About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.
The objectives of the group are:
PMID: 33090711 Journal: FEBS Journal Year: 2021 Reference: FEBS J. 2021 Apr;288(7):2184-2202. doi: 10.1111/febs.15588. Epub 2020 Nov 3. Impact factor: 5.542 Publication type: Paper in international publication Authors: Abad, Etna, Civit, Laia, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex et al. DOI: 10.1111/febs.15588
PMID: 33316348 Journal: CANCER LETTERS Year: 2021 Reference: Cancer Lett. 2021 Apr 10;503:185-196. doi: 10.1016/j.canlet.2020.12.010. Epub 2020 Dec 11. Impact factor: 8.679 Publication type: Paper in international publication Authors: Potesil, David, Zdrahal, Zbynek, OscarYanes, Lyakhovich, Alex, Graifer, Dmitry, Trifuoggi, Marco, Pagano, Giovanni, Grodzicki, Robert L, Abad, Etna, Samino, Sara et al. DOI: 10.1016/j.canlet.2020.12.010
PMID: 33172965 Journal: RNA Year: 2021 Reference: RNA. 2021 Feb;27(2):190-201. doi: 10.1261/rna.076422.120. Epub 2020 Nov 10. Impact factor: 4.942 Publication type: Paper in international publication Authors: Indacochea, Alberto, Guerrero, Santiago, Ure Ntildea, Macarena, Araujo, Ferran, Coll, Olga, Gebauer, Fatima, LLeonart, Matilde E et al. DOI: 10.1261/rna.076422.120
PMID: 28763470 Journal: PLoS One Year: 2017 Reference: PLoS One. 2017 Aug 1;12(8):e0182044. doi: 10.1371/journal.pone.0182044. eCollection 2017. Impact factor: 2.806 Publication type: Paper in international publication Authors: Li, Weiyao, Cebrian, Arancha, Gomez Del Pulgar, Teresa, Puime-Otin, Alberto, Del Puerto-Nevado, Laura, Rodriguez-Remirez, Maria, Perez, Nuria, Celdran, Angel, Gebauer, Fatima, Garcia-Foncillas, Jesus et al. DOI: 10.1371/journal.pone.0182044
PMID: 28682452 Journal: MEDICINAL RESEARCH REVIEWS Year: 2017 Reference: Med Res Rev. 2017 Nov;37(6):1275-1298. doi: 10.1002/med.21459. Epub 2017 Jul 6. Impact factor: 8.763 Publication type: Review in international publication Authors: Lleonart, Matilde E, Grodzicki, Robert, Graifer, Dmitri M, Lyakhovich, Alex et al. DOI: 10.1002/med.21459
PMID: 27918383 Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL Year: 2017 Reference: Pediatr Infect Dis J. 2017 Mar;36(3):274-281. doi: 10.1097/INF.0000000000001420. Impact factor: 2.486 Publication type: Paper in international publication Authors: Van Dyke, Melissa K, Pircon, Jean-Yves, Cohen, Robert, Madhi, Shabir A, Macias Parra, Mercedes, Al-Mazrou, Khalid, Grevers, Gerhard, Lopez, Pio, Naranjo, Laura, Pumarola, Felix et al. DOI: 10.1097/INF.0000000000001420
The sessions were aimed at establishing new collaborations to advance the prevention and treatment of this type of tumour.
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
The Biomedical Research in Cancer Stem Cells group at VHIR has identified a new therapeutic target and is working to find new therapies for this type of tumor.
