Skip to main content

Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Team

Pilar Costa Forner

Pilar Costa Forner

Predoctoral researcher
Diabetes and Metabolism
Read more
Reyes Malia, Olga

Reyes Malia, Olga

Research technician
Diabetes and Metabolism
Read more
Alba Rojano Toimil

Alba Rojano Toimil

Predoctoral researcher
Diabetes and Metabolism
Read more
Alejandra Planas Vilaseca

Alejandra Planas Vilaseca

Diabetes and Metabolism
Read more
Ana Alvarez Guaita

Ana Alvarez Guaita

Postdoctoral researcher
Diabetes and Metabolism
Read more
Andreea Ciudin Mihai

Andreea Ciudin Mihai

Main researcher
Diabetes and Metabolism
Read more
Pilar Costa Forner

Pilar Costa Forner

Predoctoral researcher
Diabetes and Metabolism
Read more
Reyes Malia, Olga

Reyes Malia, Olga

Research technician
Diabetes and Metabolism
Read more
Alba Rojano Toimil

Alba Rojano Toimil

Predoctoral researcher
Diabetes and Metabolism
Read more
Alejandra Planas Vilaseca

Alejandra Planas Vilaseca

Diabetes and Metabolism
Read more
Ana Alvarez Guaita

Ana Alvarez Guaita

Postdoctoral researcher
Diabetes and Metabolism
Read more
Andreea Ciudin Mihai

Andreea Ciudin Mihai

Main researcher
Diabetes and Metabolism
Read more

Projects

TBC

IP: Rafael Simó Canonge
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 111758
Reference: PREP2022-000737
Duration: 01/03/2024 - 29/02/2028

Ministerio de Ciencia

Mechanisms of metabolic adaptation after weight loss in obesity. Clinical phenotyping and therapeutic approach.

IP: Andreea Ciudin Mihai
Collaborators: Cristina Gamez Cenzano, Eduard Rodenas Alesina, Ana Marti Delgado, Fiorella Ximena Palmas Candia, Bruno García del Blanco, Ana Belén Méndez Fernández, Ana Maria Ciscar Bellés, Aleix Olivella San emeterio, Marta Comas Martínez, Alvaro Calabuig Goena, Enzamaría Fidilio Meli, Marco Tomasino
Funding agency: Instituto de Salud Carlos III
Funding: 165000
Reference: PI23/01209
Duration: 01/01/2024 - 31/12/2026

Funciones Alternativas de la Sex Hormone-Binding Globulin: Mecanismos Moleculares y Papel en Fisiología y Fisiopatología

IP: David Martinez Selva
Collaborators: Maria Teresa Salcedo Allende, Lorena Ramos Pérez, Pablo Gabriel Medina, Pilar Costa Forner
Funding agency: Instituto de Salud Carlos III
Funding: 190000
Reference: PI23/00544
Duration: 01/01/2024 - 31/12/2026

Nuevos retos en investigación sobre plasticidad adiposa (ADIPOBROAD)"

IP: Josep A Villena Delgado
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 0.01
Reference: RED2022-134313-T
Duration: 01/06/2023 - 31/05/2025

Ministerio de Ciencia

Publications

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration.

PMID: 38581053
Journal: Molecular Neurodegeneration
Year: 2024
Reference: Mol Neurodegener. 2024 Apr 5;19(1):32. doi: 10.1186/s13024-024-00724-w.
Impact factor:
Publication type: Paper in international publication
Authors: Dashwood, Amy; de Fuente, Alerie G; Dombrowski, Yvonne; Dooley, James; Fitzgerald, Denise C; Liston, Adrian; Llorian-Salvador, Maria; McMurran, Christopher E; Penalva, Rosana; Stitt, Alan W et al.
DOI: 10.1186/s13024-024-00724-w

Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment.

PMID: 38673411
Journal:
Year: 2024
Reference: Int J Environ Res Public Health. 2024 Apr 18;21(4):500. doi: 10.3390/ijerph21040500.
Impact factor:
Publication type: Paper in international publication
Authors: Arino-Blasco, Sergio; Ars, Joan; Barahona, Maria Jose; Castellano-Tejedor, Carmina; Ciudin, Andreea; Crespo-Maraver, Maria Cruz; Franco, Maite; Girones, Xavier; Hernandez, Cristina; Inzitari, Marco et al.
DOI: 10.3390/ijerph21040500

High-dimensional Mass Cytometry identified circulating Natural Killer T-cell subsets associated with protection from Cytomegalovirus infection in kidney transplant recipients.

PMID: 38685562
Journal: KIDNEY INTERNATIONAL
Year: 2024
Reference: Kidney Int. 2024 Apr 27:S0085-2538(24)00310-7. doi: 10.1016/j.kint.2024.03.027.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Bin, Sofia; Couzi, Lionel; Cravedi, Paolo; Crespo, Elena; Donadeu, Laura; Font-Minarro, Cristina; Hartzell, Susan; Jarque, Marta; Jouve, Thomas et al.
DOI: 10.1016/j.kint.2024.03.027

Role of Systemic Factors in Improving the Prognosis of Diabetic Retinal Disease and Predicting Response to Diabetic Retinopathy Treatment.

PMID: 38694495
Journal:
Year: 2024
Reference: Ophthalmol Sci. 2024 Feb 17;4(4):100494. doi: 10.1016/j.xops.2024.100494. eCollection 2024 Jul-Aug.
Impact factor:
Publication type: Paper in international publication
Authors: Beulens, Joline W J; Bhandari, Sanjeeb; Broadhead, Geoffrey; Chew, Emily; Colhoun, Helen; Fickweiler, Ward; Gordin, Daniel; Jeyam, Anita; Mellor, Joe; Simo, Rafael et al.
DOI: 10.1016/j.xops.2024.100494

Insights into Insulin Resistance and Calcification in the Myocardium in Type 2 Diabetes: A Coronary Artery Analysis.

PMID: 36834662
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Feb 7;24(4):3250. doi: 10.3390/ijms24043250.
Impact factor:
Publication type: Paper in international publication
Authors: Aguade-Bruix, Santiago; Aparicio-Gomez, Carolina; Gonzalez Ballester, Miguel A; Herance, Jose Raul; Hernandez, Cristina; Hernandez, Cristina; Martin-Saladich, Queralt; Pizzi, Maria Nazarena; Ramirez-Serra, Clara; Roque, Albert et al.
DOI: 10.3390/ijms24043250

Usefulness of Ultrasound in Assessing the Impact of Bariatric Surgery on Body Composition: a Pilot Study.

PMID: 36849786
Journal: OBESITY SURGERY
Year: 2023
Reference: Obes Surg. 2023 Apr;33(4):1211-1217. doi: 10.1007/s11695-023-06510-9. Epub 2023 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, N; Barahona, M J; Ibarra, M; Libran, M; Perea, V; Puertolas, N; Quiros, C; Simo, R; Simo-Servat, A et al.
DOI: 10.1007/s11695-023-06510-9

Thyroid cells from normal and autoimmune thyroid glands suppress T lymphocytes proliferation upon contact revealing a new regulatory inhibitory type of interaction independent of PD1/PDL1.

PMID: 36857863
Journal: JOURNAL OF AUTOIMMUNITY
Year: 2023
Reference: J Autoimmun. 2023 Apr;136:103013. doi: 10.1016/j.jaut.2023.103013. Epub 2023 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Abad, Maria; Alvarez-Sierra, Daniel; Bello, Irene; Caubet, Enric; Cruz Cobo, Maria; Cruz Cobo, Maria; Escriche, Alba; Escriche, Alba; Fernandez-Sanmartin, Marco Antonio; Gomez-Brey, Aroa et al.
DOI: 10.1016/j.jaut.2023.103013

Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits.

PMID: 36870015
Journal: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Year: 2023
Reference: J Endocrinol Invest. 2023 Sep;46(9):1875-1880. doi: 10.1007/s40618-023-02046-y. Epub 2023 Mar 4.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, A; Hernandez, C; Hernandez, C; Lainez, E; Ortiz-Zuniga, A M; Raguer, N; Rahnama, K; Rojano Toimil, A; Rojano Toimil, A; Simo, R et al.
DOI: 10.1007/s40618-023-02046-y

Use of multikinase inhibitors/lenvatinib in singular thyroid cancer scenarios.

PMID: 36202604
Journal: Cancer Medicine
Year: 2022
Reference: Cancer Med. 2022 Oct;11 Suppl 1:3-4. doi: 10.1002/cam4.5154.
Impact factor:
Publication type: Review in international publication
Authors: Castelo, Beatriz; Zafon, Carles et al.
DOI: 10.1002/cam4.5154

Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain.

PMID: 36187107
Journal: Frontiers in Endocrinology
Year: 2022
Reference: Front Endocrinol (Lausanne). 2022 Sep 16;13:984877. doi: 10.3389/fendo.2022.984877. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez Guivernau, Elia; Alvarez-Escola, Cristina; Araujo-Castro, Marta; Ares, Jessica; Bernabeu, Ignacio; Biagetti, Betina; Camara, Rosa; Cordido, Fernando; Diez, Juan J; Garcia Gomez, Carlos et al.
DOI: 10.3389/fendo.2022.984877

Risk of infections in patients with NAFLD and Type 2 Diabetes under treatment with SGLT2 inhibitors and relationship with liver outcomes: A retrospective case-control study.

PMID: 36093073
Journal: Frontiers in Endocrinology
Year: 2022
Reference: Front Endocrinol (Lausanne). 2022 Aug 24;13:945626. doi: 10.3389/fendo.2022.945626. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Camps-Relats, Laura; Ciudin, Andreea; Genesca, Joan; Manzano-Nunez, Ramiro; Pericas, Juan M; Pons, Monica; Prio, Alba; Rivera-Esteban, Jesus; Ruiz-Ortega, Lourdes et al.
DOI: 10.3389/fendo.2022.945626

Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes.

PMID: 36052329
Journal: Frontiers in Medicine
Year: 2022
Reference: Front Med (Lausanne). 2022 Aug 16;9:945245. doi: 10.3389/fmed.2022.945245. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Barrot, Joan; Castelblanco, Esmeralda; Franch-Nadal, Josep; Mata-Cases, Manel; Mauricio, Didac; Mundet-Tuduri, Xavier; Real, Jordi; Romero-Aroca, Pedro; Simo, Rafael; Vlacho, Bogdan et al.
DOI: 10.3389/fmed.2022.945245

Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson's Syndrome: A Case Report.

PMID: 34858324
Journal: Frontiers in Endocrinology
Year: 2021
Reference: Front Endocrinol (Lausanne). 2021 Nov 11;12:731631. doi: 10.3389/fendo.2021.731631. eCollection 2021.
Impact factor:
Publication type: Letter whit IF
Authors: Aubanell, Anton; Biagetti, Betina; Capdevila, Jaume; Chaachou, Anas; Filippi-Arriaga, Francesca; Garcia-Alvarez, Alejandro; Hernandez Hernandez, Irene; Hernando, Jorge; Martinez-Saez, Elena; Mirallas, Oriol et al.
DOI: 10.3389/fendo.2021.731631

Thyroid disorders associated with immune control point inhibitors.

PMID: 34742474
Journal: Endocrinologia Diabetes y Nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2021 Jun-Jul;68(6):408-415. doi: 10.1016/j.endien.2021.10.004. Epub 2021 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: Anda Apinaniz, Emma; Diez Gomez, Juan Jose; Fidilio, Enzamaria; Iglesias, Pedro; Navarro-Gonzalez, Elena; Romero-Lluch, Ana R; Santos Mazo, Estefania; Zafon, Carles et al.
DOI: 10.1016/j.endien.2021.10.004

Recovery of parathyroid function in patients with thyroid cancer treated by total thyroidectomy: An analysis of 685 patients with hypoparathyroidism at discharge of surgery.

PMID: 34742473
Journal: Endocrinologia Diabetes y Nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2021 Jun-Jul;68(6):398-407. doi: 10.1016/j.endien.2021.10.009.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Escola, Cristina; Anda, Emma; Baena-Nieto, Gloria; Bandres, Orosia; Blanco-Carrera, Concepcion; Diez, Juan J; Donnay, Sergio; Fernandez-Garcia, Jose Carlos; Galofre, Juan C; Iglesias, Pedro et al.
DOI: 10.1016/j.endien.2021.10.009

Bidirectional relationship between diabetes and pulmonary function: A systematic review and meta-analysis.

PMID: 32889114
Journal: DIABETES & METABOLISM
Year: 2021
Reference: Diabetes Metab. 2021 Sep;47(5):101186. doi: 10.1016/j.diabet.2020.08.003. Epub 2020 Sep 1.
Impact factor:
Publication type: Review in international publication
Authors: Cai, Yao-Hua; Han, Min; Lecube, Albert; Qi, Lu; Shu, Lin-Ping; Simo, Rafael; Yang, Jinkui; Zhang, Rui-Heng; Zhou, Jianbo et al.
DOI: 10.1016/j.diabet.2020.08.003

Assessing the user experience and usability of the PRECIOUS system: a randomized controlled trial in obese patients.

PMID: 32713290
Journal: Informatics for Health & Social Care
Year: 2020
Reference: Inform Health Soc Care. 2020 Oct 1;45(4):410-427. doi: 10.1080/17538157.2020.1776292. Epub 2020 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Castellano-Tejedor, Carmina; Ciudin, Andreea; Ginchev, Todor; Knittle, Keegan; Lusilla-Palacios, Pilar; Moreno, Jordi; Nurmi, Johanna; Parramon, Gemma; Ramos-Quiroga, Jose Antonio et al.
DOI: 10.1080/17538157.2020.1776292

Utility of Insulin Resistance in Estimating Cardiovascular Risk in Subjects with Type 1 Diabetes According to the Scores of the Steno Type 1 Risk Engine.

PMID: 32664522
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Jul 11;9(7). pii: jcm9072192. doi: 10.3390/jcm9072192.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Lara; Astiarraga, Brenno; Cano, Albert; Fernandez-Veledo, Sonia; Gonzalez-Clemente, Jose-Miguel; Gonzalez-Sastre, Montserrat; Llaurado, Gemma; Martinez, Laia; Mazarico, Isabel; Simo, Rafael et al.
DOI: 10.3390/jcm9072192

Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue.

PMID: 32652892
Journal: MOLECULAR NUTRITION & FOOD RESEARCH
Year: 2020
Reference: Mol Nutr Food Res. 2020 Sep;64(17):e1901253. doi: 10.1002/mnfr.201901253. Epub 2020 Jul 23.
Impact factor:
Publication type: Paper in international publication
Authors: Brianso-Llort, Laura; Fuertes-Rioja, Lidia; Hernandez, Cristina; Ramos-Perez, Lorena; Selva, David M; Simo, Rafael et al.
DOI: 10.1002/mnfr.201901253

Combining metabolic profiling of plasma and faeces as a fingerprint of insulin resistance in obesity.

PMID: 31708234
Journal: CLINICAL NUTRITION
Year: 2020
Reference: Clin Nutr. 2020 Jul;39(7):2292-2300. doi: 10.1016/j.clnu.2019.10.022. Epub 2019 Oct 25.
Impact factor:
Publication type: Paper in international publication
Authors: Caballano-Infantes, Estefania; Fernandez-Real, Jose-Manuel; Herance, Jose Raul; Mares, Roso; Mayneris-Perxachs, Jordi; Palomino-Schatzlein, Martina; Palomo-Buitrago, Maria-Encarnacion; Ricart, Wilfredo; Rodriguez, Maria Arnoriaga; Simo, Rafael et al.
DOI: 10.1016/j.clnu.2019.10.022

Correction to: Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis.

PMID: 31641934
Journal: ENDOCRINE
Year: 2019
Reference: Endocrine. 2019 Nov;66(2):416. doi: 10.1007/s12020-019-02108-3.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez-Escola, Cristina; Anda, Emma; Baena-Nieto, Gloria; Bandres, Orosia; Blanco Carrera, Concepcion; Diez, Juan J; Donnay, Sergio; Fernandez Garcia, Jose Carlos; Galofre, Juan Carlos; Iglesias, Pedro et al.
DOI: 10.1007/s12020-019-02108-3

Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.

PMID: 31561638
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Sep 26;8(10). pii: jcm8101549. doi: 10.3390/jcm8101549.
Impact factor:
Publication type: Paper in international publication
Authors: Aulinas, Anna; Biagetti, Betina; Castano, J P; Ferrer, Roser; Herance, J R; Luque, Raul M; Mesa, Jordi; Palomino-Schatzlein, Martina; Simo, Rafael et al.
DOI: 10.3390/jcm8101549

MEN1-associated primary hyperparathyroidism in the Spanish registry: clinical characteristics and surgical outcomes.

PMID: 31557724
Journal: Endocrine Connections
Year: 2019
Reference: Endocr Connect. 2019 Oct;8(10):1416-1424. doi: 10.1530/EC-19-0321.
Impact factor:
Publication type: Paper in international publication
Authors: Alcazar, Victoria; Alvarez-Escola, Cristina; Boix, Evangelina; Calatayud, Maria; Casteras, Anna; Forga Llenas, Lluis; Lamas, Cristina; Mesa, Jordi; Navarro, Elena; Oriola, Josep et al.
DOI: 10.1530/EC-19-0321

delta Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes.

PMID: 31529081
Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Year: 2019
Reference: Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3842-3853. doi: 10.1167/iovs.19-26761.
Impact factor:
Publication type: Paper in international publication
Authors: Datilo, Marcella N; Duarte, Diego A; Garcia-Ramirez, Marta; Lopes de Faria, Jacqueline M; Lopes de Faria, Jose B; Pasqualetto, Francieli C; Simo, Rafael et al.
DOI: 10.1167/iovs.19-26761

Metabolic fingerprint of insulin resistance in human polymorphonuclear leucocytes.

PMID: 30005063
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Jul 13;13(7):e0199351. doi: 10.1371/journal.pone.0199351. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea; Herance, Jose Raul; Hernandez, Cristina; Hernandez-Mijares, Antonio; Mateos-Gregorio, Pablo; Palomino-Schatzlein, Martina; Pineda-Lucena, Antonio; Simo, Rafael et al.
DOI: 10.1371/journal.pone.0199351

Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome.

PMID: 29995279
Journal: Current nutrition reports
Year: 2018
Reference: Current Nutrition Reports. 2018 Sep 11;7(3):161-70. doi: 10.1007/s13668-018-0228-z.
Impact factor:
Publication type: Review in international publication
Authors: Angarita, Lisse; Bermudez, Valmore; Contreras, Julio; de Bravo, Mayela Cabrera; Faria, Judith; Fidilio, Enzamaria; Kuzmar, Isaac; Mantilla, Linda Pamela; Mathew, Justin; Motlaghzadeh, Yasaman et al.
DOI: 10.1007/s13668-018-0228-z

Barcelona Longitudinal Growth Study 1995-2017.

PMID: 29885743
Journal: Endocrinologia, diabetes y nutricion
Year: 2018
Reference: Endocrinol Diabetes Nutr. 2018 Jun - Jul;65(6):311-313. doi: 10.1016/j.endinu.2018.05.002.
Impact factor:
Publication type: Editorial in national publication
Authors: Carrascosa, Antonio; Mesa, Jordi et al.
DOI: 10.1016/j.endinu.2018.05.002

Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases.

PMID: 29847632
Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Year: 2018
Reference: Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2264-2274. doi: 10.1167/iovs.17-23678.
Impact factor:
Publication type: Paper in international publication
Authors: Barber, Alistair J; Dunklebarger, Mitchell; Garcia-Ramirez, Marta; Gardner, Thomas W; Hernandez, Cristina; Laremore, Tatiana; Simo, Rafael; Simo-Servat, Olga; Sundstrom, Jeffrey M; Tiberti, Natalia et al.
DOI: 10.1167/iovs.17-23678

Association of HMGB1 with oxidative stress markers and regulators in PDR.

PMID: 29259392
Journal: MOLECULAR VISION
Year: 2017
Reference: Mol Vis. 2017 Dec 5;23:853-871. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Abu El-Asrar, Ahmed M; Ahmad, Ajmal; Alam, Kaiser; De Hertogh, Gert; Garcia-Ramirez, Marta; Mohammad, Ghulam; Mousa, Ahmed; Opdenakker, Ghislain; Siddiquei, Mohammad Mairaj; Simo, Rafael et al.
DOI:

Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome.

PMID: 29170528
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Nov 23;7(1):16102. doi: 10.1038/s41598-017-16487-y.
Impact factor:
Publication type: Paper in international publication
Authors: Aranda, Miguel; Brils, Gemma; Cuevas, Antoni; de Quixano, Beatriz Bardaji; Hespel, Theana; Lekuona, Haizea; Meseguer, Anna; Suarez, Cristina; Tornavaca, Olga; Villena, Josep A et al.
DOI: 10.1038/s41598-017-16487-y

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier.

PMID: 29168876
Journal: LAB ON A CHIP
Year: 2017
Reference: Lab Chip. 2017 Dec 19;18(1):95-105. doi: 10.1039/c7lc00795g.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta; Guimera, Anton; Hernandez, Cristina; Illa, Xavi; Simo, Rafael; Villa, Rosa; Yeste, Jose et al.
DOI: 10.1039/c7lc00795g

Mechanisms of retinal neuroprotection of calcium dobesilate: therapeutic implications.

PMID: 29171425
Journal: Neural Regeneration Research
Year: 2017
Reference: Neural Regen Res. 2017 Oct;12(10):1620-1622. doi: 10.4103/1673-5374.217333.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga; Sola-Adell, Cristina et al.
DOI: 10.4103/1673-5374.217333

Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.

PMID: 28050125
Journal: MOLECULAR VISION
Year: 2016
Reference: Mol Vis. 2016 Dec 30;22:1522-1531. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Arroba, Ana I; Beltramo, Elena; Cazzoni, Daniele; Hernandez, Cristina; Mazzeo, Aurora; Porta, Massimo; Simo, Rafael; Valverde, Angela M et al.
DOI:

The Role of Morbid Obesity in the Promotion of Metabolic Disruptions and Non-Alcoholic Steatohepatitis by Helicobacter Pylori.

PMID: 27893763
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Nov 28;11(11):e0166741. doi: 10.1371/journal.pone.0166741. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Baena, Juan Antonio; Bueno, Marta; Ciudin, Andreea; de Torres, Ines; Fort, Jose Manuel; Gutierrez, Liliana; Lecube, Albert; Lopez-Cano, Carolina; Matias-Guiu, Xavier; Pallares, Judit et al.
DOI: 10.1371/journal.pone.0166741

Efficacy and Safety of Once-Daily Insulin Degludec/Insulin Aspart versus Insulin Glargine (U100) for 52 Weeks in Insulin-Naive Patients with Type 2 Diabetes: A Randomized Controlled Trial.

PMID: 27760129
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Oct 19;11(10):e0163350. doi: 10.1371/journal.pone.0163350. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Franek, Edward; Kumar, Ajay; Mersebach, Henriette; Niemeyer, Marcus; Simo, Rafael; Wise, Jonathan et al.
DOI: 10.1371/journal.pone.0163350

New Treatments for Type 2 Diabetes Mellitus and Cardiovascular Disease. The Revolution Has Begun.

PMID: 27659856
Journal: Revista espanola de cardiologia (English ed.)
Year: 2016
Reference: Rev Esp Cardiol (Engl Ed). 2016 Nov;69(11):1005-1007. doi: 10.1016/j.rec.2016.07.009. Epub 2016 Sep 19.
Impact factor:
Publication type: Review in national publication
Authors: Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.1016/j.rec.2016.07.009

Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study.

PMID: 26338040
Journal: CARDIOVASC DIABETOL
Year: 2015
Reference: Cardiovasc Diabetol. 2015 Sep 4;14:116. doi: 10.1186/s12933-015-0279-z.
Impact factor:
Publication type: Paper in international publication
Authors: Dotta, Francesco; Festa, Andreas; Gallwitz, Baptist; Guerci, Bruno; Kiljanski, Jacek; Rosas-Guzman, Juan; Schernthaner, Guntram; Simo, Rafael; Zhou, Ming et al.
DOI: 10.1186/s12933-015-0279-z

SHBG-C57BL/ksJ-db/db: a new mouse model to study SHBG expression and regulation during obesity development.

PMID: 26441241
Journal: ENDOCRINOLOGY
Year: 2015
Reference: Endocrinology. 2015 Dec;156(12):4571-81. doi: 10.1210/en.2015-1677. Epub 2015 Oct 6.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Rivera-Gimenez, Marta; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael et al.
DOI: 10.1210/en.2015-1677

Treatment escalation options for patients with type 2 diabetes after failure of exenatide twice daily or glimepiride added to metformin: results from the prospective European Exenatide (EUREXA) study.

PMID: 25846577
Journal: DIABETES OBES METAB
Year: 2015
Reference: Diabetes Obes Metab. 2015 Jul;17(7):689-98. doi: 10.1111/dom.12471. Epub 2015 May 8.
Impact factor:
Publication type: Paper in international publication
Authors: Dotta, F; Festa, A; Gallwitz, B; Guerci, B; Kiljanski, J; Rosas-Guzman, J; Schernthaner, G; Simo, R; Zhou, M et al.
DOI: 10.1111/dom.12471

Eating disorders are frequent among type 2 diabetic patients and are associated with worse metabolic and psychological outcomes: results from a cross-sectional study in primary and secondary care settings.

PMID: 25841588
Journal: DIABETES OBES METAB
Year: 2015
Reference: Acta Diabetol. 2015 Dec;52(6):1037-44. doi: 10.1007/s00592-015-0742-z. Epub 2015 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Ayala, Luisa; Fortuny, Regina; Masmiquel, Lluis; Nicolau, Joana; Sanchis, Pilar; Simo, Rafael; Zubillaga, Ivana et al.
DOI: 10.1007/s00592-015-0742-z

Oleic acid increases hepatic sex hormone binding globulin production in men.

PMID: 24142580
Journal: MOLECULAR NUTRITION & FOOD RESEARCH
Year: 2014
Reference: Mol Nutr Food Res. 2014 Apr;58(4):760-7. doi: 10.1002/mnfr.201300304. Epub 2013 Oct 20.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Rojo-Martinez, Gemma; Rubio-Martin, Elehazara; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael; Soriguer, Federico et al.
DOI: 10.1002/mnfr.201300304

Association Between Plasma Triglycerides and HDL-Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes: A Global Case-Control Study in 13 Countries.

PMID: 24352521
Journal: CIRCULATION
Year: 2014
Reference: Circulation. 2014 Mar 4;129(9):999-1008. doi: 10.1161/CIRCULATIONAHA.113.002529. Epub 2013 Dec 18.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Rubeaan, Khalid; Aronson, Ronnie; Barzon, Isabella; Bishop, Louise; Bonora, Enzo; Bunnag, Pongamorn; Carey, Vincent J; Chuang, Lee-Ming; Davis, Timothy; Deerochanawong, Chaicharn et al.
DOI: 10.1161/CIRCULATIONAHA.113.002529

Use of Expert Consensus to Improve Atherogenic Dyslipidemia Management.

PMID: 24211004
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2014
Reference: Rev Esp Cardiol. 2014 Jan;67(1):36-44. doi: 10.1016/j.recesp.2013.06.014. Epub 2013 Nov 7.
Impact factor:
Publication type: Paper in national publication
Authors: Brea-Hernando, Angel; Diaz-Rodriguez, Angel; Gonzalez-Santos, Pedro; Hernandez-Mijares, Antonio; Mantilla-Morato, Teresa; Millan Nunez-Cortes, Jesus; Pedro-Botet, Juan; Pinto-Sala, Xavier; Simo, Rafael et al.
DOI: 10.1016/j.recesp.2013.06.014

Bariatric surgery in morbidly obese patients improves the atherogenic qualitative properties of the plasma lipoproteins.

PMID: 24674904
Journal: ATHEROSCLEROSIS
Year: 2014
Reference: Atherosclerosis. 2014 May;234(1):200-5. doi: 10.1016/j.atherosclerosis.2014.02.034. Epub 2014 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Blanco-Vaca, Francisco; Ferrer, Roser; Fort, Jose Manuel; Julve, Josep; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Perez-Cuellar, Montserrat; Rossell, Joana et al.
DOI: 10.1016/j.atherosclerosis.2014.02.034

Impact of glucose-lowering agents on the risk of cancer in type 2 diabetic patients. The barcelona case-control study.

PMID: 24278227
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Nov 21;8(11):e79968. doi: 10.1371/journal.pone.0079968.
Impact factor:
Publication type: Paper in international publication
Authors: Fuentes, Inmaculada; Hernandez, Cristina; Morros, Rosa; Mundet, Xavier; Plana-Ripoll, Oleguer; Procupet, Adriana; Puente, Diana; Simo, Rafael; Tabernero, Josep M; Vilca, Luz M et al.
DOI: 10.1371/journal.pone.0079968

Somatostatin replacement: a new strategy for treating diabetic retinopathy.

PMID: 23745546
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2013
Reference: Curr Med Chem. 2013;20(26):3251-7.
Impact factor:
Publication type: Paper in international publication
Authors: Bandello, F; Burks, D; Cunha-Vaz, J; Egan, C; Garcia-Arumi, J; Gibson, J; Harding, S P; Hernandez, Cristina; Karadeniz, S; Lang, G et al.
DOI:

Variables involved in the discordance between HbA1c and fructosamine: the glycation gap revisited.

PMID: 23776693
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Jun 12;8(6):e66696. doi: 10.1371/journal.pone.0066696. Print 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea; Mesa, Jordi; Simo, Rafael; Valladares, Silvia; Zafon, Carles et al.
DOI: 10.1371/journal.pone.0066696

Diabetes Protects from Prostate Cancer by Downregulating Androgen Receptor: New Insights from LNCaP Cells and PAC120 Mouse Model.

PMID: 24058525
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Sep 10;8(9):e74179. doi: 10.1371/journal.pone.0074179.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; De Torres, Ines; Hernandez, Cristina; Munell, Francina; Poupon, Marie-France; Selva, David M; Simo, Rafael et al.
DOI: 10.1371/journal.pone.0074179

Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications.

PMID: 22887976
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2012
Reference: Br J Ophthalmol. 2012 Oct;96(10):1285-90. Epub 2012 Aug 11.
Impact factor:
Publication type: Review in international publication
Authors: Arce, R; Bandello, F; Burks, D; Cunha-Vaz, J; Egan, C; Garcia-Arumi, J; Gibson, J; Harding, SP; Hernandez, Cristina; Karadeniz, S et al.
DOI: 10.1136/bjophthalmol-2012-302005

Thyroid cancer: molecular aspects and new therapeutic strategies.

PMID: 22848860
Journal: Journal of thyroid research
Year: 2012
Reference: J Thyroid Res. 2012;2012:847108. Epub 2012 Jul 12.
Impact factor:
Publication type: Letter or abstract
Authors: Capdevila, Jaume; Diez, Juan Jose; Grande, Enrique; Zafon, Carles et al.
DOI: 10.1155/2012/847108

Giant intrathyroidal parathyroid adenoma.

PMID: 22787355
Journal: Journal of emergencies, trauma, and shock.
Year: 2012
Reference: J Emerg Trauma Shock. 2012 Apr;5(2):196-8.
Impact factor:
Publication type: Letter or abstract
Authors: Baena, Juan Antonio; Migone, Raul; Vilallonga, Ramon; Zafon, Carlos et al.
DOI: 10.4103/0974-2700.96497

Is there a relationship between TSH levels and diabetic retinopathy in the Caucasian population?

PMID: 22717499
Journal: DIABETES RESEARCH AND CLINICAL PRACTICE
Year: 2012
Reference: Diabetes Res Clin Pract. 2012 Sep;97(3):e45-7. doi: 10.1016/j.diabres.2012.05.015. Epub 2012 Jun 18.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.diabres.2012.05.015

Capillary beta-hydroxybutyrate determination for monitoring diabetic ketoacidosis.

PMID: 21737365
Journal: Endocrinol Nutr
Year: 2011
Reference: Endocrinol Nutr. 2011 Aug-Sep;58(7):347-52. Epub 2011 Jul 6.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.endonu.2011.05.003

Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: Essential role of JAK2/ PI3K signaling.

PMID: 21620963
Journal: CELLULAR SIGNALLING
Year: 2011
Reference: Cell Signal. 2011 Oct;23(10):1596-602. Epub 2011 May 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1016/j.cellsig.2011.05.011

Neurodegeneration as an early event in diabetic retinopathy.

PMID: 21530423
Journal: Endocrinol Nutr
Year: 2011
Reference: Endocrinol Nutr. 2011 May;58(5):211-3. Epub 2011 May 6.
Impact factor:
Publication type: Letter or abstract
Authors: et al.
DOI: 10.1016/j.endonu.2011.01.008

Successful treatment of the Dunningan-type familial partial lipodystrophy with Roux-en-Y Gastric Bypass.

PMID: 21521325
Journal: CLINICAL ENDOCRINOLOGY
Year: 2011
Reference: Clin Endocrinol (Oxf). 2011 Sep;75(3):403-4. doi: 10.1111/j.1365-2265.2011.04057.x.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2265.2011.04057.x

New pathogenic candidates for diabetic macular edema detected by proteomic analysis.

PMID: 20587712
Journal: DIABETES CARE
Year: 2010
Reference: Diabetes Care. 2010 Jul;33(7):e92.
Impact factor:
Publication type: Letter or abstract
Authors: Canals, Francesc; Casado, Joan; Colome, Nuria; Corraliza, Lidia; Garcia-Pacual, Luis; Garcia-Ramirez, Marta; Hernandez, Cristina; Simo, Rafael; Villarroel, Marta et al.
DOI: 10.2337/dc10-0232

Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms?

PMID: 20827392
Journal: Experimental Diabetes Research
Year: 2010
Reference: Exp Diabetes Res. 2010;2010. pii: 714108. Epub 2010 Aug 8.
Impact factor:
Publication type: Review in international publication
Authors: Ciudin, Andreea; Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.1155/2010/714108

Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study.

PMID: 20882512
Journal: DIABETES-METABOLISM RESEARCH AND REVIEWS
Year: 2010
Reference: Diabetes Metab Res Rev. 2010 Nov;26(8):639-45. doi: 10.1002/dmrr.1131. Epub 2010 Sep 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1002/dmrr.1131

Effect of intensive insulin therapy on macular biometrics, plasma VEGF and its soluble receptor in newly diagnosed diabetic patients.

PMID: 20578202
Journal: DIABETES-METABOLISM RESEARCH AND REVIEWS
Year: 2010
Reference: Diabetes Metab Res Rev. 2010 Jul;26(5):386-92.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose; Garcia-Ramirez, Marta; Hernandez, Cristina; Losada, Eladio; Simo, Rafael; Villarroel, Marta; Zapata, Miguel A et al.
DOI: 10.1002/dmrr.1093

Apolipoprotein A1 is overexpressed in the retina of diabetic patients.

PMID: 18848320
Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY
Year: 2009
Reference: Am J Ophthalmol. 2009 Feb;147(2):319-325.e1.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta; Hernandez, Cristina; Higuera, Monica; Simo, Rafael et al.
DOI: 10.1016/j.ajo.2008.08.009

Ghrelin and apolipoprotein AIV levels show opposite trends to leptin levels during weight loss in morbidly obese patients.

PMID: 19172368
Journal: OBESITY SURGERY
Year: 2009
Reference: Obes Surg. 2009 Oct;19(10):1414-23.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Baena-Fustegueras, J A; Catalan, R; Fort, J M; Galard, R; Lecube, A; Llamas, R; Lopez-Tejero, M D; Pardina, E; Peinado-Onsurbe, J et al.
DOI: 10.1007/s11695-008-9793-3

The European Exenatide study of long-term exenatide vs. glimepiride for type 2 diabetes: rationale and patient characteristics.

PMID: 19758357
Journal: DIABETES OBESITY & METABOLISM
Year: 2009
Reference: Diabetes Obes Metab. 2009 Dec;11(12):1131-7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1463-1326.2009.01091.x

Lipoprotein lipase but not hormone-sensitive lipase activities achieve normality after surgically induced weight loss in morbidly obese patients.

PMID: 19455372
Journal: OBESITY SURGERY
Year: 2009
Reference: Obes Surg. 2009 Aug;19(8):1150-8.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Baena-Fustegueras, J A; Catalan, R; Fort, J M; Galard, R; Lecube, A; Llamas, R; Pardina, E; Peinado-Onsurbe, J; Vargas, V et al.
DOI: 10.1007/s11695-009-9853-3

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

This investment from EIT Health in the project will enable D-Sight to progress in the clinical development of its groundbreaking treatment for the early stages of diabetic retinopathy.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.