriz, Jordi et al.
DOI: 10.1038/mt.2009.198

[Natalizumab in multiple sclerosis]

PMID: 19714558
Journal: REVISTA DE NEUROLOGIA
Year: 2009
Reference: Rev Neurol. 2009 Sep 1-15;49(5):265-9.
Impact factor:
Publication type: Review in national publication
Authors: Montalban, X; Rio-Izquierdo, J et al.
DOI:

A search for new MRI criteria for dissemination in space in subjects with a clinically isolated syndrome.

PMID: 19415295
Journal: EUROPEAN RADIOLOGY
Year: 2009
Reference: Eur Radiol. 2009 Sep;19(9):2244-8.
Impact factor:
Publication type: Paper in international publication
Authors: Agosta, F; Barkhof, F; Enzinger, C; Fazekas, F; Fernando, K; Filippi, M; Frederiksen, J; Knol, D L; Korteweg, T; Miller, D H et al.
DOI: 10.1007/s00330-009-1402-x

Revision of the risk of secondary leukemia after mitoxantrone in multiple sclerosis populations is required.

PMID: 19825889
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Nov;15(11):1303-10.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458509107015

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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