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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
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Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
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Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
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Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
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Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
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Gaizka Loyola Sawmillan

Gaizka Loyola Sawmillan

Research technician
Clinical Neuroimmunology
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Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
Read more
Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
Read more
Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
Read more
Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
Read more
Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
Read more
Gaizka Loyola Sawmillan

Gaizka Loyola Sawmillan

Research technician
Clinical Neuroimmunology
Read more

Publications

Serum biomarkers at disease onset for personalized therapy in multiple sclerosis.

PMID: 39101570
Journal: BRAIN
Year: 2024
Reference: Brain. 2024 Aug 5:awae260. doi: 10.1093/brain/awae260.
Impact factor:
Publication type: Paper in international publication
Authors: Aladro, Yolanda; Alvarez-Lafuente, Roberto; Ayuso, Lucia; Blanco, Yolanda; Brieva, Luis; Casanova, Bonaventura; Chico-Garcia, Juan Luis; Comabella, Manuel; Costa-Frossard, Lucienne; Cuello, Juan Pablo et al.
DOI: 10.1093/brain/awae260

Remote Teleproctoring with the TEGUS System for Mechanical Thrombectomy in a Non-Comprehensive Stroke Center: Initial Preliminary Data On Clinical Experience.

PMID: 39179879
Journal: Clinical Neuroradiology
Year: 2024
Reference: Clin Neuroradiol. 2024 Aug 23. doi: 10.1007/s00062-024-01440-0.
Impact factor:
Publication type: Paper in international publication
Authors: Carmona, Tomas; De Dios, Marta; Diana, Francesco; Diaz, Maria Lourdes; Farrero, Jordi; Fernandez, Leandro; Fredes Araya, Arturo; Gramegna, Laura Ludovica; Hernandez, David; Pinana, Carlos et al.
DOI: 10.1007/s00062-024-01440-0

Progression independent of relapse activity in multiple sclerosis: Time to account for cognitive decline.

PMID: 39193697
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Aug 28:13524585241273037. doi: 10.1177/13524585241273037.
Impact factor:
Publication type: Editorail in international publication
Authors: Portaccio, Emilio; Tur, Carmen et al.
DOI: 10.1177/13524585241273037

Prioritizing global strategies to cure MS.

PMID: 39212111
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Aug 30:13524585241272987. doi: 10.1177/13524585241272987.
Impact factor:
Publication type: Editorail in international publication
Authors: Cobo-Calvo, Alvaro; Tintore, Mar et al.
DOI: 10.1177/13524585241272987

International Delphi Consensus on the Management of AQP4-IgG+ NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab.

PMID: 37258412
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2023
Reference: Neurol Neuroimmunol Neuroinflamm. 2023 May 31;10(4):e200124. doi: 10.1212/NXI.0000000000200124. Print 2023 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Asgari, Nasrin; Bennett, Jeffrey L; Cree, Bruce Anthony Campbell; De Seze, Jerome; Fujihara, Kazuo; Hornby, Rebecca; Huda, Saif; Kim, Ho Jin; Kissani, Najib et al.
DOI: 10.1212/NXI.0000000000200124

European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs.

PMID: 37293849
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 Jun 9. doi: 10.1111/ene.15809.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Campins, Magda; Farez, Mauricio; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Lebrun-Frenay, Christine; Magyari, Melinda; Oreja-Guevara, Celia et al.
DOI: 10.1111/ene.15809

ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs.

PMID: 37293841
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Jun 9:13524585231168043. doi: 10.1177/13524585231168043.
Impact factor:
Publication type: Review in international publication
Authors: Amato, Maria Pia; Campins, Magda; Farez, Mauricio; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Lebrun-Frenay, Christine; Magyari, Melinda; Oreja-Guevara, Celia et al.
DOI: 10.1177/13524585231168043

Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes.

PMID: 37321841
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Jun 15:jnnp-2023-331531. doi: 10.1136/jnnp-2023-331531.
Impact factor:
Publication type: Paper in international publication
Authors: Alba-Arbalat, Salut; Barkhof, Frederik; Bellenberg, Barbara; Blanco, Yolanda; Calvi, Alberto; Ciccarelli, Olga; Collorone, Sara; Dineen, Robert A; Filippi, Massimo; Fleischer, Vinzenz et al.
DOI: 10.1136/jnnp-2023-331531

Is humoral and cellular response to SARS-CoV-2 vaccine modified by DMT in patients with multiple sclerosis and other autoimmune diseases?

PMID: 35475363
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jun;28(7):1138-1145. doi: 10.1177/13524585221089540. Epub 2022 Apr 27.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Alvarez, Gary; Arrambide, Georgina; Bertran, Jordina; Bonastre, Merce; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro et al.
DOI: 10.1177/13524585221089540

Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis.

PMID: 34605323
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 May;28(6):885-899. doi: 10.1177/13524585211045545. Epub 2021 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bisecco, Alvino; Ciccarelli, Olga; De Stefano, Nicola; Eisele, Philipp; Enzinger, Christian; Filippi, Massimo; Gallo, Antonio; Gasperini, Claudio; Gass, Achim et al.
DOI: 10.1177/13524585211045545

Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study.

PMID: 34605319
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 May;28(6):910-924. doi: 10.1177/13524585211044479. Epub 2021 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Enrique; Bagger, Morten; Bar-Or, Amit; Davydovskaya, Maria; Delgado, Silvia R; Evdoshenko, Evgeniy P; Fox, Edward J; Giedraitiene, Natasa; Gross-Paju, Katrin; Haldre, Sulev et al.
DOI: 10.1177/13524585211044479

Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis.

PMID: 34841948
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 May;28(6):950-957. doi: 10.1177/13524585211053001. Epub 2021 Nov 29.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana; Montalban, Xavier; Otero-Romero, Susana et al.
DOI: 10.1177/13524585211053001

Correcting gut dysbiosis can ameliorate inflammation and promote remyelination in multiple sclerosis - Yes.

PMID: 34047231
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 Jul;27(8):1161-1162. doi: 10.1177/13524585211016723. Epub 2021 May 28.
Impact factor:
Publication type: Letter or abstract
Authors: Calvo-Barreiro, Laura; Clerico, Marinella; Espejo, Carmen et al.
DOI: 10.1177/13524585211016723

13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (I).

PMID: 34042168
Journal: REVISTA DE NEUROLOGIA
Year: 2021
Reference: Rev Neurol. 2021 Jun 1;72(11):397-406. doi: 10.33588/rn.7211.2021172.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Alonso, A; Arroyo, R; Calles, C; Castillo-Trivino, T; Comabella, M; Costa-Frossard, L; Fernandez, O; Forero, L; Ginestal, R et al.
DOI: 10.33588/rn.7211.2021172

Use of Disease-Modifying Therapies in Pediatric Relapsing-Remitting Multiple Sclerosis in the United Kingdom.

PMID: 34021056
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2021
Reference: Neurol Neuroimmunol Neuroinflamm. 2021 May 21;8(4). pii: 8/4/e1008. doi: 10.1212/NXI.0000000000001008. Print 2021 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel-Mannan, Omar A; Brownlee, Wallace; Byrne, Susan; Chitre, Manali; Ciccarelli, Olga; Coles, Alasdair; Forsyth, Rob; Hacohen, Yael; Hemingway, Cheryl; Kneen, Rachel et al.
DOI: 10.1212/NXI.0000000000001008

Cognitive dysfunction and fatigue during relapses: Taking a better look.

PMID: 34018882
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 Jun;27(7):981-982. doi: 10.1177/1352458520986957.
Impact factor:
Publication type: Editorail in international publication
Authors: Arevalo, Maria Jesus; Macaron, Gabrielle et al.
DOI: 10.1177/1352458520986957

Treatment of MOG antibody associated disorders: results of an international survey.

PMID: 32623595
Journal: JOURNAL OF NEUROLOGY
Year: 2020
Reference: J Neurol. 2020 Dec;267(12):3565-3577. doi: 10.1007/s00415-020-10026-y. Epub 2020 Jul 4.
Impact factor:
Publication type: Paper in international publication
Authors: Akman-Demir, G; Aktas, O; Altintas, A; Amato, M P; Apiwattankul, M; Arrambide, G; Banwell, B L; Bennett, J L; Boggild, M; Broadley, S et al.
DOI: 10.1007/s00415-020-10026-y

Real-time assessment of COVID-19 prevalence among multiple sclerosis patients: a multicenter European study.

PMID: 32617741
Journal: NEUROLOGICAL SCIENCES
Year: 2020
Reference: Neurol Sci. 2020 Jul 2. pii: 10.1007/s10072-020-04519-x. doi: 10.1007/s10072-020-04519-x.
Impact factor:
Publication type: Paper in international publication
Authors: Comi, Giancarlo; Cummins, Nicholas; Dalla Costa, Gloria; Dobson, Richard J B; Guerrero, Ana Isabel; Hotopf, Matthew; Leocani, Letizia; Magyari, Melinda; Montalban, Xavier; Narayan, Vaibhav A et al.
DOI: 10.1007/s10072-020-04519-x

Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease-related disability.

PMID: 32602573
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2020
Reference: Eur J Neurol. 2020 Nov;27(11):2225-2232. doi: 10.1111/ene.14421. Epub 2020 Jul 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Auger, Cristina; Cabello, Sergio; Montalban, Xavier; Pareto, Deborah; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1111/ene.14421

Keeping standards of multiple sclerosis care through the COVID-19 pandemic.

PMID: 32552382
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Sep;26(10):1153-1156. doi: 10.1177/1352458520931785. Epub 2020 Jun 19.
Impact factor:
Publication type: Editorail in international publication
Authors: Montalban, Xavier; Sastre-Garriga, Jaume; Tintore, Mar et al.
DOI: 10.1177/1352458520931785

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis.

PMID: 30940920
Journal: Nature Reviews Neurology
Year: 2019
Reference: Nat Rev Neurol. 2019 May;15(5):287-300. doi: 10.1038/s41582-019-0170-8.
Impact factor:
Publication type: Review in international publication
Authors: Montalban, Xavier; Rotstein, Dalia et al.
DOI: 10.1038/s41582-019-0170-8

The Multiple Sclerosis Care Unit.

PMID: 30351211
Journal: Multiple Sclerosis Journal
Year: 2019
Reference: Mult Scler. 2019 Apr;25(5):627-636. doi: 10.1177/1352458518807082. Epub 2018 Oct 23.
Impact factor:
Publication type: Paper in international publication
Authors: Comi, Giancarlo; Giovannoni, Gavin; Montalban, Xavier; Soelberg Sorensen, Per; Thalheim, Christoph; Zaratin, Paola et al.
DOI: 10.1177/1352458518807082

Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome.

PMID: 30915227
Journal: Multiple sclerosis journal - experimental, transla
Year: 2019
Reference: Mult Scler J Exp Transl Clin. 2019 Mar 20;5(1):2055217319836664. doi: 10.1177/2055217319836664. eCollection 2019 Jan-Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Brassat, David; Brenton, J Nicholas; Cabre, Philippe; Carra Dalliere, Clarisse; de Seze, Jerome; Durand Dubief, Francoise; Ignacio Rojas, Juan; Inglese, Matilde; Kantarci, Orhun; Langille, Megan et al.
DOI: 10.1177/2055217319836664

Does attendance at the ECTRIMS congress impact on therapeutic decisions in multiple sclerosis care?

PMID: 30911401
Journal: Multiple sclerosis journal - experimental, transla
Year: 2019
Reference: Mult Scler J Exp Transl Clin. 2019 Mar 18;5(1):2055217319835226. doi: 10.1177/2055217319835226. eCollection 2019 Jan-Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Maurino, Jorge; Montalban, Xavier; Saposnik, Gustavo; Sempere, Angel P; Terzaghi, Maria A et al.
DOI: 10.1177/2055217319835226

[New drugs for the treatment of multiple sclerosis].

PMID: 29645067
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Apr 16;66(8):253.
Impact factor:
Publication type: Editorail in international publication
Authors: Rio, J et al.
DOI:

Therapeutic Inertia in the New Landscape of Multiple Sclerosis Care.

PMID: 29615967
Journal: Frontiers in Neurology
Year: 2018
Reference: Front Neurol. 2018 Mar 20;9:174. doi: 10.3389/fneur.2018.00174. eCollection 2018.
Impact factor:
Publication type: Editorail in international publication
Authors: Montalban, Xavier; Saposnik, Gustavo et al.
DOI: 10.3389/fneur.2018.00174

The current role of MRI in differentiating multiple sclerosis from its imaging mimics.

PMID: 29582852
Journal: Nature Reviews Neurology
Year: 2018
Reference: Nat Rev Neurol. 2018 Mar 20;14(4):213. doi: 10.1038/nrneurol.2018.39.
Impact factor:
Publication type: Letter or abstract
Authors: Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; DeLuca, Gabriele C; Enzinger, Christian; Evangelou, Nikos; Fazekas, Franz; Filippi, Massimo; Frederiksen, Jette; Gasperini, Claudio et al.
DOI: 10.1038/nrneurol.2018.39

Physiotherapeutic interventions in multiple sclerosis across Europe: Regions and other factors that matter.

PMID: 29579644
Journal: Multiple Sclerosis and Related Disorders
Year: 2018
Reference: Mult Scler Relat Disord. 2018 May;22:59-67. doi: 10.1016/j.msard.2018.03.005. Epub 2018 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Alves-Guerreiro, Jose; Baert, Ilse; Bakalidou, Daphne; Beiske, Antonie; Cattaneo, Davide; Dimitrova, Erieta Nikolikj; Drabinova, Adela; Erosheva, Elena; Feys, Peter; Freeman, Jenny et al.
DOI: 10.1016/j.msard.2018.03.005

Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images.

PMID: 27884876
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2017
Reference: AJNR Am J Neuroradiol. 2017 Feb;38(2):250-256. doi: 10.3174/ajnr.A4999. Epub 2016 Nov 24.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Ciampi, E; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Vidal-Jordana, A et al.
DOI: 10.3174/ajnr.A4999

Metabolomic signatures associated with disease severity in multiple sclerosis.

PMID: 28180139
Journal: Neurology(R) neuroimmunology & neuroinflammati
Year: 2017
Reference: Neurol Neuroimmunol Neuroinflamm. 2017 Jan 27;4(2):e321. doi: 10.1212/NXI.0000000000000321. eCollection 2017 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Agirrezabal, Ion; Alonso, Cristina; Alvarez-Cermeno, Jose Carlos; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Castro, Azucena; Comabella, Manuel; Fernandez, Oscar; Kotelnikova, Ekaterina; Montalban, Xavier et al.
DOI: 10.1212/NXI.0000000000000321

Clinical practice of analysis of anti-drug antibodies against interferon beta and natalizumab in multiple sclerosis patients in Europe: A descriptive study of test results.

PMID: 28170401
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Feb 7;12(2):e0170395. doi: 10.1371/journal.pone.0170395. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Auer, Michael; Bachelet, Delphine; Broet, Philippe; Buck, Dorothea; Comabella, Manuel; Davidson, Julie; Deisenhammer, Florian; Derfuss, Tobias; Donnellan, Naoimh; Donnes, Pierre et al.
DOI: 10.1371/journal.pone.0170395

Myeloid-derived suppressor cells can be efficiently generated from human hematopoietic progenitors and peripheral blood monocytes.

PMID: 28108746
Journal: IMMUNOLOGY AND CELL BIOLOGY
Year: 2017
Reference: Immunol Cell Biol. 2017 Jul;95(6):538-548. doi: 10.1038/icb.2017.4. Epub 2017 Jan 21.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Casacuberta-Serra, Silvia; Coves, Elisabet; Espejo, Carmen; Golbano, Arantxa; Pares, Marta et al.
DOI: 10.1038/icb.2017.4

Leptomeningeal enhancement in Susac's syndrome and multiple sclerosis: Time to expect the unexpected?

PMID: 27207451
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Jun;22(7):975-6. doi: 10.1177/1352458516644677. Epub 2016 Apr 18.
Impact factor:
Publication type: Paper in international publication
Authors: Sastre-Garriga, Jaume et al.
DOI: 10.1177/1352458516644677

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.

PMID: 27207462
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Oct;22(11):1386-1396. Epub 2016 May 19.
Impact factor:
Publication type: Paper in international publication
Authors: Comi, Giancarlo; Gold, Ralf; Hartung, Hans-Peter; Montalban, Xavier; Otero-Romero, Susana; Sastre-Garriga, Jaume; Soelberg Sorensen, Per; Thompson, Alan J; Vermersch, Patrick et al.
DOI: 10.1177/1352458516643600

Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.

PMID: 27194806
Journal: G3-Genes Genomes Genetics
Year: 2016
Reference: G3 (Bethesda). 2016 Jul 7;6(7):2073-9. doi: 10.1534/g3.116.030841.
Impact factor:
Publication type: Paper in international publication
Authors: Akkad, Denis A; Aktas, Orhan; Alcina, Antonio; Alloza, Iraide; Alvarez-Cermeno, Jose Carlos; Antiguedad, Alfredo; Arroyo, Rafael; Astobiza, Ianire; Berger, Thomas; Bernales, Cecily Q et al.
DOI: 10.1534/g3.116.030841

Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.

PMID: 27183579
Journal: JOURNAL OF IMMUNOLOGY
Year: 2016
Reference: J Immunol. 2016 Jun 1;196(11):4553-65. doi: 10.4049/jimmunol.1501205. Epub 2016 May 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alloza, Iraide; Astobiza, Ianire; Carillo-Salinas, Francisco; Comabella, Manuel; Feliu, Ana; Guaza, Carmen; Lopez de Lapuente, Aitzkoa; Mecha, Miriam; Mena, Jorge; Montalban, Xavier et al.
DOI: 10.4049/jimmunol.1501205

Treating relapsing-remitting multiple sclerosis: therapy effects on brain atrophy.

PMID: 26041617
Journal: J NEUROL
Year: 2015
Reference: J Neurol. 2015 Dec;262(12):2617-26. doi: 10.1007/s00415-015-7798-0. Epub 2015 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Rovira, Alex; Sastre-Garriga, Jaume; Vidal-Jordana, Angela et al.
DOI: 10.1007/s00415-015-7798-0

[Compliance of the guidelines of the Spanish Neurology Society in the treatment of patients with multiple sclerosis].

PMID: 26204085
Journal: REV NEUROLOGIA
Year: 2015
Reference: Rev Neurol. 2015 Aug 16;61(4):145-52.
Impact factor:
Publication type: Clinical guide
Authors: Aladro-Benito, Y; Arnal-Garcia, C; Berenguer-Ruiz, L; Bujanda-Alegria, M; Calles-Hernandez, M C; Cancho-Garcia, E D; Cerda-Fayos, J; Davila-Gonzalez, P; Gobartt, Ana L; Gonzalez-Martinez, F et al.
DOI:

Predictive value of early brain atrophy on response in patients treated with interferon beta.

PMID: 26185778
Journal: Neurology(R) neuroimmunology & neuroinflammation
Year: 2015
Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Jul 2;2(4):e132. doi: 10.1212/NXI.0000000000000132. eCollection 2015 Aug.
Impact factor:
Publication type: Letter or abstract
Authors: Auger, Cristina; Montalban, Xavier; Pareto, Deborah; Perez-Miralles, Francisco Carlos; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1212/NXI.0000000000000132

A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.

PMID: 26152201
Journal: HUM MOL GENET
Year: 2015
Reference: Hum Mol Genet. 2015 Oct 1;24(19):5619-27. doi: 10.1093/hmg/ddv256. Epub 2015 Jul 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abad-Grau, Maria Del Mar; Alcina, Antonio; Alloza, Iraide; Alvarez-Cermeno, Jose Carlos; Antiguedad, Alfredo; Arroyo, Rafael; Arroyo, Rafael; Astobiza, Ianire; Barrionuevo, Cristina; Blanco, Yolanda et al.
DOI: 10.1093/hmg/ddv256

Understanding the role of gender and hormones in multiple sclerosis.

PMID: 24692502
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Apr;20(5):518-9. doi: 10.1177/1352458514528266.
Impact factor:
Publication type: Editorail in international publication
Authors: Tintore, Mar; Tur, Carmen et al.
DOI: 10.1177/1352458514528266

Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.

PMID: 24682156
Journal: Genome Biology and Evolution
Year: 2014
Reference: Genome Biol Evol. 2014 Apr;6(4):830-45. doi: 10.1093/gbe/evu066.
Impact factor:
Publication type: Paper in international publication
Authors: Agliardi, Cristina; Biasin, Mara; Bresolin, Nereo; Cagliani, Rachele; Caputo, Domenico; Clerici, Mario; Comabella, Manuel; Forni, Diego; Guerini, Franca R; Malhotra, Sunny et al.
DOI: 10.1093/gbe/evu066

MS disease activity in RESTORE: a randomized 24-week natalizumab treatment interruption study.

PMID: 24682966
Journal: NEUROLOGY
Year: 2014
Reference: Neurology. 2014 Apr 29;82(17):1491-8. doi: 10.1212/WNL.0000000000000355. Epub 2014 Mar 28.
Impact factor:
Publication type: Clinical Trials
Authors: Anderson, Britt; Cree, Bruce A C; De Seze, Jerome; Duda, Petra; Fox, Robert J; Gold, Ralf; Hartung, Hans-Peter; Jeffery, Douglas; Kappos, Ludwig; Kaufman, Michael et al.
DOI: 10.1212/WNL.0000000000000355

Preliminary validation study of the Spanish version of the satisfaction with life scale in persons with multiple sclerosis.

PMID: 23962197
Journal: DISABILITY AND REHABILITATION
Year: 2014
Reference: Disabil Rehabil. 2014;36(12):1001-5. doi: 10.3109/09638288.2013.825650. Epub 2013 Aug 20.
Impact factor:
Publication type: Paper in international publication
Authors: Den Oudsten, Brenda L; Galan, Ingrid; Lucas-Carrasco, Ramona; Power, Michael J; Sastre-Garriga, Jaume et al.
DOI: 10.3109/09638288.2013.825650

[Biomarkers in multiple sclerosis].

PMID: 23520007
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Apr 1;56(7):375-90.
Impact factor:
Publication type: Review in national publication
Authors: Alvarez-Cermeno, Jose C; Arroyo-Gonzalez, Rafael; Comabella, Manuel; Fernandez, Oscar; Garcia-Merino, Juan A; Izquierdo, Guillermo; Martinez-Yelamos, Sergio; Meca-Lallana, Jose E; Montalban, Xavier; Oreja-Guevara, Celia et al.
DOI:

Brain atrophy and lesion load predict long term disability in multiple sclerosis.

PMID: 23524331
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2013
Reference: J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1082-91. doi: 10.1136/jnnp-2012-304094. Epub 2013 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Agosta, Federica; Alonso, Julio; Barkhof, Frederik; Bodini, Benedetta; Chard, Declan T; Ciccarelli, Olga; Comi, Giancarlo; De Stefano, Nicola; Eisele, Philipp; Enzinger, Christian et al.
DOI: 10.1136/jnnp-2012-304094

Idiopathic inflammatory demyelinating diseases of the brainstem.

PMID: 23522777
Journal: SEMINARS IN ULTRASOUND CT AND MRI
Year: 2013
Reference: Semin Ultrasound CT MR. 2013 Apr;34(2):123-30. doi: 10.1053/j.sult.2013.01.003.
Impact factor:
Publication type: Review in international publication
Authors: Auger, Cristina; Rovira, Alex; Rovira, Antoni; Sastre-Garriga, Jaume et al.
DOI: 10.1053/j.sult.2013.01.003

Analysis of prognostic factors associated with longitudinally extensive transverse myelitis.

PMID: 23037550
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 May;19(6):742-8. doi: 10.1177/1352458512461968. Epub 2012 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Ayuso, Teresa; Blanco, Yolanda; Castillo, Joaquin; Corral, Juan; Gabilondo, Inigo; Graus, Francesc; Guijarro, Cristina; Iniguez, Cristina; Llufriu, Sara; Mendibe, Mar et al.
DOI: 10.1177/1352458512461968

[Stem cell-based treatment of neurologic diseases.]

PMID: 22361347
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 Jul 21;139(5):208-14. doi: 10.1016/j.medcli.2011.12.009. Epub 2012 Feb 22.
Impact factor:
Publication type: Review in national publication
Authors: ; ; et al.
DOI: 10.1016/j.medcli.2011.12.009

Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial.

PMID: 22226929
Journal: LANCET NEUROLOGY
Year: 2012
Reference: Lancet Neurol. 2012 Feb;11(2):131-9. Epub 2012 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Atkinson, Gillian; Dua, Pinky; Graff, Ole; Grove, Richard; Horrigan, Joseph; Macmanus, David; Miller, David H; Montalban, Xavier; Wardell, Claire; Weber, Thomas et al.
DOI: 10.1016/S1474-4422(11)70299-X

Natalizumab discontinuation after PML risk stratification: outcome from a shared and informed decision.

PMID: 22383232
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Aug;18(8):1193-6. doi: 10.1177/1352458512439238. Epub 2012 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458512439238

Natalizumab treatment of multiple sclerosis in Spain: results of an extensive observational study.

PMID: 22289966
Journal: JOURNAL OF NEUROLOGY
Year: 2012
Reference: J Neurol. 2012 Sep;259(9):1814-23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1007/s00415-012-6414-9

T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis.

PMID: 20627965
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2011
Reference: J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):72-7. Epub 2010 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/jnnp.2009.201574

Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI.

PMID: 21209373
Journal: NEUROLOGY
Year: 2011
Reference: Neurology. 2011 Feb 1;76(5):418-24. Epub 2011 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Agosta, F; Barkhof, F; Barkhof, F; Calabrese, M; Chard, D T; Ciccarelli, O; de Stefano, N; Fazekas, F; Filippi, M; Frederiksen, J et al.
DOI: 10.1212/WNL.0b013e31820a0cc4

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria.

PMID: 21387374
Journal: ANNALS OF NEUROLOGY
Year: 2011
Reference: Ann Neurol. 2011 Feb;69(2):292-302. doi: 10.1002/ana.22366.
Impact factor:
Publication type: Paper in international publication
Authors: Banwell, Brenda; Clanet, Michel; Cohen, Jeffrey A; Filippi, Massimo; Fujihara, Kazuo; Havrdova, Eva; Hutchinson, Michael; Kappos, Ludwig; Lublin, Fred D; Montalban, Xavier et al.
DOI: 10.1002/ana.22366

[An observational study of the effectiveness and safety of natalizumab in the treatment of multiple sclerosis.]

PMID: 21387248
Journal: REVISTA DE NEUROLOGIA
Year: 2011
Reference: Rev Neurol. 2011 Mar 16;52(6):321-330.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI:

Do multimodal evoked potentials add information to MRI in clinically isolated syndromes?

PMID: 19995838
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Jan;16(1):55-61. Epub 2009 Dec 7.
Impact factor:
Publication type: Paper in international publication
Authors: Castillo, J; Comabella, M; Horga, A; Minoves, T; Moncho, D; Montalban, X; Nos, C; Pelayo, R; Perkal, H; Rio, J et al.
DOI: 10.1177/1352458509352666

Antiviral immune response in patients with multiple sclerosis and healthy siblings.

PMID: 20203149
Journal: MULTIPLE SCLEROSIS
Year: 2010
Reference: Mult Scler. 2010 Mar;16(3):355-8.
Impact factor:
Publication type: Paper in international publication
Authors: Caballero, E; Comabella, M; Horga, A; Kakalacheva, K; Lunemann, Jd; Messmer, B; Montalban, X; Munz, C; Strowig, T et al.
DOI: 10.1177/1352458509357066

Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta.

PMID: 20163990
Journal: LANCET NEUROLOGY
Year: 2010
Reference: Lancet Neurol. 2010 Apr;9(4):381-90. Epub 2010 Feb 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/S1474-4422(10)70033-8

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis.

PMID: 20089954
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2010
Reference: N Engl J Med. 2010 Feb 4;362(5):402-15. Epub 2010 Jan 20.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1056/NEJMoa0907839

Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial.

PMID: 19815268
Journal: LANCET
Year: 2009
Reference: Lancet. 2009 Oct 31;374(9700):1503-11.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/S0140-6736(09)61259-9

Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.

PMID: 19667218
Journal: ARCHIVES OF NEUROLOGY
Year: 2009
Reference: Arch Neurol. 2009 Aug;66(8):972-8.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Craig, David W; Fernandez, Marta; Martin, Roland; Montalban, Xavier; Morcillo-Suarez, Carlos; Navarro, Arcadi; Rio, Jordi et al.
DOI: 10.1001/archneurol.2009.150

Predicting responders to therapies for multiple sclerosis.

PMID: 19794514
Journal: Nat Rev Neurol
Year: 2009
Reference: Nat Rev Neurol. 2009 Oct;5(10):553-60.
Impact factor:
Publication type: Letter or abstract
Authors: Comabella, Manuel; Montalban, Xavier; Rio, Jordi et al.
DOI: 10.1038/nrneurol.2009.139

A single-centre, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis.

PMID: 19797261
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Oct;15(10):1195-205.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458509106937

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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