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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Team

Monica Higuera Urbano

Monica Higuera Urbano

Research technician
Liver Diseases
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Mònica Pons Delgado

Mònica Pons Delgado

Predoctoral researcher
Liver Diseases
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Montserrat Gomez Perez

Montserrat Gomez Perez

Liver Diseases
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Sergi Colomer Castell

Sergi Colomer Castell

Predoctoral researcher
Liver Diseases
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Susana Anton Calvo

Susana Anton Calvo

Administration and Management
Liver Diseases
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Monica Higuera Urbano

Monica Higuera Urbano

Research technician
Liver Diseases
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Mònica Pons Delgado

Mònica Pons Delgado

Predoctoral researcher
Liver Diseases
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Montserrat Gomez Perez

Montserrat Gomez Perez

Liver Diseases
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Sergi Colomer Castell

Sergi Colomer Castell

Predoctoral researcher
Liver Diseases
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Susana Anton Calvo

Susana Anton Calvo

Administration and Management
Liver Diseases
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Publications

Steatotic liver disease and HIV: an agenda for 2030.

PMID: 38972321
Journal: Lancet HIV
Year: 2024
Reference: Lancet HIV. 2024 Jul 4:S2352-3018(24)00097-3. doi: 10.1016/S2352-3018(24)00097-3.
Impact factor:
Publication type: Paper in international publication
Authors: Arora, Anish K; Bansal, Meena B; Berzigotti, Annalisa; Dedes, Nikos; Guaraldi, Giovanni; Jimenez-Masip, Alba; Lazarus, Jeffrey V; Navarro, Jordi; Pericas, Juan M; Ramirez Mena, Adria et al.
DOI: 10.1016/S2352-3018(24)00097-3

Needs assessment for creation of a platform trial network in metabolic-dysfunction associated steatohepatitis.

PMID: 39014214
Journal: Communications medicine
Year: 2024
Reference: Commun Med (Lond). 2024 Jul 16;4(1):144. doi: 10.1038/s43856-024-00560-5.
Impact factor:
Publication type: Paper in international publication
Authors: Anstee, Quentin M; Banales, Jesus M; Di Prospero, Nicholas; Genesca, Joan; Jimenez-Masip, Alba; Koenig, Franz; Martinez-Gomez, Maria; Munoz-Martinez, Sergio; Pericas, Juan M; Ratziu, Vlad et al.
DOI: 10.1038/s43856-024-00560-5

A roadmap for clinical trials in MASH-related compensated cirrhosis.

PMID: 39020089
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2024
Reference: Nat Rev Gastroenterol Hepatol. 2024 Jul 17. doi: 10.1038/s41575-024-00955-8.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Anstee, Quentin M; Augustin, Salvador; Bataller, Ramon; Berzigotti, Annalisa; Ciudin, Andreea; Francque, Sven; Genesca, Joan; Hernandez-Gea, Virginia; Pericas, Juan M et al.
DOI: 10.1038/s41575-024-00955-8

Alcohol consumption and liver phenotype of individuals with alpha-1 antitrypsin deficiency.

PMID: 39031304
Journal: LIVER INTERNATIONAL
Year: 2024
Reference: Liver Int. 2024 Jul 19. doi: 10.1111/liv.16044.
Impact factor:
Publication type: Paper in international publication
Authors: Amzou, Samira; Bartel, Marc; Frankova, Sona; Fromme, Malin; Genesca, Joan; Guldiken, Nurdan; Krag, Aleksander; Luo, Yizhao; Mandorfer, Mattias; Miravitlles, Marc et al.
DOI: 10.1111/liv.16044

Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial.

PMID: 36624448
Journal: World Journal of Emergency Surgery
Year: 2023
Reference: World J Emerg Surg. 2023 Jan 9;18(1):4. doi: 10.1186/s13017-023-00475-x.
Impact factor:
Publication type: Paper in international publication
Authors: Bayona, Juan Gabriel; Carrillo, Diana Cristina; Chica-Yanten, Julian; Garcia, Alberto F; Manzano-Nunez, Ramiro; Mejia, Jorge Humberto; Naranjo, Maria Paula; Ordonez, Carlos A; Ospina-Tascon, Gustavo Adolfo; Puyana, Juan Carlos et al.
DOI: 10.1186/s13017-023-00475-x

Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection.

PMID: 36695578
Journal: Microbiology Spectrum
Year: 2023
Reference: Microbiol Spectr. 2023 Feb 14;11(1):e0466422. doi: 10.1128/spectrum.04664-22. Epub 2023 Jan 25.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Bosch, Albert; Costafreda, Maria I; Guix, Susana; Llorens-Revull, Meritxell; Pinto, Rosa M; Piron, Maria; Rando, Ariadna; Rico, Angie; Riveiro-Barciela, Mar et al.
DOI: 10.1128/spectrum.04664-22

Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection.

PMID: 36697207
Journal: GUT
Year: 2023
Reference: Gut. 2023 Jul;72(7):1385-1398. doi: 10.1136/gutjnl-2022-328041. Epub 2023 Jan 25.
Impact factor:
Publication type: Paper in international publication
Authors: Asselah, Tarik; Beumont, Maria; Biermer, Michael; Bourgeois, Stefan; Buti, Maria; Chan, Henry L Y; Hou, Jinlin; Janczewska, Ewa; Janssen, Harry L A; Kalmeijer, Ronald et al.
DOI: 10.1136/gutjnl-2022-328041

mTOR inhibitors a potential predisposing factor for chronic hepatitis E: Results from the prospective collaborative CHES Study (Chronic Hepatitis E Screening in patients with immune impairment and increased transaminases levels)

PMID: 36731726
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Dec;46(10):764-773. doi: 10.1016/j.gastrohep.2023.01.010. Epub 2023 Jan 31.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, Virginia Robles; Barciela, Mar Riveiro; Berastegui, Cristina; Bilbao, Itxarone; Buti, Maria; Camprecios, Joan Martinez; Castells, Lluis; Cots, Meritxell Ventura; Diez, Basilio Rodriguez; Eliz, Maria Garcia et al.
DOI: 10.1016/j.gastrohep.2023.01.010

Ultra Deep Sequencing of Circulating Cell-Free DNA as a Potential Tool for Hepatocellular Carcinoma Management.

PMID: 36010868
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Aug 11;14(16). pii: cancers14163875. doi: 10.3390/cancers14163875.
Impact factor:
Publication type: Paper in international publication
Authors: Bermudez-Ramos, Maria; Bilbao, Itxarone; Gregori, Josep; Guerrero-Murillo, Mercedes; Higuera, Monica; Martinez-Camprecios, Joan; Merino, Xavier; Minguez, Beatriz; Quer, Josep; Rodriguez-Frias, Francisco et al.
DOI: 10.3390/cancers14163875

Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain.

PMID: 36003985
Journal: Infection and Drug Resistance
Year: 2022
Reference: Infect Drug Resist. 2022 Aug 18;15:4637-4644. doi: 10.2147/IDR.S367715. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Costa, Josep; Dopico, Eva; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Martinez, Miguel J; Niubo, Jordi; Quer, Josep; Rando-Matos, Yolanda; Rando-Segura, Ariadna et al.
DOI: 10.2147/IDR.S367715

Smart and eco-friendly N-isopropylacrylamide and cellulose hydrogels as a safe dual-drug local cancer therapy approach.

PMID: 35988981
Journal: Carbohydrate Polymers
Year: 2022
Reference: Carbohydr Polym. 2022 Nov 1;295:119859. doi: 10.1016/j.carbpol.2022.119859. Epub 2022 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Duran-Lara, Esteban F; Hide, Diana; Llaguno, Monserrat; Martell, Maria; Oliva, Mireia; Rafael, Diana; Raurell, Imma; Roca-Melendres, Maria Merce et al.
DOI: 10.1016/j.carbpol.2022.119859

Enterohepatic shunt-driven cholemia predisposes to liver cancer.

PMID: 35988658
Journal: Gastroenterology
Year: 2022
Reference: Gastroenterology. 2022 Dec;163(6):1658-1671.e16. doi: 10.1053/j.gastro.2022.08.033. Epub 2022 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: Abokor, Ahmed A; Albanes, Demetrius; Bovilla, Venugopal R; Bretin, Alexis C A; Ciudin, Andreea; Florio, Andrea A; Freeman, Gordon J; Gewirtz, Andrew T; Gohara, Amira F; Golonka, Rachel M et al.
DOI: 10.1053/j.gastro.2022.08.033

Monitoring Emergence of the SARS-CoV-2 B.1.1.7 Variant through the Spanish National SARS-CoV-2 Wastewater Surveillance System (VATar COVID-19).

PMID: 34397216
Journal: ENVIRONMENTAL SCIENCE & TECHNOLOGY
Year: 2021
Reference: Environ Sci Technol. 2021 Sep 7;55(17):11756-11766. doi: 10.1021/acs.est.1c03589. Epub 2021 Aug 16.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Ana; Anton, Andres; Bosch, Albert; Carcereny, Albert; Cascales, Jenifer; Diaz-Reolid, Azahara; Garcia-Cehic, Damir; Gregori, Josep; Guix, Susana; Lois, Marta et al.
DOI: 10.1021/acs.est.1c03589

Exploring the diversity of coronavirus in sewage during COVID-19 pandemic: Don't miss the forest for the trees.

PMID: 34391155
Journal: SCIENCE OF THE TOTAL ENVIRONMENT
Year: 2021
Reference: Sci Total Environ. 2021 Dec 15;800:149562. doi: 10.1016/j.scitotenv.2021.149562. Epub 2021 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Abril, Josep F; Andres, Cristina; Anton, Andres; Bofill-Mas, Silvia; Fores, Eva; Girones, Rosina; Itarte, Marta; Martinez-Puchol, Sandra; Mejias-Molina, Cristina; Quer, Josep et al.
DOI: 10.1016/j.scitotenv.2021.149562

Tacrolimus as an Effective and Durable Second-Line Treatment for Chronic Autoimmune Hepatitis: A Multicentric Study.

PMID: 32860579
Journal: DIGESTIVE DISEASES AND SCIENCES
Year: 2021
Reference: Dig Dis Sci. 2021 Aug;66(8):2826-2832. doi: 10.1007/s10620-020-06569-9. Epub 2020 Aug 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Banares-Canizares, Rafael; Calleja, Jose Luis; de la Mata, Manuel; Diaz-Fontenla, Fernando; Ferre-Aracil, Carlos; Llovet, Laura-Patricia; Londono, Maria-Carlota; Riveiro-Barciela, Mar; Rodriguez-Peralvarez, Manuel et al.
DOI: 10.1007/s10620-020-06569-9

Predictors of cardiovascular outcomes after surgery in severe tricuspid regurgitation: clinical, imaging and hemodynamic prospective study.

PMID: 33960932
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol. 2021 Aug;74(8):655-663. doi: 10.1016/j.rec.2020.09.008. Epub 2020 Oct 21.
Impact factor:
Publication type: Paper in national publication
Authors: Aviles, Augusto Sao; Calabria, Hug Cuellar; Dentamaro, Ilaria; Ferreira-Gonzalez, Ignacio; Garcia-Moreno, Laura Gutierrez; Gonzalez-Alujas, Maria Teresa; Lozano-Torres, Jordi; Mas, Pilar Tornos; Masip, Artur Evangelista; Otaegui, Imanol et al.
DOI: 10.1016/j.rec.2020.09.008

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients.

PMID: 32752979
Journal: Emerging Microbes & Infections
Year: 2020
Reference: Emerg Microbes Infect. 2020 Dec;9(1):1900-1911. doi: 10.1080/22221751.2020.1806735.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Andres, Cristina; Anton, Andres; Campins, Magda; Codina, Maria Gema; Esperalba, Juliana; Esteban, Juan Ignacio; Ferrer, Ricard; Garcia-Cehic, Damir; Goterris, Lidia et al.
DOI: 10.1080/22221751.2020.1806735

Proceedings of the 25th Annual Congress of the International Liver Transplantation Society.

PMID: 32732832
Journal: TRANSPLANTATION
Year: 2020
Reference: Transplantation. 2020 Aug;104(8):1560-1565. doi: 10.1097/TP.0000000000003160.
Impact factor:
Publication type: Paper in international publication
Authors: Bhangui, Prashant; Campos Varela, Isabel; Chadha, Ryan; Chan, Albert; De Martin, Eleonora; Goldaracena, Nicolas; Hessheimer, Amelia; Kabacam, Gokhan; Kalisvaart, Marit; Kirchner, Varvara et al.
DOI: 10.1097/TP.0000000000003160

Quasispecies dynamics and clinical significance of HCV antiviral resistance.

PMID: 30315919
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2020
Reference: Int J Antimicrob Agents. 2020 Jul;56(1):105562. doi: 10.1016/j.ijantimicag.2018.10.005. Epub 2018 Oct 10.
Impact factor:
Publication type: Paper in international publication
Authors: Perales, Celia et al.
DOI: 10.1016/j.ijantimicag.2018.10.005

GEHEP 010 STUDY: PREVALENCE AND DISTRIBUTION OF HEPATITIS B VIRUS GENOTYPES IN SPAIN (2000-2016).

PMID: 32711039
Journal: JOURNAL OF INFECTION
Year: 2020
Reference: J Infect. 2020 Oct;81(4):600-606. doi: 10.1016/j.jinf.2020.07.019. Epub 2020 Jul 22.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Antonio; Alvarez, Marta; Basaras, Miren; Buti, Maria; de Castro, Ana Blazquez; de la Cruz, Daniel Navarro; Fernandez-Cuenca, Felipe; Fuentes, Ana; Garcia, Federico; Garcia-Arata, Isabel et al.
DOI: 10.1016/j.jinf.2020.07.019

Liver Fibrosis and Metabolic Alterations in Adults with Alpha1 Antitrypsin Deficiency Caused by the Pi*ZZ Mutation.

PMID: 31121167
Journal: GASTROENTEROLOGY
Year: 2019
Reference: Gastroenterology. 2019 Sep;157(3):705-719.e18. doi: 10.1053/j.gastro.2019.05.013. Epub 2019 May 20.
Impact factor:
Publication type: Paper in international publication
Authors: Aigner, Elmar; Arslanow, Anita; Bals, Robert; Barrecheguren, Miriam; Bento-Miranda, Mario; Bzdok, Danilo; Costa, Dalila; Dolman, Grace E; Fromme, Malin; Gaspar, Rui et al.
DOI: 10.1053/j.gastro.2019.05.013

Whole-genome characterization and resistance-associated substitutions in a new HCV genotype 1 subtype.

PMID: 31118701
Journal: Infection and Drug Resistance
Year: 2019
Reference: Infect Drug Resist. 2019 Apr 24;12:947-955. doi: 10.2147/IDR.S195441. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Escarda, Ana; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Macia, Maria Dolores; Quer, Josep; Rodriguez-Frias, Francisco; von Massow, Georg et al.
DOI: 10.2147/IDR.S195441

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

PMID: 31113593
Journal: Annals of Hepatology
Year: 2019
Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Rafael; Fernandez-Codina, Andreu; Martinez-Valle, Fernando; Merino-Casabiel, Xavier; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa; Torres, Ines de et al.
DOI: 10.5604/01.3001.0012.7916

Efficacy and Safety of a Two-Drug Direct-Acting Antiviral Agent Regimen Ruzasvir 180 mg and Uprifosbuvir 450 mg for 12 Weeks in Adults with Chronic Hepatitis C Virus Genotype 1, 2, 3, 4, 5, or 6.

PMID: 31108015
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2019
Reference: J Viral Hepat. 2019 Sep;26(9):1127-1138. doi: 10.1111/jvh.13132. Epub 2019 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Kaushik; Ari, Ziv Ben; Barr, Eliav; Bernhardi, David C; Borgia, Sergio; Brown, Ashley; Burnevich, Eduard; Burnevich, Eduard Z; Buti, Maria; Cohen, Michal et al.
DOI: 10.1111/jvh.13132

Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study.

PMID: 29963780
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2018
Reference: Am J Transplant. 2018 Oct;18(10):2513-2522. doi: 10.1111/ajt.14996. Epub 2018 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Abradelo, M; Aguero, F; Aguero, F; Aguilera, V; Aguilera, Victoria; Almohalla, C; Alonso, M P; Antela, A; Araiz, J J; Arminanzas, C et al.
DOI: 10.1111/ajt.14996

Efficacy of Sofosbuvir and Velpatasvir, With and Without Ribavirin, in Patients With HCV genotype 3 Infection and Cirrhosis.

PMID: 29958855
Journal: GASTROENTEROLOGY
Year: 2018
Reference: Gastroenterology. 2018 Oct;155(4):1120-1127.e4. doi: 10.1053/j.gastro.2018.06.042. Epub 2018 Jun 27.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Raul J; Brainard, Diana M; Buti, Maria; Calleja, Jose Luis; Camus, Gregory; Carrion, Jose Antonio; Casado, Marta; Esteban, Rafael; Forns, Xavier; Lens, Sabela et al.
DOI: 10.1053/j.gastro.2018.06.042

Letter: direct-acting anti-viral (DAA) therapy needs strong safety and efficacy check-authors' reply.

PMID: 29939414
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2018
Reference: Aliment Pharmacol Ther. 2018 Jul;48(2):235-236. doi: 10.1111/apt.14820.
Impact factor:
Publication type: Letter or abstract
Authors: Brainard, D M; Buti, M; Chokkalingam, A P; Osinusi, A O; Reddy, K R; Singer, A W; Telep, L E et al.
DOI: 10.1111/apt.14820

Correction: Randomized prospective study evaluating tenofovir disoproxil fumarate prophylaxis against hepatitis B virus reactivation in anti-HBc-positive patients with rituximab-based regimens to treat hematologic malignancies: The Preblin study.

PMID: 29940039
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Jun 25;13(6):e0199926. doi: 10.1371/journal.pone.0199926. eCollection 2018.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Calleja, Jose L; Castillo, Pilar; Esteban, Rafael; Garcia-Retortillo, Montserrat; Gutierrez, Maria L; Lopez, Javier; Manzano, Maria L; Martin, Leticia; Morano, Luis E et al.
DOI: 10.1371/journal.pone.0199926

Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease.

PMID: 28696510
Journal: HEPATOLOGY
Year: 2017
Reference: Hepatology. 2017 Dec;66(6):1980-1988. doi: 10.1002/hep.29363. Epub 2017 Oct 30.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Augustin, Salvador; Berzigotti, Annalisa; Blasco, Helene; Bosch, Jaime; Bureau, Christophe; Genesca, Joan; Maurice, James B; Ney, Michel; Pons, Monica et al.
DOI: 10.1002/hep.29363

Epidemiological trends of HIV-1 infection in blood donors from Catalonia, Spain (2005-2014).

PMID: 28681400
Journal: TRANSFUSION
Year: 2017
Reference: Transfusion. 2017 Sep;57(9):2164-2173. doi: 10.1111/trf.14195. Epub 2017 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Casamitjana, Natalia; Esteban, Juan Ignacio; Gregori, Josep; Piron, Maria; Puig, Lluis; Quer, Josep; Ribera, Esteban; Sauleda, Silvia et al.
DOI: 10.1111/trf.14195

The ART-SCORE is not an effective tool for optimizing patient selection for DEB-TACE retreatment. A multicentre Spanish study.

PMID: 28676199
Journal: Gastroenterologia y Hepatologia
Year: 2017
Reference: Gastroenterol Hepatol. 2017 Oct;40(8):515-524. doi: 10.1016/j.gastrohep.2017.05.009. Epub 2017 Jul 1.
Impact factor:
Publication type: Paper in national publication
Authors: Arenas, Juan; Bustamante-Schneider, Javier; Castells, Lluis; de la Mata, Manuel; Diaz-Beveridge, Roberto; Diez-Miranda, Iratxe; Fernandez-Castroagudin, Javier; Irurzun, Javier; Molina-Perez, Esther; Monge-Romero, Maria Isabel et al.
DOI: 10.1016/j.gastrohep.2017.05.009

Cost-effectiveness of a hepatitis B virus screening strategy to prevent reactivation in patients with hematologic neoplasms.

PMID: 28648087
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2017
Reference: Rev Esp Enferm Dig. 2017 Sep;109(9):619-626. doi: 10.17235/reed.2017.4693/2016.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casado, Miguel Angel; Crespo, Javier; Esteban, Rafael; Oyaguez, Itziar; Torres, Covadonga et al.
DOI: 10.17235/reed.2017.4693/2016

New real-time-PCR method to identify single point mutations in hepatitis C virus.

PMID: 27920481
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2016
Reference: World J Gastroenterol. 2016 Nov 21;22(43):9604-9612.
Impact factor:
Publication type: Paper in international publication
Authors: Belmonte, Irene; Buti, Maria; Chen, Qian; Esteban, Juan Ignacio; Esteban, Rafael; Garcia-Cehic, Damir; Gregori, Josep; Llorens, Meritxell; Nieto, Leonardo; Ordeig, Laura et al.
DOI: 10.3748/wjg.v22.i43.9604

HCVerso1 and 2: faldaprevir with deleobuvir (BI 207127) and ribavirin for treatment-naive patients with chronic hepatitis C virus genotype-1b infection.

PMID: 27920566
Journal: Clinical and experimental gastroenterology
Year: 2016
Reference: Clin Exp Gastroenterol. 2016 Nov 24;9:351-363. eCollection 2016.
Impact factor:
Publication type: Clinical Trials
Authors: Andreone, Pietro; Aslanyan, Stella; Buti, Maria; Calinas, Filipe; Castelli, Francesco; Colombo, Massimo; Deng, Qiqi; Kukolj, George; Mensa, Federico J; Nelson, David R et al.
DOI: 10.2147/CEG.S111116

Does Matching Donor-Recipient Age Affect Long-Term Survival in Liver Transplantation?

PMID: 27857033
Journal: Annals of Transplantation
Year: 2016
Reference: Ann Transplant. 2016 Nov 18;21:708-716.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Caralt, Mireia; Castells, Lluis; Charco, Ramon; Dopazo, Cristina; Fernandez de Sevilla, Elena; Lazaro, Jose Luis et al.
DOI: 10.12659/AOT.900767

Impact of ornithine phenylacetate (OCR-002) in lowering plasma ammonia after upper gastrointestinal bleeding in cirrhotic patients.

PMID: 27803737
Journal: Therapeutic Advances in Gastroenterology
Year: 2016
Reference: Therap Adv Gastroenterol. 2016 Nov;9(6):823-835. Epub 2016 Jul 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado-Tapias, Edilmar; Arranz, Jose Antonio; Blanco-Grau, Albert; Concepcion, Mar; Cordoba, Juan; Fuentes, Inma; Gely, Cristina; Genesca, Joan; Minguez, Beatriz; Roman, Eva et al.
DOI: 10.1177/1756283X16658252

[Lead-in period and week 8 as predictive tools for response to boceprevir therapy: a retrospective study of Spanish real clinical practice].

PMID: 25976446
Journal: GASTROENT HEPAT-BARC
Year: 2015
Reference: Gastroenterol Hepatol. 2015 Nov;38(9):517-24. doi: 10.1016/j.gastrohep.2015.04.002. Epub 2015 May 12.
Impact factor:
Publication type: Paper in national publication
Authors: Barcena, Rafael; Berenguer, Marina; Buti, Maria; Calleja, Jose Luis; Crespo, Javier; Fernandez, Inmaculada; Gonzalez, Olga; Lopez, Jesus; Perez, Francisco et al.
DOI: 10.1016/j.gastrohep.2015.04.002

Therapy for hepatitis C genotype 3: moving forward.

PMID: 25967352
Journal: J VIRAL HEPATITIS
Year: 2015
Reference: J Viral Hepat. 2015 Sep;22(9):683-90. doi: 10.1111/jvh.12419. Epub 2015 May 13.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, M; Esteban, R; Llaneras, J; Riveiro-Barciela, M et al.
DOI: 10.1111/jvh.12419

Impact of long-term tenofovir disoproxil fumarate on incidence of hepatocellular carcinoma in patients with chronic hepatitis B.

PMID: 26177866
Journal: CANCER-AM CANCER SOC
Year: 2015
Reference: Cancer. 2015 Oct 15;121(20):3631-8. doi: 10.1002/cncr.29537. Epub 2015 Jul 15.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar Schall, Raul E; Berg, Thomas; Buti, Maria; Dinh, Phillip V; Flaherty, John F; Fung, Scott; Gurel, Selim; Jacobson, Ira; Kim, W Ray; Loomba, Rohit et al.
DOI: 10.1002/cncr.29537

Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment.

PMID: 26071337
Journal: J CLIN VIROL
Year: 2015
Reference: J Clin Virol. 2015 Jul;68:56-60. doi: 10.1016/j.jcv.2015.05.010. Epub 2015 May 14.
Impact factor:
Publication type: Paper in international publication
Authors: Ampuero, Javier; Andrade, Raul J; Buti, Maria; Cabezas, Joaquin; Calleja, Jose Luis; Crespo, Javier; Del Campo, Jose Antonio; Fernandez, Inmaculada; Forns, Xavier; Lens, Sabela et al.
DOI: 10.1016/j.jcv.2015.05.010

Study of hepatitis B virus quasispecies by ultra-deep pyrosequencing: Resolving the nitty-gritty.

PMID: 23907754
Journal: HEPATOLOGY
Year: 2014
Reference: Hepatology. 2014 Mar;59(3):1210-2. doi: 10.1002/hep.26647. Epub 2014 Jan 13.
Impact factor:
Publication type: Letter whit IF
Authors: Buti, Maria; Esteban, Rafael; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1002/hep.26647

A MELD-based model to determine risk of mortality among patients with acute variceal bleeding.

PMID: 24148622
Journal: GASTROENTEROLOGY
Year: 2014
Reference: Gastroenterology. 2014 Feb;146(2):412-19.e3. doi: 10.1053/j.gastro.2013.10.018. Epub 2013 Oct 19.
Impact factor:
Publication type: Clinical Trials
Authors: Abraldes, Juan G; Augustin, Salvador; Bastiampillai, Ravin; Berzigotti, Annalisa; Bosch, Jaume; Casu, Stefania; Garcia-Pagan, Joan Carles; Genesca, Joan; Gonzalez, Antonio; Keough, Adam et al.
DOI: 10.1053/j.gastro.2013.10.018

Early predictors of antiviral treatment response in liver transplant recipients with recurrent hepatitis C genotype 1.

PMID: 24620835
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, H; Bes, M; Campos-Varela, I; Caralt, M; Castells, L; Charco, R; Esteban, J I; Esteban, R; Guardia, J; Rodriguez-Frias, F et al.
DOI: 10.1111/jvh.12246

Rebleeding Prophylaxis Improved Outcomes in Patients With Hepatocellular Carcinoma: Is It Feasible in All Patients? Reply

PMID: 24619472
Journal: HEPATOLOGY
Year: 2014
Reference: Hepatology. 2014 Nov;60(5):1795-6. doi: 10.1002/hep.27119. Epub 2014 Sep 29.
Impact factor:
Publication type: Letter whit IF
Authors: Bosch, Jaime; Genesca, Joan; Ripoll, Cristina et al.
DOI: 10.1002/hep.27119

Hepatitis E virus: new faces of an old infection.

PMID: 24114815
Journal: Annals of Hepatology
Year: 2013
Reference: Ann Hepatol. 2013 Nov-Dec;12(6):861-70.
Impact factor: 1.671
Publication type: Review in international publication
Authors: Riveiro-Barciela, Mar, Rodriguez-Frias, Francisco, Buti, Maria et al.
DOI:

Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.

PMID: 24222943
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: World J Gastroenterol. 2013 Nov 7;19(41):6995-7023. doi: 10.3748/wjg.v19.i41.6995.
Impact factor: 2.547
Publication type: Review in international publication
Authors: Rodriguez-Frias, Francisco, Buti, Maria, Tabernero, David, Homs, Maria et al.
DOI: 10.3748/wjg.v19.i41.6995

Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina.

PMID: 24124326
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: World J Gastroenterol. 2013 Sep 21;19(35):5813-27. doi: 10.3748/wjg.v19.i35.5813.
Impact factor: 2.547
Publication type: Paper in international publication
Authors: del Pino, Noemi, Oubina, Jose Raul, Rodriguez-Frias, Francisco, Esteban, Juan Ignacio, Buti, Maria, Otero, Teresa, Gregori, Josep, Garcia-Cehic, Damir, Camos, Silvia, Cubero, Maria et al.
DOI: 10.3748/wjg.v19.i35.5813

A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model.

PMID: 23523552
Journal: ANTIVIRAL RESEARCH
Year: 2013
Reference: Antiviral Res. 2013 May;98(2):273-83. doi: 10.1016/j.antiviral.2013.03.007. Epub 2013 Mar 20.
Impact factor: 3.925
Publication type: Paper in international publication
Authors: Ramirez, Clara, Gregori, Josep, Tabernero, David, Camos, Silvia, Casillas, Rosario, Quer, Josep, Esteban, Rafael, Homs, Maria, Rodriguez-Frias, Francisco, Buti, Maria et al.
DOI: 10.1016/j.antiviral.2013.03.007

Efficacy and safety of entecavir in clinical practice in treatment-naive Caucasian chronic hepatitis B patients.

PMID: 22382708
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2012
Reference: Eur J Gastroenterol Hepatol. 2012 May;24(5):535-42. doi: 10.1097/MEG.0b013e3283511287.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/MEG.0b013e3283511287

Successful conversion from twice-daily to once-daily tacrolimus in liver transplantation: observational multicenter study.

PMID: 21958123
Journal: CLINICAL TRANSPLANTATION
Year: 2012
Reference: Clin Transplant. 2012 Jan;26(1):E32-E37. doi: 10.1111/j.1399-0012.2011.01521.x. Epub 2011 Sep 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1399-0012.2011.01521.x

Adding banding ligation is effective as rescue therapy to prevent variceal rebleeding in haemodynamic non-responders to pharmacological therapy.

PMID: 21890439
Journal: DIGESTIVE AND LIVER DISEASE
Year: 2012
Reference: Dig Liver Dis. 2012 Jan;44(1):55-60. doi: 10.1016/j.dld.2011.07.019. Epub 2011 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.dld.2011.07.019

Blockage of the afferent sensitive pathway prevents sympathetic atrophy and hemodynamic alterations in rat portal hypertension.

PMID: 22292477
Journal: LIVER INTERNATIONAL
Year: 2012
Reference: Liver Int. 2012 Sep;32(8):1295-305. doi: 10.1111/j.1478-3231.2012.02762.x. Epub 2012 Jan 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1478-3231.2012.02762.x

Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B.

PMID: 20955704
Journal: GASTROENTEROLOGY
Year: 2011
Reference: Gastroenterology. 2011 Jan;140(1):132-43. Epub 2010 Oct 16.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1053/j.gastro.2010.10.011

Boceprevir for previously treated chronic HCV genotype 1 infection.

PMID: 21449784
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2011
Reference: N Engl J Med. 2011 Mar 31;364(13):1207-17.
Impact factor:
Publication type: Paper in international publication
Authors: Afdhal, N; Albrecht, Janice K; Alric, L; Anderson, F; Bacon, B; Bacon, Bruce R; Balart, L; Ben Ali, S; Bennett, M; Berg, T et al.
DOI: 10.1056/NEJMoa1009482

Effects of Branched-Chain Amino Acids Supplementation in Patients With Cirrhosis and a Previous Episode of Hepatic Encephalopathy: A Randomized Study.

PMID: 21326220
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2011
Reference: Am J Gastroenterol. 2011 Jun;106(6):1081-8. Epub 2011 Feb 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/ajg.2011.9

HBV core region variability: effect of antiviral treatments on main epitopic regions.

PMID: 21311107
Journal: ANTIVIRAL THERAPY
Year: 2011
Reference: Antivir Ther. 2011;16(1):37-49.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Rafael; Fernandez-Fernandez, Pilar; Homs, Maria; Jardi, Rosendo; Quer, Josep; Rodriguez-Frias, Francisco; Schaper, Melanie; Tabernero, David et al.
DOI: 10.3851/IMP1701

Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.

PMID: 20374224
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2010
Reference: Aliment Pharmacol Ther. 2010 Jul;32(1):97-104. Epub 2010 Mar 31.
Impact factor: 4.357
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1365-2036.2010.04319.x

Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D.

PMID: 20346531
Journal: JOURNAL OF HEPATOLOGY
Year: 2010
Reference: J Hepatol. 2010 May;52(5):658-64. Epub 2010 Mar 5.
Impact factor: 7.818
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1016/j.jhep.2009.10.036

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.

PMID: 19208682
Journal: GENOME RESEARCH
Year: 2009
Reference: Genome Res. 2009 Mar;19(3):438-51.
Impact factor: 10.176
Publication type: Paper in international publication
Authors: Fernandez, Agustin F, Rosales, Cecilia, Lopez-Nieva, Pilar, Grana, Osvaldo, Ballestar, Esteban, Ropero, Santiago, Espada, Jesus, Melo, Sonia A, Lujambio, Amaia, Fraga, Mario F et al.
DOI: 10.1101/gr.083550.108

Use of the novel INNO-LiPA line probe assay for detection of hepatitis B virus variants that confer resistance to entecavir therapy.

PMID: 19052182
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2009
Reference: J Clin Microbiol. 2009 Feb;47(2):485-8.
Impact factor: 3.945
Publication type: Paper in international publication
Authors: Buti, Maria, Esteban, Rafael, Schaper, Melanie, Jardi, Rosendo, Rodriguez-Frias, Francisco, Tabernero, David, Homs, Maria et al.
DOI: 10.1128/JCM.01678-08

Hepatitis C virus (HCV)-specific T-cell responses among recombinant immunoblot assay-3-indeterminate blood donors: a confirmatory evidence of HCV exposure.

PMID: 19222816
Journal: TRANSFUSION
Year: 2009
Reference: Transfusion. 2009 Jul;49(7):1296-305.
Impact factor: 3.475
Publication type: Paper in international publication
Authors: Guardia, Jaime, Sauleda, Silvia, Puig, Lluis, Cubero, Maria, Quer, Josep, Piron, Maria, Bes, Marta, Esteban, Juan Ignacio, Casamitjana, Natalia et al.
DOI: 10.1111/j.1537-2995.2009.02103.x

Successful use of entecavir for a severe case of reactivation of hepatitis B virus following polychemotherapy containing rituximab.

PMID: 19836097
Journal: JOURNAL OF HEPATOLOGY
Year: 2009
Reference: J Hepatol. 2009 Dec;51(6):1091-6.
Impact factor: 7.056
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1016/j.jhep.2009.07.012

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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