About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.
IP: Meritxell Ventura Cots Collaborators: Immaculada Raurell Saborit, Juan Manuel Pericàs Pulido, Laura Puente Ramo, Elena de Sena Fernández, Ares Aurora Villagrasa Vilella, Juan Bañares Sanchez, Jesus Manuel Rivera Esteban Funding agency: Instituto de Salud Carlos III Funding: 183920 Reference: PI22/01770 Duration: 01/01/2023 - 31/12/2025
IP: Ramón Vilallonga Puy Collaborators: Mercedes Pérez Lafuente, Nuria Roson Gradaille, Laura Puente Ramo, Carla Gonzalez Junyent, Marta Comas Martínez, Alba Rojano Toimil, Arturo Cirera De Tudela, Jesus Manuel Rivera Esteban Funding agency: Instituto de Salud Carlos III Funding: 171820 Reference: PI22/00880 Duration: 01/01/2023 - 31/12/2025
IP: Maria Antonia Emilia Meneghini Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas, Mercedes López González Funding agency: Instituto de Salud Carlos III Funding: 111320 Reference: PI22/00749 Duration: 01/01/2023 - 31/12/2025
IP: Meritxell Ventura Cots Collaborators: - Funding agency: Instituto de Salud Carlos III Funding: 180000 Reference: JR19/00015 Duration: 31/03/2020 - 30/03/2024
PMID: 37326326 Journal: HEPATOLOGY Year: 2023 Reference: Hepatology. 2023 Jun 21. doi: 10.1097/HEP.0000000000000431. Impact factor: Publication type: Paper in international publication Authors: Buti, Maria; Buti, Maria; Ghany, Marc G; Lampertico, Pietro; Lee, Hannah M et al. DOI: 10.1097/HEP.0000000000000431
PMID: 37377088 Journal: JOURNAL OF HEPATOLOGY Year: 2023 Reference: J Hepatol. 2023 Jun 21:S0168-8278(23)00417-8. doi: 10.1016/j.jhep.2023.06.002. Impact factor: Publication type: Review in international publication Authors: Buti, Maria; Buti, Maria; Ghany, Marc G; Lampertico, Pietro; Lee, Hannah M et al. DOI: 10.1016/j.jhep.2023.06.002
PMID: 37716616 Journal: Clinical Gastroenterology and Hepatology Year: 2023 Reference: Clin Gastroenterol Hepatol. 2023 Sep 14:S1542-3565(23)00708-5. doi: 10.1016/j.cgh.2023.08.038. Impact factor: Publication type: Paper in international publication Authors: Aigner, Elmar; Amzou, Samira; Bals, Robert; Benini, Federica; Bewersdorf, Lisa; Burbaum, Barbara; Denk, Helmut; Frankova, Sona; Fraughen, Daniel D; Fromme, Malin et al. DOI: 10.1016/j.cgh.2023.08.038
PMID: 37734683 Journal: JOURNAL OF HEPATOLOGY Year: 2023 Reference: J Hepatol. 2023 Sep 19:S0168-8278(23)05096-1. doi: 10.1016/j.jhep.2023.09.011. Impact factor: Publication type: Paper in international publication Authors: Ahn, Sang Hoon; Berg, Thomas; Buti, Maria; Buti, Maria; Calleja, Jose Luis; Chun, Ho Soo; Dalekos, George N; Goulis, John; Janssen, Harry LA; Jun, Dae Won et al. DOI: 10.1016/j.jhep.2023.09.011
PMID: 35788977 Journal: CLINICAL DRUG INVESTIGATION Year: 2022 Reference: Clin Drug Investig. 2022 Jul 5. pii: 10.1007/s40261-022-01174-2. doi: 10.1007/s40261-022-01174-2. Impact factor: 2.859 Publication type: Letter or abstract Authors: Minguez, Beatriz; Lledo-Navarro, Jose Luis et al. DOI: 10.1007/s40261-022-01174-2
PMID: 35722299 Journal: Frontiers in Microbiology Year: 2022 Reference: Front Microbiol. 2022 May 26;13:876409. doi: 10.3389/fmicb.2022.876409. eCollection 2022. Impact factor: 5.64 Publication type: Paper in international publication Authors: Codina, Maria Gema, Martin, Maria Carmen, Castillo, Carla, Garcia-Comunas, Karen, Vasquez-Mercado, Rodrigo, Martins-Martins, Reginald, Colomer-Castell, Sergi, Pumarola, Tomas, Campins, Magda, Quer, Josep et al. DOI: 10.3389/fmicb.2022.876409
PMID: 35708486 Journal: HUMAN MOLECULAR GENETICS Year: 2022 Reference: Hum Mol Genet. 2022 Jun 16. pii: 6607933. doi: 10.1093/hmg/ddac132. Impact factor: 6.15 Publication type: Paper in international publication Authors: Silbiger, Vivian N, Quintela, Ines, Ceballos, Francisco C, Pita, Guillermo, Lorenzo-Salazar, Jose M, Gonzalez-Montelongo, Rafaela, Gago-Dominguez, Manuela, Porras, Marta Sevilla, Castano, Jair Antonio Tenorio, Nevado, Julian et al. DOI: 10.1093/hmg/ddac132
PMID: 35702721 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin (Engl Ed). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcle.2021.05.021. Epub 2022 Jun 9. Impact factor: 1.725 Publication type: Paper in international publication Authors: Domingo-Baldrich, Eva, Michelena, Xabier, Meza, Beatriz, Garcia-Vives, Eloi, Gil-Vila, Albert, Sarrapio-Lorenzo, Javier, Romero-Ruperto, Sheila, Sanpedro-Jimenez, Francesc, Arranz-Betegon, Maria, Fernandez-Codina, Andreu et al. DOI: 10.1016/j.medcle.2021.05.021
PMID: 34181772 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2021 Reference: Aliment Pharmacol Ther. 2021 Aug;54(4):462-469. doi: 10.1111/apt.16485. Epub 2021 Jun 28. Impact factor: 8.171 Publication type: Paper in international publication Authors: Roade, Luisa, Palom, Adriana, Sopena, Sara, Riveiro-Barciela, Mar, Carvalho-Gomes, Angela, Madejon, Antonio, Rodriguez-Tajes, Sergio, Lens, Sabela, Berenguer-Hayme, Marina, Rodriguez-Frias, Francisco et al. DOI: 10.1111/apt.16485
PMID: 34121244 Journal: TRANSPLANT INTERNATIONAL Year: 2021 Reference: Transpl Int. 2021 Oct;34(10):1908-1913. doi: 10.1111/tri.13946. Epub 2021 Jul 27. Impact factor: 3.782 Publication type: Paper in international publication Authors: Campos-Varela, Isabel, Len, Oscar, Villagrasa, Ares, Marquez-Algaba, Ester, Esperalba, Juliana, Dopazo, Cristina, Los-Arcos, Ibai, Anton, Andres, Castells, Lluis et al. DOI: 10.1111/tri.13946
PMID: 34104210 Journal: Therapeutic Advances in Gastroenterology Year: 2021 Reference: Therap Adv Gastroenterol. 2021 May 30;14:17562848211016567. doi: 10.1177/17562848211016567. eCollection 2021. Impact factor: 4.409 Publication type: Paper in international publication Authors: Campos-Varela, Isabel, Villagrasa, Ares, Simon-Talero, Macarena, Riveiro-Barciela, Mar, Ventura-Cots, Meritxell, Aguilera-Castro, Lara, Alvarez-Lopez, Patricia, Nordahl, Emilie A, Rivera-Esteban, Jesus M, Romero, Alba et al. DOI: 10.1177/17562848211016567
PMID: 34041466 Journal: JHEP reports : innovation in hepatology Year: 2021 Reference: JHEP Rep. 2021 Mar 17;3(3):100280. doi: 10.1016/j.jhepr.2021.100280. eCollection 2021 Jun. Impact factor: 0 Publication type: Paper in international publication Authors: Buti, Maria, Stepanova, Maria, Palom, Adriana, Riveiro-Barciela, Mar, Nader, Fatema, Roade, Luisa, Esteban, Rafael, Younossi, Zobair et al. DOI: 10.1016/j.jhepr.2021.100280
PMID: 32673741 Journal: JOURNAL OF HEPATOLOGY Year: 2020 Reference: J Hepatol. 2020 Oct;73(4):842-854. doi: 10.1016/j.jhep.2020.06.013. Epub 2020 Jul 13. Impact factor: 20.582 Publication type: Paper in international publication Authors: Elsharkawy, Ahmed, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar et al. DOI: 10.1016/j.jhep.2020.06.013
PMID: 32558485 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2020 Reference: N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17. Impact factor: 74.699 Publication type: Paper in international publication Authors: My, Ilaria, Ellinghaus, David, Degenhardt, Frauke, Bujanda, Luis, Buti, Maria, Albillos, Agustin, Invernizzi, Pietro, Fernandez, Javier, Prati, Daniele, Baselli, Guido et al. DOI: 10.1056/NEJMoa2020283
PMID: 32523313 Journal: WORLD JOURNAL OF GASTROENTEROLOGY Year: 2020 Reference: World J Gastroenterol. 2020 May 28;26(20):2584-2598. doi: 10.3748/wjg.v26.i20.2584. Impact factor: 3.665 Publication type: Paper in international publication Authors: Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Yll, Marcal, Cortese, Maria Francesca, Guerrero-Murillo, Mercedes, Orriols, Gerard, Gregori, Josep, Casillas, Rosario, Gonzalez, Carolina et al. DOI: 10.3748/wjg.v26.i20.2584
PMID: 32515985 Journal: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Year: 2020 Reference: Am J Respir Cell Mol Biol. 2020 Oct;63(4):444-451. doi: 10.1165/rcmb.2020-0021OC. Impact factor: 5.373 Publication type: Paper in international publication Authors: Matamala, Nerea, Gomez-Mariano, Gema, Perez, Jose Antonio, Baladron, Beatriz, Torres-Duran, Maria, Michel, Francisco Javier, Saez, Raquel, Hernandez-Perez, Jose Maria, Belmonte, Irene, Rodriguez-Frias, Francisco et al. DOI: 10.1165/rcmb.2020-0021OC
PMID: 29776712 Journal: JOURNAL OF HEPATOLOGY Year: 2018 Reference: J Hepatol. 2018 Jul;69(1):262-264. doi: 10.1016/j.jhep.2018.04.003. Impact factor: 14.911 Publication type: Letter or abstract Authors: Urban, Stephan, Suarez-Amaran, Lester, Usai, Carla, Di Scala, Marianna, Godoy, Cristina, Ni, Yi, Hommel, Mirja, Palomo, Laura, Segura, Victor, Olague, Cristina et al. DOI: 10.1016/j.jhep.2018.04.003
PMID: 29669837 Journal: JOURNAL OF VIROLOGY Year: 2018 Reference: J Virol. 2018 Jun 13;92(13). pii: JVI.01891-17. doi: 10.1128/JVI.01891-17. Print 2018 Jul 1. Impact factor: 4.368 Publication type: Paper in international publication Authors: Schulze Zur Wiesch, Julian, Raziorrouh, Bijan, Hoffmann, Daniel, Smedile, Antonina, Rizzetto, Mario, Wedemeyer, Heiner, Timm, Jorg, Antes, Iris, Neumann-Haefelin, Christoph, Protzer, Ulrike et al. DOI: 10.1128/JVI.01891-17
PMID: 29113028 Journal: HEPATOLOGY Year: 2018 Reference: Hepatology. 2018 Apr;67(4):1485-1498. doi: 10.1002/hep.29646. Epub 2018 Feb 19. Impact factor: 14.079 Publication type: Paper in international publication Authors: Garcia-Lezana, Teresa, Raurell, Imma, Bravo, Miren, Torres-Arauz, Manuel, Salcedo, Maria Teresa, Santiago, Alba, Schoenenberger, Andreu, Manichanh, Chaysavanh, Genesca, Joan, Martell, Maria et al. DOI: 10.1002/hep.29646
PMID: 29456407 Journal: WORLD JOURNAL OF GASTROENTEROLOGY Year: 2018 Reference: World J Gastroenterol. 2018 Feb 14;24(6):680-692. doi: 10.3748/wjg.v24.i6.680. Impact factor: 3.3 Publication type: Paper in international publication Authors: Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Casillas, Rosario, Tabernero, David, Gregori, Josep, Belmonte, Irene, Cortese, Maria Francesca, Gonzalez, Carolina, Riveiro-Barciela, Mar et al. DOI: 10.3748/wjg.v24.i6.680
PMID: 28835776 Journal: Therapeutic Advances in Gastroenterology Year: 2017 Reference: Therap Adv Gastroenterol. 2017 Aug;10(8):619-629. doi: 10.1177/1756283X17715198. Epub 2017 Jun 27. Impact factor: 3.648 Publication type: Paper in international publication Authors: Genesca, Joan, Augustin, Salvador, Esteban, Rafael, Pons, Monica, Santos, Begona, Simon-Talero, Macarena, Ventura-Cots, Meritxell, Riveiro-Barciela, Mar et al. DOI: 10.1177/1756283X17715198
PMID: 28752445 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2017 Reference: Methods Mol Biol. 2017;1639:45-60. doi: 10.1007/978-1-4939-7163-3_5. Impact factor: 0 Publication type: Paper in international publication Authors: Belmonte, Irene, Montoto, Luciana, Rodriguez-Frias, Francisco et al. DOI: 10.1007/978-1-4939-7163-3_5
PMID: 28700391 Journal: AIDS Year: 2017 Reference: AIDS. 2017 Jul 31;31(12):1653-1663. doi: 10.1097/QAD.0000000000001527. Impact factor: 5.003 Publication type: Paper in international publication Authors: Caballero, Estrella, Aguilera, Antonio, Requena, Silvia, de Lejarazu, Raul Ortiz, Piron, Maria, Gonzalez, Rocio, Jimenez, Ana, Roc, Lourdes, Trevino, Ana, Benito, Rafael et al. DOI: 10.1097/QAD.0000000000001527
PMID: 28681400 Journal: TRANSFUSION Year: 2017 Reference: Transfusion. 2017 Sep;57(9):2164-2173. doi: 10.1111/trf.14195. Epub 2017 Jul 5. Impact factor: 3.386 Publication type: Paper in international publication Authors: Bes, Marta, Piron, Maria, Casamitjana, Natalia, Gregori, Josep, Esteban, Juan Ignacio, Ribera, Esteban, Quer, Josep, Puig, Lluis, Sauleda, Silvia et al. DOI: 10.1111/trf.14195
Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.
The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.
The research team used nanotechnology to deliver the drug directly to liver cells, which eliminated side effects without reducing effectiveness.
Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.
