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Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Team

Efráin Santiago Cordero Vázquez

Efráin Santiago Cordero Vázquez

Predoctoral researcher
Diabetes and Metabolism
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Elia Rojas Montserrat

Elia Rojas Montserrat

Administration and Management
Diabetes and Metabolism
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Enzamaría Fidilio Meli

Enzamaría Fidilio Meli

Predoctoral researcher
Diabetes and Metabolism
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Eva Sanz Sapera

Eva Sanz Sapera

Predoctoral researcher
Diabetes and Metabolism
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Irene Hernández Hernández

Irene Hernández Hernández

Predoctoral researcher
Diabetes and Metabolism
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Judit Amigó Farran

Judit Amigó Farran

Predoctoral researcher
Diabetes and Metabolism
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Efráin Santiago Cordero Vázquez

Efráin Santiago Cordero Vázquez

Predoctoral researcher
Diabetes and Metabolism
Read more
Elia Rojas Montserrat

Elia Rojas Montserrat

Administration and Management
Diabetes and Metabolism
Read more
Enzamaría Fidilio Meli

Enzamaría Fidilio Meli

Predoctoral researcher
Diabetes and Metabolism
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Eva Sanz Sapera

Eva Sanz Sapera

Predoctoral researcher
Diabetes and Metabolism
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Irene Hernández Hernández

Irene Hernández Hernández

Predoctoral researcher
Diabetes and Metabolism
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Judit Amigó Farran

Judit Amigó Farran

Predoctoral researcher
Diabetes and Metabolism
Read more

Projects

BIO-STREAM: Multi-Pillar Framework for children Anti-Obesity Behavior building on an EU biobank, Micro Moments and Mobile Recommendation Systems

IP: Andreea Ciudin Mihai
Collaborators: Marta Comas Martínez, Olga Reyes Malia, Graciela Gastelum Varela, José Raul Herance Camacho
Funding agency: EUROPEAN COMMISSION
Funding: 317500
Reference: BIO-STREAM_HE-HLTH-STAYHLTH2022
Duration: 01/05/2023 - 30/04/2027

Utilitat de la inteligència artificial en l’anàlisi d’imatges de retina per identificar els pacients amb major risc de progressió de la retinopatia diabètica en el món real

IP: Olga Simó Servat
Collaborators: -
Funding agency: Associació Catalana de Diabetis
Funding: 10000
Reference: ACD/PROJECTES22/SIMO
Duration: 09/03/2023 - 08/03/2025

Beca VHIR PhD

IP: Josep A Villena Delgado
Collaborators: Beca VHIR PhD, Laia Perez Lasarte, Rafael Simó Canonge, Laura Hidalgo Corbacho, Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/LAURA_H
Duration: 01/04/2023 - 31/03/2026

OBESIMM - Explorando los efectos de la alimentación restringida en el tiempo sobre la funcióin inmune de individuos obesos: una aproximación multi-ómica

IP: Josep A Villena Delgado
Collaborators: Rosario Pardo Diaz, Andreea Ciudin Mihai, Marta Comas Martínez, Ramón Vilallonga Puy, Enzamaría Fidilio Meli
Funding agency: Instituto de Salud Carlos III
Funding: 248050
Reference: AC22/00023
Duration: 01/01/2023 - 31/12/2025

Publications

Integrated image-based deep learning and language models for primary diabetes care.

PMID: 39030266
Journal: NATURE MEDICINE
Year: 2024
Reference: Nat Med. 2024 Jul 19. doi: 10.1038/s41591-024-03139-8.
Impact factor:
Publication type: Paper in international publication
Authors: Abdullah, Adina; Bao, Yuqian; Bascaran, Covadonga; Bee, Yong Mong; Chan, Juliana C N; Chen, Li Jia; Chen, Tingli; Cheng, Ching-Yu; Cheng, Di; Cheung, Carol Y et al.
DOI: 10.1038/s41591-024-03139-8

Artificial intelligence for diabetes care: current and future prospects.

PMID: 39054035
Journal: Lancet Diabetes & Endocrinology
Year: 2024
Reference: Lancet Diabetes Endocrinol. 2024 Aug;12(8):569-595. doi: 10.1016/S2213-8587(24)00154-2.
Impact factor:
Publication type: Paper in international publication
Authors: Bee, Yong Mong; Ekinci, Elif Ilhan; Goh, Jocelyn Hui Lin; Guan, Zhouyu; Jia, Weiping; Li, Huating; Lim, Chwee Teck; Lim, Cynthia Ciwei; Lim, Lee-Ling; Lim, Quan Hziung et al.
DOI: 10.1016/S2213-8587(24)00154-2

Radiation recall reaction induced by gemcitabine/docetaxel in children: A retrospective study on risk factors and outcomes.

PMID: 39086114
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Jul 31:e31221. doi: 10.1002/pbc.31221.
Impact factor:
Publication type: Paper in international publication
Authors: Castaneda, Alicia; Garraus, Moira; Larrosa, Cristina; Mico, Soraya; Mora, Jaume; Perez-Jaume, Sara; Ramos, Monica; Sanchez, Monica et al.
DOI: 10.1002/pbc.31221

Anti-HLA serological response to CD38-targeting desensitization therapy is challenged by peripheral memory B-cells in highly sensitized kidney transplant candidates.

PMID: 39134120
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2024
Reference: Am J Transplant. 2024 Aug 10:S1600-6135(24)00490-8. doi: 10.1016/j.ajt.2024.08.004.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Brar, Amarpali; Carmagnat, Maryvonnick; Caroline, Pilon; Carrera, Claudia; Casanova-Ferrer, Franc; Crespo, Elena; Cruzado, Josep; Donadeu, Laura; Flavio, Vincenti et al.
DOI: 10.1016/j.ajt.2024.08.004

Mortality in acromegaly diagnosed in the elderly in Spain is higher in women compared to the general Spanish population.

PMID: 36916151
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2023
Reference: J Clin Endocrinol Metab. 2023 Aug 18;108(9):2193-2202. doi: 10.1210/clinem/dgad141.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Escola, Cristina; Araujo-Castro, Marta; Ares, Jessica; Bernabeu, Ignacio; Biagetti, Betina; Camara, Rosa; Cordido, Fernando; Diez, Juan J; Gaztambide, Sonia; Gomez, Carlos Garcia et al.
DOI: 10.1210/clinem/dgad141

Serum glial fibrillary acidic protein and neurofilament light chain as biomarkers of retinal neurodysfunction in early diabetic retinopathy: results of the EUROCONDOR study.

PMID: 36959506
Journal: ACTA DIABETOLOGICA
Year: 2023
Reference: Acta Diabetol. 2023 Jun;60(6):837-844. doi: 10.1007/s00592-023-02076-1. Epub 2023 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Cunha-Vaz, Jose; Frydkjaer-Olsen, Ulrik; Garcia-Arumi, Jose; Grauslund, Jakob; Harding, Simon P; Hernandez, Cristina; Hernandez, Cristina; Porta, Massimo; Ribeiro, Luisa; Scanlon, Peter et al.
DOI: 10.1007/s00592-023-02076-1

Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors.

PMID: 37033229
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Mar 22;14:1129213. doi: 10.3389/fendo.2023.1129213. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aulinas, Anna; Biagetti, Betina; Blanco, Alberto; Carrato, Cristina; Casano-Sancho, Paula; Cordero, Esteban; Gil, Joan; Hostalot, Cristina; Ibanez-Dominguez, Javier; Jorda, Mireia et al.
DOI: 10.3389/fendo.2023.1129213

Integrative and Collaborative Approach in the Chronic Management of Obesity in Primary and Tertiary Care Setting: Vall Hebron-SAP Muntanya Healthcare Route.

PMID: 36535242
Journal: Obesity Facts
Year: 2023
Reference: Obes Facts. 2023;16(3):249-254. doi: 10.1159/000528207. Epub 2022 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alarcon, Iris; Ciudin, Andreea; Comas, Marta; Guillaumet, Anna; Lopez, Silvia; Morer, Carla; Nogues, Raquel; Ovejas, Aida; Romero, Rosa; Santos, Maria et al.
DOI: 10.1159/000528207

New Insights into Treating Early and Advanced Stage Diabetic Retinopathy.

PMID: 35955655
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jul 31;23(15). pii: ijms23158513. doi: 10.3390/ijms23158513.
Impact factor:
Publication type: Review in international publication
Authors: Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.3390/ijms23158513

Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists.

PMID: 35925404
Journal: ACTA DIABETOLOGICA
Year: 2022
Reference: Acta Diabetol. 2022 Nov;59(11):1437-1442. doi: 10.1007/s00592-022-01928-6. Epub 2022 Aug 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abreu, Cristina; Garcia-Ramirez, Marta; Gomez-Peralta, Fernando; Gomez-Rodriguez, Sara; Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.1007/s00592-022-01928-6

Initial Clinical and Treatment Patterns of Advanced Differentiated Thyroid Cancer. ERUDIT Study.

PMID: 35900793
Journal: European Thyroid Journal
Year: 2022
Reference: Eur Thyroid J. 2022 Aug 11;11(5). pii: ETJ-21-0111. doi: 10.1530/ETJ-21-0111. Print 2022 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: Aller, Javier; Arguelles, Inaki; Castelo, Beatriz; Crespo, Guillermo; Duran-Poveda, Manuel; Gajate, Pablo; Galofre, Juan Carlos; Gomez-Balaguer, Marcelino; Gonzalez, Cintia; Guadalix, Sonsoles et al.
DOI: 10.1530/ETJ-21-0111

Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic Retinopathy.

PMID: 35883908
Journal: Antioxidants
Year: 2022
Reference: Antioxidants (Basel). 2022 Jul 21;11(7). pii: antiox11071418. doi: 10.3390/antiox11071418.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Deas-Just, Anna; Hernandez, Cristina; Huerta, Jordi; Ramos, Hugo; Simo, Rafael et al.
DOI: 10.3390/antiox11071418

Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD).

PMID: 34680405
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Sep 22;9(10). pii: biomedicines9101289. doi: 10.3390/biomedicines9101289.
Impact factor:
Publication type: Paper in international publication
Authors: Aspichueta, Patricia; Banares, Rafael; Bechmann, Lars P; Benede-Ubieto, Raquel; Bruns, Tony; Ciudin, Andreea; Cubero, Francisco Javier; Estevez-Vazquez, Olga; Gomez-Santos, Beatriz; Guo, Feifei et al.
DOI: 10.3390/biomedicines9101289

Pharmacological and safety profile of a prolonged-release lanreotide formulation in acromegaly.

PMID: 34664531
Journal: Expert Review of Clinical Pharmacology
Year: 2021
Reference: Expert Rev Clin Pharmacol. 2021 Dec;14(12):1551-1560. doi: 10.1080/17512433.2021.1986004. Epub 2021 Nov 8.
Impact factor:
Publication type: Paper in international publication
Authors: Badiu, Corin; Biagetti, Betina; Durand-Gasselin, Lucie; Neggers, Sebastian; Petit, Anne; Petrossians, Patrick; Regnault, Benjamin; Rich, David; Shafigullina, Zulfiya; Shustov, Sergey et al.
DOI: 10.1080/17512433.2021.1986004

Immunotherapy-induced isolated ACTH deficiency in cancer therapy.

PMID: 34609950
Journal: ENDOCRINE-RELATED CANCER
Year: 2021
Reference: Endocr Relat Cancer. 2021 Oct 27;28(12):783-792. doi: 10.1530/ERC-21-0228.
Impact factor:
Publication type: Paper in international publication
Authors: Biagetti, Betina; Cabezas-Agricola, Jose Manuel; Cobo, Diana Ariadel; Diez, Juan Jose; Fernandez-Pombo, Antia; Garcia Gomez, Carlos; Gavira, Javier; Genua, Idoia; Guerrero-Perez, Fernando; Iglesias, Pedro et al.
DOI: 10.1530/ERC-21-0228

Laparoscopic Versus Robot-Assisted Roux-en-Y Gastric Bypass: A Center of Excellence for the EAC-BC Experience.

PMID: 34612707
Journal: Journal of Laparoendoscopic & Advanced Surgical Techniques
Year: 2021
Reference: J Laparoendosc Adv Surg Tech A. 2021 Oct 5. doi: 10.1089/lap.2021.0528.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, Manel; Caubet, Enric; Ciudin, Andrea; Fort, Jose Manuel; Garcia Ruiz de Gordejuela, Amador; Gonzalez, Oscar; Pera-Ferreruela, Meritxell; Petrola, Carlos; Rodriguez-Luna, Maria Rita; Roriz-Silva, Renato et al.
DOI: 10.1089/lap.2021.0528

A Translational In Vivo and In Vitro Metabolomic Study Reveals Altered Metabolic Pathways in Red Blood Cells of Type 2 Diabetes.

PMID: 32471219
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 May 27;9(6). pii: jcm9061619. doi: 10.3390/jcm9061619.
Impact factor:
Publication type: Paper in international publication
Authors: Aparicio-Gomez, Carolina; Ciudin, Andreea; Gutierrez-Carcedo, Patricia; Herance, Jose Raul; Hernandez, Cristina; Lamas-Domingo, Ruben; Mares, Roso; Palomino-Schatzlein, Martina; Simo, Rafael et al.
DOI: 10.3390/jcm9061619

Cost-Effectiveness Analysis of Exenatide versus GLP-1 Receptor Agonists in Patients with Type 2 Diabetes Mellitus.

PMID: 31338828
Journal: PharmacoEconomics - open
Year: 2020
Reference: Pharmacoecon Open. 2020 Jun;4(2):277-286. doi: 10.1007/s41669-019-0171-y.
Impact factor:
Publication type: Paper in international publication
Authors: Capel, Margarita; Ciudin, Andreea; Mareque, Maria; Oyaguez, Itziar; Rodriguez-Rincon, Raquel Maria; Simon, Susana et al.
DOI: 10.1007/s41669-019-0171-y

Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis.

PMID: 32446679
Journal: METABOLISM-CLINICAL AND EXPERIMENTAL
Year: 2020
Reference: Metabolism. 2020 Aug;109:154265. doi: 10.1016/j.metabol.2020.154265. Epub 2020 May 22.
Impact factor:
Publication type: Review in international publication
Authors: Dorans, Kirsten S; Han, Min; Simo, Rafael; Tang, Xingyao; Yang, Jinkui; Zhou, Jian-Bo et al.
DOI: 10.1016/j.metabol.2020.154265

Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

PMID: 32445622
Journal: LANCET NEUROLOGY
Year: 2020
Reference: Lancet Neurol. 2020 Aug;19(8):699-710. doi: 10.1016/S1474-4422(20)30139-3. Epub 2020 May 20.
Impact factor:
Publication type: Review in international publication
Authors: Biessels, Geert Jan; Nobili, Flavio; Scheltens, Philip; Simo, Rafael; Teunissen, Charlotte E et al.
DOI: 10.1016/S1474-4422(20)30139-3

Acromegaly remission, SIADH and pituitary function recovery after macroadenoma apoplexy

PMID: 31310082
Journal: Endocrinology, diabetes & metabolism case repo
Year: 2019
Reference: Endocrinol Diabetes Metab Case Rep. 2019 Jul 15;2019(1). doi: 10.1530/EDM-19-0057.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, F; Biagetti, B; Sanz-Sapera, E; Sarria-Estrada, S et al.
DOI: 10.1530/EDM-19-0057

Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis.

PMID: 31317524
Journal: ENDOCRINE
Year: 2019
Reference: Endocrine. 2019 Nov;66(2):405-415. doi: 10.1007/s12020-019-02014-8. Epub 2019 Jul 17.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Escola, Cristina; Anda, Emma; Baena-Nieto, Gloria; Bandres, Orosia; Blanco Carrera, Concepcion; Carlos Galofre, Juan; de la Vega, Manel Sahun; Diez, Juan J; Donnay, Sergio; Garcia, Jose Carlos Fernandez et al.
DOI: 10.1007/s12020-019-02014-8

Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study.

PMID: 31277226
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Jul 3;8(7). pii: jcm8070964. doi: 10.3390/jcm8070964.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea; Fidilio, Enzamaria; Hernandez, Cristina; Lecube, Albert; Mesa, Jordi; Ortiz, Angel; Pich, Sara; Salas, Eduardo; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.3390/jcm8070964

Visual impairment in aging and cognitive decline: experience in a Memory Clinic.

PMID: 31213626
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Jun 18;9(1):8698. doi: 10.1038/s41598-019-45055-9.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelnour, Carla; Alegret, Montserrat; Benaque, Alba; Boada, Merce; Castilla-Marti, Miguel; Ciudin, Andreea; de Rojas, Itziar; Espinosa, Ana; Gil, Silvia; Hernandez, Cristina et al.
DOI: 10.1038/s41598-019-45055-9

Semaglutide, reduction in HbA1c and the risk of diabetic retinopathy.

PMID: 29178519
Journal: DIABETES OBESITY & METABOLISM
Year: 2018
Reference: Diabetes Obes Metab. 2018 Apr;20(4):889-897. doi: 10.1111/dom.13172. Epub 2018 Jan 8.
Impact factor:
Publication type: Paper in international publication
Authors: Bain, Stephen C; Helmark, Ida Caroe; Larsen, Michael; Leiter, Lawrence A; Lingvay, Ildiko; Matthews, David; Simo, Rafael; Vilsboll, Tina; Wijayasinghe, Nelun et al.
DOI: 10.1111/dom.13172

Somatostatin and diabetic retinopathy: an evolving story.

PMID: 29464407
Journal: ENDOCRINE
Year: 2018
Reference: Endocrine. 2018 Apr;60(1):1-3. doi: 10.1007/s12020-018-1561-0. Epub 2018 Feb 20.
Impact factor:
Publication type: Editorail in international publication
Authors: Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.1007/s12020-018-1561-0

Increased global DNA hypomethylation in distant metastatic and dedifferentiated thyroid cancer.

PMID: 29165662
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2018
Reference: J Clin Endocrinol Metab. 2018 Feb 1;103(2):397-406. doi: 10.1210/jc.2017-01613.
Impact factor:
Publication type: Paper in international publication
Authors: Buj, Raquel; Iglesias, Carmela; Jorda, Mireia; Klein Hesselink, E N; Klein Hesselink, M S; Links, T P; Mauricio, Didac; Montero-Conde, Cristina; Peinado, Miguel A; Puig-Domingo, Manel et al.
DOI: 10.1210/jc.2017-01613

Silymarin prevents diabetes-induced hyperpermeability in human retinal endothelial cells.

PMID: 29422244
Journal: Endocrinologia, diabetes y nutricion
Year: 2018
Reference: Endocrinol Diabetes Nutr. 2018 Apr;65(4):200-205. doi: 10.1016/j.endinu.2017.12.004. Epub 2018 Feb 13.
Impact factor:
Publication type: Paper in national publication
Authors: Garcia-Ramirez, Marta; Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga; Turch, Mireia et al.
DOI: 10.1016/j.endinu.2017.12.004

Retinal Microperimetry: A New Tool for Identifying Type 2 Diabetic Patients at Risk of Developing Alzheimer s Disease.

PMID: 28951388
Journal: DIABETES
Year: 2017
Reference: Diabetes. 2017 Dec;66(12):3098-3104. doi: 10.2337/db17-0382. Epub 2017 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arcos, Gabriel; Boada, Merce; Ciudin, Andreea; Diego, Susana; Hernandez, Cristina; Hernandez, Isabel; Sanabria, Angela; Simo, Rafael; Simo-Servat, Olga; Sotolongo, Oscar et al.
DOI: 10.2337/db17-0382

Serum Surfactant Protein D as a Biomarker for Measuring Lung Involvement in Obese Type 2 Diabetic Patients.

PMID: 28945872
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2017
Reference: J Clin Endocrinol Metab. 2017 Nov 1;102(11):4109-4116. doi: 10.1210/jc.2017-00913.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea; Garcia-Ramirez, Marta; Gutierrez, Liliana; Hernandez, Cristina; Hernandez, Marta; Lecube, Albert; Lopez-Cano, Carolina; Munoz, Xavier; Sanchez, Enric; Seminario, Asuncion et al.
DOI: 10.1210/jc.2017-00913

Pulmonary function and sleep breathing: two new targets for type 2 diabetes care.

PMID: 28938479
Journal: ENDOCRINE REVIEWS
Year: 2017
Reference: Endocr Rev. 2017 Dec 1;38(6):550-573. doi: 10.1210/er.2017-00173.
Impact factor:
Publication type: Review in international publication
Authors: Barbe, Ferran; Hernandez, Cristina; Lecube, Albert; Lopez-Cano, Carolina; Pallayova, Maria; Punjabi, Naresh M; Simo, Rafael; Turino, Cecilia et al.
DOI: 10.1210/er.2017-00173

DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders.

PMID: 28924151
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Sep 18;7(1):11762. doi: 10.1038/s41598-017-12084-1.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Javier; Berdasco, Maria; Boubekeur, Amina M; Caminal, Josep M; Catala-Mora, Jaume; Corella, Dolores; de Torres, Carmen; Esteller, Manel; Gomez, Antonio; Hernandez, Cristina et al.
DOI: 10.1038/s41598-017-12084-1

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

PMID: 27267343
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Year: 2016
Reference: Biochim Biophys Acta. 2016 Sep;1862(9):1663-74. doi: 10.1016/j.bbadis.2016.05.024. Epub 2016 Jun 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alcalde-Estevez, Elena; Arroba, Ana I; Cazzoni, Daniele; de la Villa, Pedro; FGarcia Fernandez, Jose M; Garcia-Ramirez, Marta; Hernandez, Cristina; Mellet, Carmen Ortiz; Sanchez-Fernandez, Elena M; Simo, Rafael et al.
DOI: 10.1016/j.bbadis.2016.05.024

Diabetes mellitus and Alzheimer's disease: An unforgettable relation.

PMID: 26826774
Journal: ZYGOTE
Year: 2016
Reference: Endocrinol Nutr. 2016 May;63(5):191-193. doi: 10.1016/j.endonu.2015.12.004. Epub 2016 Jan 28.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea et al.
DOI: 10.1016/j.endonu.2015.12.004

Diabetic retinopathy.

PMID: 27159554
Journal: Nature reviews. Disease primers
Year: 2016
Reference: Nat Rev Dis Primers. 2016 Mar 17;2:16012. doi: 10.1038/nrdp.2016.12.
Impact factor:
Publication type: Paper in international publication
Authors: Cheung, Chui Ming Gemmy; Larsen, Michael; Sharma, Sanjay; Simo, Rafael; Wong, Tien Y et al.
DOI: 10.1038/nrdp.2016.12

Neuroprotection as a Therapeutic Target for Diabetic Retinopathy.

PMID: 27123463
Journal: Journal of Diabetes Research
Year: 2016
Reference: J Diabetes Res. 2016;2016:9508541. doi: 10.1155/2016/9508541. Epub 2016 Mar 31.
Impact factor:
Publication type: Review in national publication
Authors: Casini, Giovanni; Dal Monte, Massimo; Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.1155/2016/9508541

Expression of YY1 in Differentiated Thyroid Cancer.

PMID: 25698133
Journal: ENDOCR PATHOL
Year: 2015
Reference: Endocr Pathol. 2015 May;26(2):111-8. doi: 10.1007/s12022-015-9359-6.
Impact factor:
Publication type: Paper in international publication
Authors: Arribas, Jessica; Castellvi, Josep; Marcos, Ricard; Velazquez, Antonia; Zafon, Carles et al.
DOI: 10.1007/s12022-015-9359-6

Pharmacological induction of mitochondrial biogenesis as a therapeutic strategy for the treatment of type 2 diabetes.

PMID: 26212547
Journal: BIOCHEM PHARMACOL
Year: 2015
Reference: Biochem Pharmacol. 2015 Nov 1;98(1):16-28. doi: 10.1016/j.bcp.2015.06.032. Epub 2015 Jul 23.
Impact factor:
Publication type: Paper in international publication
Authors: Pardo, Rosario; Villena, Josep A; Zamora, Monica et al.
DOI: 10.1016/j.bcp.2015.06.032

Preoperative TSH level and risk of thyroid cancer in patients with nodular thyroid disease: nodule size contribution.

PMID: 25066642
Journal: Endocrinología y Nutrición
Year: 2015
Reference: Endocrinol Nutr. 2015 Jan;62(1):24-8. doi: 10.1016/j.endonu.2014.06.002. Epub 2014 Jul 25.
Impact factor:
Publication type: Paper in national publication
Authors: Mesa, Jordi; Obiols, Gabriel; Zafon, Carles et al.
DOI: 10.1016/j.endonu.2014.06.002

Is fenofibrate a reasonable treatment for diabetic microvascular disease?

PMID: 25772642
Journal: CURR DIABETES REP
Year: 2015
Reference: Curr Diab Rep. 2015 May;15(5):24. doi: 10.1007/s11892-015-0599-0.
Impact factor:
Publication type: Paper in international publication
Authors: Hernandez, Cristina; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.1007/s11892-015-0599-0

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives.

PMID: 24183659
Journal: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Year: 2014
Reference: Trends Endocrinol Metab. 2014 Jan;25(1):23-33. doi: 10.1016/j.tem.2013.09.005. Epub 2013 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bandello, F; Burks, D; Cunha-Vaz, J; Egan, C; Garcia-Arumi, J; Gibson, J; Grauslund, J; Harding, S; Hernandez, Cristina; Karadeniz, S et al.
DOI: 10.1016/j.tem.2013.09.005

[Decalogue of clinical recommendations on atherogenic dyslipidemia].

PMID: 24365580
Journal: Clínica e investigación en arteriosclerosis
Year: 2014
Reference: Clin Investig Arterioscler. 2014 Jan-Feb;26(1):38-40. doi: 10.1016/j.arteri.2013.11.007. Epub 2013 Dec 21.
Impact factor:
Publication type: Letter or abstract
Authors: Brea, Angel; Diaz, Angel; Gonzalez-Santos, Pedro; Hernandez-Mijares, Antonio; Mantilla, Teresa; Millan, Jesus; Pedro-Botet, Juan; Pinto, Xavier; Simo, Rafael et al.
DOI: 10.1016/j.arteri.2013.11.007

Escape and lipodystrophy in acromegaly during pegvisomant therapy, a retrospective multicentre Spanish study.

PMID: 24612232
Journal: CLIN ENDOCRINOL
Year: 2014
Reference: Clin Endocrinol (Oxf). 2014 Dec;81(6):883-90. doi: 10.1111/cen.12440. Epub 2014 Mar 19.
Impact factor: 3.353
Publication type: Paper in international publication
Authors: Gaztambide, Sonia, Salinas, Isabel, Pozo, Carlos Del, Castells, Ignasi, Villabona, Carles, Biagetti, Betina, Webb, Susan M, Camara, Rosa, Blanco, Concepcion, Alvarez-Escola, Cristina et al.
DOI: 10.1111/cen.12440

Cushing's disease in 2012.

PMID: 24041670
Journal: Endocrinologia y nutricion : organo de la Sociedad
Year: 2014
Reference: Endocrinol Nutr. 2014 Feb;61(2):93-9. doi: 10.1016/j.endonu.2013.05.003. Epub 2013 Sep 14.
Impact factor: 1.881
Publication type: Review in national publication
Authors: Obiols Alfonso, Gabriel, Biagetti Biagetti, Betina, Chacon Oreja, Ana, Salvador Rodriguez, Javier et al.
DOI: 10.1016/j.endonu.2013.05.003

Weight-Related Quality of Life in Spanish Obese Subjects Suitable for Bariatric Surgery is Lower Than in Their North American Counterparts: a Case-Control Study.

PMID: 23090430
Journal: OBESITY SURGERY
Year: 2013
Reference: Obes Surg. 2013 Apr;23(4):509-14. doi: 10.1007/s11695-012-0791-0.
Impact factor:
Publication type: Paper in international publication
Authors: Arrizabalaga, Juan-Jose; Burguera, Bartolome; Caixas, Assumpta; Calanas, Alfonso; Cordido, Fernando; Crosby, Ross D; Diaz, Maria-Jesus; Garcia-Luna, Pedro-Pablo; Goday, Albert; Iglesias, Paloma et al.
DOI: 10.1007/s11695-012-0791-0

Clinical spectrum of MEN2A in a large family caused by the infrequent RET mutation Cys609Phe.

PMID: 22734615
Journal: CLINICAL GENETICS
Year: 2013
Reference: Clin Genet. 2013 Apr;83(4):384-7. doi: 10.1111/j.1399-0004.2012.01921.x. Epub 2012 Jul 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1111/j.1399-0004.2012.01921.x

Bariatric Surgery Outcomes in a European Centre of Excellence (CoE).

PMID: 23645480
Journal: OBESITY SURGERY
Year: 2013
Reference: Obes Surg. 2013 Aug;23(8):1324-32. doi: 10.1007/s11695-013-0980-5.
Impact factor:
Publication type: Review in international publication
Authors: Armengol, Manel; Caubet, Enric; Fort, Jose Manuel; Gonzalez, Oscar; Lecube, Albert; Mesa, Jordi; Vilallonga, Ramon et al.
DOI: 10.1007/s11695-013-0980-5

Impaired endothelial function is not associated with arterial stiffness in adults with type 1 diabetes.

PMID: 23643350
Journal: DIABETES & METABOLISM
Year: 2013
Reference: Diabetes Metab. 2013 Sep;39(4):355-62. doi: 10.1016/j.diabet.2013.03.006. Epub 2013 May 3.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, L; Berlanga, E; Ceperuelo-Mallafre, V; Gonzalez-Clemente, J M; Llaurado, G; Simo, R; Vendrell, J; Vilardell, C et al.
DOI: 10.1016/j.diabet.2013.03.006

Psychometric Evaluation of the IWQOL-Lite (Spanish Version) When Applied to a Sample of Obese Patients Awaiting Bariatric Surgery.

PMID: 21898041
Journal: OBESITY SURGERY
Year: 2012
Reference: Obes Surg. 2012 May;22(5):802-9. doi: 10.1007/s11695-011-0518-7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1007/s11695-011-0518-7

Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy.

PMID: 22167324
Journal: ENDOCRINE
Year: 2012
Reference: Endocrine. 2012 Apr;41(2):220-6. Epub 2011 Dec 14.
Impact factor:
Publication type: Review in international publication
Authors: ; et al.
DOI: 10.1007/s12020-011-9579-6

Inability of rhTSH to predict the evolution from subclinical hypothyroidism to overt disease. A pilot study.

PMID: 21521938
Journal: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Year: 2012
Reference: J Endocrinol Invest. 2012 Jan;35(1):25-7. Epub 2011 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.3275/7684

Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions.

PMID: 21826649
Journal: JOURNAL OF CELLULAR PHYSIOLOGY
Year: 2012
Reference: J Cell Physiol. 2012 Jun;227(6):2352-62. doi: 10.1002/jcp.22970.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1002/jcp.22970

Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1beta by suppressing AMP-activated protein kinase (AMPK) activation.

PMID: 21369818
Journal: DIABETOLOGIA
Year: 2011
Reference: Diabetologia. 2011 Jun;54(6):1543-53. Epub 2011 Mar 3.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1007/s00125-011-2089-5

TNF-alpha system and lung function impairment in obesity.

PMID: 21296591
Journal: CYTOKINE
Year: 2011
Reference: Cytokine. 2011 May;54(2):121-4. Epub 2011 Feb 5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.cyto.2011.01.010

Prevalence and risk factors accounting for true silent myocardial ischemia: a pilot case-control study comparing type 2 diabetic with non-diabetic control subjects.

PMID: 21255408
Journal: Cardiovascular Diabetology
Year: 2011
Reference: Cardiovasc Diabetol. 2011 Jan 21;10:9. doi: 10.1186/1475-2840-10-9.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1186/1475-2840-10-9

Management of patients with hernia or incisional hernia undergoing surgery for morbid obesity.

PMID: 21188167
Journal: Journal of obesity
Year: 2011
Reference: J Obes. 2011;2011:860942. Epub 2010 Dec 5.
Impact factor:
Publication type: Letter or abstract
Authors: Armengol, Manuel; Baena, Juan Antonio; Fort, Jose Manuel; Gonzalez, Oscar; Lecube, Albert; Vilallonga, Ramon et al.
DOI: 10.1155/2011/860942

Metabolic fingerprints of proliferative diabetic retinopathy. An 1H NMR-based metabonomic approach using vitreous humor.

PMID: 20375324
Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Year: 2010
Reference: Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4416-21. Epub 2010 Apr 7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1167/iovs.10-5348

Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery.

PMID: 20020222
Journal: OBESITY SURGERY
Year: 2010
Reference: Obes Surg. 2010 Apr;20(4):454-61. Epub 2009 Dec 18.
Impact factor:
Publication type: Paper in international publication
Authors: Lecube, Albert; Lloberes, Patricia; Mesa, Jordi; Morell, Ferran; Romero, Odile; Sampol, Gabriel; Simo, Rafael et al.
DOI: 10.1007/s11695-009-0033-2

Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study.

PMID: 20217039
Journal: DIABETOLOGIA
Year: 2010
Reference: Diabetologia. 2010 Jun;53(6):1210-6. Epub 2010 Mar 9.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; et al.
DOI: 10.1007/s00125-010-1700-5

Different Effects of Thiazolidinediones on Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus: Pioglitazone versus Rosiglitazone.

PMID: 20210732
Journal: Current Drug Safety
Year: 2010
Reference: Curr Drug Saf. 2010 Jul 2;5(3):234-44.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI:

Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis.

PMID: 19447103
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 Oct 15;315(17):3004-13.
Impact factor:
Publication type: Paper in international publication
Authors: Barbosa-Desongles, Anna; Barquinero, Jordi; Hurtado, Antoni; Morote, Joan; Munell, Francina; Pinos, Tomas; Poupon, Marie-France; Reventos, Jaume; Santamaria-Martinez, Albert; Seoane, Joan et al.
DOI: 10.1016/j.yexcr.2009.05.007

Advances in the medical treatment of diabetic retinopathy.

PMID: 19638526
Journal: DIABETES CARE
Year: 2009
Reference: Diabetes Care. 2009 Aug;32(8):1556-62.
Impact factor:
Publication type: Review in international publication
Authors: Hernandez, Cristina; Simo, Rafael et al.
DOI: 10.2337/dc09-0565

Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy.

PMID: 19823802
Journal: DIABETOLOGIA
Year: 2009
Reference: Diabetologia. 2009 Dec;52(12):2633-41.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00125-009-1548-8

Effects of high glucose concentration on the barrier function and the expression of tight junction proteins in human retinal pigment epithelial cells.

PMID: 19660451
Journal: EXPERIMENTAL EYE RESEARCH
Year: 2009
Reference: Exp Eye Res. 2009 Dec;89(6):913-20.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1016/j.exer.2009.07.017

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The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

This investment from EIT Health in the project will enable D-Sight to progress in the clinical development of its groundbreaking treatment for the early stages of diabetic retinopathy.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.