About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.
IP: Joan Genescà Ferrer Collaborators: Mònica Pons Delgado Funding agency: Instituto de Salud Carlos III Funding: 180000 Reference: JR21/00064 Duration: 01/01/2022 - 31/12/2025
IP: Josep Quer Sivila Collaborators: - Funding agency: VHIR Funding: 225000 Reference: VHIR/SENIORITY_NO_ERC/21/QUER Duration: 01/05/2021 - 30/04/2026
IP: Victor Manuel Vargas Blasco Collaborators: Ester Palacio Gutierrez, Mª Eulàlia Molinas Guilera, Olga Sánchez- Maroto Carrizo, Amaia Latasa Arrazubi, Joan Genescà Ferrer, Cesar Jimenez Hernandez Funding agency: EUROPEAN COMMISSION Funding: 409557 Reference: LIVERHOPE_H2020RTD2016 Duration: 01/01/2017 - 28/02/2023
IP: Joan Genescà Ferrer Collaborators: Immaculada Raurell Saborit, Torrens Buscató, Maria Margarita, Ares Aurora Villagrasa Vilella, Mònica Pons Delgado Funding agency: Instituto de Salud Carlos III Funding: 196020 Reference: PI18/00947 Duration: 01/01/2019 - 30/06/2023
PMID: 37745192 Journal: JHEP Reports Year: 2023 Reference: JHEP Rep. 2023 Jul 13;5(10):100842. doi: 10.1016/j.jhepr.2023.100842. eCollection 2023 Oct. Impact factor: Publication type: Paper in international publication Authors: Berg, Thomas; Bes, Marta; Buti, Maria; Buti, Maria; Casillas, Rosario; Esteban, Rafael; Esteban, Rafael; Palom, Adriana; Pfefferkorn, Maria; Rando-Segura, Ariadna et al. DOI: 10.1016/j.jhepr.2023.100842
PMID: 37769952 Journal: Gastroenterology Year: 2023 Reference: Gastroenterology. 2023 Sep 26:S0016-5085(23)05068-0. doi: 10.1053/j.gastro.2023.09.033. Impact factor: Publication type: Paper in international publication Authors: Agarwal, K; Ahn, S H; Berg, T; Boonstra, A; Brakenhoff, S M; Brunetto, M; Buti, M; Buti, M; Carey, I; Chen, C-H et al. DOI: 10.1053/j.gastro.2023.09.033
PMID: 37771546 Journal: JHEP Reports Year: 2023 Reference: JHEP Rep. 2023 Jul 13;5(10):100847. doi: 10.1016/j.jhepr.2023.100847. eCollection 2023 Oct. Impact factor: Publication type: Paper in international publication Authors: Abramov, Frida; Agarwal, Kosh; Ahn, Sang Hoon; Brunetto, Maurizia; Buti, Maria; Buti, Maria; Chan, Henry L Y; Chang, Ting-Tsung; Chuang, Wan Long; Flaherty, John F et al. DOI: 10.1016/j.jhepr.2023.100847
PMID: 37789462 Journal: Parasites & Vectors Year: 2023 Reference: Parasit Vectors. 2023 Oct 3;16(1):343. doi: 10.1186/s13071-023-05942-7. Impact factor: Publication type: Paper in international publication Authors: Aixut, Sandra; Crego-Vicente, Beatriz; Febrer-Sendra, Begona; Fernandez-Soto, Pedro; Martinez-Camprecios, Joan; Martinez-Camprecios, Joan; Mediavilla, Alejandro; Molina, Israel; Molina, Israel; Muro, Antonio et al. DOI: 10.1186/s13071-023-05942-7
PMID: 35658996 Journal: LANCET Year: 2022 Reference: Lancet. 2022 Jun 4;399(10341):2155. doi: 10.1016/S0140-6736(22)00915-1. Impact factor: 79.323 Publication type: Letter or abstract Authors: Banares, Juan, Aceituno, Laia, Jimenez, Alba, Maynard, Avonello, Escobar, Eduardo Dacosta, Aleman, Carmen et al. DOI: 10.1016/S0140-6736(22)00915-1
PMID: 35643936 Journal: LIVER INTERNATIONAL Year: 2022 Reference: Liver Int. 2022 May 28. doi: 10.1111/liv.15323. Impact factor: 5.828 Publication type: Paper in international publication Authors: Calleja, Jose Luis, Rivera-Esteban, Jesus, Aller, Rocio, Hernandez Conde, Marta, Abad, Javier, Pericas, Juan M, Serra, Miguel Angel, Escudero, Amparo, Ampuero, Javier, Lucena, Ana et al. DOI: 10.1111/liv.15323
PMID: 35635535 Journal: LIVER INTERNATIONAL Year: 2022 Reference: Liver Int. 2022 May 30. doi: 10.1111/liv.15327. Impact factor: 5.828 Publication type: Paper in international publication Authors: Martro, Elisa, Ouaarab, Hakima, Saludes, Veronica, Buti, Maria, Trevino, Begona, Roade, Luisa, Egea-Cortes, Laia, Reyes-Urena, Juliana, Not, Anna, Majo, Xavier et al. DOI: 10.1111/liv.15327
PMID: 35625751 Journal: Biomedicines Year: 2022 Reference: Biomedicines. 2022 Apr 28;10(5). pii: biomedicines10051015. doi: 10.3390/biomedicines10051015. Impact factor: 6.081 Publication type: Paper in international publication Authors: Gabriel-Medina, Pablo, Ferrer-Costa, Roser, Rodriguez-Frias, Francisco, Ciudin, Andreea, Augustin, Salvador, Rivera-Esteban, Jesus, Pericas, Juan M, Selva, David Martinez et al. DOI: 10.3390/biomedicines10051015
PMID: 34014280 Journal: Disease Models & Mechanisms Year: 2021 Reference: Dis Model Mech. 2021 May 1;14(5). pii: 268318. doi: 10.1242/dmm.048884. Epub 2021 May 20. Impact factor: 5.758 Publication type: Paper in international publication Authors: Bravo, Miren, Raurell, Imma, Barbera, Aurora, Hide, Diana, Gil, Mar, Estrella, Federico, Salcedo, Maria Teresa, Augustin, Salvador, Genesca, Joan, Martell, Maria et al. DOI: 10.1242/dmm.048884
PMID: 33880971 Journal: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS Year: 2021 Reference: Expert Rev Mol Diagn. 2021 Apr;21(4):381-396. doi: 10.1080/14737159.2021.1913055. Epub 2021 Apr 21. Impact factor: 5.225 Publication type: Review in international publication Authors: Garcia-Garcia, Selene, Cortese, Maria Francesca, Rodriguez-Algarra, Francisco, Tabernero, David, Rando-Segura, Ariadna, Quer, Josep, Buti, Maria, Rodriguez-Frias, Francisco et al. DOI: 10.1080/14737159.2021.1913055
PMID: 33278456 Journal: JOURNAL OF HEPATOLOGY Year: 2021 Reference: J Hepatol. 2021 May;74(5):1064-1074. doi: 10.1016/j.jhep.2020.11.043. Epub 2020 Dec 2. Impact factor: 25.083 Publication type: Paper in international publication Authors: Garcia-Lopez, Mireia, Lens, Sabela, Pallett, Laura J, Testoni, Barbara, Rodriguez-Tajes, Sergio, Marino, Zoe, Bartres, Concepcion, Garcia-Pras, Ester, Leonel, Thais, Perpinan, Elena et al. DOI: 10.1016/j.jhep.2020.11.043
PMID: 33227350 Journal: JOURNAL OF HEPATOLOGY Year: 2021 Reference: J Hepatol. 2021 May;74(5):1097-1108. doi: 10.1016/j.jhep.2020.11.019. Epub 2020 Nov 20. Impact factor: 25.083 Publication type: Paper in international publication Authors: Francoz, Claire, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, Jose Presa et al. DOI: 10.1016/j.jhep.2020.11.019
PMID: 32496109 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2020 Reference: Rev Esp Enferm Dig. 2020 Sep;112(9):712-715. doi: 10.17235/reed.2020.6600/2019. Impact factor: 1.591 Publication type: Paper in international publication Authors: Armengol Bertroli, Jordi, Pascasio-Hernandez, Mario Jose, Benages Curell, Anna, Castillo Cejas, Maria Dolores, Pigrau Pastor, Marc, Sihuay Diburga, Denisse, Guevara Cubas, Jorge, Castro-Reyes, Luz Maria, Jimenez Hernandez, Cesar, Tasayco Huaman, Stephanie et al. DOI: 10.17235/reed.2020.6600/2019
PMID: 32336663 Journal: Surgery for Obesity and Related Diseases Year: 2020 Reference: Surg Obes Relat Dis. 2020 Sep;16(9):1361-1369. doi: 10.1016/j.soard.2020.03.013. Epub 2020 Mar 20. Impact factor: 3.812 Publication type: Paper in international publication Authors: Talavera-Urquijo, Eider, Beisani, Marc, Balibrea, Jose M, Alverdy, John C et al. DOI: 10.1016/j.soard.2020.03.013
PMID: 32329119 Journal: LIVER INTERNATIONAL Year: 2020 Reference: Liver Int. 2020 Aug;40(8):1906-1916. doi: 10.1111/liv.14489. Epub 2020 Jun 3. Impact factor: 5.175 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Barreira-Diaz, Ana, Vidal-Gonzalez, Judit, Munoz-Couselo, Eva, Martinez-Valle, Fernando, Viladomiu, Lluis, Minguez, Beatriz, Ortiz-Velez, Carolina, Castells, Lluis, Esteban, Rafael et al. DOI: 10.1111/liv.14489
PMID: 31816146 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2020 Reference: J Viral Hepat. 2020 Apr;27(4):453-455. doi: 10.1111/jvh.13245. Epub 2019 Dec 18. Impact factor: 3.561 Publication type: Paper in international publication Authors: Martinez-Camprecios, Joan, Bonis Puig, Sara, Pons Delgado, Monica, Salcedo Allende, Maria Teresa, Minguez Rosique, Beatriz, Genesca Ferrer, Joan et al. DOI: 10.1111/jvh.13245
PMID: 29239718 Journal: JOURNAL OF GENERAL VIROLOGY Year: 2018 Reference: J Gen Virol. 2018 Jan;99(1):97-102. doi: 10.1099/jgv.0.000996. Epub 2017 Dec 14. Impact factor: 2.514 Publication type: Paper in international publication Authors: Chen, Qian, Riveiro-Barciela, Mar, Buti, Maria, Esteban, Rafael, Esteban, Juan Ignacio, Rodriguez-Frias, Francisco, Quer, Josep, Llorens, Meritxell, Perales, Celia, Soria, Maria Eugenia et al. DOI: 10.1099/jgv.0.000996
PMID: 28988126 Journal: VIRUS RESEARCH Year: 2018 Reference: Virus Res. 2018 Jan 2;243:52-59. doi: 10.1016/j.virusres.2017.10.003. Epub 2017 Oct 4. Impact factor: 2.484 Publication type: Paper in international publication Authors: Sopena, Sara, Godoy, Cristina, Tabernero, David, Homs, Maria, Gregori, Josep, Riveiro-Barciela, Mar, Ruiz, Alicia, Esteban, Rafael, Buti, Maria, Rodriguez-Frias, Francisco et al. DOI: 10.1016/j.virusres.2017.10.003
PMID: 28608619 Journal: TRANSPLANT INTERNATIONAL Year: 2017 Reference: Transpl Int. 2017 Oct;30(10):1041-1050. doi: 10.1111/tri.12999. Epub 2017 Jul 27. Impact factor: 3.079 Publication type: Paper in international publication Authors: Testillano, Milagros, Salcedo, Magdalena, Prieto, Martin, Castells, Lluis, Pascasio, Juan Manuel, Alvarez, Jose Luis Montero, Fernandez, Inmaculada, Sanchez-Antolin, Gloria, Gonzalez-Dieguez, Luisa, Garcia-Gonzalez, Miguel et al. DOI: 10.1111/tri.12999
PMID: 27323654 Journal: ARCHIVOS DE BRONCONEUMOLOGIA Year: 2017 Reference: Arch Bronconeumol. 2017 Jan;53(1):13-18. doi: 10.1016/j.arbres.2016.05.003. Epub 2016 Jun 17. Impact factor: 2.979 Publication type: Paper in national publication Authors: Blanco, Ignacio, Martinez, Maria Teresa, Rodriguez, Esther, Bustamante, Ana, Casas, Francisco, Cadenas, Sergio, Hernandez, Jose M, Lazaro, Lourdes, Torres, Maria, Curi, Sergio et al. DOI: 10.1016/j.arbres.2016.05.003
PMID: 28585554 Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Year: 2017 Reference: Am J Gastroenterol. 2017 Sep;112(9):1400-1409. doi: 10.1038/ajg.2017.157. Epub 2017 Jun 6. Impact factor: 9.566 Publication type: Paper in international publication Authors: Roget, Merce, Lens, Sabela, Fernandez, Inmaculada, Rodriguez-Tajes, Sergio, Hontangas, Vanessa, Vergara, Mercedes, Forne, Montserrat, Calleja, Jose Luis, Diago, Moises, Llaneras, Jordi et al. DOI: 10.1038/ajg.2017.157
PMID: 28527664 Journal: JOURNAL OF HEPATOLOGY Year: 2017 Reference: J Hepatol. 2017 Oct;67(4):669-679. doi: 10.1016/j.jhep.2017.05.010. Epub 2017 May 18. Impact factor: 12.486 Publication type: Paper in international publication Authors: Ni, Yi, Hommel, Mirja, Palomo, Laura, Segura, Victor, Olague, Cristina, Vales, Africa, Ruiz-Ripa, Alicia, Buti, Maria, Salido, Eduardo, Prieto, Jesus et al. DOI: 10.1016/j.jhep.2017.05.010
Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.
The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.
The research team used nanotechnology to deliver the drug directly to liver cells, which eliminated side effects without reducing effectiveness.
Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.
