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Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS)

CRIPS is a research group focusing on severe acute respiratory infections and sepsis. 

The objective is to develop projects on clinical and translational research in hospital-acquired pneumonia, community-acquired pneumonia, and severe viral respiratory infections, such as influenza and COVID-19. CRIPS also develop epidemiological studies focused on risk and prognostic factors for multi-resistant pathogens, validation of ventilator-associated events in ventilated adult and pediatric patients, incorporating artificial intelligence techniques. It also highlights evidence-based medicine (EBM) research, evaluating therapies and prevention strategies and participating in the formulation of clinical practice guidelines, as part of CIBERES and the European Society for Clinical Microbiology and Infections. The EBM research focuses on knowledge translation to get research findings to the point of decision making, providing health-related recommendations, focusing on clinical research and relevance of care. 

CRIPS collaborate on a Local (UIC, IDIAP), National (CIBERES), and International level (CHU Nimes, Uolo University, ISARIC and Pneumo-Inspire Networks).

Publications

Effect of High Altitude on the Survival of COVID-19 Patients in Intensive Care Unit: A Cohort Study.

PMID: 35532089
Journal: JOURNAL OF INTENSIVE CARE MEDICINE
Year: 2022
Reference: J Intensive Care Med. 2022 May 9:8850666221099827. doi: 10.1177/08850666221099827.
Impact factor: 3.51
Publication type: Paper in international publication
Authors: Barberan, Jose Luis, Paredes, Juan Pablo, Cevallos, Monica, Montenegro, Francisco, Puertas, Soraya, Briones, Killen, Martinez, Marlon, Velez-Paez, Jorge, Montalvo-Villagomez, Mario, Herrera, Luis et al.
DOI: 10.1177/08850666221099827

Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: A Systematic Review.

PMID: 35533977
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2022
Reference: Anaesth Crit Care Pain Med. 2022 May 6;41(4):101098. doi: 10.1016/j.accpm.2022.101098.
Impact factor: 4.132
Publication type: Review in international publication
Authors: Martinez-Reviejo, Raquel, Tejada, Sofia, Cipriano, Ana, Nur Karakoc, Hanife, Manuel, Oriol, Rello, Jordi et al.
DOI: 10.1016/j.accpm.2022.101098

Ventilator-associated events in children: A multicentre prospective cohort study.

PMID: 35477009
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2022
Reference: Anaesth Crit Care Pain Med. 2022 Jun;41(3):101072. doi: 10.1016/j.accpm.2022.101072. Epub 2022 Apr 25.
Impact factor: 4.132
Publication type: Paper in international publication
Authors: Flores-Gonzalez, Jose Carlos, Mendizabal, Mikel, Sanchez-Granados, Jose Manuel, Martinez-Padilla, Maria Carmen, Perez, Rosalia, Abril-Molina, Ana, Tejada, Sofia, Roca, David, Serrano-Megias, Marta, Rello, Jordi et al.
DOI: 10.1016/j.accpm.2022.101072

Epidemiology and Age-Related Mortality in Critically Ill Patients With Intra-Abdominal Infection or Sepsis: An International Cohort Study.

PMID: 35460850
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2022
Reference: Int J Antimicrob Agents. 2022 Jul;60(1):106591. doi: 10.1016/j.ijantimicag.2022.106591. Epub 2022 Apr 20.
Impact factor: 5.283
Publication type: Paper in international publication
Authors: Mikstacki, Adam, Montravers, Philippe, Paiva, Jose Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francois, Tomescu, Dana, Vogelaers, Dirk, Blot, Stijn, Maseda, Emilio et al.
DOI: 10.1016/j.ijantimicag.2022.106591

Value of Preoperative Use of Statins as a Protective Factor for Severe Graft Dysfunction After Lung Transplantation: A Multicenter Propensity Score Analysis.

PMID: 34001351
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2021
Reference: Arch Bronconeumol (Engl Ed). 2021 Apr 26. pii: S0300-2896(21)00137-X. doi: 10.1016/j.arbres.2021.04.016.
Impact factor: 4.872
Publication type: Letter whit IF
Authors: Jauregui, Alberto, Bello, Irene, Sandiumenge, Alberto, Coll, Elisabeth, de la Torre, Mercedes, Mosteiro, Fernando, Alvarez, Carlos, Mora, Victor, Minambres, Eduardo, Crowley, Silvana et al.
DOI: 10.1016/j.arbres.2021.04.016

Post-acute COVID-19 Syndrome (PACS): A public health emergency.

PMID: 33965645
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2021
Reference: Anaesth Crit Care Pain Med. 2021 Jun;40(3):100882. doi: 10.1016/j.accpm.2021.100882. Epub 2021 May 21.
Impact factor: 4.132
Publication type: Editorail in international publication
Authors: Rello, Jordi, James, Arthur, Reyes, Luis Felipe et al.
DOI: 10.1016/j.accpm.2021.100882

Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort.

PMID: 33872917
Journal: JOURNAL OF CRITICAL CARE
Year: 2021
Reference: J Crit Care. 2021 Aug;64:114-119. doi: 10.1016/j.jcrc.2021.03.014. Epub 2021 Apr 17.
Impact factor: 3.425
Publication type: Paper in international publication
Authors: Van de Louw, Andry, Mokart, Djamel, Metaxa, Victoria, Benoit, Dominique, Barratt-Due, Andreas, Soares, Marcio, Pickkers, Peter, Antonelli, Massimo, Demoule, Alexandre, Schellongowski, Peter et al.
DOI: 10.1016/j.jcrc.2021.03.014

Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials.

PMID: 33358065
Journal: European Journal of Internal Medicine
Year: 2021
Reference: Eur J Intern Med. 2021 Apr;86:54-65. doi: 10.1016/j.ejim.2020.12.010. Epub 2021 Jan 5.
Impact factor: 4.624
Publication type: Paper in international publication
Authors: Tejada, Sofia, Jansson, Miia, Sole-Lleonart, Candela, Rello, Jordi et al.
DOI: 10.1016/j.ejim.2020.12.010

Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium.

PMID: 33172592
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2020
Reference: Anaesth Crit Care Pain Med. 2020 Oct 22. pii: S2352-5568(20)30240-X. doi: 10.1016/j.accpm.2020.10.008.
Impact factor: 2.707
Publication type: Review in international publication
Authors: Rello, Jordi, Belliato, Mirko, Dimopoulos, Meletios-Athanasios, Giamarellos-Bourboulis, Evangelos J, Jaksic, Vladimir, Martin-Loeches, Ignacio, Mporas, Iosif, Pelosi, Paolo, Poulakou, Garyphallia, Pournaras, Spyridon et al.
DOI: 10.1016/j.accpm.2020.10.008

COVID-19, steroids and other immunomodulators: The jigsaw is not complete.

PMID: 33115684
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2020
Reference: Anaesth Crit Care Pain Med. 2020 Dec;39(6):699-701. doi: 10.1016/j.accpm.2020.10.011. Epub 2020 Oct 25.
Impact factor: 2.707
Publication type: Editorail in international publication
Authors: Rello, Jordi, Waterer, Grant W, Bourdiol, Alexandre, Roquilly, Antoine et al.
DOI: 10.1016/j.accpm.2020.10.011

Artificial Intelligence for clinical decision support in Critical Care, required and accelerated by COVID-19.

PMID: 33099016
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2020
Reference: Anaesth Crit Care Pain Med. 2020 Dec;39(6):691-693. doi: 10.1016/j.accpm.2020.09.010. Epub 2020 Oct 21.
Impact factor: 2.707
Publication type: Editorail in international publication
Authors: Jansson, Miia, Rubio, Juanjo, Gavalda, Ricard, Rello, Jordi et al.
DOI: 10.1016/j.accpm.2020.09.010

Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status.

PMID: 33090310
Journal: Annals of Intensive Care
Year: 2020
Reference: Ann Intensive Care. 2020 Oct 22;10(1):146. doi: 10.1186/s13613-020-00764-7.
Impact factor: 4.124
Publication type: Paper in international publication
Authors: Mokart, Djamel, Darmon, Michael, Schellongowski, Peter, Azoulay, Elie, Bisbal, Magali, Canet, Emmanuel, Pickkers, Peter, Soares, Marcio, Rello, Jordi, Bauer, Philippe R et al.
DOI: 10.1186/s13613-020-00764-7

Factors associated with ventilator-associated events: an international multicenter prospective cohort study.

PMID: 31236736
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2019
Reference: Eur J Clin Microbiol Infect Dis. 2019 Sep;38(9):1693-1699. doi: 10.1007/s10096-019-03596-x. Epub 2019 Jun 24.
Impact factor: 2.591
Publication type: Paper in international publication
Authors: Rello, Jordi, Ramirez-Estrada, Sergio, Romero, Anabel, Arvaniti, Kostoula, Koulenti, Despoina, Nseir, Saad, Oztoprak, Nefise, Bouadma, Lila, Vidaur, Loreto, Lagunes, Leonel et al.
DOI: 10.1007/s10096-019-03596-x

Management of ventilator-associated pneumonia (VAP) caused by resistant gram-negative bacteria: which is the best strategy to treat?

PMID: 31210549
Journal: Expert Review of Respiratory Medicine
Year: 2019
Reference: Expert Rev Respir Med. 2019 Aug;13(8):787-798. doi: 10.1080/17476348.2019.1632195. Epub 2019 Jun 24.
Impact factor: 2.622
Publication type: Paper in international publication
Authors: Sarda, Cristina, Fazal, Farhan, Rello, Jordi et al.
DOI: 10.1080/17476348.2019.1632195

Multicentric study on total pancreatectomies.

PMID: 31164217
Journal: CIRUGIA ESPANOLA
Year: 2019
Reference: Cir Esp. 2019 Aug - Sep;97(7):377-384. doi: 10.1016/j.ciresp.2019.04.004. Epub 2019 Jun 1.
Impact factor: 0.835
Publication type: Paper in national publication
Authors: de Miguel Ibanez, Ricardo, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, Briceno, Javier, Miyar-de Leon, Alberto, Serradilla, Mario, Moya-Herraiz, Angel, Fabregat Prous, Joan, Secanella, Lluis, Larrea Y Olea, Javier et al.
DOI: 10.1016/j.ciresp.2019.04.004

Diagnosis and Outcome of Acute Respiratory Failure in Immunocompromised after Bronchoscopy.

PMID: 31109985
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2019
Reference: Eur Respir J. 2019 Jul 25;54(1). pii: 13993003.02442-2018. doi: 10.1183/13993003.02442-2018. Print 2019 Jul.
Impact factor: 11.807
Publication type: Paper in international publication
Authors: Seguin, Amelie, Metaxa, Victoria, Lemiale, Virginie, Burghi, Gaston, Demoule, Alexandre, Karvunidis, Thomas, Cotoia, Antonella, Klepstad, Pal, Moller, Ann M, Mokart, Djamel et al.
DOI: 10.1183/13993003.02442-2018

Severe community-acquired pneumonia: optimal management.

PMID: 28067676
Journal: CURRENT OPINION IN INFECTIOUS DISEASES
Year: 2017
Reference: Curr Opin Infect Dis. 2017 Apr;30(2):240-247. doi: 10.1097/QCO.0000000000000349.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Rello, Jordi, Leoni, Davide et al.
DOI: 10.1097/QCO.0000000000000349

FLOR Index to Predict the Need of Mechanical Ventilation in Patients With Pneumonia Treated With High Flow Nasal Cannula.

PMID: 24638346
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):180A. doi: 10.1378/chest.1823812.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Caralt Ramisa, Berta, Roca, Oriol, Masclans, Joan Ramon, Garcia de Acilu, Marina, Rello, Jordi et al.
DOI: 10.1378/chest.1823812

Plasma ST2 Predicts Mortality in Patients With Acute Respiratory Distress Syndrome.

PMID: 24638340
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):174A. doi: 10.1378/chest.1822406.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Garcia de Acilu, Marina, Roca, Oriol, Masclans, Joan Ramon, Ruano, Laura, Rello, Jordi et al.
DOI: 10.1378/chest.1822406

Pneumonia and lung ultrasound in the intensive care unit.

PMID: 24638338
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):171A. doi: 10.1378/chest.1806646.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Parra, Ana, Perez, Purificacion, Serra, Joaquim, Roca, Oriol, Masclans, Joan Ramon, Rello, Jordi et al.
DOI: 10.1378/chest.1806646

Impact of the 2009 influenza A H1N1 pandemic on invasive pneumococcal disease in adults.

PMID: 24456230
Journal: SCAND J INFECT DIS
Year: 2014
Reference: Scand J Infect Dis. 2014 Mar;46(3):185-92. doi: 10.3109/00365548.2013.867072. Epub 2014 Jan 24.
Impact factor: 1.64
Publication type: Paper in international publication
Authors: Ardanuy, Carmen, Pedro-Botet, M Luisa, Burgos, Joaquin, Lujan, Manel, Gimenez, Montse, Rello, Jordi, Planes, Ana, Fontanals, Dionisia, Casas, Irma, Mateu, Lourdes et al.
DOI: 10.3109/00365548.2013.867072

Acute respiratory distress syndrome and stem cells: a small beginning or a strategy doomed to never gestate?

PMID: 23540875
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2013
Reference: Am J Respir Crit Care Med. 2013 Apr 1;187(7):674-5.
Impact factor: 11.041
Publication type: Editorail in international publication
Authors: Waterer, Grant W, Rello, Jordi et al.
DOI:

Innovative continuous non-invasive cuffless blood pressure monitoring based on photoplethysmography technology.

PMID: 23740275
Journal: INTENSIVE CARE MEDICINE
Year: 2013
Reference: Intensive Care Med. 2013 Sep;39(9):1618-25. doi: 10.1007/s00134-013-2964-2. Epub 2013 Jun 6.
Impact factor: 5.258
Publication type: Paper in international publication
Authors: Ruiz-Rodriguez, Juan C, Caballero, Jesus, Garcia-Roche, Alejandra, Riera, Jordi, Nuvials, Xavier, de Nadal, Miriam, de Sola-Morales, Oriol, Serra, Joaquim, Rello, Jordi, Ribas, Vicent et al.
DOI: 10.1007/s00134-013-2964-2

Middle ear effusion in mechanically ventilated patients: effects of the nasogastric tube.

PMID: 22781339
Journal: Respiratory Care
Year: 2013
Reference: Respir Care. 2013 Feb;58(2):273-8. doi: 10.4187/respcare.01911.
Impact factor: 2.03
Publication type: Paper in international publication
Authors: Condomines, Jordi Rello, Pena, Miriam Gonzalez, Massana, Enric Figuerola, Gutierrez, Pilar Hernandez et al.
DOI: 10.4187/respcare.01911

An unusual case of organizing pneumonia and infection by P. jirovecii.

PMID: 23044282
Journal: Medicina Intensiva
Year: 2013
Reference: Med Intensiva. 2013 May;37(4):299-300. doi: 10.1016/j.medin.2012.08.005. Epub 2012 Oct 6.
Impact factor: 1.323
Publication type: Letter whit IF
Authors: Caralt-Ramisa, B, Fernandez-Codina, A, Bravo, C, Rello, J, Farre, M, Masclans, J R et al.
DOI: 10.1016/j.medin.2012.08.005

First influenza season after the 2009 pandemic influenza: characteristics of intensive care unit admissions in adults and children in Vall d'Hebron Hospital.

PMID: 21851487
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2012
Reference: Clin Microbiol Infect. 2012 Apr;18(4):374-80. doi: 10.1111/j.1469-0691.2011.03617.x. Epub 2011 Aug 18.
Impact factor: 4.54
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1469-0691.2011.03617.x

[Paediatric ventricular assist: a healthcare reality with an encouraging future].

PMID: 22402103
Journal: ANALES DE PEDIATRIA
Year: 2012
Reference: An Pediatr (Barc). 2012 Mar;76(3):117-9.
Impact factor: 0.77
Publication type: Editorial in national publication
Authors: Sanchez de Toledo, J, Balcells, J et al.
DOI: 10.1016/j.anpedi.2012.01.026

Initial Management Of Pneumonia And Sepsis. Factors associated with improved outcome.

PMID: 21828033
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2012
Reference: Eur Respir J. 2012 Jan;39(1):156-62. Epub 2011 Aug 4.
Impact factor: 5.895
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1183/09031936.00188710

Ventilator-associated pneumonia caused by ESKAPE organisms: cause, clinical features, and management.

PMID: 22366995
Journal: CURRENT OPINION IN PULMONARY MEDICINE
Year: 2012
Reference: Curr Opin Pulm Med. 2012 May;18(3):187-93. doi: 10.1097/MCP.0b013e328351f974.
Impact factor: 3.075
Publication type: Review in international publication
Authors: , et al.
DOI: 10.1097/MCP.0b013e328351f974

Return of the flu: leadership, teamwork and foresight.

PMID: 21737180
Journal: Medicina Intensiva
Year: 2011
Reference: Med Intensiva. 2011 Nov;35(8):460-2. Epub 2011 Jul 6.
Impact factor: 1.496
Publication type: Editorial in national publication
Authors: , et al.
DOI: 10.1016/j.medin.2011.05.018

Predicting mortality in hospitalized patients with 2009 H1N1 influenza pneumonia.

PMID: 21396216
Journal: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Year: 2011
Reference: Int J Tuberc Lung Dis. 2011 Apr;15(4):542-6.
Impact factor: 2.557
Publication type: Paper in international publication
Authors: Figueroa, S, Saavedra, F, Pryluka, D, Inzunza, C, Torres, A, Alvare, P, Fernandez, P, Barros, M, Gomez, Y, Contreras, C et al.
DOI: 10.5588/ijtld.10.0539

Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis.

PMID: 21694907
Journal: Infect Drug Resist
Year: 2011
Reference: Infect Drug Resist. 2011;4:31-41. Epub 2011 Jan 25.
Impact factor:
Publication type: Letter or abstract
Authors: Rello, Jordi, Pahissa, Albert, Sorde, Roger et al.
DOI: 10.2147/IDR.S16263

Effect of antibiotic diversity on ventilator-associated pneumonia caused by ESKAPE Organisms

PMID: 21659436
Journal: CHEST
Year: 2011
Reference: Chest. 2011 Sep;140(3):643-51. Epub 2011 Jun 9.
Impact factor: 6.519
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1378/chest.11-0462

Blog

News

A study, in which Vall d'Hebron has participated, has analysed all the interventions of this type carried out between 2006 and 2020.

The work of the multinational team, which has reviewed the records of more than one million patients who have received a new organ, has found significant differences between women and men

The scientific review reports that changes in the respiratory system flora due to pollution increase the risk of suffering a hospital infection caused by multidrug-resistant organisms.