About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Medicine still has many challenges to solve specially on complex diseases were a large number of both, genetic and environmental factors are involved. Among them, neurodegenerative and autoimmune disorders affecting the central nervous system have attracted attention because CNS is difficult to access and to manipulate with classical pharmacological treatments and, in addition, there are no effective curative treatments for these diseases. To address these problems, we have focused our research interests in gene therapy strategies for autoimmune diseases and neurodegenerative disorders specially those associated to aging.
PMID: 34857831 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Dec 2;11(1):23358. doi: 10.1038/s41598-021-02694-1. Impact factor: 4.38 Publication type: Paper in international publication Authors: Kagiava, A, Richter, J, Tryfonos, C, Leal-Julia, M, Sargiannidou, I, Christodoulou, C, Bosch, A, Kleopa, K A et al. DOI: 10.1038/s41598-021-02694-1
PMID: 34576188 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2021 Reference: Int J Mol Sci. 2021 Sep 16;22(18). pii: ijms221810025. doi: 10.3390/ijms221810025. Impact factor: 5.924 Publication type: Paper in international publication Authors: Aubets, Eva, Chillon, Miguel, Ciudad, Carlos J, Noe, Veronique et al. DOI: 10.3390/ijms221810025
PMID: 33786805 Journal: Neurotherapeutics Year: 2021 Reference: Neurotherapeutics. 2021 Apr;18(2):1113-1126. doi: 10.1007/s13311-021-01025-6. Epub 2021 Mar 30. Impact factor: 7.62 Publication type: Paper in international publication Authors: Modol-Caballero, Guillem, Garcia-Lareu, Belen, Herrando-Grabulosa, Mireia, Verdes, Sergi, Lopez-Vales, Ruben, Pages, Gemma, Chillon, Miguel, Navarro, Xavier, Bosch, Assumpcio et al. DOI: 10.1007/s13311-021-01025-6
PMID: 33572045 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Feb 9;13(2). pii: nu13020562. doi: 10.3390/nu13020562. Impact factor: 5.719 Publication type: Paper in international publication Authors: Vogel-Gonzalez, Marina, Tallo-Parra, Marc, Herrera-Fernandez, Victor, Perez-Vilaro, Gemma, Chillon, Miguel, Nogues, Xavier, Gomez-Zorrilla, Silvia, Lopez-Montesinos, Inmaculada, Arnau-Barres, Isabel, Sorli-Redo, Maria Luisa et al. DOI: 10.3390/nu13020562
PMID: 26491879 Journal: ACS Nano Year: 2015 Reference: ACS Nano. 2015 Nov 24;9(11):10826-33. doi: 10.1021/acsnano.5b03417. Epub 2015 Oct 28. Impact factor: 12.881 Publication type: Paper in international publication Authors: Ortega-Esteban, Alvaro, Condezo, Gabriela N, Perez-Berna, Ana J, Chillon, Miguel, Flint, S Jane, Reguera, David, San Martin, Carmen, de Pablo, Pedro J et al. DOI: 10.1021/acsnano.5b03417
PMID: 26178997 Journal: JOURNAL OF VIROLOGY Year: 2015 Reference: J Virol. 2015 Sep;89(18):9653-64. doi: 10.1128/JVI.01453-15. Epub 2015 Jul 15. Impact factor: 4.439 Publication type: Paper in international publication Authors: San Martin, Carmen, Condezo, Gabriela N, Marabini, Roberto, Ayora, Silvia, Carazo, Jose M, Alba, Raul, Chillon, Miguel et al. DOI: 10.1128/JVI.01453-15
PMID: 24299455 Journal: HUM GENE THER Year: 2014 Reference: Hum Gene Ther. 2014 Mar;25(3):199-211. doi: 10.1089/hum.2013.152. Epub 2014 Jan 23. Impact factor: 3.623 Publication type: Paper in international publication Authors: Ariza, Lorena, Gimenez-Llort, Lydia, Pages, Gemma, Garcia-Lareu, Belen, Serratrice, Nicolas, Cots, Dan, Thwaite, Rosemary, Chillon, Miguel, Kremer, Eric J, Bosch, Assumpcio et al. DOI: 10.1089/hum.2013.152
PMID: 24846610 Journal: NEUROSCIENCE Year: 2014 Reference: Neuroscience. 2014 Aug 22;274:250-9. doi: 10.1016/j.neuroscience.2014.05.015. Epub 2014 May 15. Impact factor: 3.327 Publication type: Paper in international publication Authors: Ariza, L, Pages, G, Garcia-Lareu, B, Cobianchi, S, Ruberte, J, Otaegui, P J, Chillon, M, Navarro, X, Bosch, A et al. DOI: 10.1016/j.neuroscience.2014.05.015
PMID: 24132485 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2014 Reference: Methods Mol Biol. 2014;1089:159-73. doi: 10.1007/978-1-62703-679-5_12. Impact factor: 0 Publication type: Paper in international publication Authors: Penalva, Cristina, Monfar, Merce, Chillon, Miguel, Piedra, Jose, Ontiveros, Maria, Miravet, Susana et al. DOI: 10.1007/978-1-62703-679-5_12
PMID: 24132489 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2014 Reference: Methods Mol Biol. 2014;1089:231-43. doi: 10.1007/978-1-62703-679-5_16. Impact factor: 0 Publication type: Paper in international publication Authors: Miralles, Marta, Garcia, Marc, Tejero, Marcos, Bosch, Assumpcio, Chillon, Miguel et al. DOI: 10.1007/978-1-62703-679-5_16
PMID: 23922808 Journal: PLoS One Year: 2013 Reference: PLoS One. 2013 Jul 26;8(7):e69808. doi: 10.1371/journal.pone.0069808. Print 2013. Impact factor: 3.73 Publication type: Paper in international publication Authors: Licursi, Valerio, Costa, Rossella, Roncaglia, Enrica, Gennetier, Aurelie, Ibanes, Sandy, Chillon, Miguel, Negri, Rodolfo, Tagliafico, Enrico, Kremer, Eric J, Saggio, Isabella et al. DOI: 10.1371/journal.pone.0069808
PMID: 24020980 Journal: Human Gene Therapy Methods Year: 2013 Reference: Hum Gene Ther Methods. 2013 Dec;24(6):372-80. doi: 10.1089/hgtb.2013.124. Epub 2013 Oct 8. Impact factor: 0 Publication type: Paper in international publication Authors: Laborda, Eduardo, Puig-Saus, Cristina, Cascallo, Manel, Chillon, Miguel, Alemany, Ramon et al. DOI: 10.1089/hgtb.2013.124
The treatment, licensed to Klotho Neurosciences, is based on a technology developed at the Universitat Autònoma de Barcelona (UAB) with the participation of VHIR.
The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.
This gene therapy protects mice against cognitive deficits associated with aging, improves motor function, and delays the onset of diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.
Check the current rates for the services offered by the Gene Therapy at Nervous System research group.
