Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS)

CRIPS is a research group focusing on severe acute respiratory infections and sepsis.

The objective is to develop projects on clinical and translational research in hospital-acquired pneumonia, community-acquired pneumonia, and severe viral respiratory infections, such as influenza and COVID-19. CRIPS also develop epidemiological studies focused on risk and prognostic factors for multi-resistant pathogens, validation of ventilator-associated events in ventilated adult and pediatric patients, incorporating artificial intelligence techniques. It also highlights evidence-based medicine (EBM) research, evaluating therapies and prevention strategies and participating in the formulation of clinical practice guidelines, as part of CIBERES and the European Society for Clinical Microbiology and Infections. The EBM research focuses on knowledge translation to get research findings to the point of decision making, providing health-related recommendations, focusing on clinical research and relevance of care.

CRIPS collaborate on a Local (UIC, IDIAP), National (CIBERES), and International level (CHU Nimes, Uolo University, ISARIC and Pneumo-Inspire Networks).

Projects

Aquest any no hi ha projectes actius.

Publications

Influenza myocarditis in paediatric patients.

PMID: 34889174
Journal: CARDIOLOGY IN THE YOUNG
Year: 2022
Reference: Cardiol Young. 2022 Jul;32(7):1188-1190. doi: 10.1017/S1047951121004777. Epub 2021 Dec 10.
Impact factor: 1.093
Publication type: Paper in international publication
Authors: Gran, Ferran, Dolader, Paola, Balcells, Joan et al.
DOI: 10.1017/S1047951121004777

Positive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia-an ESGFOR based narrative case-control review.

PMID: 35813341
Journal: Annals of Translational Medicine
Year: 2022
Reference: Ann Transl Med. 2022 Jun;10(11):644. doi: 10.21037/atm-22-605.
Impact factor: 3.932
Publication type: Review in international publication
Authors: Saegeman, Veroniek, Cohen, Marta C, Abasolo, Lydia, Rello, Jordi, Fernandez-Gutierrez, Benjamin, Fernandez-Rodriguez, Amparo et al.
DOI: 10.21037/atm-22-605

Challenges in Respiratory Syncytial Virus in Adults With Severe Community-acquired Pneumonia.

PMID: 35680305
Journal: CHEST
Year: 2022
Reference: Chest. 2022 Jun;161(6):1434-1435. doi: 10.1016/j.chest.2022.01.050.
Impact factor: 9.41
Publication type: Editorail in international publication
Authors: Rello, Jordi, Sabater-Riera, Joan et al.
DOI: 10.1016/j.chest.2022.01.050

Coexisting Purpuric and Pseudo-Chilblain Lesions in COVID-19 Patients.

PMID: 35532774
Journal: Skinmed
Year: 2022
Reference: Skinmed. 2022 Apr 30;20(2):155-158. eCollection 2022.
Impact factor: 0
Publication type: Letter or abstract
Authors: Tammaro, Antonella, Adebanjo, Ganiyat Adenike Ralitsa, Parisella, Francesca Romana, Rello, Jordi, Ramirez-Estrada, Sergio, Alexander, Shehani et al.
DOI:

Local reactions to the second dose of the BNT162 COVID-19 vaccine.

PMID: 34031953
Journal: Dermatologic Therapy
Year: 2021
Reference: Dermatol Ther. 2021 Jul;34(4):e15000. doi: 10.1111/dth.15000. Epub 2021 Jun 1.
Impact factor: 2.851
Publication type: Letter or abstract
Authors: Tammaro, Antonella, De Marco, Gabriella, Rello, Jordi, Parisella, Francesca Romana, Adebanjo, Ganiyat Adenike Ralitsa et al.
DOI: 10.1111/dth.15000

Impact of vaccinating pregnant women against pertussis on hospitalizations of children under one year of age in a tertiary hospital in Catalonia.

PMID: 34020822
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 May 18. pii: S0213-005X(21)00088-4. doi: 10.1016/j.eimc.2021.04.004.
Impact factor: 1.731
Publication type: Paper in national publication
Authors: Ruiz-Botia, Irene, Riera-Bosch, M Teresa, Rodriguez-Losada, Olalla, Soler-Palacin, Pere, Melendo, Susana, Moraga-Llop, Fernando, Balcells-Ramirez, Joan, Otero-Romero, Susana, Armadans-Gil, Lluis et al.
DOI: 10.1016/j.eimc.2021.04.004

Mortality Benefit Inconclusive, Based on This Review Response

PMID: 34021997
Journal: CHEST
Year: 2021
Reference: Chest. 2021 Apr;159(4):1677-1678. doi: 10.1016/j.chest.2020.11.029. Epub 2021 Apr 6.
Impact factor: 9.41
Publication type: Letter or abstract
Authors: Zasowski, Evan J, Bassetti, Matteo, Blasi, Francesco, Rello, Jordi, Sotgiu, Giovanni, Tavoschi, Lara, Arber, Mick R, McCool, Rachael, Patterson, Jacoby V, Longshaw, Christopher M et al.
DOI: 10.1016/j.chest.2020.11.029

Transient upper limb ischaemia during veno-arterial extracorporeal membrane oxygenation in a child.

PMID: 34000021
Journal: Interactive cardiovascular and thoracic surgery
Year: 2021
Reference: Interact Cardiovasc Thorac Surg. 2021 Oct 29;33(5):803-806. doi: 10.1093/icvts/ivab153.
Impact factor: 0
Publication type: Paper in international publication
Authors: Izquierdo-Blasco, Jaume, Riaza, Lucia, Pujol, Montse, Gran, Ferran, Fernandez-Doblas, Joaquin, Perez-Andreu, Joaquin, Abella, Raul F, Balcells, Joan et al.
DOI: 10.1093/icvts/ivab153

Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin.

PMID: 31915838
Journal: INTENSIVE CARE MEDICINE
Year: 2020
Reference: Intensive Care Med. 2020 Apr;46(4):766-770. doi: 10.1007/s00134-019-05890-w. Epub 2020 Jan 8.
Impact factor:
Publication type: Paper in international publication
Authors: Arvaniti, Kostoula; Bassetti, Matteo; Blot, Stijn; Boisson, Matthieu; Bougle, Adrien; Constantin, Jean-Michel; Dhanani, Jayesh; Dimopoulos, George; Dugernier, Jonathan; Ehrmann, Stephan et al.
DOI: 10.1007/s00134-019-05890-w

The effects of sedatives, neuromuscular blocking agents and opioids on ventilator-associated events.

PMID: 31913933
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2020
Reference: Eur J Anaesthesiol. 2020 Feb;37(2):67-69. doi: 10.1097/EJA.0000000000001132.
Impact factor:
Publication type: Editorail in international publication
Authors: Pena-Lopez, Yolanda; Ramirez-Estrada, Sergio; Rello, Jordi et al.
DOI: 10.1097/EJA.0000000000001132

Levels of evidence supporting clinical practice guidelines on invasive aspergillosis.

PMID: 31901113
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2020
Reference: Eur J Clin Microbiol Infect Dis. 2020 May;39(5):903-913. doi: 10.1007/s10096-019-03794-7. Epub 2020 Jan 3.
Impact factor:
Publication type: Paper in international publication
Authors: Blot, Stijn; Campogiani, Laura; Ferreira-Coimbra, Joao; Rello, Jordi; Tejada, Sofia et al.
DOI: 10.1007/s10096-019-03794-7

Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.

PMID: 31385399
Journal: RESPIROLOGY
Year: 2020
Reference: Respirology. 2020 May;25(5):543-551. doi: 10.1111/resp.13663. Epub 2019 Aug 5.
Impact factor: 4.88
Publication type: Paper in international publication
Authors: Martin-Loeches, Ignacio, Villafuerte, David, Aliberti, Stefano, Soni, Nilam J, Faverio, Paola, Marcos, Pedro J, Wunderink, Richard G, Rodriguez, Alejandro, Sibila, Oriol, Sanz, Francisco et al.
DOI: 10.1111/resp.13663

Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together.

PMID: 31361683
Journal: Current Opinion in Critical Care
Year: 2019
Reference: Curr Opin Crit Care. 2019 Oct;25(5):430-437. doi: 10.1097/MCC.0000000000000637.
Impact factor: 2.54
Publication type: Paper in international publication
Authors: Blot, Stijn, Rello, Jordi, Koulenti, Despoina et al.
DOI: 10.1097/MCC.0000000000000637

Pneumonia versus Graft Dysfunction as the cause of acute respiratory failure after Lung Transplant: A 4-year multicenter prospective study in 153 adults requiring intensive care (ICU) admission.

PMID: 31346003
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2019
Reference: Eur Respir J. 2019 Oct 1;54(3). pii: 13993003.01512-2018. doi: 10.1183/13993003.01512-2018. Print 2019 Sep.
Impact factor: 11.807
Publication type: Paper in international publication
Authors: Mazo, Cristopher, Pont, Teresa, Ballesteros, Maria A, Lopez, Eloisa, Rellan, Luzdivina, Robles, Juan C, Rello, Jordi et al.
DOI: 10.1183/13993003.01512-2018

Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis.

PMID: 31342206
Journal: Annals of Intensive Care
Year: 2019
Reference: Ann Intensive Care. 2019 Jul 24;9(1):86. doi: 10.1186/s13613-019-0559-y.
Impact factor: 3.931
Publication type: Paper in international publication
Authors: Vidaur, Loreto, Totorika, Izarne, Montes, Milagrosa, Vicente, Diego, Rello, Jordi, Cilla, Gustavo et al.
DOI: 10.1186/s13613-019-0559-y

Severe influenza: overview in critically ill patients.

PMID: 31313681
Journal: Current Opinion in Critical Care
Year: 2019
Reference: Curr Opin Crit Care. 2019 Oct;25(5):449-457. doi: 10.1097/MCC.0000000000000638.
Impact factor: 2.54
Publication type: Paper in international publication
Authors: Sarda, Cristina, Palma, Pedro, Rello, Jordi et al.
DOI: 10.1097/MCC.0000000000000638

Nebulization of Antiinfective Agents in Invasively Mechanically Ventilated Adults: A Systematic Review and Meta-analysis.

PMID: 28248714
Journal: ANESTHESIOLOGY
Year: 2017
Reference: Anesthesiology. 2017 May;126(5):890-908. doi: 10.1097/ALN.0000000000001570.
Impact factor: 5.66
Publication type: Paper in international publication
Authors: Dhanani, Jayesh, Sole-Lleonart, Candela, Rouby, Jean-Jacques, Blot, Stijn, Poulakou, Garyfallia, Chastre, Jean, Palmer, Lucy B, Bassetti, Matteo, Luyt, Charles-Edouard, Pereira, Jose M et al.
DOI: 10.1097/ALN.0000000000001570

A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients.

PMID: 28159015
Journal: CRITICAL CARE
Year: 2017
Reference: Crit Care. 2017 Feb 4;21(1):22. doi: 10.1186/s13054-017-1601-9.
Impact factor: 5.358
Publication type: Paper in international publication
Authors: Rello, Jordi, Krenn, Claus-Georg, Locker, Gottfried, Burgmann, Heinz, Welte, Tobias, Klingler, Anton, Hochreiter, Romana, Westritschnig, Kerstin, Joannidis, Michael, Lyons, Arthur et al.
DOI: 10.1186/s13054-017-1601-9

Theranostics in severe influenza.

PMID: 28094139
Journal: Lancet Respiratory Medicine
Year: 2017
Reference: Lancet Respir Med. 2017 Feb;5(2):91-92. doi: 10.1016/S2213-2600(17)30005-X. Epub 2017 Jan 14.
Impact factor: 19.287
Publication type: Review in international publication
Authors: Rello, Jordi et al.
DOI: 10.1016/S2213-2600(17)30005-X

Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy.

PMID: 28093651
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2017
Reference: Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1097-1104. doi: 10.1007/s10096-016-2894-3. Epub 2017 Jan 16.
Impact factor: 2.727
Publication type: Paper in international publication
Authors: Borgatta, B, Lagunes, L, Imbiscuso, A T, Larrosa, M N, Lujan, M, Rello, J et al.
DOI: 10.1007/s10096-016-2894-3

Precision medicine for the treatment of severe pneumonia in intensive care.

PMID: 26789703
Journal: Expert Review of Vaccines
Year: 2016
Reference: Expert Rev Respir Med. 2016;10(3):297-316. doi: 10.1586/17476348.2016.1144477. Epub 2016 Feb 9.
Impact factor: 4.222
Publication type: Paper in international publication
Authors: Perez, Antonio, Rello, Jordi et al.
DOI: 10.1586/17476348.2016.1144477

Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia.

PMID: 26727202
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Jan 4;11(1):e0145929. doi: 10.1371/journal.pone.0145929. eCollection 2016.
Impact factor: 3.057
Publication type: Paper in international publication
Authors: Bello, Salvador, Martin-Villasclaras, Juan, Borderias, Luis, Rajas, Olga, Capelastegui, Alberto, Zalacain, Rafael, Mendez, Raul, Reyes, Soledad, Torres, Antoni, Menendez, Rosario et al.
DOI: 10.1371/journal.pone.0145929

Pseudomonas aeruginosa ventilator-associated pneumonia management.

PMID: 26855594
Journal: Phytotaxa
Year: 2016
Reference: Infect Drug Resist. 2016 Jan 20;9:7-18. doi: 10.2147/IDR.S50669. eCollection 2016.
Impact factor: 1.087
Publication type: Review in national publication
Authors: Ramirez-Estrada, Sergio, Borgatta, Barbara, Rello, Jordi et al.
DOI: 10.2147/IDR.S50669

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.

PMID: 26433783
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2016
Reference: J Antimicrob Chemother. 2016 Jan;71(1):196-207. doi: 10.1093/jac/dkv288. Epub 2015 Oct 3.
Impact factor: 4.919
Publication type: Paper in international publication
Authors: Dupont, Herve, Abdul-Aziz, Mohd H, Lipman, Jeffrey, Akova, Murat, Bassetti, Matteo, De Waele, Jan J, Dimopoulos, George, Dulhunty, Joel, Kaukonen, Kirsi-Maija, Koulenti, Despoina et al.
DOI: 10.1093/jac/dkv288

Prevalence, risk factors, and mortality for ventilator-associated pneumonia in middle-aged, old, and very old critically ill patients*.

PMID: 24158167
Journal: CRIT CARE MED
Year: 2014
Reference: Crit Care Med. 2014 Mar;42(3):601-9. doi: 10.1097/01.ccm.0000435665.07446.50.
Impact factor: 6.147
Publication type: Paper in international publication
Authors: Blot, Stijn, Koulenti, Despoina, Dimopoulos, George, Martin, Claude, Komnos, Apostolos, Krueger, Wolfgang A, Spina, Giuseppe, Armaganidis, Apostolos, Rello, Jordi et al.
DOI: 10.1097/01.ccm.0000435665.07446.50

Early postoperative management of lung transplantation.

PMID: 24518214
Journal: MINERVA ANESTESIOL
Year: 2014
Reference: Minerva Anestesiol. 2014 Nov;80(11):1234-45. Epub 2014 Feb 11.
Impact factor: 2.272
Publication type: Paper in national publication
Authors: Leal, S, Sacanell, J, Riera, J, Masclans, J R, Rello, J et al.
DOI:

Complications in the immediate postoperatory of lung transplantation: three years of practice at a high-experienced center.

PMID: 24638776
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):631A. doi: 10.1378/chest.1799525.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Riera, Jordi, Caralt, Berta, Augustin, Salvador, Masclans, Joan Ramon, Canela, Merce, Roman, Antonio, Rello, Jordi et al.
DOI: 10.1378/chest.1799525

ICU readmission of a lung transplant recipient with acute respiratory failure.

PMID: 24638713
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):563A. doi: 10.1378/chest.1823743.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Acuna, Mauricio, Riera, Jordi, Rello, Jordi, Roman, Antonio et al.
DOI: 10.1378/chest.1823743

Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading?

PMID: 23812337
Journal: INTENSIVE CARE MEDICINE
Year: 2013
Reference: Intensive Care Med. 2013 Sep;39(9):1644-6. doi: 10.1007/s00134-013-2983-z. Epub 2013 Jun 28.
Impact factor: 5.258
Publication type: Editorail in international publication
Authors: Rello, Jordi, Lipman, Jeffrey et al.
DOI: 10.1007/s00134-013-2983-z

Predicting treatment failure in severe sepsis and septic shock: looking for the Holy Grail.

PMID: 24004571
Journal: CRITICAL CARE
Year: 2013
Reference: Crit Care. 2013 Sep 4;17(5):180. doi: 10.1186/cc12877.
Impact factor: 4.718
Publication type: Editorail in international publication
Authors: Ruiz-Rodriguez, Juan Carlos, Rello, Jordi et al.
DOI: 10.1186/cc12877

Update in pulmonary infections 2012.

PMID: 23675715
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2013
Reference: Am J Respir Crit Care Med. 2013 May 15;187(10):1061-6. doi: 10.1164/rccm.201302-0262UP.
Impact factor: 11.041
Publication type: Review in international publication
Authors: Chastre, Jean, Rello, Jordi et al.
DOI: 10.1164/rccm.201302-0262UP

Antibiotic stewardship in hospital-acquired pneumonia.

PMID: 23648898
Journal: CHEST
Year: 2013
Reference: Chest. 2013 May;143(5):1195-6. doi: 10.1378/chest.12-2729.
Impact factor: 5.854
Publication type: Editorail in international publication
Authors: Rello, Jordi et al.
DOI: 10.1378/chest.12-2729

Drotrecogin Alfa (Activated) in Adults with Septic Shock.

PMID: 22616830
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2012
Reference: N Engl J Med. 2012 May 31;366(22):2055-64. doi: 10.1056/NEJMoa1202290. Epub 2012 May 22.
Impact factor: 53.298
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1056/NEJMoa1202290

Severe sepsis mortality prediction with logistic regression over latent factors

PMID: 90000003
Journal: EXPERT SYSTEMS WITH APPLICATIONS
Year: 2012
Reference: Expert Syst. Appl. 39 (2) 1937-1943. 10.1016/j.eswa.2011.08.054
Impact factor: 2.203
Publication type: Paper in international publication
Authors: , , , et al.
DOI: 10.1016/j.eswa.2011.08.054

Elevation of creatine kinase is associated with worse outcomes in 2009 pH1N1 influenza A infection.

PMID: 22527080
Journal: INTENSIVE CARE MEDICINE
Year: 2012
Reference: Intensive Care Med. 2012 Jul;38(7):1152-61. doi: 10.1007/s00134-012-2565-5. Epub 2012 Apr 18.
Impact factor: 5.399
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1007/s00134-012-2565-5

A Clinical Algorithm to Diagnose Invasive Pulmonary Aspergillosis in Critically Ill Patients.

PMID: 22517788
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2012
Reference: Am J Respir Crit Care Med. 2012 Jul 1;186(1):56-64. Epub 2012 Apr 19.
Impact factor: 11.08
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1164/rccm.201111-1978OC

Increased mortality associated with meticillin-resistant Staphylococcus aureus (MRSA) infection in the Intensive Care Unit: results from the EPIC II study.

PMID: 21798720
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2011
Reference: Int J Antimicrob Agents. 2011 Oct;38(4):331-5. Epub 2011 Jul 28.
Impact factor: 3.787
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.ijantimicag.2011.05.013

The spectrum of pneumococcal empyema in adults in the early 21st century.

PMID: 21765073
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2011
Reference: Clin Infect Dis. 2011 Aug;53(3):254-61.
Impact factor: 8.186
Publication type: Paper in international publication
Authors: Pahissa, Albert, Burgos, Joaquin, Lujan, Manel, Falco, Vicenc, Sanchez, Ana, Puig, Mireia, Borrego, Astrid, Fontanals, Dionisia, Planes, Ana M, Rello, Jordi et al.
DOI: 10.1093/cid/cir354

Determinants of Choice and Prescription Patterns in Empiric Antibiotic Therapy for HAP/VAP.

PMID: 20847075
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2011
Reference: Eur Respir J. 2011 Jun;37(6):1332-9. Epub 2010 Sep 16.
Impact factor: 5.922
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1183/09031936.00093010

Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain.

PMID: 20946335
Journal: RESPIROLOGY
Year: 2011
Reference: Respirology. 2011 Jan;16(1):78-85. doi: 10.1111/j.1440-1843.2010.01874.x.
Impact factor: 1.865
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1111/j.1440-1843.2010.01874.x

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Dr. Raúl Felipe Abella, Dr. Joan Balcells and Dr. Ferran Gran