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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Team

Villagrasa Vilella, Ares Aurora

Villagrasa Vilella, Ares Aurora

Senior researcher
Liver Diseases
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Aina Marti Carretero

Aina Marti Carretero

Predoctoral researcher
Liver Diseases
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Ana  Barreira Diaz

Ana Barreira Diaz

Liver Diseases
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Beatriz Minguez Rosique

Beatriz Minguez Rosique

Main researcher
Liver Diseases
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Damir Garcia Cehic

Damir Garcia Cehic

Research technician
Liver Diseases
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David Tabernero Caellas

David Tabernero Caellas

Senior researcher
Liver Diseases
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Villagrasa Vilella, Ares Aurora

Villagrasa Vilella, Ares Aurora

Senior researcher
Liver Diseases
Read more
Aina Marti Carretero

Aina Marti Carretero

Predoctoral researcher
Liver Diseases
Read more
Ana  Barreira Diaz

Ana Barreira Diaz

Liver Diseases
Read more
Beatriz Minguez Rosique

Beatriz Minguez Rosique

Main researcher
Liver Diseases
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Damir Garcia Cehic

Damir Garcia Cehic

Research technician
Liver Diseases
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David Tabernero Caellas

David Tabernero Caellas

Senior researcher
Liver Diseases
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Projects

Impacto de la cirugía bariátrica en la hemodinámica portal en pacientes con obesidad mórbida y NAFLD. Estudio HEYMDAL.

IP: Ramón Vilallonga Puy
Collaborators: Mercedes Pérez Lafuente, Nuria Roson Gradaille, Laura Puente Ramo, Carla Gonzalez Junyent, Marta Comas Martínez, Alba Rojano Toimil, Arturo Cirera De Tudela, Elisa Merino Peña, Clara Pañella Vilamú, Ana Maria Ciscar Bellés, Carlos Petrola Chacón
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI22/00880
Duration: 01/01/2023 - 31/12/2025

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2025

pendent

IP: Joan Genescà Ferrer
Collaborators: Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 180000
Reference: JR21/00064
Duration: 01/01/2022 - 31/12/2025

Seniority no ERC

IP: Josep Quer Sivila
Collaborators: -
Funding agency: VHIR
Funding: 225000
Reference: VHIR/SENIORITY_NO_ERC/21/QUER
Duration: 01/05/2021 - 30/04/2026

Publications

An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study.

PMID: 38607809
Journal: HEPATOLOGY
Year: 2024
Reference: Hepatology. 2024 Apr 12. doi: 10.1097/HEP.0000000000000883.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Agrawal, Rohit; Ahn, Joseph C; Arab, Juan P; Arnold, Jorge; Arrese, Marco; Attar, Bashar; Ayala-Valverde, Maria; Ayares, Gustavo; Bataller, Ramon et al.
DOI: 10.1097/HEP.0000000000000883

Phenotypes of MASLD-associated hepatocellular carcinoma.

PMID: 38604295
Journal: Clinical Gastroenterology and Hepatology
Year: 2024
Reference: Clin Gastroenterol Hepatol. 2024 Apr 9:S1542-3565(24)00310-0. doi: 10.1016/j.cgh.2024.03.028.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Bermudez-Ramos, Maria; Cusido, M Serra; Francque, Sven M; Higuera, Monica; Jimenez-Masip, Alba; Martinez-Gomez, Maria; Minguez, Beatriz; Munoz-Martinez, Sergio; Pericas, Juan M et al.
DOI: 10.1016/j.cgh.2024.03.028

Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbab le, gut-restricted adsorbent in models and patients with cirrhosis.

PMID: 38621924
Journal: GUT
Year: 2024
Reference: Gut. 2024 Apr 15:gutjnl-2023-330699. doi: 10.1136/gutjnl-2023-330699.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Andreola, Fausto; Arroyo, Vicente; Avery, Thomas; Caraceni, Paolo; Church, Karen; Clasen, Frederick; Cordero, Paul; Cortez-Pinto, Helena; Cox, I Jane et al.
DOI: 10.1136/gutjnl-2023-330699

Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure.

PMID: 38672603
Journal: Cancers
Year: 2024
Reference: Cancers (Basel). 2024 Apr 16;16(8):1521. doi: 10.3390/cancers16081521.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Higuera, Monica; Minguez, Beatriz; Vargas-Accarino, Elena et al.
DOI: 10.3390/cancers16081521

Risk scores' performance and their impact on operative decision-making in left-sided endocarditis: a cohort study.

PMID: 36346471
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2023
Reference: Eur J Clin Microbiol Infect Dis. 2023 Jan;42(1):33-42. doi: 10.1007/s10096-022-04516-2. Epub 2022 Nov 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alcocer, J; Almela, M; Ambrosioni, J; Barriuso, C; Castella, M; Castro, P; Dahl, A; Falces, C; Fernandez-Cisneros, A; Garcia-de-la-Maria, C et al.
DOI: 10.1007/s10096-022-04516-2

Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding.

PMID: 36328772
Journal: GUT
Year: 2023
Reference: Gut. 2023 Apr;72(4):749-758. doi: 10.1136/gutjnl-2022-326975. Epub 2022 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Albillos, Agustin; Alvarado, Edilmar; Amitrano, Lucio; Banares, Rafael; Bosch, Jaume; Bureau, Christophe; Calleja, Jose Luis; Canete, Nouria; Casanovas, Georgina et al.
DOI: 10.1136/gutjnl-2022-326975

Securing Wider EU Commitment to the Elimination of HCV.

PMID: 36196744
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Feb;43(2):276-291. doi: 10.1111/liv.15446. Epub 2022 Dec 14.
Impact factor:
Publication type: Review in international publication
Authors: Aghemo, Alessio; Bakoyannis, Kostas; Baptista-Leite, Ricardo; Bartoli, Marco; Bruggmann, Philip; Busoi, Cristian-Silviu; Buti, Maria; Carballo, Manuel; Castera, Laurent; Colom Farran, Joan et al.
DOI: 10.1111/liv.15446

Platform trials to overcome major shortcomings of traditional clinical trials in non-alcoholic steatohepatitis? Pros and Cons.

PMID: 36216134
Journal: JOURNAL OF HEPATOLOGY
Year: 2023
Reference: J Hepatol. 2023 Feb;78(2):442-447. doi: 10.1016/j.jhep.2022.09.021. Epub 2022 Oct 8.
Impact factor:
Publication type: Review in international publication
Authors: Aaes-Jorgensen, Anders; Anstee, Quentin M; Anstee, Quentin M; Balthaus, Tania; Capuano, George; de Preville, Natalie; Di Prospero, Nicholas A; Di Prospero, Nicholas A; Duca, Anna; Genesca, Joan et al.
DOI: 10.1016/j.jhep.2022.09.021

Detection of non-enveloped hepatitis E virus in plasma of infected blood donors.

PMID: 34865052
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2022
Reference: J Infect Dis. 2022 Nov 11;226(10):1753-1760. doi: 10.1093/infdis/jiab589.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Costafreda, Maria Isabel; Piron, Maria; Rico, Angie; Sauleda, Silvia et al.
DOI: 10.1093/infdis/jiab589

Are Women's Empowerment and Income Inequality Associated with Excess Weight in Latin American Cities?

PMID: 36357625
Journal: JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
Year: 2022
Reference: J Urban Health. 2022 Dec;99(6):1091-1103. doi: 10.1007/s11524-022-00689-5. Epub 2022 Nov 10.
Impact factor:
Publication type: Paper in international publication
Authors: Anza Ramirez, Cecilia; Belvis Costes, Francesc; Benach, Joan; Lazo, Mariana; Mazariegos, Monica; Menezes, Mariana Carvalho; Moore, Kari; Ortigoza, Ana; Perez Ferrer, Carolina; Pericas, Juan M et al.
DOI: 10.1007/s11524-022-00689-5

Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.

PMID: 36214066
Journal: Hepatology Communications
Year: 2022
Reference: Hepatol Commun. 2022 Dec;6(12):3324-3334. doi: 10.1002/hep4.2091. Epub 2022 Oct 10.
Impact factor:
Publication type: Paper in international publication
Authors: Chan, Jean L; Ciarleglio, Maria; Deng, Yanhong; Garcia-Tsao, Guadalupe; Genesca, Joan; Pons, Monica; Rabiee, Anahita et al.
DOI: 10.1002/hep4.2091

Deaths of Despair: A Scoping Review on the Social Determinants of Drug Overdose, Alcohol-Related Liver Disease and Suicide.

PMID: 36231697
Journal: International Journal of Environmental Research and Public Health
Year: 2022
Reference: Int J Environ Res Public Health. 2022 Sep 29;19(19). pii: ijerph191912395. doi: 10.3390/ijerph191912395.
Impact factor:
Publication type: Review in international publication
Authors: Benach, Joan; Beseran, Elisabet; Cash-Gibson, Lucinda; Pericas, Juan M; Porter, Keshia M Pollack; Ventura-Cots, Meritxell et al.
DOI: 10.3390/ijerph191912395

Effects of Albumin on Survival after a Hepatic Encephalopathy Episode: Randomized Double-Blind Trial and Meta-Analysis.

PMID: 34768404
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Oct 23;10(21). pii: jcm10214885. doi: 10.3390/jcm10214885.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado-Tapias, Edilmar; Amador, Alberto; Ardevol, Alba; Ariza, Xavier; Calleja, Jose Luis; Canete, Nuria; Casas Rodrigo, Meritxell; Clemente-Sanchez, Ana; Genesca, Joan; Llop, Elba et al.
DOI: 10.3390/jcm10214885

What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review.

PMID: 34768539
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Oct 28;10(21). pii: jcm10215019. doi: 10.3390/jcm10215019.
Impact factor:
Publication type: Review in international publication
Authors: Benach, Joan; Lazarus, Jeffrey V; Pericas, Juan M; Talens, Mar; Tumas, Natalia et al.
DOI: 10.3390/jcm10215019

Correction to: Association between circulating alpha-1 antitrypsin polymers and lung and liver disease.

PMID: 34719403
Journal: RESPIRATORY RESEARCH
Year: 2021
Reference: Respir Res. 2021 Nov 1;22(1):283. doi: 10.1186/s12931-021-01874-x.
Impact factor:
Publication type: Letter or abstract
Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Farago, Georgina; Gabriel-Medina, Pablo; Genesca, Joan; Loeb, Eduardo; Miranda, Elena; Miravitlles, Marc; Nunez, Alexa et al.
DOI: 10.1186/s12931-021-01874-x

Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis.

PMID: 34712934
Journal: JHEP Reports
Year: 2021
Reference: JHEP Rep. 2021 Sep 27;3(6):100368. doi: 10.1016/j.jhepr.2021.100368. eCollection 2021 Dec.
Impact factor:
Publication type: Letter whit IF
Authors: Abraldes, Juan G; Albillos, Agustin; Alvarado, Eldimar; Aracil, Carlos; Augustin, Salvador; Banares, Rafael; Blanco, Carolina; Bosch, Jaime; Calleja, Jose Luis; Falcon-Perez, Juan Manuel et al.
DOI: 10.1016/j.jhepr.2021.100368

Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(double dagger).

PMID: 31730789
Journal: JOURNAL OF HEPATOLOGY
Year: 2020
Reference: J Hepatol. 2020 Mar;72(3):539-557. doi: 10.1016/j.jhep.2019.11.003. Epub 2019 Nov 12.
Impact factor:
Publication type: Review in international publication
Authors: Berg, Thomas; Brunetto, Maurizia R; Buchholz, Stephanie; Buti, Maria; Chan, Henry L Y; Chang, Kyong-Mi; Cornberg, Markus; Dandri, Maura; Dusheiko, Geoffrey; Feld, Jordan J et al.
DOI: 10.1016/j.jhep.2019.11.003

Dissimilar Conservation Pattern in Hepatitis C Virus Mutant Spectra, Consensus Sequences, and Data Banks.

PMID: 33121037
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Oct 27;9(11). pii: jcm9113450. doi: 10.3390/jcm9113450.
Impact factor:
Publication type: Paper in international publication
Authors: Avila, Ana Isabel de; Briones, Carlos; Domingo, Esteban; Gallego, Isabel; Garcia-Crespo, Carlos; Gomez, Jordi; Gregori, Josep; Martinez-Gonzalez, Brenda; Perales, Celia; Quer, Josep et al.
DOI: 10.3390/jcm9113450

Trends in Diagnosis of Alpha-1 Antitrypsin Deficiency Between 2015 and 2019 in a Reference Laboratory.

PMID: 33116457
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2020
Reference: Int J Chron Obstruct Pulmon Dis. 2020 Oct 7;15:2421-2431. doi: 10.2147/COPD.S269641. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Blanco-Grau, Albert; Esquinas, Cristina; Ferrer, Roser; Genesca, Joan; Lopez-Martinez, Rosa M; Miravitlles, Marc; Nunez, Alexa; Pons, Monica et al.
DOI: 10.2147/COPD.S269641

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage.

PMID: 33076429
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Oct 15;12(10). pii: cancers12102986. doi: 10.3390/cancers12102986.
Impact factor:
Publication type: Paper in international publication
Authors: Campillo-Marcos, Ignacio; Garcia-Gonzalez, Raul; Lazo, Pedro A; Morejon-Garcia, Patricia; Salzano, Marcella et al.
DOI: 10.3390/cancers12102986

Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH).

PMID: 31594683
Journal: Gastroenterologia y Hepatologia
Year: 2019
Reference: Gastroenterol Hepatol. 2019 Nov;42(9):579-592. doi: 10.1016/j.gastrohep.2019.09.002. Epub 2019 Oct 5.
Impact factor:
Publication type: Paper in international publication
Authors: Acin, Enrique; Albillos, Agustin; Berenguer, Juan; Berenguer, Marina; Buti, Maria; Calleja, Jose Luis; Colom, Joan; Crespo, Javier; Fernandez Rodriguez, Conrado; Fernandez, Inmaculada et al.
DOI: 10.1016/j.gastrohep.2019.09.002

Synergistic lethal mutagenesis of hepatitis C virus.

PMID: 31570400
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2019
Reference: Antimicrobial Agents and Chemotherapy. 2019 Dec 30;63(12).. doi: 10.1128/AAC.01653-19.
Impact factor:
Publication type: Paper in international publication
Authors: de Avila, Ana I; Domingo, Esteban; Esteban, Jaime; Esteban, Juan Ignacio; Fernandez-Roblas, Ricardo; Gadea, Ignacio; Gallego, Isabel; Garcia-Crespo, Carlos; Gomez, Jordi; Gregori, Josep et al.
DOI: 10.1128/AAC.01653-19

Deep-sequencing study of HCV G4a resistance-associated substitutions in Egyptian patients failing DAA treatment.

PMID: 31571936
Journal: Infection and Drug Resistance
Year: 2019
Reference: Infect Drug Resist. 2019 Sep 10;12:2799-2807. doi: 10.2147/IDR.S214735. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Amer, Fatma; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Hammad, Noha M; Nieto-Aponte, Leonardo; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Yousif, Monkez M et al.
DOI: 10.2147/IDR.S214735

Effectiveness, safety/tolerability of OBV/PTV/r +/- DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study.

PMID: 31550267
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Sep 24;14(9):e0221567. doi: 10.1371/journal.pone.0221567. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Ahumada, Adriana; Aldamiz-Echevarria, Teresa; Baliellas, Carme; Barril, Guillermina; Benlloch, Salvador; Bonet, Lucia; Carmona, Isabel; Castano, Manuel A; Castro, Angeles; de Alvaro, Cristina et al.
DOI: 10.1371/journal.pone.0221567

Toll Like Receptor-7 and -9 agonists improve Hepatitis C Virus replication and infectivity inhibition by plasmacytoid dendritic cells.

PMID: 30232187
Journal: JOURNAL OF VIROLOGY
Year: 2018
Reference: J Virol. 2018 Nov 12;92(23). pii: JVI.01219-18. doi: 10.1128/JVI.01219-18. Print 2018 Dec 1.
Impact factor:
Publication type: Paper in international publication
Authors: Domingo, E; Dominguez-Molina, B; Gallego, I; Leal, M; Machmach, K; Perales, C; Ruiz-Mateos, E; Shedon, J; Tarancon-Diez, L et al.
DOI: 10.1128/JVI.01219-18

The pharmacological interactions between direct-acting antivirals for the treatment of chronic hepatitis c and psychotropic drugs.

PMID: 30199279
Journal: Expert Review of Clinical Pharmacology
Year: 2018
Reference: Expert Rev Clin Pharmacol. 2018 Oct;11(10):999-1030. doi: 10.1080/17512433.2018.1519392. Epub 2018 Sep 29.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Martinez-Rebollar, Maria; Roncero, Carlos; Villegas, Jose Luis et al.
DOI: 10.1080/17512433.2018.1519392

Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction.

PMID: 30186817
Journal: Canadian Journal of Gastroenterology and Hepatology
Year: 2018
Reference: Can J Gastroenterol Hepatol. 2018 Aug 16;2018:1672621. doi: 10.1155/2018/1672621. eCollection 2018.
Impact factor:
Publication type: Clinical Trials
Authors: Bilbao, Itxarone; Caralt, Mireia; Castells, Lluis; Charco, Ramon; Dopazo, Cristina; Gomez-Gavara, Concepcion; Lazaro, Jose Luis; Pando, Elizabeth; Pando, Elizabeth et al.
DOI: 10.1155/2018/1672621

Psychotropic Drugs and Liver Toxicity.

PMID: 30188878
Journal: AMERICAN JOURNAL OF THERAPEUTICS
Year: 2018
Reference: Am J Ther. 2018 Sep/Oct;25(5):e601-e602. doi: 10.1097/MJT.0000000000000615.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cristina; Gomez-Lumbreras, Ainhoa; Marcos-Fosch, Cristina et al.
DOI: 10.1097/MJT.0000000000000615

Successful continuation of HCV treatment following liver transplantation.

PMID: 27906834
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 May;101(5):1009-1012. doi: 10.1097/TP.0000000000001596.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Calleja, Jose Luis; Carrillo, Carlos Fernandez; Castells, Lluis; Crespo, Gonzalo; de la Revilla, Juan; Fabrega, Emilio; Fernandez, Inmaculada; Hernandez, Victoria; Londono, Maria-Carlota et al.
DOI: 10.1097/TP.0000000000001596

Validating the Baveno VI recommendations for screening varices.

PMID: 27826055
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Feb;66(2):459-460. doi: 10.1016/j.jhep.2016.09.027. Epub 2016 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Genesca, Joan; Pons, Monica et al.
DOI: 10.1016/j.jhep.2016.09.027

The optimal timing of hepatitis C therapy in transplant eligible patients with Child B and C Cirrhosis: A Cost-Effectiveness Analysis.

PMID: 27495755
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 May;101(5):987-995. doi: 10.1097/TP.0000000000001400.
Impact factor:
Publication type: Paper in international publication
Authors: Afdhal, Nezam H; Buti, Maria; Curry, Michael P; Dufour, Jean-Francois; Firdoos, Saima; Flamm, Steve; Hughes, Michael S; Tapper, Elliot B et al.
DOI: 10.1097/TP.0000000000001400

Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B.

PMID: 27534671
Journal: GUT
Year: 2017
Reference: Gut. 2017 Nov;66(11):2013-2023. doi: 10.1136/gutjnl-2015-309300. Epub 2016 Aug 17.
Impact factor:
Publication type: Paper in international publication
Authors: Bayliss, Julianne; Buti, Maria; Colledge, Danni; Edwards, Rosalind; Gaggar, Anuj; Gane, Ed; Hammond, Rachel; Jackson, Kathleen; Janssen, Harry L A; Kitrinos, Kathryn M et al.
DOI: 10.1136/gutjnl-2015-309300

Combination of Tenofovir Disoproxil Fumarate and Peginterferon alfa-2a Increases Loss of Hepatitis B Surface Antigen in Patients with Chronic Hepatitis B.

PMID: 26453773
Journal: GASTROENTEROLOGY
Year: 2016
Reference: Gastroenterology. 2016 Jan;150(1):134-144.e10. doi: 10.1053/j.gastro.2015.09.043. Epub 2015 Oct 8.
Impact factor:
Publication type: Paper in international publication
Authors: Ahn, Sang Hoon; Buti, Maria; Caruntu, Florin A; Chan, Henry Ly; Charuworn, Prista; Chuang, Wan-Long; Corsa, Amoreena; Dinh, Phillip; Elkashab, Magdy; Flisiak, Robert et al.
DOI: 10.1053/j.gastro.2015.09.043

Daclatasvir plus simeprevir with or without ribavirin for the treatment of chronic hepatitis C virus genotype 1 infection.

PMID: 26453968
Journal: JOURNAL OF HEPATOLOGY
Year: 2016
Reference: J Hepatol. 2016 Feb;64(2):292-300. doi: 10.1016/j.jhep.2015.09.024. Epub 2015 Oct 8.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Assi, M Tarek; Banyai, Tivadar; Beumont-Mauviel, Maria; Bifano, Marc; Boparai, Navdeep; Bourliere, Marc; Bronowicki, Jean-Pierre; Buti, Maria; Cheung, Kin; Gadano, Adrian et al.
DOI: 10.1016/j.jhep.2015.09.024

Grazoprevir, Elbasvir, and Ribavirin for Chronic Hepatitis C Virus Genotype 1 Infection After Failure of Pegylated Interferon and Ribavirin With an Earlier-Generation Protease Inhibitor: Final 24-Week Results From C-SALVAGE.

PMID: 26371152
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2016
Reference: Clin Infect Dis. 2016 Jan 1;62(1):32-6. doi: 10.1093/cid/civ722. Epub 2015 Sep 14.
Impact factor:
Publication type: Paper in international publication
Authors: Barr, Eliav; Buti, Maria; Calleja, Jose L; DiNubile, Mark J; Forns, Xavier; Gilbert, Christopher; Gordon, Stuart C; Hofer, Harald; Howe, Anita Y M; Lawitz, Eric et al.
DOI: 10.1093/cid/civ722

Ribavirin concentration determines treatment success of first-generation DAA-based chronic HCV therapy.

PMID: 26378941
Journal: ANTIVIRAL THERAPY
Year: 2016
Reference: Antivir Ther. 2016;21(2):153-9. doi: 10.3851/IMP2994. Epub 2015 Sep 17.
Impact factor:
Publication type: Paper in international publication
Authors: Burger, David M; Buti, Maria; de Kanter, Clara Tmm; DeMasi, Ralph; Dofferhoff, Anton Sm; Drenth, Joost Ph; Ouwerkerk-Mahadevan, Sivi; Witek, James; Zeuzem, Stefan et al.
DOI: 10.3851/IMP2994

Alisporivir with peginterferon/ribavirin in patients with chronic hepatitis C genotype 1 infection who failed to respond to or relapsed after prior interferon-based therapy: FUNDAMENTAL, a Phase II trial.

PMID: 25412795
Journal: J VIRAL HEPATITIS
Year: 2015
Reference: J Viral Hepat. 2015 Jul;22(7):596-606. doi: 10.1111/jvh.12360. Epub 2014 Nov 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alberti, A; Brass, C; Buti, M; Calistru, P; Chuang, W-L; Davis, G L; Flisiak, R; Goeser, T; Horban, A; Kao, J-H et al.
DOI: 10.1111/jvh.12360

Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians.

PMID: 25011935
Journal: GUT
Year: 2015
Reference: Gut. 2015 Aug;64(8):1289-95. doi: 10.1136/gutjnl-2014-307023. Epub 2014 Jul 10.
Impact factor:
Publication type: Paper in international publication
Authors: Arends, Pauline; Berg, Thomas; Brown, Ashley; Buti, Maria; Carey, Ivana; de Knegt, Robert J; Deterding, Katja; Fasano, Massimo; Hansen, Bettina; Janssen, Harry L A et al.
DOI: 10.1136/gutjnl-2014-307023

Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension.

PMID: 26047908
Journal: J HEPATOL
Year: 2015
Reference: J Hepatol. 2015 Sep;63(3):743-52. doi: 10.1016/j.jhep.2015.05.022. Epub 2015 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Aabakken, Lars; Abraldes, Juan G; Abraldes, Juan G; Albillos, Augustin; Augustin, Salvador; Bajaj, Jasmohan; Bajaj, Jasmohan; Banares, Rafael; Berzigotti, Annalisa; Berzigotti, Annalisa et al.
DOI: 10.1016/j.jhep.2015.05.022

Complex Genotype Mixtures Analyzed by Deep Sequencing in Two Different Regions of Hepatitis B Virus.

PMID: 26714168
Journal: PLOS ONE
Year: 2015
Reference: PLoS One. 2015 Dec 29;10(12):e0144816. doi: 10.1371/journal.pone.0144816. eCollection 2015.
Impact factor:
Publication type: Paper in international publication
Authors: Blasi, Maria; Buti, Maria; Caballero, Andrea; Casillas, Rosario; Esteban, Rafael; Gonzalez, Carolina; Gregori, Josep; Homs, Maria; Nieto, Leonardo; Quer, Josep et al.
DOI: 10.1371/journal.pone.0144816

The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm.

PMID: 24713005
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 May;21 Suppl 1:34-59. doi: 10.1111/jvh.12248.
Impact factor:
Publication type: Paper in international publication
Authors: Akarca, U; Aleman, S; Balik, I; Berg, T; Bihl, F; Bilodeau, M; Blasco, A J; Brandao Mello, C E; Bruggmann, P; Buti, M et al.
DOI: 10.1111/jvh.12248

Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C.

PMID: 24316262
Journal: GASTROENTEROLOGY
Year: 2014
Reference: Gastroenterology. 2014 Mar;146(3):744-753.e3. doi: 10.1053/j.gastro.2013.11.047. Epub 2013 Dec 4.
Impact factor:
Publication type: Clinical Trials
Authors: Agarwal, Kosh; Bertelsen, Kirk; Brown, Robert S Jr; Buti, Maria; De Masi, Ralph; De Meyer, Sandra; Hezode, Christophe; Horsmans, Yves; Janczewska, Ewa; Luo, Donghan et al.
DOI: 10.1053/j.gastro.2013.11.047

Boceprevir plus peginterferon alpha-2b/ribavirin in chronic hepatitis C genotype 1: impact of baseline viral load on sustained virologic response.

PMID: 24177376
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2014
Reference: J Clin Gastroenterol. 2014 May-Jun;48(5):435-43. doi: 10.1097/MCG.0000000000000000.
Impact factor:
Publication type: Paper in international publication
Authors: Albrecht, Janice K; Bacon, Bruce; Brass, Clifford A; Bronowicki, Jean-Pierre; Burroughs, Margaret; Buti, Maria; Gordon, Stuart C; Hu, Ke-Qin; Jacobson, Ira M; Lawitz, Eric J et al.
DOI: 10.1097/MCG.0000000000000000

Relevance of a full-length genomic RNA standard and a thermal-shock step for optimal hepatitis delta virus quantification.

PMID: 24989607
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2014
Reference: J Clin Microbiol. 2014 Sep;52(9):3334-8. doi: 10.1128/JCM.00940-14. Epub 2014 Jul 2.
Impact factor:
Publication type: Paper in international publication
Authors: Blasi, Maria; Buti, Maria; Dandri, Maura; Esteban, Rafael; Giersch, Katja; Homs, Maria; Lutgehetmann, Marc; Rodriguez-Frias, Francisco et al.
DOI: 10.1128/JCM.00940-14

Imaging of hepatitis C virus infection in liver grafts after liver transplantation.

PMID: 23548198
Journal: JOURNAL OF HEPATOLOGY
Year: 2013
Reference: J Hepatol. 2013 Aug;59(2):271-8. doi: 10.1016/j.jhep.2013.03.023. Epub 2013 Mar 30.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Helena; Castells, Lluis; Coto-Llerena, Mairene; Crespo, Gonzalo; Fernandez-Carrillo, Carlos; Forns, Xavier; Koutsoudakis, George; Mensa, Laura; Miquel, Rosa; Navasa, Miquel et al.
DOI: 10.1016/j.jhep.2013.03.023

Faldaprevir and deleobuvir for HCV genotype 1 infection.

PMID: 23944300
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2013
Reference: N Engl J Med. 2013 Aug 15;369(7):630-9. doi: 10.1056/NEJMoa1213557.
Impact factor:
Publication type: Paper in international publication
Authors: Asselah, Tarik; Bocher, Wulf-Otto; Bourliere, Marc; Bronowicki, Jean-Pierre; Buti, Maria; Gallivan, John-Paul; Gane, Ed J; Kukolj, George; Lohse, Ansgar W; Mensa, Federico J et al.
DOI: 10.1056/NEJMoa1213557

Rebleeding prophylaxis improves outcomes in patients with hepatocellular carcinoma. A multicenter case-control study.

PMID: 23908019
Journal: HEPATOLOGY
Year: 2013
Reference: Hepatology. 2013 Dec;58(6):2079-88. doi: 10.1002/hep.26629. Epub 2013 Oct 15.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Albillos, Agustin; Aracil, Carles; Araujo, Isis K; Augustin, Salvador; Banares, Rafael; Bosch, Jaime; Canete, Nuria; Catalina, Maria Vega; Cirera, Isabel et al.
DOI: 10.1002/hep.26629

Hepatitis C virus reinfection among prisoners with sustained virological response after treatment for chronic hepatitis C.

PMID: 23523577
Journal: JOURNAL OF HEPATOLOGY
Year: 2013
Reference: J Hepatol. 2013 Jul;59(1):45-51. doi: 10.1016/j.jhep.2013.03.008. Epub 2013 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Cayla, J A; da Silva, A; Esteban, J I; Guerrero, R A; Marco, A; Ortiz, J; Roget, M; Sarriera, C; Sole, C; Teixido, N et al.
DOI: 10.1016/j.jhep.2013.03.008

Cognitive dysfunction in cirrhosis is associated with falls. A prospective study.

PMID: 22213000
Journal: HEPATOLOGY
Year: 2012
Reference: Hepatology. 2012 Jun;55(6):1922-30. doi: 10.1002/hep.25554. Epub 2012 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/hep.25554

Liver Retransplantation in HIV-Infected Patients: A Prospective Cohort Study.

PMID: 22703615
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2012
Reference: Am J Transplant. 2012 Sep;12(9):2465-76. doi: 10.1111/j.1600-6143.2012.04142.x. Epub 2012 Jun 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1600-6143.2012.04142.x

Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino Acid changes in the hepatitis B virus genome.

PMID: 22666402
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(5):e37874. doi: 10.1371/journal.pone.0037874. Epub 2012 May 30.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Camos, Silvia; Cubero, Maria; Domingo, Esteban; Esteban, Juan I; Esteban, Rafael; Ferrer-Costa, Carles; Garcia-Cehic, Damir; Guardia, Jaume; Homs, Maria et al.
DOI: 10.1371/journal.pone.0037874

Alterations in the Common Pathway of Coagulation During Weight Loss Induced by Gastric Bypass in Severely Obese Patients.

PMID: 22193919
Journal: Obesity
Year: 2012
Reference: Obesity (Silver Spring). 2012 May;20(5):1048-56. doi: 10.1038/oby.2011.361. Epub 2011 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/oby.2011.361

Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series.

PMID: 21762481
Journal: BMC GASTROENTEROLOGY
Year: 2011
Reference: BMC Gastroenterol. 2011 Jul 15;11:80.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/1471-230X-11-80

Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus emtricitabine in patients with chronic hepatitis B: A European multicenter study.

PMID: 21767570
Journal: ANTIVIRAL RESEARCH
Year: 2011
Reference: Antiviral Res. 2011 Oct;92(1):90-5. Epub 2011 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.antiviral.2011.07.003

Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome.

PMID: 21742757
Journal: NUCLEIC ACIDS RESEARCH
Year: 2011
Reference: Nucleic Acids Res. 2011 Oct;39(19):8457-71. Epub 2011 Jul 8.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/nar/gkr451

Biexponential Analysis of Diffusion-Tensor Imaging of the Brain in Patients with Cirrhosis before and after Liver Transplantation.

PMID: 21700786
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2011
Reference: AJNR Am J Neuroradiol. 2011 Sep;32(8):1510-7. Epub 2011 Jun 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.3174/ajnr.A2533

[Predicting very early rebleeding after acute variceal bleeding based in classification and regression tree analysis (CRTA).]

PMID: 20423778
Journal: Revista de gastroenterologia de Mexico
Year: 2010
Reference: Rev Gastroenterol Mex. 2010 Jan-Mar;75(1):12-21.
Impact factor:
Publication type: Letter or abstract
Authors: Altamirano, J; Augustin, S; Camargo, L; Flores-Arroyo, A; Genesca, J; Gonzalez-Angulo, A; Martinez, B; Muntaner, L; Zapata, L et al.
DOI:

Optimization of Liver Transplantation as a Treatment of Intrahepatic Hepatocellular Carcinoma Recurrence After Partial Liver Resection: Experience of a Single European Series.

PMID: 20411387
Journal: WORLD JOURNAL OF SURGERY
Year: 2010
Reference: World J Surg. 2010 Sep;34(9):2146-54.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00268-010-0583-4

Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.

PMID: 20374224
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2010
Reference: Aliment Pharmacol Ther. 2010 Jul;32(1):97-104. Epub 2010 Mar 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2036.2010.04319.x

Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D.

PMID: 20346531
Journal: JOURNAL OF HEPATOLOGY
Year: 2010
Reference: J Hepatol. 2010 May;52(5):658-64. Epub 2010 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jhep.2009.10.036

Apolipoprotein A1 is overexpressed in the retina of diabetic patients.

PMID: 18848320
Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY
Year: 2009
Reference: Am J Ophthalmol. 2009 Feb;147(2):319-325.e1.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta; Hernandez, Cristina; Higuera, Monica; Simo, Rafael et al.
DOI: 10.1016/j.ajo.2008.08.009

Ghrelin and apolipoprotein AIV levels show opposite trends to leptin levels during weight loss in morbidly obese patients.

PMID: 19172368
Journal: OBESITY SURGERY
Year: 2009
Reference: Obes Surg. 2009 Oct;19(10):1414-23.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Baena-Fustegueras, J A; Catalan, R; Fort, J M; Galard, R; Lecube, A; Llamas, R; Lopez-Tejero, M D; Pardina, E; Peinado-Onsurbe, J et al.
DOI: 10.1007/s11695-008-9793-3

[Seroprevalence study of hepatitis B among orienteers]

PMID: 19386323
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 May 9;132(17):649-53.
Impact factor:
Publication type: Paper in national publication
Authors: Bleda, Maria Jose; Castilla, Jesus; De Mateo, Salvador; Echevarria, Jose Manuel; Gallardo, Virtudes; Garcia, Luis; Garcia, Miguel Angel; Garcia, Visitacion; Hernando, Victoria; Jardi, Rosendo et al.
DOI: 10.1016/j.medcli.2008.09.041

Lipoprotein lipase but not hormone-sensitive lipase activities achieve normality after surgically induced weight loss in morbidly obese patients.

PMID: 19455372
Journal: OBESITY SURGERY
Year: 2009
Reference: Obes Surg. 2009 Aug;19(8):1150-8.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Baena-Fustegueras, J A; Catalan, R; Fort, J M; Galard, R; Lecube, A; Llamas, R; Pardina, E; Peinado-Onsurbe, J; Vargas, V et al.
DOI: 10.1007/s11695-009-9853-3

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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