About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.
The objectives of the group are:
PMID: 32841735 Journal: Translational Research Year: 2021 Reference: Transl Res. 2021 Mar;229:135-141. doi: 10.1016/j.trsl.2020.08.009. Epub 2020 Aug 22. Impact factor: Publication type: Review in international publication Authors: Gonzalez-Cabo, Pilar; Lyakhovich, Alex; Pagano, Giovanni; Pallardo, Federico V; Rodriguez, Laura R; Trifuoggi, Marco et al. DOI: 10.1016/j.trsl.2020.08.009
PMID: 33172965 Journal: RNA Year: 2021 Reference: RNA. 2021 Feb;27(2):190-201. doi: 10.1261/rna.076422.120. Epub 2020 Nov 10. Impact factor: Publication type: Paper in international publication Authors: Araujo, Ferran; Coll, Olga; Gebauer, Fatima; Guerrero, Santiago; Indacochea, Alberto; LLeonart, Matilde E; Ure Ntildea, Macarena et al. DOI: 10.1261/rna.076422.120
PMID: 34421416 Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG Year: 2021 Reference: J Pediatr Pharmacol Ther. 2021;26(6):643-646. doi: 10.5863/1551-6776-26.6.643. Epub 2021 Aug 16. Impact factor: 0 Publication type: Paper in international publication Authors: Danés, Imma, Ortega, Juan, Vila, Jorgina, Morgenstern, Andrés, Vendrell, Lourdes et al. DOI: 10.5863/1551-6776-26.6.643
PMID: 34394703 Journal: Nano Today Year: 2021 Reference: Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101056. Epub 2020 Dec 20. Impact factor: 20.722 Publication type: Paper in international publication Authors: Buzon, Maria J, Puntes, Victor, Genesca, Meritxell, Astorga-Gamaza, Antonio, Vitali, Michele, Borrajo, Mireya L, Jaime, Carlos, Bastus, Neus, Serra-Peinado, Carla, Luque-Ballesteros, Laura et al. DOI: 10.1016/j.nantod.2020.101056
PMID: 28006041 Journal: JAMA Otolaryngology-Head & Neck Surgery Year: 2017 Reference: JAMA Otolaryngol Head Neck Surg. 2017 Apr 1;143(4):341-349. doi: 10.1001/jamaoto.2016.3537. Impact factor: 2.951 Publication type: Paper in international publication Authors: Hernandez, F Javier, Lansford, Bryan, Douglis, Franklin, Esterhuizen, Kenneth, Spektor, Zorik, Pumarola, Felix, Ismail, Khaleed, Lanier, Brent, Hussain, Iftikhar, Ansley, John et al. DOI: 10.1001/jamaoto.2016.3537
PMID: 27693455 Journal: CANCER LETTERS Year: 2017 Reference: Cancer Lett. 2017 Jan 1;384:60-69. doi: 10.1016/j.canlet.2016.09.023. Epub 2016 Sep 28. Impact factor: 5.992 Publication type: Paper in international publication Authors: Lyakhovich, Alex, Lleonart, Matilde E, Graifer, Dmitry, Esner, Milan et al. DOI: 10.1016/j.canlet.2016.09.023
PMID: 29072692 Journal: Cell Death & Disease Year: 2017 Reference: Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544. Impact factor: 5.965 Publication type: Paper in international publication Authors: Mir, Cristina, Feliciano, Andrea, Garcia-Mayea, Yoelsis, Jubierre, Luz, Hernandez-Losa, Javier, Paciucci, Rosanna, Sansano, Irene, Sun, Yilin, Cajal, Santiago Ramon Y, Kondon, Hiroshi et al. DOI: 10.1038/cddis.2017.544
PMID: 28757873 Journal: International journal of otolaryngology Year: 2017 Reference: Int J Otolaryngol. 2017;2017:5185268. doi: 10.1155/2017/5185268. Epub 2017 Jul 3. Impact factor: 0 Publication type: Paper in international publication Authors: Graterol, D, Mir, C, Garcia-Vaquero, C, Brana, I, Pardo, A N, Rochera-Villach, M I, Lyakhovich, A, LLeonart, M E, Lorente, J et al. DOI: 10.1155/2017/5185268
PMID: 25687884 Journal: CANCER LETTERS Year: 2015 Reference: Cancer Lett. 2015 May 28;361(1):33-8. doi: 10.1016/j.canlet.2015.02.020. Epub 2015 Feb 14. Impact factor: 5.621 Publication type: Paper in international publication Authors: Shyamsunder, Pavithra, Verma, Rama S, Lyakhovich, Alex et al. DOI: 10.1016/j.canlet.2015.02.020
The sessions were aimed at establishing new collaborations to advance the prevention and treatment of this type of tumour.
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
The Biomedical Research in Cancer Stem Cells group at VHIR has identified a new therapeutic target and is working to find new therapies for this type of tumor.
