About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our research group is focused on studying the pathophysiology of migraine and other primary headaches using preclinical, translational and clinical research.
Migraine will allow us to define the brain’s adaptive, sensory/cognitive functions, through genetics, epigenetics, neurophysiology, neuromolecular and neuroanatomical information with an interest in developing clinical therapeutic solutions, with the goal on having an impact on suffering and increasing the well-being.
IP: Marta Vila Pueyo Collaborators: - Funding agency: Fundació "La Caixa" Funding: 305100 Reference: LCF/BQ/PI23/11970015 Duration: 31/12/2023 - 30/12/2026
IP: Patricia Pozo Rosich Collaborators: Alicia Alpuente Ruiz, Laila Asskour, Eulalia Gine Cipres, Victor José Gallardo Lopez, Edoardo Caronna Funding agency: Instituto de Salud Carlos III Funding: 369930 Reference: PMP22/00189 Duration: 01/01/2023 - 31/12/2025
IP: Patricia Pozo Rosich Collaborators: Alicia Alpuente Ruiz, Laila Asskour, Eulalia Gine Cipres, Marta Torres Ferrús, Victor José Gallardo Lopez, Nara Ikumi Montserrat, Marta Vila Pueyo, Edoardo Caronna Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 0.01 Reference: 2021 SGR 00406 Duration: 01/01/2022 - 30/06/2025
IP: Marta Torres Ferrús Collaborators: Alicia Alpuente Ruiz, Laila Asskour, Eulalia Gine Cipres, Victor José Gallardo Lopez, Edoardo Caronna, Laura Gómez Dabó Funding agency: Instituto de Salud Carlos III Funding: 75020 Reference: PI22/01530 Duration: 01/01/2023 - 31/12/2025
PMID: 38416486 Journal: CEPHALALGIA Year: 2024 Reference: Cephalalgia. 2024 Feb;44(2):3331024241230279. doi: 10.1177/03331024241230279. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Cerda-Company, Xim; Gallardo, Victor J; Ikumi, Nara; Marti-Marca, Angela; Pozo-Rosich, Patricia; Torre-Sune, Anna de la; Vila-Ballo, Adria et al. DOI: 10.1177/03331024241230279
PMID: 38431253 Journal: Neurologia Year: 2024 Reference: Neurologia (Engl Ed). 2024 Feb 29:S2173-5808(24)00048-8. doi: 10.1016/j.nrleng.2024.02.009. Impact factor: Publication type: Clinical guide Authors: Beltran-Blasco, I; Belvis, R; Diaz-Insa, S; Gago-Veiga, A B; Garcia-Azorin, D; Garcia-Ull, J; Gonzalez-Garcia, N; Irimia, P; Lainez, J M; Latorre, G et al. DOI: 10.1016/j.nrleng.2024.02.009
PMID: 38529698 Journal: CURRENT OPINION IN NEUROLOGY Year: 2024 Reference: Curr Opin Neurol. 2024 Mar 27. doi: 10.1097/WCO.0000000000001267. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1097/WCO.0000000000001267
PMID: 38628031 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2024 Reference: Eur J Neurol. 2024 Apr 16:e16308. doi: 10.1111/ene.16308. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Bolay, Hayrunnisa; Caronna, Edoardo; De Tommaso, Marina; Deligianni, Christina I; Ekizoglu, Esme; Gobel, Carl H; Irimia-Sieira, Pablo; Kristoffersen, Espen Saxhaug; Lampl, Christian; Mitsikostas, Dimos-Dimtirios D et al. DOI: 10.1111/ene.16308
PMID: 36633206 Journal: HEADACHE Year: 2023 Reference: Headache. 2023 Feb;63(2):183-184. doi: 10.1111/head.14464. Epub 2023 Jan 12. Impact factor: Publication type: Editorail in international publication Authors: Caronna, Edoardo; Pozo-Rosich, Patricia et al. DOI: 10.1111/head.14464
PMID: 36705326 Journal: HEADACHE Year: 2023 Reference: Headache. 2023 May;63(5):642-651. doi: 10.1111/head.14470. Epub 2023 Jan 27. Impact factor: Publication type: Paper in international publication Authors: Adams, Hieab H H; Anttila, Verneri; Aromaa, Arpo J; Artto, Ville; Belin, Andrea C; Boomsma, Dorret I; Borck, Guntram; Borte, Sigrid; Buring, Julie E; Byrnes, Andrea E et al. DOI: 10.1111/head.14470
PMID: 36759321 Journal: CEPHALALGIA Year: 2023 Reference: Cephalalgia. 2023 Feb;43(2):3331024221146317. doi: 10.1177/03331024221146317. Impact factor: Publication type: Paper in international publication Authors: Cormand, Bru; Cuenca-Leon, Ester; Fernandez-Castillo, Noelia; Kulis, Marta; Macaya, Alfons; Martin-Subero, Jose Ignacio; Pozo-Rosich, Patricia; Queiros, Ana C; Sintas, Celia; Vila-Pueyo, Marta et al. DOI: 10.1177/03331024221146317
PMID: 36759209 Journal: CEPHALALGIA Year: 2023 Reference: Cephalalgia. 2023 Feb;43(2):3331024221145916. doi: 10.1177/03331024221145916. Impact factor: Publication type: Review in international publication Authors: Gallardo, Victor Jose; Pozo-Rosich, Patricia; Vila-Pueyo, Marta et al. DOI: 10.1177/03331024221145916
PMID: 36105771 Journal: Frontiers in Neurology Year: 2022 Reference: Front Neurol. 2022 Aug 29;13:966424. doi: 10.3389/fneur.2022.966424. eCollection 2022. Impact factor: Publication type: Editorail in international publication Authors: Shrivastava, Surya; Vila-Pueyo, Marta; Woldeamanuel, Yohannes W et al. DOI: 10.3389/fneur.2022.966424
PMID: 36078699 Journal: International Journal of Environmental Research and Public Health Year: 2022 Reference: Int J Environ Res Public Health. 2022 Sep 2;19(17). pii: ijerph191710975. doi: 10.3390/ijerph191710975. Impact factor: Publication type: Paper in international publication Authors: Ahmed, Fayyaz; Alpuente, Alicia; Andreou, Anna; Baraldi, Carlo; Brunelli, Nicoletta; Butera, Calogera; Cevoli, Sabina; Colombo, Bruno; Filatova, Elena; Filippi, Massimo et al. DOI: 10.3390/ijerph191710975
PMID: 36071614 Journal: CEPHALALGIA Year: 2022 Reference: Cephalalgia. 2022 Dec;42(14):1498-1509. doi: 10.1177/03331024221123081. Epub 2022 Sep 7. Impact factor: Publication type: Paper in international publication Authors: Ambrosini, Anna; Baykan, Betul; Buse, Dawn C; de Boer, Irene; Halker Singh, Rashmi B; Jensen, Rigmor H; Pozo-Rosich, Patricia; Tassoreli, Cristina; Terwindt, Gisela M et al. DOI: 10.1177/03331024221123081
PMID: 36064285 Journal: NEUROLOGIA Year: 2022 Reference: Neurologia (Engl Ed). 2022 Sep;37(7):564-574. doi: 10.1016/j.nrleng.2018.12.016. Epub 2021 Feb 5. Impact factor: Publication type: Review in international publication Authors: Camina Muniz, J; Gago-Veiga, A B; Garcia-Azorin, D; Gonzalez-Quintanilla, V; Ordas, C M; Pozo-Rosich, P; Santos-Lasaosa, S; Torres-Ferrus, M; Viguera-Romero, J et al. DOI: 10.1016/j.nrleng.2018.12.016
PMID: 34643891 Journal: Pain and Therapy Year: 2021 Reference: Pain Ther. 2021 Dec;10(2):1691-1708. doi: 10.1007/s40122-021-00331-3. Epub 2021 Oct 13. Impact factor: Publication type: Paper in international publication Authors: Gaul, Charly; Lucas, Christian; Martelletti, Paolo; Pozo-Rosich, Patricia; Ramsden, Emma; Ritter, Shannon; Snellman, Josefin; Watson, David P B et al. DOI: 10.1007/s40122-021-00331-3
PMID: 34643953 Journal: HEADACHE Year: 2021 Reference: Headache. 2021 Oct;61(9):1299-1301. doi: 10.1111/head.14211. Epub 2021 Oct 13. Impact factor: Publication type: Editorail in international publication Authors: Bobker, Sarah M; Charleston, Larry 4th; Gelfand, Amy A; Halker Singh, Rashmi B; Houle, Timothy T; Orr, Serena L; Powers, Scott W; Pozo-Rosich, Patricia; Pradhan, Amynah; Robbins, Matthew S et al. DOI: 10.1111/head.14211
PMID: 34620085 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2021 Reference: J Headache Pain. 2021 Oct 7;22(1):120. doi: 10.1186/s10194-021-01328-1. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Gallardo, Victor Jose; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1186/s10194-021-01328-1
PMID: 34601726 Journal: HEADACHE Year: 2021 Reference: Headache. 2021 Oct;61(9):1403-1410. doi: 10.1111/head.14225. Epub 2021 Oct 3. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Cerda-Company, Xim; Gallardo, Victor J; Lainez, Jose Miguel; Leira, Rogelio; Pozo-Rosich, Patricia; Sanchez Del Rio, Margarita; Torres-Ferrus, Marta; Trochet, Jerome et al. DOI: 10.1111/head.14225
PMID: 32895902 Journal: REVISTA DE NEUROLOGIA Year: 2020 Reference: Rev Neurol. 2020 Sep 16;71(6):199-204. doi: 10.33588/rn.7106.2020269. Impact factor: Publication type: Paper in national publication Authors: Bailon, C; Guerrero-Peral, A L; Ignacio, E; Layos-Romero, A; Martin-Delgado, J; Mira, J J; Pascual, J; Pozo-Rosich, P; Torres, A et al. DOI: 10.33588/rn.7106.2020269
PMID: 32797631 Journal: HEADACHE Year: 2020 Reference: Headache. 2020 Sep;60(8):1673-1682. doi: 10.1111/head.13925. Epub 2020 Aug 14. Impact factor: Publication type: Paper in international publication Authors: Athwal, Bal; Frattale, Ilaria; Gryglas-Dworak, Anna; Latysheva, Nina; Ornello, Raffaele; Pozo-Rosich, Patricia; Ruscheweyh, Ruth; Sacco, Simona; Stark, Catherine D; Torres Ferrus, Marta et al. DOI: 10.1111/head.13925
PMID: 32722936 Journal: CEPHALALGIA Year: 2020 Reference: Cephalalgia. 2020 Sep;40(10):1026-1044. doi: 10.1177/0333102420941839. Epub 2020 Jul 28. Impact factor: Publication type: Paper in international publication Authors: Ashina, Messoud; Becker, Werner J; Diener, Hans-Christoph; Dodick, David W; Ferrari, Michel D; Goadsby, Peter J; Hoek, Thomas C van den; Houle, Timothy T; Lipton, Richard B; Martinelli, Daniele et al. DOI: 10.1177/0333102420941839
PMID: 32664898 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2020 Reference: J Headache Pain. 2020 Jul 14;21(1):90. doi: 10.1186/s10194-020-01135-0. Impact factor: Publication type: Review in international publication Authors: Abramova, Ekaterina; Benemei, Silvia; Brunelli, Nicoletta; Caronna, Edoardo; Diana, Paola; Gapeshin, Roman; Hofacker, Maxi Dana; Labastida-Ramirez, Alejandro; MaassenVanDenBrink, Antoinette; Maestrini, Ilaria et al. DOI: 10.1186/s10194-020-01135-0
PMID: 29169810 Journal: NEUROLOGIA Year: 2019 Reference: Neurologia. 2019 Jul - Aug;34(6):408-417. doi: 10.1016/j.nrl.2017.09.008. Epub 2017 Nov 21. Impact factor: Publication type: Paper in national publication Authors: Cuadrado, M L; Gago-Veiga, A B; Guerrero, A L; Irimia, P; Lainez, J M; Leira, R; Pascual, J; Pozo-Rosich, P; Sanchez Del Rio, M; Santos-Lasaosa, S et al. DOI: 10.1016/j.nrl.2017.09.008
PMID: 31668411 Journal: LANCET Year: 2019 Reference: Lancet. 2019 Nov 9;394(10210):1765-1774. doi: 10.1016/S0140-6736(19)32504-8. Epub 2019 Oct 23. Impact factor: Publication type: Review in international publication Authors: Charles, Andrew; Pozo-Rosich, Patricia et al. DOI: 10.1016/S0140-6736(19)32504-8
PMID: 31522546 Journal: CEPHALALGIA Year: 2019 Reference: Cephalalgia. 2019 Oct;39(12):1475-1487. doi: 10.1177/0333102419876920. Epub 2019 Sep 15. Impact factor: Publication type: Paper in international publication Authors: Al-Karagholi, Mohammad Al-Mahdi; Ashina, Messoud; Diener, Hans-Christoph; Ferrari, Michel D; Gaul, Charly; Goadsby, Peter J; Hoffmann, Jan; Lainez, Miguel Ja; Liebler, Eric; Magis, Delphine et al. DOI: 10.1177/0333102419876920
PMID: 31513849 Journal: NEUROBIOLOGY OF LEARNING AND MEMORY Year: 2019 Reference: Neurobiol Learn Mem. 2019 Dec;166:107085. doi: 10.1016/j.nlm.2019.107085. Epub 2019 Sep 9. Impact factor: Publication type: Paper in international publication Authors: Laine, Matti; Lehtonen, Minna; Rodriguez-Fornells, Antoni; Rostan, Carles; Salmi, Juha; Soveri, Anna; Vila-Ballo, Adria et al. DOI: 10.1016/j.nlm.2019.107085
PMID: 27461182 Journal: NEUROLOGIA Year: 2018 Reference: Neurologia. 2018 Apr;33(3):160-164. doi: 10.1016/j.nrl.2016.05.016. Epub 2016 Jul 25. Impact factor: Publication type: Paper in national publication Authors: Gago Veiga, A; Guerrero Peral, A L; Pozo-Rosich, P; Santos Lasaosa, S; Viguera Romero, J et al. DOI: 10.1016/j.nrl.2016.05.016
PMID: 29731251 Journal: NEURON Year: 2018 Reference: Neuron. 2018 May 16;98(4):743-753.e4. doi: 10.1016/j.neuron.2018.04.014. Epub 2018 May 3. Impact factor: Publication type: Paper in international publication Authors: Agee, Michelle; Alipanahi, Babak; Anttila, Verneri; Anttila, Verneri; Artto, Ville; Artto, Ville; Auton, Adam; Belin, Andrea Carmine; Belin, Andrea Carmine; Bell, Robert K et al. DOI: 10.1016/j.neuron.2018.04.014
PMID: 29930110 Journal: SCIENCE Year: 2018 Reference: Science. 2018 Jun 22;360(6395). pii: 360/6395/eaap8757. doi: 10.1126/science.aap8757. Impact factor: Publication type: Paper in international publication Authors: Adams, Hieab H H; Air, Tracy; Al-Chalabi, Ammar; Alda, Martin; Alegret, Montserrat; Alfredsson, Lars; Amouyel, Philippe; Andlauer, Till F M; Andreassen, Ole A; Anjorin, Adebayo et al. DOI: 10.1126/science.aap8757
PMID: 30386285 Journal: Frontiers in Neurology Year: 2018 Reference: Front Neurol. 2018 Oct 16;9:808. doi: 10.3389/fneur.2018.00808. eCollection 2018. Impact factor: Publication type: Paper in international publication Authors: Caronna, Edoardo; Gallardo, Victor Jose; Hernandez-Beltran, Natalia; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.3389/fneur.2018.00808
PMID: 28766236 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2017 Reference: J Headache Pain. 2017 Dec;18(1):78. doi: 10.1186/s10194-017-0784-4. Epub 2017 Aug 1. Impact factor: Publication type: Paper in international publication Authors: Aurora, Sheena K; DeGryse, Ronald; Halker, Rashmi; Manack Adams, Aubrey; Matharu, Manjit; Pozo-Rosich, Patricia et al. DOI: 10.1186/s10194-017-0784-4
PMID: 28566750 Journal: Scientific Reports Year: 2017 Reference: Sci Rep. 2017 May 31;7(1):2514. doi: 10.1038/s41598-017-02554-x. Impact factor: Publication type: Paper in international publication Authors: Barroeta, Isabel; Carreno, Oriel; Cormand, Bru; Corominas, Roser; Cuenca-Leon, Ester; Fernandez-Castillo, Noelia; Macaya, Alfons; Roig, Carles; Sintas, Celia; Toma, Claudio et al. DOI: 10.1038/s41598-017-02554-x
PMID: 25792688 Journal: CEPHALALGIA Year: 2015 Reference: Cephalalgia. 2015 Dec;35(14):1298-307. doi: 10.1177/0333102415576723. Epub 2015 Mar 19. Impact factor: Publication type: Paper in international publication Authors: Charbit, A R; Goadsby, P J; Pozo-Rosich, P; Storer, R J et al. DOI: 10.1177/0333102415576723
PMID: 24445160 Journal: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY Year: 2014 Reference: Eur J Paediatr Neurol. 2014 May;18(3):430-3. doi: 10.1016/j.ejpn.2013.12.011. Epub 2014 Jan 8. Impact factor: Publication type: Paper in international publication Authors: Cormand, Bru; Elorza, Xabier; Fernandez-Fernandez, Jose M; Flotats-Bastardes, Marina; Gene, Gemma G; Macaya, Alfons; Sintas, Celia; Valverde, Miguel A; Vila-Pueyo, Marta et al. DOI: 10.1016/j.ejpn.2013.12.011
PMID: 22327697 Journal: ACTA NEUROCHIRURGICA Year: 2012 Reference: Acta Neurochir Suppl. 2012;114:221-5. Impact factor: Publication type: Paper in international publication Authors: de la Calzada, Maria Dolores; Galard, Rosa; Merino, Mari Angels; Mestres, Olga; Poca, Maria Antonia; Pozo-Rosich, Patricia; Sahuquillo, Juan; Serrano, Elena; Solana, Elisabeth et al. DOI: 10.1007/978-3-7091-0956-4_43
PMID: 22162417 Journal: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Year: 2012 Reference: Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):94-103. doi: 10.1002/ajmg.b.32007. Epub 2011 Dec 7. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; ; et al. DOI: 10.1002/ajmg.b.32007
Two international studies led by Vall d'Hebron recommend early administration of specific drugs to prevent migraine to achieve a better response to therapy.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
The study, conducted in more than 770 people, concludes that atogepant reduces the frequency of migraine attacks and the need to take medication.
