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Headache and Neurological Pain

Our research group is focused on studying the pathophysiology of migraine and other primary headaches using preclinical, translational and clinical research.

Migraine will allow us to define the brain’s adaptive, sensory/cognitive functions, through genetics, epigenetics, neurophysiology, neuromolecular and neuroanatomical information with an interest in developing clinical therapeutic solutions, with the goal on having an impact on suffering and increasing the well-being.

Team

Patricia Pozo Rosich

Patricia Pozo Rosich

Head of group
Headache and Neurological Pain
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Marta Torres Ferrús

Marta Torres Ferrús

Main researcher
Headache and Neurological Pain
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Marta Vila Pueyo

Marta Vila Pueyo

Main researcher
Headache and Neurological Pain
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Alicia Alpuente Ruiz

Alicia Alpuente Ruiz

Headache and Neurological Pain
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Gliga , Otilia

Gliga , Otilia

Predoctoral researcher
Headache and Neurological Pain
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Joana Rosell Mirmi

Joana Rosell Mirmi

Research technician
Headache and Neurological Pain
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Patricia Pozo Rosich

Patricia Pozo Rosich

Head of group
Headache and Neurological Pain
Read more
Marta Torres Ferrús

Marta Torres Ferrús

Main researcher
Headache and Neurological Pain
Read more
Marta Vila Pueyo

Marta Vila Pueyo

Main researcher
Headache and Neurological Pain
Read more
Alicia Alpuente Ruiz

Alicia Alpuente Ruiz

Headache and Neurological Pain
Read more
Gliga , Otilia

Gliga , Otilia

Predoctoral researcher
Headache and Neurological Pain
Read more
Joana Rosell Mirmi

Joana Rosell Mirmi

Research technician
Headache and Neurological Pain
Read more

Research lines

Genetics of migraine and other primary headaches

IP: -

Neuroimaging research of migraine and other primary headaches

IP: -

Neurophysiological research of migraine and other primary headaches

IP: -

Projects

Biomarcadores neuroinflamatorios en pacientes con migraña: prueba de concepto para el diagnóstico molecular de la enfermedad

IP: Marta Vila Pueyo
Collaborators: Laila Asskour, Patricia Pozo Rosich, Victor José Gallardo Lopez, Otilia Gliga
Funding agency: Fundación Eugenio Rodríguez Pascual
Funding: 24990
Reference: FERP-2023-MVP
Duration: 17/01/2024 - 16/01/2026

X

IP: Patricia Pozo Rosich
Collaborators: Otilia Gliga, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 89900
Reference: FI23/00149
Duration: 01/01/2024 - 31/12/2027

Digitalization in Migraine

IP: Patricia Pozo Rosich
Collaborators: Edoardo Caronna, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 180000
Reference: JR23/00065
Duration: 01/01/2024 - 31/12/2027

Assessing the role of glial cells in migraine and its chronification

IP: Marta Vila Pueyo
Collaborators: Laila Asskour, Victor José Gallardo Lopez
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 175000
Reference: PID2022-137287NA-I00
Duration: 01/09/2023 - 31/08/2026

Ministerio de Ciencia

Publications

Patterns of response to anti-calcitonin gene-related peptide monoclonal antibodies during first 6 months of treatment in resistant migraine patients: Impact on outcome.

PMID: 37038303
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 Jul;30(7):1937-1944. doi: 10.1111/ene.15816. Epub 2023 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alpuente, Alicia; Caronna, Edoardo; Gallardo, Victor J; Gine-Cipres, Eulalia; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al.
DOI: 10.1111/ene.15816

Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial.

PMID: 37516125
Journal: LANCET
Year: 2023
Reference: Lancet. 2023 Jul 26:S0140-6736(23)01049-8. doi: 10.1016/S0140-6736(23)01049-8.
Impact factor:
Publication type: Paper in international publication
Authors: Ailani, Jessica; Ashina, Messoud; Boinpally, Ramesh; De Abreu Ferreira, Rosa; Finnegan, Michelle; Goadsby, Peter J; Guo, Hua; Lipton, Richard B; Lu, Kaifeng; McCusker, Emily et al.
DOI: 10.1016/S0140-6736(23)01049-8

Headache in COVID-19 and Long COVID: to Know Facts for Clinical Practice.

PMID: 37665495
Journal: Current Neurology and Neuroscience Reports
Year: 2023
Reference: Curr Neurol Neurosci Rep. 2023 Sep 4. doi: 10.1007/s11910-023-01296-w.
Impact factor:
Publication type: Review in international publication
Authors: Caronna, Edoardo; Gomez-Dabo, Laura; Melgarejo-Martinez, Laura; Pozo-Rosich, Patricia; Pozo-Rosich, Patricia et al.
DOI: 10.1007/s11910-023-01296-w

Mode and site of action of therapies targeting CGRP signaling.

PMID: 37691118
Journal: JOURNAL OF HEADACHE AND PAIN
Year: 2023
Reference: J Headache Pain. 2023 Sep 11;24(1):125. doi: 10.1186/s10194-023-01644-8.
Impact factor:
Publication type: Review in international publication
Authors: Braniste, Diana; Burstein, Rami; Caronna, Edoardo; Chkhitunidze, Nino; Dapkute, Austeja; Gollion, Cedric; Gudadze, Tamari; Hoffmann, Jan; Labastida-Ramirez, Alejandro; Meksa, Liga et al.
DOI: 10.1186/s10194-023-01644-8

The selective 5-HT(1F) receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache.

PMID: 34600443
Journal: BRITISH JOURNAL OF PHARMACOLOGY
Year: 2022
Reference: Br J Pharmacol. 2022 Feb;179(3):358-370. doi: 10.1111/bph.15699. Epub 2021 Nov 16.
Impact factor:
Publication type: Paper in international publication
Authors: Goadsby, Peter J; Holland, Philip R; Johnson, Kirk W; Loraine, Howard J; Murdock, Paul R; Page, Keith; Vila-Pueyo, Marta; Woodrooffe, Amanda J et al.
DOI: 10.1111/bph.15699

Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs.

PMID: 35354072
Journal: European Journal of Pharmacology
Year: 2022
Reference: Eur J Pharmacol. 2022 May 5;922:174905. doi: 10.1016/j.ejphar.2022.174905. Epub 2022 Mar 27.
Impact factor:
Publication type: Paper in international publication
Authors: Araya, Erika Ivanna; Baggio, Darciane Favero; Chichorro, Juliana Geremias; Koren, Laura de Oliveira; Schwarting, Rainer K W et al.
DOI: 10.1016/j.ejphar.2022.174905

Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients.

PMID: 35166156
Journal: CEPHALALGIA
Year: 2022
Reference: Cephalalgia. 2022 Jul;42(8):804-809. doi: 10.1177/03331024211068074. Epub 2022 Feb 15.
Impact factor: 6.295
Publication type: Paper in international publication
Authors: Pozo-Rosich, Patricia; de Lorenzo, Inigo; Garcia-Azorin, David; Layos-Romero, Almudena; Porta-Etessam, Jesus; Membrilla, Javier A; Caronna, Edoardo; Gonzalez-Martinez, Alicia; Mencia, Alvaro Sierra; Segura, Tomas et al.
DOI: 10.1177/03331024211068074

Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial.

PMID: 35716692
Journal: LANCET NEUROLOGY
Year: 2022
Reference: Lancet Neurol. 2022 Jul;21(7):597-607. doi: 10.1016/S1474-4422(22)00185-5.
Impact factor: 44.182
Publication type: Paper in international publication
Authors: Lanteri-Minet, Michel; Pozo-Rosich, Patricia; Ettrup, Anders; Christoffersen, Cecilie Laurberg; Josiassen, Mette Krog; Phul, Ravinder; Sperling, Bjorn; Ashina, Messoud et al.
DOI: 10.1016/S1474-4422(22)00185-5

Safety of anti-CGRP monoclonal antibodies in patients with migraine during the COVID-19 pandemic: Present and future implications.

PMID: 33832802
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia (Engl Ed). 2021 Mar 19;36(8):611-7. doi: 10.1016/j.nrl.2021.03.003.
Impact factor:
Publication type: Paper in international publication
Authors: Alpuente, A; Caronna, E; Gago-Veiga, A B; Irimia Sieira, P; Jose Gallardo, V; Lopez-Bravo, A; Lopez-Veloso, A C; Porta-Etessam, J; Pozo-Rosich, P; Sanchez-Mateo, N M et al.
DOI: 10.1016/j.nrl.2021.03.003

In search of a gold standard patient-reported outcome measure to use in the evaluation and treatment-decision making in migraine prevention. A real-world evidence study.

PMID: 34903177
Journal: JOURNAL OF HEADACHE AND PAIN
Year: 2021
Reference: J Headache Pain. 2021 Dec 13;22(1):151. doi: 10.1186/s10194-021-01366-9.
Impact factor: 7.277
Publication type: Paper in international publication
Authors: Gallardo, Victor J, Alpuente, Alicia, Pozo-Rosich, Patricia, Torres-Ferrus, Marta, Caronna, Edoardo et al.
DOI: 10.1186/s10194-021-01366-9

Headache as a Symptom of COVID-19: Narrative Review of 1-Year Research.

PMID: 34766205
Journal: Current Pain and Headache Reports
Year: 2021
Reference: Curr Pain Headache Rep. 2021 Nov 11;25(11):73. doi: 10.1007/s11916-021-00987-8.
Impact factor: 3.494
Publication type: Review in international publication
Authors: Caronna, Edoardo, Pozo-Rosich, Patricia et al.
DOI: 10.1007/s11916-021-00987-8

The impact of a digital platform on migraine patient-centered outcome research. Evaluation of midolordecabeza.org, a headache website in Spanish.

PMID: 34601726
Journal: HEADACHE
Year: 2021
Reference: Headache. 2021 Oct;61(9):1403-1410. doi: 10.1111/head.14225. Epub 2021 Oct 3.
Impact factor: 5.887
Publication type: Paper in international publication
Authors: Gallardo, Victor J, Alpuente, Alicia, Cerda-Company, Xim, Torres-Ferrus, Marta, Sanchez Del Rio, Margarita, Lainez, Jose Miguel, Leira, Rogelio, Trochet, Jerome, Pozo-Rosich, Patricia et al.
DOI: 10.1111/head.14225

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.

PMID: 33146036
Journal: CEPHALALGIA
Year: 2020
Reference: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157.
Impact factor: 4.868
Publication type: Paper in international publication
Authors: Caronna, Edoardo, Ballve, Alejandro, Llaurado, Arnau, Gallardo, Victor Jose, Maria Ariton, Diana, Lallana, Sofia, Maza, Samuel Lopez, Gadea, Marta Olive, Quibus, Laura, Restrepo, Juan Luis et al.
DOI: 10.1177/0333102420965157

Visual-reward driven changes of movement during action execution.

PMID: 32968102
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Sep 23;10(1):15527. doi: 10.1038/s41598-020-72220-2.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Marti-Marca, Angela, Deco, Gustavo, Cos, Ignasi et al.
DOI: 10.1038/s41598-020-72220-2

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence.

PMID: 32664898
Journal: JOURNAL OF HEADACHE AND PAIN
Year: 2020
Reference: J Headache Pain. 2020 Jul 14;21(1):90. doi: 10.1186/s10194-020-01135-0.
Impact factor: 4.797
Publication type: Review in international publication
Authors: Caronna, Edoardo, Benemei, Silvia, Labastida-Ramirez, Alejandro, Abramova, Ekaterina, Brunelli, Nicoletta, Diana, Paola, Gapeshin, Roman, Hofacker, Maxi Dana, Pias, Enrique Martinez, Maestrini, Ilaria et al.
DOI: 10.1186/s10194-020-01135-0

Impact of Puberty in Pediatric Migraine: A Pilot Prospective Study.

PMID: 32657062
Journal: Journal of Clinical Neurology
Year: 2020
Reference: J Clin Neurol. 2020 Jul;16(3):416-422. doi: 10.3988/jcn.2020.16.3.416.
Impact factor: 2.439
Publication type: Paper in international publication
Authors: Fonseca, Elena, Macaya, Alfons, Pozo-Rosich, Patricia, Gallardo, Victor Jose, Torres-Ferrus, Marta et al.
DOI: 10.3988/jcn.2020.16.3.416

Working memory updating training modulates a cascade of event-related potentials depending on task load.

PMID: 31513849
Journal: NEUROBIOLOGY OF LEARNING AND MEMORY
Year: 2019
Reference: Neurobiol Learn Mem. 2019 Dec;166:107085. doi: 10.1016/j.nlm.2019.107085. Epub 2019 Sep 9.
Impact factor: 3.01
Publication type: Paper in international publication
Authors: Salmi, Juha, Vila-Ballo, Adria, Soveri, Anna, Rostan, Carles, Rodriguez-Fornells, Antoni, Lehtonen, Minna, Laine, Matti et al.
DOI: 10.1016/j.nlm.2019.107085

Early efficacy and late gain in chronic and high-frequency episodic migraine with OnabotulinumtoxinA.

PMID: 31220392
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2019
Reference: Eur J Neurol. 2019 Dec;26(12):1464-1470. doi: 10.1111/ene.14028. Epub 2019 Jul 18.
Impact factor: 4.387
Publication type: Paper in international publication
Authors: Alpuente, Alicia, Gallardo, Victor Jose, Torres-Ferrus, Marta, Alvarez-Sabin, Jose, Pozo-Rosich, Patricia et al.
DOI: 10.1111/ene.14028

How much do calcitonin gene-related peptide monoclonal antibodies improve the quality of life in migraine? A patient's perspective.

PMID: 30950844
Journal: CURRENT OPINION IN NEUROLOGY
Year: 2019
Reference: Curr Opin Neurol. 2019 Jun;32(3):395-404. doi: 10.1097/WCO.0000000000000689.
Impact factor: 4.647
Publication type: Paper in international publication
Authors: Torres-Ferrus, Marta, Alpuente, Alicia, Pozo-Rosich, Patricia et al.
DOI: 10.1097/WCO.0000000000000689

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.

PMID: 30834194
Journal: Epilepsy & behavior case reports
Year: 2019
Reference: Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019.
Impact factor: 0
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Alpuente, Alicia, Maisterra, Olga, Sueiras, Maria, Sarria, Silvana, Guzman, Lorena, Abraira, Laura, Salas-Puig, Javier, Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2019.01.008

OnabotulinumtoxinA: An Effective Tool in the Therapeutic Arsenal for Chronic Migraine With Medication Overuse.

PMID: 30386285
Journal: Frontiers in Neurology
Year: 2018
Reference: Front Neurol. 2018 Oct 16;9:808. doi: 10.3389/fneur.2018.00808. eCollection 2018.
Impact factor: 3.508
Publication type: Paper in international publication
Authors: Caronna, Edoardo, Gallardo, Victor Jose, Hernandez-Beltran, Natalia, Torres-Ferrus, Marta, Pozo-Rosich, Patricia et al.
DOI: 10.3389/fneur.2018.00808

Cost of status epilepticus (SE): Effects of delayed treatment and SE duration.

PMID: 30384104
Journal: EPILEPSY & BEHAVIOR
Year: 2018
Reference: Epilepsy Behav. 2018 Dec;89:8-14. doi: 10.1016/j.yebeh.2018.09.046. Epub 2018 Oct 26.
Impact factor: 2.6
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Parejo, Beatriz, Abraira, Laura, Gutierrez-Viedma, Alvaro, Alpuente, Alicia, Abarrategui, Belen, Toledo, Manuel, Mazuela, Gonzalo, Salas-Puig, Xavier, Garcia-Morales, Irene et al.
DOI: 10.1016/j.yebeh.2018.09.046

Myasthenia gravis following alemtuzumab therapy for multiple sclerosis.

PMID: 30143565
Journal: NEUROLOGY
Year: 2018
Reference: Neurology. 2018 Sep 25;91(13):622-624. doi: 10.1212/WNL.0000000000006251. Epub 2018 Aug 24.
Impact factor: 8.055
Publication type: Paper in international publication
Authors: Midaglia, Luciana, Gratacos, Margarida, Caronna, Edoardo, Raguer, Nuria, Sastre-Garriga, Jaume, Montalban, Xavier, Tintore, Mar et al.
DOI: 10.1212/WNL.0000000000006251

Neural signatures for active maintenance and interference during working memory updating.

PMID: 29339147
Journal: BIOLOGICAL PSYCHOLOGY
Year: 2018
Reference: Biol Psychol. 2018 Feb;132:233-243. doi: 10.1016/j.biopsycho.2018.01.007. Epub 2018 Jan 12.
Impact factor: 2.891
Publication type: Paper in international publication
Authors: Vila-Ballo, Adria, Salmi, Juha, Soveri, Anna, Lehtonen, Minna, Laine, Matti, Rodriguez-Fornells, Antoni et al.
DOI: 10.1016/j.biopsycho.2018.01.007

Thesis

Neurophysiological correlates of sensory attentional processing in migraine during the interictal phase

PhD student: Angela Barbara Marti Marca
Director/s: Patricia Pozo Rosich, Adria Vila Ballo
University: Universitat Autònoma de Barcelona
Year: 2023

Impacte dels mecanismes epigenètics en la migranya. Identificació i validació de patrons d’expressió diferencial de microARNs en pacients amb migranya

PhD student: Victor José Gallardo Lopez
Director/s: Patricia Pozo Rosich, José Alvarez Sabin
University: Universitat Autònoma de Barcelona
Year: 2023

Migraine molecular phenotyping through the study of the calcitonin gene-related peptide: towards precision medicine

PhD student: Alicia Alpuente Ruiz
Director/s: José Alvarez Sabin, Patricia Pozo Rosich
University:
Year: 2023

Cefalea atribuïda a COVID-19: una oportunitat per avançar en el coneixement de la fisiopatologia de les cefalees

PhD student: Edoardo Caronna
Director/s: Patricia Pozo Rosich, José Alvarez Sabin
University:
Year: 2022

Blog

News

Two international studies led by Vall d'Hebron recommend early administration of specific drugs to prevent migraine to achieve a better response to therapy.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

The study, conducted in more than 770 people, concludes that atogepant reduces the frequency of migraine attacks and the need to take medication.