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Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Team

Angel Michael Ortiz Zuñiga

Angel Michael Ortiz Zuñiga

Postdoctoral researcher
Diabetes and Metabolism
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Anna Deàs Just

Anna Deàs Just

Predoctoral researcher
Diabetes and Metabolism
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Betina Biagetti Biagetti

Betina Biagetti Biagetti

Diabetes and Metabolism
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Carles Zafon Llopis

Carles Zafon Llopis

Main researcher
Diabetes and Metabolism
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Cristina Hernández Pascual

Cristina Hernández Pascual

Main researcher
Diabetes and Metabolism
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David Martinez Selva

David Martinez Selva

Main researcher
Diabetes and Metabolism
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Angel Michael Ortiz Zuñiga

Angel Michael Ortiz Zuñiga

Postdoctoral researcher
Diabetes and Metabolism
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Anna Deàs Just

Anna Deàs Just

Predoctoral researcher
Diabetes and Metabolism
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Betina Biagetti Biagetti

Betina Biagetti Biagetti

Diabetes and Metabolism
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Carles Zafon Llopis

Carles Zafon Llopis

Main researcher
Diabetes and Metabolism
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Cristina Hernández Pascual

Cristina Hernández Pascual

Main researcher
Diabetes and Metabolism
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David Martinez Selva

David Martinez Selva

Main researcher
Diabetes and Metabolism
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Projects

New Biomarker for NAFLD and NASH Development and Progression

IP: David Martinez Selva
Collaborators: -
Funding agency: Fundació "La Caixa"
Funding: 50000
Reference: CAIXAIMPULSE/CI23-20154
Duration: 12/12/2023 - 12/12/2025

Incorporació personal suport al grup Diabetis i metabolisme

IP: Rafael Simó Canonge
Collaborators: Miriam Izquierdo Sans
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 76000
Reference: SLT028/23/000272
Duration: 01/08/2023 - 31/12/2025

DESARROLLO DE EDL6D, UN PÉPTIDO MIMÉTICO DE SHBG PARA EL TRATAMIENTO DE LA ENFERMEDAD DEL HÍGADO GRASO NO ALCOHÓLICO (NAFLD) Y LA ESTEATOHEPATITIS NO ALCOHÓLICA (NASH)

IP: David Martinez Selva
Collaborators: Lidia Fuertes Rioja
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 370568
Reference: CPP2022-009831
Duration: 01/07/2023 - 30/06/2026

Ministerio de Ciencia

Topical administration of sitagliptin in experimental models of diabetic retinopathy and glaucoma: delving into mechanisms of action and changing the therapeutic positioning (“Sit@Retina”).

IP: Rafael Simó Canonge
Collaborators: Maria Llorian Salvador
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 321250
Reference: PID2022-138544OB-I00
Duration: 01/09/2023 - 31/08/2026

Ministerio de Ciencia

Publications

Genetic risk score based on obesity-related genes and progression in weight loss after bariatric surgery: a 60-month follow-up study.

PMID: 38744640
Journal: Surgery for Obesity and Related Diseases
Year: 2024
Reference: Surg Obes Relat Dis. 2024 Apr 6:S1550-7289(24)00132-1. doi: 10.1016/j.soard.2024.04.002.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas, Concepcion; Azcona-Granada, Natalia; Caixas, Assumpta; Ciudin, Andreea; Lecube, Albert; Luna, Alexis; Mas-Bermejo, Patricia; Pena, Elionora; Rigla, Mercedes; Rosa, Araceli et al.
DOI: 10.1016/j.soard.2024.04.002

Use of polygenic risk scores to assess weight loss after bariatric surgery: a five-year follow-up study.

PMID: 38821212
Journal: JOURNAL OF GASTROINTESTINAL SURGERY
Year: 2024
Reference: J Gastrointest Surg. 2024 May 29:S1091-255X(24)00485-2. doi: 10.1016/j.gassur.2024.05.029.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas, Concepcion; Caixas, Assumpta; Ciudin, Andreea; Lecube, Albert; Mas-Bermejo, Patricia; Pena, Elionora; Rigla, Mercedes; Rosa, Araceli; Simo, Rafael et al.
DOI: 10.1016/j.gassur.2024.05.029

Oral phytate supplementation on the progression of mild cognitive impairment, brain iron deposition and diabetic retinopathy in patients with type 2 diabetes: a concept paper for a randomized double blind placebo controlled trial (the PHYND trial).

PMID: 38872972
Journal: Frontiers in Endocrinology
Year: 2024
Reference: Front Endocrinol (Lausanne). 2024 May 30;15:1332237. doi: 10.3389/fendo.2024.1332237. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Amengual, Guillermo J; Espino, Ana; Estremera, Ana; Gomila, Isabel; Grases, Felix; Masmiquel, Lluis; Nicolau, Joana; Pujol, Antelm; Ribes, Jose L; Rigo, Elena et al.
DOI: 10.3389/fendo.2024.1332237

Recent Advances on Sex Hormone-Binding Globulin Regulation by Nutritional Factors: Clinical Implications.

PMID: 38934352
Journal: MOLECULAR NUTRITION & FOOD RESEARCH
Year: 2024
Reference: Mol Nutr Food Res. 2024 Jun 27:e2400020. doi: 10.1002/mnfr.202400020.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Guaita, Anna; Brianso-Llort, Laura; Hernandez, Cristina; Ramos-Perez, Lorena; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael et al.
DOI: 10.1002/mnfr.202400020

Executive summary of the position statement of the Spanish Societies SEQC(ML)/SEEN/SEEP. Recommendations for the measurement of sex steroids in clinical practice.

PMID: 36894451
Journal: Endocrinologia Diabetes y Nutricion
Year: 2023
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2023 Mar 7:S2530-0180(23)00036-7. doi: 10.1016/j.endien.2023.03.004.
Impact factor:
Publication type: Paper in international publication
Authors: Argente, Jesus; Biagetti, Betina; Casals, Gregori; Escobar-Morreale, Hector F; Ferrer Costa, Roser; Sesmilo, Gemma; Urgell Rull, Eulalia et al.
DOI: 10.1016/j.endien.2023.03.004

Executive summary of the consensus document on hypophysitis of the Neuroendocrinology Area of Knowledge of the Spanish Society of Endocrinology and Nutrition.

PMID: 36894450
Journal: Endocrinologia Diabetes y Nutricion
Year: 2023
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2023 Mar 7:S2530-0180(23)00037-9. doi: 10.1016/j.endien.2023.01.001.
Impact factor:
Publication type: Paper in international publication
Authors: Biagetti, Betina; Cordido, Fernando; Diez, Juan J; Guerrero-Perez, Fernando; Iglesias, Pedro; Vicente, Almudena et al.
DOI: 10.1016/j.endien.2023.01.001

Clinical practice guidelines. Let's identify them.

PMID: 37890718
Journal: Cirugia espanola
Year: 2023
Reference: Cir Esp (Engl Ed). 2023 Oct 25:S2173-5077(23)00175-8. doi: 10.1016/j.cireng.2023.10.001.
Impact factor:
Publication type: Editorail in international publication
Authors: Alcazar, Victoria; Anda, Emma; Arrieta, Francisco; Biagetti, Betina; Cano, Manuel Lopez; de Assin Valverde, Andres Ruiz; Diez, Juan Jose; Garcia Gomez, Carlos; Guerrero-Perez, Fernando; Iglesias, Pedro et al.
DOI: 10.1016/j.cireng.2023.10.001

Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: Findings from Clinical and Experimental Studies.

PMID: 36904168
Journal: Nutrients
Year: 2023
Reference: Nutrients. 2023 Feb 25;15(5):1169. doi: 10.3390/nu15051169.
Impact factor:
Publication type: Paper in international publication
Authors: Alcubierre, Nuria; Bogdanov, Patricia; Castelblanco, Esmeralda; Granado-Casas, Minerva; Hernandez, Cristina; Hernandez, Cristina; Hernandez, Marta; Jurjo, Carmen; Mauricio, Didac; Navarrete-Munoz, Eva Maria et al.
DOI: 10.3390/nu15051169

Enterohepatic shunt-driven cholemia predisposes to liver cancer.

PMID: 35988658
Journal: Gastroenterology
Year: 2022
Reference: Gastroenterology. 2022 Dec;163(6):1658-1671.e16. doi: 10.1053/j.gastro.2022.08.033. Epub 2022 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: Abokor, Ahmed A; Albanes, Demetrius; Bovilla, Venugopal R; Bretin, Alexis C A; Ciudin, Andreea; Florio, Andrea A; Freeman, Gordon J; Gewirtz, Andrew T; Gohara, Amira F; Golonka, Rachel M et al.
DOI: 10.1053/j.gastro.2022.08.033

Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers.

PMID: 35979662
Journal: Clinical and Translational Medicine
Year: 2022
Reference: Clin Transl Med. 2022 Aug;12(8):e1001. doi: 10.1002/ctm2.1001.
Impact factor:
Publication type: Paper in international publication
Authors: Blasco, Maria A; Caleiras, Eduardo; Cascon, Alberto; Curras-Freixes, Maria; Galofre, Juan Carlos; Garcia-Tobar, Laura; Gil, Eduardo; Gonzalez-Garcia, Patricia; Gonzalez-Neira, Anna; Guadalix, Sonsoles et al.
DOI: 10.1002/ctm2.1001

Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms.

PMID: 35955859
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Aug 5;23(15). pii: ijms23158721. doi: 10.3390/ijms23158721.
Impact factor:
Publication type: Review in international publication
Authors: Biagetti, Betina; Simo, Rafael et al.
DOI: 10.3390/ijms23158721

New Insights into Treating Early and Advanced Stage Diabetic Retinopathy.

PMID: 35955655
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jul 31;23(15). pii: ijms23158513. doi: 10.3390/ijms23158513.
Impact factor:
Publication type: Review in international publication
Authors: Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.3390/ijms23158513

Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina.

PMID: 34713467
Journal: JOURNAL OF NEUROSCIENCE RESEARCH
Year: 2021
Reference: J Neurosci Res. 2021 Dec;99(12):3103-3120. doi: 10.1002/jnr.24978. Epub 2021 Oct 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Comella, Joan X; Hernandez, Cristina; Huo, Jianxin; Lam, Kong-Peng; Lopez-Soriano, Joaquin; Perez-Garcia, M Jose; Ramos, Hugo; Ruiz Lasa, Agustin; Sampedro, Joel et al.
DOI: 10.1002/jnr.24978

Decreased endostatin in db/db retinas is associated with optic disc intravitreal vascularization.

PMID: 34688624
Journal: EXPERIMENTAL EYE RESEARCH
Year: 2021
Reference: Exp Eye Res. 2021 Nov;212:108801. doi: 10.1016/j.exer.2021.108801. Epub 2021 Oct 21.
Impact factor:
Publication type: Paper in international publication
Authors: Bonet, Aina; Casellas, Alba; Mendes-Jorge, Luisa; Nacher, Victor; Pampalona, Judit; Ramos, David; Rodriguez-Baeza, Alfonso; Ruberte, Jesus; Simo, Rafael; Valenca, Andreia et al.
DOI: 10.1016/j.exer.2021.108801

Molecular Pathways in Prolactinomas: Translational and Therapeutic Implications.

PMID: 34681905
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Oct 18;22(20). pii: ijms222011247. doi: 10.3390/ijms222011247.
Impact factor:
Publication type: Review in international publication
Authors: Biagetti, Betina; Simo, Rafael et al.
DOI: 10.3390/ijms222011247

Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD).

PMID: 34680405
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Sep 22;9(10). pii: biomedicines9101289. doi: 10.3390/biomedicines9101289.
Impact factor:
Publication type: Paper in international publication
Authors: Aspichueta, Patricia; Banares, Rafael; Bechmann, Lars P; Benede-Ubieto, Raquel; Bruns, Tony; Ciudin, Andreea; Cubero, Francisco Javier; Estevez-Vazquez, Olga; Gomez-Santos, Beatriz; Guo, Feifei et al.
DOI: 10.3390/biomedicines9101289

Sarcopenic obesity: a new challenge in the practical clinic.

PMID: 32565081
Journal: Endocrinologia Diabetes y Nutricion
Year: 2020
Reference: Endocrinol Diabetes Nutr. 2020 Dec;67(10):672-681. doi: 10.1016/j.endinu.2020.03.004. Epub 2020 Jun 18.
Impact factor:
Publication type: Review in national publication
Authors: Barahona, Maria Jose; Ciudin, Andreea; Palmas, Fiorella; Simo-Servat, Andreu et al.
DOI: 10.1016/j.endinu.2020.03.004

Diabetic retinopathy: looking beyond the eyes.

PMID: 32556614
Journal: DIABETOLOGIA
Year: 2020
Reference: Diabetologia. 2020 Aug;63(8):1662-1664. doi: 10.1007/s00125-020-05195-4. Epub 2020 Jun 18.
Impact factor:
Publication type: Letter or abstract
Authors: Avogaro, Angelo; Simo, Rafael; Stehouwer, Coen D A et al.
DOI: 10.1007/s00125-020-05195-4

The ERM complex: a new player involved in diabetes-induced vascular leakage.

PMID: 30332939
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2020
Reference: Curr Med Chem. 2020;27(18):3012-3022. doi: 10.2174/0929867325666181016162327.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.2174/0929867325666181016162327

The extent of surgery for low-risk 1-4 cm papillary thyroid carcinoma: a catch-22 situation. A retrospective analysis of 497 patients based on the 2015 ATA Guidelines recommendation 35.

PMID: 32507966
Journal: ENDOCRINE
Year: 2020
Reference: Endocrine. 2020 Dec;70(3):538-543. doi: 10.1007/s12020-020-02371-9. Epub 2020 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Alcalde, Juan; Anda Apinaniz, Emma; Galofre, Juan C; Garcia Goni, Marta; Perdomo, Carolina; Pineda, Javier; Ruiz Rey, Irati; Zafon, Carles et al.
DOI: 10.1007/s12020-020-02371-9

Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study.

PMID: 31500371
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Sep 8;8(9). pii: jcm8091412. doi: 10.3390/jcm8091412.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Nuria; Carbonell, Marc; Castelblanco, Esmeralda; Hernandez, Cristina; Jurjo, Carme; Mauricio, Didac; Ramirez-Morros, Anna; Real, Jordi; Simo, Rafael; Traveset, Alicia et al.
DOI: 10.3390/jcm8091412

Arterial stiffness is highly correlated with the scores obtained from the Steno Type 1 Risk Engine in subjects with T1DM.

PMID: 31483791
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Sep 4;14(9):e0220206. doi: 10.1371/journal.pone.0220206. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Lara; Ballesta, Silvia; Cano, Albert; Gonzalez-Clemente, Jose-Miguel; Gonzalez-Sastre, Montserrat; Llaurado, Gemma; Luchtenberg, Maria-Florencia; Mazarico, Isabel; Megia, Ana; Simo, Rafael et al.
DOI: 10.1371/journal.pone.0220206

[Parenteral domiciliary nutrition Program: 32 years of clinical experience].

PMID: 31475838
Journal: Nutricion Hospitalaria
Year: 2019
Reference: Nutr Hosp. 2019 Oct 17;36(5):1011-1018. doi: 10.20960/nh.02461.
Impact factor:
Publication type: Letter or abstract
Authors: Badia Tahull, Maria B; Fernandez Alvarez, Monica; Garcia-Sancho de la Jordana, Paula; Leiva Baldosa, Elisabet; Lopez Urdiales, Rafael; Planas-Vilaseca, Alejandra; Simo Servat, Andreu; Virgili Casas, Maria Nuria et al.
DOI: 10.20960/nh.02461

SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes.

PMID: 31344857
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2019
Reference: Int J Mol Sci. 2019 Jul 24;20(15). pii: ijms20153615. doi: 10.3390/ijms20153615.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Egido, Jesus; Espejo, Carmen; Garcia-Ramirez, Marta; Gomez-Guerrero, Carmen; Hernandez, Cristina; Prieto, Ignacio; Sampedro, Joel; Simo, Rafael; Sola-Adell, Cristina et al.
DOI: 10.3390/ijms20153615

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes.

PMID: 29774170
Journal: Translational Vision Science & Technology
Year: 2018
Reference: Transl Vis Sci Technol. 2018 May 14;7(3):6. doi: 10.1167/tvst.7.3.6. eCollection 2018 May.
Impact factor:
Publication type: Paper in international publication
Authors: Chen, Han; Ford, Michael; Lease, Joshua; Russo, Mariano; Siedlecki, Christopher A; Simo, Rafael; Sundstrom, Jeffrey M; Wang, Weiwei; Weber, Sarah R; Xu, Li-Chong et al.
DOI: 10.1167/tvst.7.3.6

Early evolutionary divergence between papillary and anaplastic thyroid cancers.

PMID: 29648575
Journal: ANNALS OF ONCOLOGY
Year: 2018
Reference: Ann Oncol. 2018 Jun 1;29(6):1454-1460. doi: 10.1093/annonc/mdy123.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, C; Cameselle-Teijeiro, J M; Capdevila, J; Caratu, G; Hernando, J; Iglesias, C; Mancuso, F F; Matias-Guiu, X; Matos, I; Mayor, R et al.
DOI: 10.1093/annonc/mdy123

Kallikreins stepwise scoring reveals three subtypes of papillary thyroid cancer with prognostic applications.

PMID: 29635968
Journal: THYROID
Year: 2018
Reference: Thyroid. 2018 May;28(5):601-612. doi: 10.1089/thy.2017.0501.
Impact factor:
Publication type: Paper in international publication
Authors: Buj, Raquel; Diez-Villanueva, Anna; Jorda, Mireia; Mallona, Izaskun; Mate, Jose L; Mauricio, Didac; Peinado, Miguel A; Puig-Domingo, Manel; Reverter, Jordi Lluis; Roca, Miriea et al.
DOI: 10.1089/thy.2017.0501

Author Correction: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.

PMID: 29555933
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Mar 19;8(1):5046. doi: 10.1038/s41598-018-23159-y.
Impact factor:
Publication type: Letter or abstract
Authors: Brianso-Llort, Laura; Hammond, Geoffrey L; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael; Torres-Torronteras, J et al.
DOI: 10.1038/s41598-018-23159-y

Ectopic Cushing's syndrome: Paradoxical effect of somatostatin analogs.

PMID: 29056252
Journal: Endocrinologia, diabetes y nutricion
Year: 2017
Reference: Endocrinol Diabetes Nutr. 2017 May;64(5):276-278. doi: 10.1016/j.endinu.2017.01.004. Epub 2017 Mar 16.
Impact factor:
Publication type: Paper in national publication
Authors: Biagetti, Betina; Iglesias, Carmela; Mesa, Jordi; Ortiz-Z, Angel; Simo-Servat, Olga et al.
DOI: 10.1016/j.endinu.2017.01.004

Cancer Immunotherapy and endocrinology: A new opportunity for multidisciplinary collaboration.

PMID: 29050701
Journal: Endocrinologia, diabetes y nutricion
Year: 2017
Reference: Endocrinol Diabetes Nutr. 2017 Nov;64(9):461-463. doi: 10.1016/j.endinu.2017.10.001.
Impact factor:
Publication type: Paper in national publication
Authors: Zafon Llopis, Carles et al.
DOI: 10.1016/j.endinu.2017.10.001

Technical Options for Malabsorption Issues After Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy.

PMID: 28952026
Journal: OBESITY SURGERY
Year: 2017
Reference: Obes Surg. 2017 Dec;27(12):3344-3348. doi: 10.1007/s11695-017-2931-z.
Impact factor:
Publication type: Paper in international publication
Authors: Balibrea, Jose Maria; Caubet, Enric; Ciudin, Andrea; Curell, Anna; Fort, Jose Manuel; Gonzalez, Oscar; Ortiz-Zuniga, Angel Michael; Vilallonga, Ramon et al.
DOI: 10.1007/s11695-017-2931-z

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.

PMID: 28947831
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Sep 25;7(1):12284. doi: 10.1038/s41598-017-12509-x.
Impact factor:
Publication type: Paper in international publication
Authors: Brianso-Llort, Laura; Hammond, Geoffrey L; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael; Torres-Torrenteras, Javier et al.
DOI: 10.1038/s41598-017-12509-x

EndoG knockout mice show increased brown adipocyte recruitment in white adipose tissue and improved glucose homeostasis.

PMID: 27547848
Journal: ENDOCRINOLOGY
Year: 2016
Reference: Endocrinology. 2016 Oct;157(10):3873-3887. doi: 10.1210/en.2015-1334. Epub 2016 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Beiroa, Daniel; Blasco, Natividad; Canas, Xavier; Nogueiras, Ruben; Pardo, Rosario; Sanchis, Daniel; Simo, Rafael; Vila, Maria; Villena, Josep A et al.
DOI: 10.1210/en.2015-1334

Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy.

PMID: 27552833
Journal: ACTA DIABETOLOGICA
Year: 2016
Reference: Acta Diabetol. 2016 Dec;53(6):957-964. doi: 10.1007/s00592-016-0895-4. Epub 2016 Aug 23.
Impact factor:
Publication type: Paper in national publication
Authors: Arroba, Ana I; Beltramo, Elena; Hernandez, Cristina; Lopatina, Tatiana; Mazzeo, Aurora; Porta, Massimo; Simo, Rafael; Valverde, Angela M et al.
DOI: 10.1007/s00592-016-0895-4

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology.

PMID: 27376090
Journal: Journal of Diabetes Research
Year: 2016
Reference: J Diabetes Res. 2016;2016:5263798. Epub 2016 Jun 8.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.1155/2016/5263798

Global Assessment of the Impact of Type 2 Diabetes on Sleep through Specific Questionnaires. A Case-Control Study.

PMID: 27315083
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Jun 17;11(6):e0157579. doi: 10.1371/journal.pone.0157579. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Abreu, Cristina; Ciudin, Andreea; Gomez-Peralta, Fernando; Hernandez, Cristina; Lecube, Albert; Martinez, Maria Dolores; Mestre, Olga; Romero, Odile; Sampol, Gabriel; Sanchez, Enric et al.
DOI: 10.1371/journal.pone.0157579

Photocoagulation of human retinal pigment epithelium in vitro: unravelling the effects on ARPE-19 by transcriptomics and proteomics.

PMID: 25604382
Journal: ACTA OPHTHALMOL
Year: 2015
Reference: Acta Ophthalmol. 2015 Jun;93(4):348-54. doi: 10.1111/aos.12649. Epub 2015 Jan 21.
Impact factor:
Publication type: Paper in international publication
Authors: Agardh, Carl-David; Agardh, Elisabet; Bennet, Hedvig; Canals, Francesc; de la Torre, Carolina; Fex, Malin; Hansson, Ola; Hernandez, Cristina; Simo, Rafael; Tababat-Khani, Poya et al.
DOI: 10.1111/aos.12649

Morbidly "Healthy" Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia.

PMID: 25515498
Journal: OBES SURG
Year: 2015
Reference: Obes Surg. 2015 Aug;25(8):1380-91. doi: 10.1007/s11695-014-1528-z.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Balibrea, Jose Maria; Caubet, Enric; Ferrer, Roser; Fort, Jose Manuel; Gonzalez, Oscar; Lecube, Albert; Oller, Laura; Pardina, Eva; Peinado-Onsurbe, Julia et al.
DOI: 10.1007/s11695-014-1528-z

Beneficial Effects of Fenofibric Acid on Overexpression of Extracellular Matrix Components, COX-2, and Impairment of Endothelial Permeability Associated with Diabetic Retinopathy.

PMID: 26297615
Journal: EXP EYE RES
Year: 2015
Reference: Exp Eye Res. 2015 Nov;140:124-129. doi: 10.1016/j.exer.2015.08.010. Epub 2015 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Kim, Dongjoon; Roy, Sayon; Roy, Sumon; Simo, Rafael et al.
DOI: 10.1016/j.exer.2015.08.010

A descriptive study of the characteristics of differentiated thyroid cancer in Catalonia during the period 1998-2012. The CECaT registry.

PMID: 25979187
Journal: Endocrinologia y nutricion : organo de la Sociedad
Year: 2015
Reference: Endocrinol Nutr. 2015 Jun-Jul;62(6):264-9. doi: 10.1016/j.endonu.2015.03.005. Epub 2015 May 13.
Impact factor:
Publication type: Paper in national publication
Authors: Bella, Maria Rosa; Biarnes, Josefina; Castells, Ignasi; Garcia-Pascual, Luis; Gonzalez, Cintia; Halperin, Irene; Mauricio, Didac; Megia, Ana; Pizarro, Eduarda; Puig-Domingo, Manel et al.
DOI: 10.1016/j.endonu.2015.03.005

Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives.

PMID: 24627166
Journal: ENDOCRINE
Year: 2014
Reference: Endocrine. 2014 Jun;46(2):209-14. doi: 10.1007/s12020-014-0232-z. Epub 2014 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.1007/s12020-014-0232-z

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy.

PMID: 24652720
Journal: DIABETES CARE
Year: 2014
Reference: Diabetes Care. 2014 Apr;37(4):893-9. doi: 10.2337/dc13-2002.
Impact factor:
Publication type: Paper in international publication
Authors: Antonetti, David A; Simo, Rafael; Sundstrom, Jeffrey M et al.
DOI: 10.2337/dc13-2002

Thyroid Hormone Upregulates Zinc-alpha2-glycoprotein Production in the Liver but Not in Adipose Tissue.

PMID: 24465683
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Jan 21;9(1):e85753. doi: 10.1371/journal.pone.0085753. eCollection 2014 Jan 21.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Puig-Domingo, Manel; Saez-Lopez, Cristina; Selva, David M; Simo, Rafael; Soldevila, Berta et al.
DOI: 10.1371/journal.pone.0085753

Glycogen storage in the human retinal pigment epithelium: a comparative study of diabetic and non-diabetic donors.

PMID: 24458975
Journal: ACTA DIABETOLOGICA
Year: 2014
Reference: Acta Diabetol. 2014 Aug;51(4):543-52. doi: 10.1007/s00592-013-0549-8. Epub 2014 Jan 24.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta; Garcia-Rocha, Mar; Guinovart, Joan J; Hernandez, Cristina; Saez-Lopez, Cristina; Simo, Rafael; Valverde, Angela M et al.
DOI: 10.1007/s00592-013-0549-8

Mice lacking PGC-1beta in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance.

PMID: 24049736
Journal: Molecular metabolism
Year: 2013
Reference: Mol Metab. 2013 Jun 5;2(3):215-26. doi: 10.1016/j.molmet.2013.05.004.
Impact factor:
Publication type: Letter or abstract
Authors: Enguix, Natalia; Gonzalez, Agusti; Kralli, Anastasia; Lopez, Victor M; Pardo, Rosario; Simo, Rafael; Villena, Josep A et al.
DOI: 10.1016/j.molmet.2013.05.004

Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis.

PMID: 23568601
Journal: DIABETES-METABOLISM RESEARCH AND REVIEWS
Year: 2013
Reference: Diabetes Metab Res Rev. 2013 Sep;29(6):499-506. doi: 10.1002/dmrr.2419.
Impact factor:
Publication type: Paper in international publication
Authors: Canals, Francesc; Casado, Joan; Colome, Nuria; Corraliza, Lidia; Garcia-Pascual, Luis; Garcia-Ramirez, Marta; Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.1002/dmrr.2419

SPECT/CT sentinel lymph node identification in papillary thyroid cancer: lymphatic staging and surgical management improvement.

PMID: 23907326
Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Year: 2013
Reference: Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1645-55. doi: 10.1007/s00259-013-2476-x. Epub 2013 Aug 2.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, Manuel; Castell-Conesa, Joan; Castellvi, Josep; Caubet, Enric; Fort, Jose Manuel; Garcia-Burillo, Amparo; Gonzalez, Oscar; Iglesias, Carmela; Mesa, Jordi; Roca Bielsa, Isabel et al.
DOI: 10.1007/s00259-013-2476-x

Height Gain at Adult-Height Age in 184 Short Patients Treated with Growth Hormone from Prepubertal Age to Near Adult-Height Age is Not Related to GH Secretory Status at GH Therapy Onset.

PMID: 23548791
Journal: Hormone Research in Paediatrics
Year: 2013
Reference: Horm Res Paediatr. 2013;79:145-56. doi: 10.1159/000348540. Epub 2013 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Albisu, M A; Audi, L; Bel, J; Campos, A; Carrascosa, A; Clemente, M; Del Pozo, C; Fernandez-Cancio, M; Gomez, J M; Gussinye, M et al.
DOI: 10.1159/000348540

Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.

PMID: 22683137
Journal: LANCET
Year: 2012
Reference: Lancet. 2012 Jun 16;379(9833):2270-8. doi: 10.1016/S0140-6736(12)60479-6. Epub 2012 Jun 9.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/S0140-6736(12)60479-6

Alterations in the Common Pathway of Coagulation During Weight Loss Induced by Gastric Bypass in Severely Obese Patients.

PMID: 22193919
Journal: Obesity
Year: 2012
Reference: Obesity (Silver Spring). 2012 May;20(5):1048-56. doi: 10.1038/oby.2011.361. Epub 2011 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/oby.2011.361

Neuroprotection in Diabetic Retinopathy.

PMID: 22581259
Journal: Current Diabetes Reports
Year: 2012
Reference: Curr Diab Rep. 2012 Aug;12(4):329-37. doi: 10.1007/s11892-012-0284-5.
Impact factor:
Publication type: Paper in international publication
Authors: ; et al.
DOI: 10.1007/s11892-012-0284-5

Only C-reactive protein, but not TNF-alpha or IL6, reflects the improvement in inflammation after bariatric surgery.

PMID: 22038572
Journal: OBESITY SURGERY
Year: 2012
Reference: Obes Surg. 2012 Jan;22(1):131-9.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Catalan, Roberto; Ferrer, Roser; Fort, Jose Manuel; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Rivero, Joaquin; Vargas, Victor et al.
DOI: 10.1007/s11695-011-0546-3

Successful treatment of the Dunningan-type familial partial lipodystrophy with Roux-en-Y Gastric Bypass.

PMID: 21521325
Journal: CLINICAL ENDOCRINOLOGY
Year: 2011
Reference: Clin Endocrinol (Oxf). 2011 Sep;75(3):403-4. doi: 10.1111/j.1365-2265.2011.04057.x.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2265.2011.04057.x

Isolated langerhans cell histiocytosis of the thyroid in an adult female: one-year followup.

PMID: 21461403
Journal: International Journal of Endocrinology
Year: 2011
Reference: Int J Endocrinol. 2011;2011:898302. Epub 2011 Mar 6.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, Manuel; Baena, Juan Antonio; Ciudin, Andrea; Fort, Jose Manuel; Gonzalez, Oscar; Mesa, Jordi; Ruiz Marcellan, Mari Carmen; Vilallonga, Ramon et al.
DOI: 10.1155/2011/898302

[Long term treatment with growth hormone deficiency in adults.]

PMID: 21411111
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 May 28;136(15):659-64. Epub 2011 Mar 15.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; et al.
DOI: 10.1016/j.medcli.2010.07.030

Differential effects of gemfibrozil and fenofibrate on reverse cholesterol transport from macrophages to feces in vivo.

PMID: 21126601
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Year: 2011
Reference: Biochim Biophys Acta. 2011 Feb;1811(2):104-10. Epub 2010 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.bbalip.2010.11.006

Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes.

PMID: 20426819
Journal: BMC Neurology
Year: 2010
Reference: BMC Neurol. 2010 Apr 28;10:27. doi: 10.1186/1471-2377-10-27.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/1471-2377-10-27

APOH is increased in the plasma and liver of type 2 diabetic patients with metabolic syndrome.

PMID: 19878946
Journal: ATHEROSCLEROSIS
Year: 2010
Reference: Atherosclerosis. 2010 Mar;209(1):201-5. Epub 2009 Oct 6.
Impact factor:
Publication type: Paper in international publication
Authors: ; Cabre, Anna; Castro, Antoni; Cespedes, Ela; Girona, Josefa; Guardiola, Montse; Lazaro, Iolanda; Masana, Lluis; Selva, David M; Simo, Rafael et al.
DOI: 10.1016/j.atherosclerosis.2009.09.072

[Usefulness of the immunohistochemical analysis of several molecular markers in the characterization of papillary thyroid carcinoma with initial lymph node metastasis.]

PMID: 20403734
Journal: Endocrinol Nutr
Year: 2010
Reference: Endocrinol Nutr. 2010 Apr;57(4):165-9. Epub 2010 Apr 18.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI: 10.1016/j.endonu.2010.02.005

Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial.

PMID: 20194881
Journal: CIRCULATION
Year: 2010
Reference: Circulation. 2010 Mar 16;121(10):1176-87. Epub 2010 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: Abizaid, Alexandre; Abrahamson, M; Abundes-Velasco, Arturo; Aftring, Paul; Agarwal, Jai; Aggrawal, Naveen; Aggrawal, Naveen; Aguilar, Gerardo; Aguirre, Frank; Ahmed, I et al.
DOI: 10.1161/CIRCULATIONAHA.109.881003

Lipoprotein lipase but not hormone-sensitive lipase activities achieve normality after surgically induced weight loss in morbidly obese patients.

PMID: 19455372
Journal: OBESITY SURGERY
Year: 2009
Reference: Obes Surg. 2009 Aug;19(8):1150-8.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Baena-Fustegueras, J A; Catalan, R; Fort, J M; Galard, R; Lecube, A; Llamas, R; Pardina, E; Peinado-Onsurbe, J; Vargas, V et al.
DOI: 10.1007/s11695-009-9853-3

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

PMID: 19688338
Journal: DIABETOLOGIA
Year: 2009
Reference: Diabetologia. 2009 Oct;52(10):2046-55.
Impact factor:
Publication type: Paper in international publication
Authors: Antic, S; Lalic, N; Ravn, G M; Russell-Jones, D; Schmitz, O; Sethi, B K; Simo, R; Vaag, A; Zdravkovic, M et al.
DOI: 10.1007/s00125-009-1472-y

[A decade of recombinant human thyrotropin]

PMID: 19393392
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Apr 18;132(14):560-4.
Impact factor:
Publication type: Review or editorial in national publication
Authors: Mesa, Jordi; Rodriguez-Merchan, Beatriz et al.
DOI: 10.1016/j.medcli.2008.09.029

Glucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload.

PMID: 19444865
Journal: DIABETES-METABOLISM RESEARCH AND REVIEWS
Year: 2009
Reference: Diabetes Metab Res Rev. 2009 Jul;25(5):403-10.
Impact factor:
Publication type: Review in international publication
Authors: Hernandez, Cristina; Lecube, Albert; Simo, Rafael et al.
DOI: 10.1002/dmrr.972

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The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

This investment from EIT Health in the project will enable D-Sight to progress in the clinical development of its groundbreaking treatment for the early stages of diabetic retinopathy.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.