About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.
The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.
IP: Pere Soler Palacín
IP: Andrea Martín Nalda, Pere Soler Palacín
IP: Antoni Soriano Arandes, Maria Espiau Guarner
IP: Jacques Gabriel Rivière, Pere Soler Palacín
IP: Pere Soler Palacín Collaborators: Laura Batlle Masó, Maria Cristina Díaz de Heredia Rubio, Roger Colobran Oriol, Thaïs Murciano Carrillo, Constantino Sábado Álvarez, Miriam Gonzalez Amores, Janire Perurena Prieto, Andrea Martín Nalda, Lucas Moreno Martín-Retortillo, Jacques Gabriel Rivière Funding agency: Instituto de Salud Carlos III Funding: 179993.75 Reference: AC23_2/00033 Duration: 01/01/2024 - 31/12/2026
IP: Roger Colobran Oriol Collaborators: Romina Dieli Crimi, Aina Aguiló Cucurull, Laura Batlle Masó, Andrea Martín Nalda, Neus Castells Sarret Funding agency: Instituto de Salud Carlos III Funding: 208750 Reference: PI23/00161 Duration: 01/01/2024 - 31/12/2026
IP: Pere Soler Palacín Collaborators: Laura Batlle Masó, Laia Perez Lasarte Funding agency: Ministerio de Universidades Funding: 0.01 Reference: MIU/M_SALAS/2022/BATLLE Duration: 01/01/2023 - 31/12/2024
IP: Pere Soler Palacín Collaborators: Antoni Soriano Arandes, Jorgina Vila Soler, Laura Batlle Masó, Natalia Ana Mendoza Palomar, Maria Espiau Guarner, Aurora Fernandez Polo, Núria Worner Tomasa, Laura Lopez Seguer, Miriam Gonzalez Amores, Susana Melendo Perez, Sonia Rodriguez Tello, Andrea Martín Nalda, Claudia Broto Cortes, Marie Antoinette Frick, Jacques Gabriel Rivière Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 0.01 Reference: 2021 SGR 00441 Duration: 01/01/2022 - 30/06/2025
PMID: 38175961 Journal: JOURNAL OF EXPERIMENTAL MEDICINE Year: 2024 Reference: J Exp Med. 2024 Feb 5;221(2):e20231353. doi: 10.1084/jem.20231353. Epub 2024 Jan 4. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Abi Haidar, Anthony; Abolhassani, Hassan; Ahlijah, Gloria; Andreakos, Evangelos; Arseguel, Vincent; Asano, Takaki; Bastard, Paul; Belot, Alexandre; Beziat, Vivien et al. DOI: 10.1084/jem.20231353
PMID: 38184654 Journal: Genome Medicine Year: 2024 Reference: Genome Med. 2024 Jan 6;16(1):6. doi: 10.1186/s13073-023-01278-0. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Abel, Laurent; Abolhassani, Hassan; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Muhsen, Saleh Zaid; Allende, Luis M; Alonso-Arias, Rebeca; Alosaimi, Mohammed Faraj; Alsohime, Fahad M; Arias, Andres Augusto et al. DOI: 10.1186/s13073-023-01278-0
PMID: 36978299 Journal: Antibiotics-Basel Year: 2023 Reference: Antibiotics (Basel). 2023 Feb 22;12(3):432. doi: 10.3390/antibiotics12030432. Impact factor: Publication type: Paper in international publication Authors: de Alarcon, Aristides; Fernandez-Polo, Aurora; Fernandez-Rubio, Beatriz; Gil-Navarro, Maria V; Gutierrez-Urbon, Jose Maria; Gutierrez-Valencia, Alicia; Herrera-Hidalgo, Laura; Lopez-Cortes, Luis E; Luque-Marquez, Rafael; Luque-Pardos, Sonia et al. DOI: 10.3390/antibiotics12030432
PMID: 36538032 Journal: SCIENCE Year: 2023 Reference: Science. 2023 Feb 10;379(6632):eabo3627. doi: 10.1126/science.abo3627. Epub 2023 Feb 10. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Abel, Laurent; Abolhassani, Hassan; Aguilera-Albesa, Sergio; Aiuti, Alessandro; Akcan, Ozge Metin; Akcay, Nihal; Alavoine, Loubna; Alkan, Gulsum; Alkhater, Suzan A et al. DOI: 10.1126/science.abo3627
PMID: 37020259 Journal: Genome Medicine Year: 2023 Reference: Genome Med. 2023 Apr 5;15(1):22. doi: 10.1186/s13073-023-01173-8. Impact factor: Publication type: Paper in international publication Authors: Abad, Jorge; Abad, Sebastien; Abassi, Radhiya; Abdelhadi, Nour Mekki; Abdellaoui, Abdelrafie; Abdelmalek, Abdelkrim; Abdoul, Hendy; Abel, Laurent; Abel, Laurent; Abel, Laurent et al. DOI: 10.1186/s13073-023-01173-8
PMID: 37268527 Journal: Anales de pediatria Year: 2023 Reference: An Pediatr (Engl Ed). 2023 May 31:S2341-2879(23)00111-4. doi: 10.1016/j.anpede.2023.03.010. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Alonso, David; Ferres Ramis, Laia; Martinez Campos, Leticia; Mendoza-Palomar, Natalia; Perez-Albert, Paula; Rincon-Lopez, Elena Maria; Soler-Palacin, Pere et al. DOI: 10.1016/j.anpede.2023.03.010
PMID: 35120649 Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA Year: 2022 Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Feb;40(2):51-52. doi: 10.1016/j.eimce.2021.12.007. Impact factor: 1.731 Publication type: Editorail in international publication Authors: Fernandez-Polo, Aurora; Soler-Palacin, Pere et al. DOI: 10.1016/j.eimce.2021.12.007
PMID: 35120651 Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA Year: 2022 Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Feb;40(2):59-65. doi: 10.1016/j.eimce.2021.05.012. Impact factor: 1.731 Publication type: Paper in international publication Authors: Villanueva-Bueno, Cristina; Montecatine-Alonso, Elena; Jimenez-Parrilla, Francisco; Fernandez-Llamazares, Cecilia M; Manrique-Rodriguez, Silvia; Zamora-Flores, Elena; Dolz, Elisenda; Fernandez-Polo, Aurora; Catillo-Salinas, Felix; Comunas, Juanjo et al. DOI: 10.1016/j.eimce.2021.05.012
PMID: 35134165 Journal: CLINICAL INFECTIOUS DISEASES Year: 2022 Reference: Clin Infect Dis. 2022 Jan 20. pii: 6520762. doi: 10.1093/cid/ciab928. Impact factor: 9.079 Publication type: Paper in international publication Authors: Shaheen, Shareef; Hayden, Randall; Suganda, Sri; Zaoutis, Theoklis E; Chang, Yeh-Chung; Yin, Dwight E; Huppler, Anna R; Danziger-Isakov, Lara; Muller, William J; Roilides, Emmanuel et al. DOI: 10.1093/cid/ciab928
PMID: 35255492 Journal: NATURE Year: 2022 Reference: Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Impact factor: 49.962 Publication type: Paper in international publication Authors: Tsinaslanidis, George; Birkinshaw, Isobel; Carter, Joseph; Howard, Kate; Ingham, Joanne; Joy, Rosie; Pearson, Harriet; Roche, Samantha; Scott, Zoe; Bancroft, Hollie et al. DOI: 10.1038/s41586-022-04576-6
PMID: 34155260 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Jun 21;11(1):12940. doi: 10.1038/s41598-021-92381-y. Impact factor: Publication type: Paper in international publication Authors: Arostegui, Juan I; Batlle-Maso, Laura; Bonet, Nuria; Casals, Ferran; Lobon, Irene; Marques-Bonet, Tomas; Mensa-Vilaro, Anna; Solis-Moruno, Manuel et al. DOI: 10.1038/s41598-021-92381-y
PMID: 34748988 Journal: Travel Medicine and Infectious Disease Year: 2021 Reference: Travel Med Infect Dis. 2021 Nov-Dec;44:102196. doi: 10.1016/j.tmaid.2021.102196. Epub 2021 Nov 5. Impact factor: 6.211 Publication type: Paper in international publication Authors: Comelli, Agnese, Guarner, Maria Espiau, Tomasoni, Lina Rachele, Zamboni, Agnese Fanetti, Pavon, Belen Moreno, Zanotti, Paola, Caligaris, Silvio, Matteelli, Alberto, Soriano-Arandes, Antoni, Castelli, Francesco et al. DOI: 10.1016/j.tmaid.2021.102196
PMID: 34575764 Journal: Journal of Fungi Year: 2021 Reference: J Fungi (Basel). 2021 Sep 5;7(9). pii: jof7090726. doi: 10.3390/jof7090726. Impact factor: 5.816 Publication type: Letter or abstract Authors: Velasco-Nuno, Monica, Mendoza-Palomar, Natalia, Melendo-Perez, Susana, Balcells, Joan, Izquierdo-Blasco, Jaume, Martin-Gomez, Maria Teresa, Soler-Palacin, Pere, Riviere, Jacques G et al. DOI: 10.3390/jof7090726
PMID: 34413140 Journal: Science Immunology Year: 2021 Reference: Sci Immunol. 2021 Aug 19;6(62). pii: 6/62/eabl4348. doi: 10.1126/sciimmunol.abl4348. Impact factor: 17.727 Publication type: Paper in international publication Authors: Morelle, Guillaume, Asano, Takaki, Boisson, Bertrand, Onodi, Fanny, Shahrooei, Mohammad, Darazam, Ilad Alavi, Olyaei, Nasrin Alipour, Mansouri, Davood, Hatipoglu, Nevin, Palabiyik, Figen et al. DOI: 10.1126/sciimmunol.abl4348
PMID: 32837964 Journal: Anales de pediatria Year: 2020 Reference: An Pediatr (Engl Ed). 2020 Aug;93(2):132-133. doi: 10.1016/j.anpede.2020.05.002. Epub 2020 Jul 1. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Diaz de Heredia, Cristina; Moreno, Lucas; Riviere, Jacques G; Soler Palacin, Pere; Velasco Puyo, Pablo et al. DOI: 10.1016/j.anpede.2020.05.002
PMID: 33160709 Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA Year: 2020 Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2020 Oct 13;39(8):415-6. doi: 10.1016/j.eimc.2020.10.004. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Anton, Andres; Borras-Bermejo, Blanca; Soler-Palacin, Pere; Soriano-Arandes, Antoni et al. DOI: 10.1016/j.eimc.2020.10.004
PMID: 33161954 Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA Year: 2020 Reference: Enferm Infecc Microbiol Clin. 2020 Nov;38(9):438-443. doi: 10.1016/j.eimc.2020.07.001. Impact factor: 1.654 Publication type: Review in national publication Authors: Aguilera Cros, Clara, Cordero, Elisa, Goycochea-Valdivia, Walter, Mendez-Echevarria, Ana, Allende, Luis M, Alsina, Laia, Bravo Garcia-Morato, Maria, Gil-Herrera, Juana, Gudiol, Carlota, Len-Abad, Oscar et al. DOI: 10.1016/j.eimc.2020.07.001
PMID: 33161963 Journal: Journal of Allergy and Clinical Immunology-In Practice Year: 2020 Reference: J Allergy Clin Immunol Pract. 2020 Nov - Dec;8(10):3342-3347. doi: 10.1016/j.jaip.2020.05.008. Impact factor: 7.574 Publication type: Review in international publication Authors: Cordero, Elisa, Goycochea-Valdivia, Walter, Mendez-Echevarria, Ana, Allende, Luis M, Alsina, Laia, Bravo Garcia-Morato, Maria, Neth, Olaf, Rodriguez-Gallego, Carlos, Santos-Perez, Juan Luis, Rodriguez Pena, Rebeca et al. DOI: 10.1016/j.jaip.2020.05.008
PMID: 31695692 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Oct 22;10:2406. doi: 10.3389/fimmu.2019.02406. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Argudo-Ramirez, Ana, Martin-Nalda, Andrea, Pajares-Garcia, Sonia, Gonzalez de Aledo-Castillo, Jose M, Martinez-Gallo, Monica, Garcia-Prat, Marina, Colobran, Roger, Riviere, Jacques G, Quintero, Yania, Collado, Tatiana et al. DOI: 10.3389/fimmu.2019.02406
PMID: 31681265 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Oct 1;10:2325. doi: 10.3389/fimmu.2019.02325. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Rudilla, Francesc, Franco-Jarava, Clara, Martinez-Gallo, Monica, Garcia-Prat, Marina, Martin-Nalda, Andrea, Riviere, Jacques, Aguilo-Cucurull, Aina, Mongay, Laura, Vidal, Francisco, Solanich, Xavier et al. DOI: 10.3389/fimmu.2019.02325
PMID: 31663686 Journal: Molecular Genetics & Genomic Medicine Year: 2019 Reference: Mol Genet Genomic Med. 2019 Dec;7(12):e1016. doi: 10.1002/mgg3.1016. Epub 2019 Oct 30. Impact factor: 2.448 Publication type: Paper in international publication Authors: Martin-Nalda, Andrea, Cueto-Gonzalez, Anna M, Argudo-Ramirez, Ana, Marin-Soria, Jose L, Martinez-Gallo, Monica, Colobran, Roger, Plaja, Albert, Castells, Neus, Riviere, Jacques, Tizzano, Eduardo F et al. DOI: 10.1002/mgg3.1016
PMID: 30386343 Journal: Frontiers in Immunology Year: 2018 Reference: Front Immunol. 2018 Oct 16;9:2397. doi: 10.3389/fimmu.2018.02397. eCollection 2018. Impact factor: 5.511 Publication type: Paper in international publication Authors: Soler-Palacin, Pere, Garcia-Prat, Marina, Martin-Nalda, Andrea, Franco-Jarava, Clara, Riviere, Jacques G, Plaja, Alberto, Bezdan, Daniela, Bosio, Mattia, Martinez-Gallo, Monica, Ossowski, Stephan et al. DOI: 10.3389/fimmu.2018.02397
PMID: 21420916 Journal: ANALES DE PEDIATRIA Year: 2011 Reference: An Pediatr (Barc). 2011 Jul;75(1):13-20. doi: 10.1016/j.anpedi.2011.01.006. Epub 2011 Mar 21. Impact factor: 0.57 Publication type: Paper in national publication Authors: Lera Carballo, E, Worner, N T, Sancosmed Ron, M, Fabregas Martori, A, Casquero Cossio, A, Cebrian Rubio, R et al. DOI: 10.1016/j.anpedi.2011.01.006
PhD student: Jorgina Vila Soler Director/s: Carlos Rodrigo Gonzalo de Liria, Andres Antón Pagarolas University: Universitat Autònoma de Barcelona Year: 2023
PhD student: Aurora Fernandez Polo Director/s: Pere Soler Palacín University: Universidad Autònoma de Barcelona Year: 2022
PhD student: Marina García Prat Director/s: Pere Soler Palacín, Roger Colobran Oriol University: Universidad Autònoma de Barcelona Year: 2022
PhD student: Susana Melendo Perez Director/s: Pere Soler Palacín University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Jose Maria Valle T-Figueras Director/s: Pere Soler Palacín University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Natalia Ana Mendoza Palomar Director/s: Pere Soler Palacín, Félix Castillo Salinas University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Maria Teresa Riera Bosch, Maria Teresa Riera Bosch, Maria Teresa Riera Bosch Director/s: Pere Soler Palacín University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Maria Espiau Guarner Director/s: Pere Soler Palacín, Diego Yeste Fernandez University: Universidad Autònoma de Barcelona Year: 2017
PhD student: Isabel Vives Oñós, Isabel Vives Oñós Director/s: Pere Soler Palacín University: Universidad Autònoma de Barcelona Year: 2017
PhD student: Antoni Soriano Arandes Director/s: Mario Marotta Baleriola University: Universitat de Barcelona Year: 2017
PhD student: Marta Dapena Archilés, Marta Dapena Archilés Director/s: Pere Soler Palacín, Antonio Carrascosa Lezcano, Antonio Carrascosa Lezcano University: Universitat de Barcelona Year: 2016
PhD student: Concepción Figueras Nadal Director/s: Alfredo Gallart Català University: Universidad Autònoma de Barcelona Year: 2010
PhD student: Pere Soler Palacín Director/s: Concepción Figueras Nadal University: Universidad Autònoma de Barcelona Year: 2010
PhD student: Pere Soler Palacín Director/s: Concepción Figueras Nadal University: Universidad Autònoma de Barcelona Year: 2007
PhD student: Concepción Figueras Nadal Director/s: University: Universidad Autònoma de Barcelona Year: 2006
So far, 240 volunteers have been recruited within all the centres set to join adolescents’ clinical trial (named HH3) to test the efficacy, tolerability, and safety of the BIMERVAX® COVID-19 vaccine in adolescents aged 12 to 17.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
The study, which is part of the European RECOMB project, is currently recruiting volunteers.
