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Microbiome Research

The Microbiome Research’s group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include developing molecular as well as bioinformatics tools to characterize the microbiome structure and function, discovering micro-biomarkers for diagnosis and prognosis, investigating how fecal microbiota transplantation could be used as a therapeutic strategy, and evaluating the impact of diet on the gut microbial ecosystem The Microbiome Lab is a multidisciplinary team, composed of molecular biologists, bioinformaticians, and physicians. The group tackles several clinical fields including inflammatory bowel diseases, diabetes, liver diseases, pre-term birth, and critical illness.

Team

Mayorga Ayala, Luis Fernando

Mayorga Ayala, Luis Fernando

Predoctoral researcher
Microbiome Research
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Chaysavanh Manichanh

Chaysavanh Manichanh

Head of group
Microbiome Research
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Sara Vega Abellaneda

Sara Vega Abellaneda

Research technician
Microbiome Research
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Mayorga Ayala, Luis Fernando

Mayorga Ayala, Luis Fernando

Predoctoral researcher
Microbiome Research
Read more
Chaysavanh Manichanh

Chaysavanh Manichanh

Head of group
Microbiome Research
Read more
Sara Vega Abellaneda

Sara Vega Abellaneda

Research technician
Microbiome Research
Read more

Projects

Evaluate the effect of diet on the gut microbial community

IP: Chaysavanh Manichanh
Collaborators: Zaida Soler Luque, Judit Álvarez González
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI21/00262
Duration: 01/01/2022 - 31/12/2025

Inflammatory Bowel Disease and Microbiome: Diagnosis and prediction of disease activity from the lab to the patients

IP: Chaysavanh Manichanh
Collaborators: Claudia Maria Herrera de Guise, Natalia Borruel Sainz, Francesc Casellas Jordá, Francisca Yañez Araya
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI20/00130
Duration: 01/01/2021 - 31/12/2024

Publications

Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.

PMID: 38017705
Journal: Gut Microbes
Year: 2023
Reference: Gut Microbes. 2023 Dec;15(2):2287618. doi: 10.1080/19490976.2023.2287618. Epub 2023 Nov 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bougnoux, Marie-Elisabeth; Cole, Nathaniel; Consortium, Milieu Interieur; d'Enfert, Christophe; Delavy, Margot; Dubois, Florian; Duffy, Darragh; Le Chatelier, Emmanuelle; Manichanh, Chaysavanh; Patin, Etienne et al.
DOI: 10.1080/19490976.2023.2287618

A Randomized Trial of Dolutegravir Plus Darunavir/Cobicistat as a Switch Strategy in HIV-1-Infected Patients With Resistance to at Least 2 Antiretroviral Classes.

PMID: 38023553
Journal: Open Forum Infectious Diseases
Year: 2023
Reference: Open Forum Infect Dis. 2023 Oct 31;10(11):ofad542. doi: 10.1093/ofid/ofad542. eCollection 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Arpa, Berta; Bernal, Enrique; Clotet, Bonaventura; Corral-Pujol, Marta; Cosovanu, Catalina; Curran, Adria; Domingo, Pere; Egia-Mendikute, Leire; Gutierrez, Felix; Imaz, Arkaitz et al.
DOI: 10.1093/ofid/ofad542

Long-term effect of tocilizumab on mortality, readmissions, persistent symptoms and lung function in SARS-CoV-2 patients 1 year after hospital discharge: A matched cohort study.

PMID: 38029650
Journal: Respiratory Medicine and Research
Year: 2023
Reference: Respir Med Res. 2023 Nov 4;84:101064. doi: 10.1016/j.resmer.2023.101064.
Impact factor:
Publication type: Paper in international publication
Authors: Berastegui, Cristina; Berlana, David; Bougnoux, Marie-Elisabeth; Cardona-Pascual, Ignacio; Cole, Nathaniel; Consortium, Milieu Interieur; d'Enfert, Christophe; Delavy, Margot; Dubois, Florian; Duffy, Darragh et al.
DOI: 10.1016/j.resmer.2023.101064

Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involving competition for nutrients.

PMID: 38098063
Journal: Microbiome
Year: 2023
Reference: Microbiome. 2023 Dec 14;11(1):275. doi: 10.1186/s40168-023-01693-w.
Impact factor:
Publication type: Paper in international publication
Authors: Canalda-Baltrons, Aleix; d'Enfert, Christophe; Manichanh, Chaysavanh; Xie, Zixuan et al.
DOI: 10.1186/s40168-023-01693-w

Blog

News

The study also linked improved microbiota diversity to better liver function.

This work sets the basis for future research aimed at a deeper understanding of the microbiota and the effect of nutrition.

These are the results of a study published in Nature Communications and led by the Vall d'Hebron Research Institute (VHIR), the University of Lleida (UdL) and the Biomedical Research Institute of Lleida (IRBLleida).

Rates

Check the current rates of the services offered by the Microbiome Research group

We are looking for healthy volunteers for a study on the microbiota and eating habits

We are looking for approximately 1,000 volunteers who will have to answer a very simple questionnaire about their eating habits and provide a stool sample, 3 times over the course of a year.

More information