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Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS)

CRIPS is a research group focusing on severe acute respiratory infections and sepsis. 

The objective is to develop projects on clinical and translational research in hospital-acquired pneumonia, community-acquired pneumonia, and severe viral respiratory infections, such as influenza and COVID-19. CRIPS also develop epidemiological studies focused on risk and prognostic factors for multi-resistant pathogens, validation of ventilator-associated events in ventilated adult and pediatric patients, incorporating artificial intelligence techniques. It also highlights evidence-based medicine (EBM) research, evaluating therapies and prevention strategies and participating in the formulation of clinical practice guidelines, as part of CIBERES and the European Society for Clinical Microbiology and Infections. The EBM research focuses on knowledge translation to get research findings to the point of decision making, providing health-related recommendations, focusing on clinical research and relevance of care. 

CRIPS collaborate on a Local (UIC, IDIAP), National (CIBERES), and International level (CHU Nimes, Uolo University, ISARIC and Pneumo-Inspire Networks).

Publications

LYMPHOCYTIC THYROIDITIS TRANSCRIPTOMIC PROFILES SUPPORT THE ROLE OF CHECKPOINT PATHWAYS AND B CELLS IN PATHOGENESIS.

PMID: 35403441
Journal: THYROID
Year: 2022
Reference: Thyroid. 2022 Jun;32(6):682-693. doi: 10.1089/thy.2021.0694. Epub 2022 May 25.
Impact factor: 6.568
Publication type: Paper in international publication
Authors: Zafon, Carles, Alvarez de la Sierra, Daniel, Marin-Sanchez, Ana, Gomez-Brey, Aroa, Bello, Irene, Caubet, Enric, Moreno-Llorente, Pablo, Petit, Anna, Pujol-Borrell, Ricardo, Gonzalez, Oscar et al.
DOI: 10.1089/thy.2021.0694

Survival in rhino-orbito-cerebral mucormycosis: An international, multicenter ID-IRI study.

PMID: 35304041
Journal: European Journal of Internal Medicine
Year: 2022
Reference: Eur J Intern Med. 2022 Jun;100:56-61. doi: 10.1016/j.ejim.2022.03.008. Epub 2022 Mar 15.
Impact factor: 4.624
Publication type: Paper in international publication
Authors: Gunduz, Mehmet, Cag, Yasemin, Erdem, Hakan, Ural, Serap, Tasbakan, Meltem, Tattevin, Pierre, Tombak, Anil, Ozturk-Engin, Derya, Tartar, Ayse Sagmak, Batirel, Ayse et al.
DOI: 10.1016/j.ejim.2022.03.008

Impact of central venous pressure on the mortality of patients with sepsis-related acute kidney injury: a propensity score-matched analysis based on the MIMIC IV database.

PMID: 35280402
Journal: Annals of Translational Medicine
Year: 2022
Reference: Ann Transl Med. 2022 Feb;10(4):199. doi: 10.21037/atm-22-588.
Impact factor: 3.932
Publication type: Paper in international publication
Authors: Wang, Xinrui, Li, Bo, Rello, Jordi, Kim, Won Young, Wang, Xiaoting, Hu, Zhenjie, Huo, Yan et al.
DOI: 10.21037/atm-22-588

Protecting adults at risk of pneumococcal infection and influenza from exposure to SARS-CoV-2.

PMID: 34406914
Journal: Human Vaccines & Immunotherapeutics
Year: 2022
Reference: Hum Vaccin Immunother. 2022 Dec 31;18(1):1-7. doi: 10.1080/21645515.2021.1957647. Epub 2021 Aug 18.
Impact factor: 3.452
Publication type: Review in international publication
Authors: McIntosh, Edwin David George, Feemster, K, Rello, J et al.
DOI: 10.1080/21645515.2021.1957647

Neuraminidase inhibitors and single dose baloxavir are effective and safe in uncomplicated influenza: a meta-analysis of randomized controlled trials.

PMID: 33861168
Journal: Expert Review of Clinical Pharmacology
Year: 2021
Reference: Expert Rev Clin Pharmacol. 2021 Jul;14(7):901-918. doi: 10.1080/17512433.2021.1917378. Epub 2021 Apr 26.
Impact factor: 5.05
Publication type: Paper in international publication
Authors: Tejada, Sofia, Tejo, Alexandre M, Pena-Lopez, Yolanda, Forero, Carlos G, Corbella, Xavier, Rello, Jordi et al.
DOI: 10.1080/17512433.2021.1917378

Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance.

PMID: 33090711
Journal: FEBS Journal
Year: 2021
Reference: FEBS J. 2021 Apr;288(7):2184-2202. doi: 10.1111/febs.15588. Epub 2020 Nov 3.
Impact factor: 5.542
Publication type: Paper in international publication
Authors: Abad, Etna, Civit, Laia, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex et al.
DOI: 10.1111/febs.15588

Managing adult patients with infectious diseases in emergency departments: international ID-IRI study.

PMID: 33734040
Journal: JOURNAL OF CHEMOTHERAPY
Year: 2021
Reference: J Chemother. 2021 Sep;33(5):302-318. doi: 10.1080/1120009X.2020.1863696. Epub 2021 Mar 18.
Impact factor: 1.714
Publication type: Paper in international publication
Authors: Ceviker, Sevil Alkan, Erdem, Hakan, Hargreaves, Sally, Ankarali, Handan, Caskurlu, Hulya, Aslan, Selda, Dar, Razi Even, Abdalla, Esam, Monzon-Camps, Helena, Baljic, Rusmir et al.
DOI: 10.1080/1120009X.2020.1863696

[Restrictive cardiomyopathy: Importance of early diagnosis].

PMID: 33712406
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Mar 9. pii: S1695-4033(20)30498-7. doi: 10.1016/j.anpedi.2020.11.012.
Impact factor: 1.5
Publication type: Letter whit IF
Authors: Brunet-Garcia, Laia, Roses-Noguer, Ferran, Betrian, Pedro, Balcells, Joan, Gran, Ferran et al.
DOI: 10.1016/j.anpedi.2020.11.012

Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center.

PMID: 33063032
Journal: Critical care explorations
Year: 2020
Reference: Crit Care Explor. 2020 Sep 28;2(10):e0228. doi: 10.1097/CCE.0000000000000228. eCollection 2020 Oct.
Impact factor: 0
Publication type: Paper in international publication
Authors: Cortina, Alexandra, Riera, Jordi, Argudo, Eduard, Martinez-Martinez, Maria, Garcia, Sandra, Garcia-de-Acilu, Marina, Santafe, Manel, Diaz, Candido, Contreras, Sofia, Resta, Paula et al.
DOI: 10.1097/CCE.0000000000000228

Severe palmar hyperkeratosis and haematochezia in COVID-19.

PMID: 33070420
Journal: Dermatologic Therapy
Year: 2020
Reference: Dermatol Ther. 2020 Nov;33(6):e14423. doi: 10.1111/dth.14423. Epub 2020 Oct 26.
Impact factor: 2.327
Publication type: Letter whit IF
Authors: Tammaro, Antonella, Adebanjo, Ganiyat Adenike Ralitsa, Chello, Camilla, Parisella, Francesca Romana, Rello, Jordi, Del Nonno, Franca, Scarabello, Alessandra et al.
DOI: 10.1111/dth.14423

A systematic review on the impact of appropriate versus inappropriate initial antibiotic therapy on the outcomes of patients with severe bacterial infections.

PMID: 33045353
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2020
Reference: Int J Antimicrob Agents. 2020 Dec;56(6):106184. doi: 10.1016/j.ijantimicag.2020.106184. Epub 2020 Oct 9.
Impact factor: 4.621
Publication type: Review in international publication
Authors: Blasi, Francesco, Goossens, Herman, Sotgiu, Giovanni, Tavoschi, Lara, Zasowski, Evan J, Arber, Mick R, McCool, Rachael, Patterson, Jacoby V, Longshaw, Christopher M, Lopes, Sara et al.
DOI: 10.1016/j.ijantimicag.2020.106184

Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020).

PMID: 33020069
Journal: European Respiratory Review
Year: 2020
Reference: Eur Respir Rev. 2020 Oct 5;29(157). pii: 29/157/200287. doi: 10.1183/16000617.0287-2020. Print 2020 Sep 30.
Impact factor: 6.22
Publication type: Review in international publication
Authors: Krishnan, Jerry A, Bai, Chunxue, Chotirmall, Sanjay H, Rello, Jordi, Alba, George A, Ginns, Leo C, Hough, Catherine L, Jagpal, Sugeet, Jeon, Kyeongman, Johkoh, Takeshi et al.
DOI: 10.1183/16000617.0287-2020

Alternatives to antibiotics in an era of difficult-to-treat resistance: new insights.

PMID: 31092053
Journal: Expert Review of Clinical Pharmacology
Year: 2019
Reference: Expert Rev Clin Pharmacol. 2019 Jul;12(7):635-642. doi: 10.1080/17512433.2019.1619454. Epub 2019 May 27.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Rello, Jordi, Parisella, Francesca Romana, Perez, Antonio et al.
DOI: 10.1080/17512433.2019.1619454

Valuing antibiotics: The role of the hospital clinician.

PMID: 31085298
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2019
Reference: Int J Antimicrob Agents. 2019 Jul;54(1):16-22. doi: 10.1016/j.ijantimicag.2019.05.012. Epub 2019 May 11.
Impact factor: 4.615
Publication type: Editorail in international publication
Authors: Masterton, Robert G, Bassetti, Matteo, Chastre, Jean, MacDonald, Alan G, Rello, Jordi, Seaton, R Andrew, Welte, Tobias, West, Peter, Wilcox, Mark H et al.
DOI: 10.1016/j.ijantimicag.2019.05.012

Plasma levels of mid-regional pro-adrenomedullin in sepsis are associated with risk of death.

PMID: 30207133
Journal: Minerva Anestesiologica
Year: 2019
Reference: Minerva Anestesiol. 2019 Apr;85(4):366-375. doi: 10.23736/S0375-9393.18.12687-3. Epub 2018 Sep 10.
Impact factor: 2.84
Publication type: Paper in international publication
Authors: Rodriguez-Gutierrez, Juan F, Estella Garcia, Angel, Fernandez-Ruiz, Laura, Gonzalez-Garcia, Maria A, Rello, Jordi, Austria, Rafael Bohollo de, Valenzuela-Mendez, Blanca, Valenzuela-Sanchez, Francisco et al.
DOI: 10.23736/S0375-9393.18.12687-3

Cytokine release syndrome. Reviewing a new entity in the intensive care unit.

PMID: 30922608
Journal: Medicina Intensiva
Year: 2019
Reference: Med Intensiva. 2019 Nov;43(8):480-488. doi: 10.1016/j.medin.2019.01.009. Epub 2019 Mar 25.
Impact factor: 1.982
Publication type: Paper in national publication
Authors: Roche, Alejandra Garcia, Lagares, Candido Diaz, Elez, Elena, Roca, Ricard Ferrer et al.
DOI: 10.1016/j.medin.2019.01.009

[Diaphragmatic defect, congenital heart disease, agonadism: a new case of PAGOD syndrome.]

PMID: 24582125
Journal: AN PEDIATR
Year: 2014
Reference: An Pediatr (Barc). 2014 Dec;81(6):e34-5. doi: 10.1016/j.anpedi.2013.11.009. Epub 2014 Feb 26.
Impact factor: 0.722
Publication type: Letter whit IF
Authors: Gil, L, Sanchez-de-Toledo, J, Ferreres, J C, Vendrell, T, Ruiz-Campillo, C W, Balcells, J et al.
DOI: 10.1016/j.anpedi.2013.11.009

Risk factors for respiratory failure in pneumococcal pneumonia. The importance of pneumococcal serotypes.

PMID: 23845720
Journal: EUR RESPIR J
Year: 2014
Reference: Eur Respir J. 2014 Feb;43(2):545-53. doi: 10.1183/09031936.00050413. Epub 2013 Jul 11.
Impact factor: 7.125
Publication type: Paper in international publication
Authors: M Planes, Ana, Puig, Mireia, Rello, Jordi, Falco, Vicenc, Pahissa, Albert, Bermudo, Guadalupe, Fontanals, Dionisia, Lujan, Manel, Burgos, Joaquin, Larrosa, M Nieves et al.
DOI: 10.1183/09031936.00050413

Impact of the emergence of non-vaccine pneumococcal serotypes on the clinical presentation and outcome of adults with invasive pneumococcal pneumonia.

PMID: 22583156
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2013
Reference: Clin Microbiol Infect. 2013 Apr;19(4):385-91. doi: 10.1111/j.1469-0691.2012.03895.x. Epub 2012 May 14.
Impact factor: 4.578
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1469-0691.2012.03895.x

A care bundle approach for prevention of ventilator-associated pneumonia.

PMID: 22439889
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2013
Reference: Clin Microbiol Infect. 2013 Apr;19(4):363-9. doi: 10.1111/j.1469-0691.2012.03808.x. Epub 2012 Mar 22.
Impact factor: 4.578
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1469-0691.2012.03808.x

[Incident reporting system and management of incidents. Implementation and improvement actions derived for patient safety. One year experience.]

PMID: 23246168
Journal: MEDICINA CLINICA
Year: 2013
Reference: Med Clin (Barc). 2013 Apr 15;140(7):320-4. doi: 10.1016/j.medcli.2012.09.038. Epub 2012 Dec 13.
Impact factor: 1.399
Publication type: Paper in national publication
Authors: Angles, Roser, Llinas, Montserrat, Alerany, Carme, Garcia, Maria Victoria et al.
DOI: 10.1016/j.medcli.2012.09.038

Antifungal prophylaxis in the postoperative period of lung transplant surgery in Spain.

PMID: 23260267
Journal: Medicina Intensiva
Year: 2013
Reference: Med Intensiva. 2013 Apr;37(3):201-205. doi: 10.1016/j.medin.2012.10.003. Epub 2012 Dec 20.
Impact factor: 1.323
Publication type: Paper in national publication
Authors: Sacanell, J, Rey, T, Lopez, E, Vicente, R, Ballesteros, M A, Iranzo, R, Robles, J C, Restrepo, M I, Rello, J et al.
DOI: 10.1016/j.medin.2012.10.003

Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza.

PMID: 22240033
Journal: JOURNAL OF INFECTION
Year: 2012
Reference: J Infect. 2012 Mar;64(3):311-8. doi: 10.1016/j.jinf.2011.12.010. Epub 2012 Jan 2.
Impact factor: 4.126
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.jinf.2011.12.010

Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock. A prospective pilot study.

PMID: 22257436
Journal: Medicina Intensiva
Year: 2012
Reference: Med Intensiva. 2012 Oct;36(7):475-80. doi: 10.1016/j.medin.2011.11.024. Epub 2012 Jan 16.
Impact factor: 1.072
Publication type: Paper in national publication
Authors: , , , , , , et al.
DOI: 10.1016/j.medin.2011.11.024

E. coli O104:H4 outbreak and haemolytic-uraemic syndrome.

PMID: 22244215
Journal: Medicina Intensiva
Year: 2012
Reference: Med Intensiva. 2012 Nov;36(8):576-83. doi: 10.1016/j.medin.2011.11.022. Epub 2012 Jan 13.
Impact factor: 1.072
Publication type: Review in national publication
Authors: , , et al.
DOI: 10.1016/j.medin.2011.11.022

Mortality and Regional Oxygen Saturation Index in Septic Shock Patients: A Pilot Study.

PMID: 21610429
Journal: JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
Year: 2011
Reference: J Trauma. 2011 May;70(5):1145-1152.
Impact factor: 3.129
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1097/TA.0b013e318216f72c

The Relevance of Drug Volume of Distribution in Antibiotic Dosing.

PMID: 21554218
Journal: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Year: 2011
Reference: Curr Pharm Biotechnol. 2011 Dec 1;12(12):1996-2001.
Impact factor: 3.455
Publication type: Review in international publication
Authors: , et al.
DOI:

Emerging drugs for pneumococcal pneumonia.

PMID: 21486118
Journal: EXPERT OPINION ON EMERGING DRUGS
Year: 2011
Reference: Expert Opin Emerg Drugs. 2011 Sep;16(3):459-77. doi: 10.1517/14728214.2011.576669. Epub 2011 Apr 12.
Impact factor: 3.284
Publication type: Review in international publication
Authors: , , , et al.
DOI: 10.1517/14728214.2011.576669

First influenza season after the 2009 pandemic influenza: report of the first 300 ICU admissions in Spain.

PMID: 21496964
Journal: Medicina Intensiva
Year: 2011
Reference: Med Intensiva. 2011 May;35(4):208-16. Epub 2011 Apr 14.
Impact factor: 1.496
Publication type: Paper in national publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.medin.2011.03.001

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