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Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Publications

First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results.

PMID: 38060199
Journal: CLINICAL CANCER RESEARCH
Year: 2023
Reference: Clin Cancer Res. 2023 Dec 7. doi: 10.1158/1078-0432.CCR-23-2084.
Impact factor:
Publication type: Paper in international publication
Authors: Alarcon, Oriol Pujol; Alonso, Sara Castellanos; Andres-Peiro, Jose-Vicente; Barrios, Carlos H; Bondarenko, Igor; Boni, Valentina; Carulla, Marta Altayo; Chae, Yeesoo; Dent, Rebecca; Espinosa, Enrique et al.
DOI: 10.1158/1078-0432.CCR-23-2084

Multiligament knee injuries. Ten years' experience at a public university, level I Trauma Center.

PMID: 38147073
Journal: European journal of orthopaedic surgery & traumatology
Year: 2023
Reference: Eur J Orthop Surg Traumatol. 2023 Dec 26. doi: 10.1007/s00590-023-03807-4.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Peiro, Jose Vicente; Blasco-Casado, Ferran; Cao Yao, Juan Carlos; Castellet-Feliu, Enric; Garcia-Albo, Enrique; Joshi-Jubert, Nayana; Minguell-Monyart, Joan; Navas Mendez, Jesus; Pijoan, Bueno Joan; Portas-Torres, Irene et al.
DOI: 10.1007/s00590-023-03807-4

Mobile applications to prescribe physical exercise in frail older adults: review of the available tools in app stores.

PMID: 38157286
Journal: AGE AND AGEING
Year: 2023
Reference: Age Ageing. 2023 Dec 1;52(12):afad227. doi: 10.1093/ageing/afad227.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Peiro, Jose Vicente; Blasco-Casado, Ferran; Carrion, Carme; Castellet-Feliu, Enric; de Sola-Morales, Oriol; Eis, Sophie; Garcia-Albo, Enrique; Gine-Garriga, Maria; Inzitari, Marco; Joshi-Jubert, Nayana et al.
DOI: 10.1093/ageing/afad227

Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit.

PMID: 38188336
Journal: Frontiers in Medicine
Year: 2023
Reference: Front Med (Lausanne). 2023 Dec 20;10:1301001. doi: 10.3389/fmed.2023.1301001. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bajana, Ivan; Camos, Silvia; Castellanos, Sara; Chiscano-Camon, Luis; Corona, Pablo; Ferrer, Ricard; Ferrer-Costa, Roser; Joshi-Jubert, Nayana; Martin, Laura; Martin-Rodriguez, Cristina et al.
DOI: 10.3389/fmed.2023.1301001

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial.

PMID: 36244384
Journal: LANCET
Year: 2022
Reference: Lancet. 2022 Oct 15;400(10360):1334-1344. doi: 10.1016/S0140-6736(22)01652-X.
Impact factor:
Publication type: Paper in international publication
Authors: Abbott, Harper; Acerboni-Flores, Francesc; Achor, Timothy S; Adams, John D; Al-Asiri, Jamal; Alavedra-Massana, Anna; Alnasser, Ahmad; Altman, Kyle M; Amirhekmat, Arya; Anderson, Matthew et al.
DOI: 10.1016/S0140-6736(22)01652-X

Association of Patient-Level and Hospital-Level Factors With Timely Fracture Care by Race.

PMID: 36449289
Journal: JAMA Network Open
Year: 2022
Reference: JAMA Netw Open. 2022 Nov 1;5(11):e2244357. doi: 10.1001/jamanetworkopen.2022.44357.
Impact factor:
Publication type: Paper in international publication
Authors: Abbott, Harper; Acerboni-Flores, Francesc; Achor, Timothy S; Adams, John D; Al-Asiri, Jamal; Alavedra-Massana, Anna; Alnasser, Ahmad; Altman, Kyle M; Amirhekmat, Arya; Anderson, Matthew et al.
DOI: 10.1001/jamanetworkopen.2022.44357

A pilot study of circulating levels of TGF-beta1 and TGF-beta2 as biomarkers of bone healing in patients with non-hypertrophic pseudoarthrosis of long bones.

PMID: 34950754
Journal: Bone reports
Year: 2022
Reference: Bone Rep. 2021 Dec 9;16:101157. doi: 10.1016/j.bonr.2021.101157. eCollection 2022 Jun.
Impact factor: 0
Publication type: Paper in international publication
Authors: Chaverri, Daniel; Vivas, Daniel; Gallardo-Villares, Santiago; Granell-Escobar, Fernando; Pinto, Javier A; Vives, Joaquim et al.
DOI: 10.1016/j.bonr.2021.101157

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial.

PMID: 34989778
Journal: JAMA Oncology
Year: 2022
Reference: JAMA Oncol. 2022 Mar 1;8(3):345-353. doi: 10.1001/jamaoncol.2021.6628.
Impact factor: 31.777
Publication type: Paper in international publication
Authors: Betournay, Marysa; Cheng, Edward Y; Doung, Yee-Cheen; Ferguson, Peter C; Giglio, Victoria; Hayden, James; Heels-Ansdell, Diane; Khan, Shah Alam; Sampath Kumar, Venkatesan; McKay, Paula et al.
DOI: 10.1001/jamaoncol.2021.6628

SARS-Cov-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative report.

PMID: 33539280
Journal: Blood Transfusion
Year: 2021
Reference: Blood Transfus. 2021 Mar;19(2):158-167. doi: 10.2450/2021.0259-20. Epub 2021 Jan 15.
Impact factor:
Publication type: Paper in international publication
Authors: Argelagues, Enric; Coll, Ruth; Contreras, Enric; Delgadillo, Joaquin; Garcia-Lopez, Joan; Grifols, Joan Ramon; Guasch, Rosa; Herrero, Maria J; Lopez, Isabel; Madrigal, Alejandro et al.
DOI: 10.2450/2021.0259-20

Derivation of Mesenchymal Stromal Cells from Ovine Umbilical Cord Wharton's Jelly.

PMID: 33484488
Journal: Current protocols
Year: 2021
Reference: Curr Protoc. 2021 Jan;1(1):e18. doi: 10.1002/cpz1.18.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Carreras-Sanchez, Irene; Lopez-Fernandez, Alba; Rojas-Marquez, Raquel; Velez, Roberto; Vives, Joaquim et al.
DOI: 10.1002/cpz1.18

Three-stage limb salvage in tibial fracture related infection with composite bone and soft-tissue defect.

PMID: 34936017
Journal: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
Year: 2021
Reference: Arch Orthop Trauma Surg. 2021 Dec 22. pii: 10.1007/s00402-021-04299-9. doi: 10.1007/s00402-021-04299-9.
Impact factor: 3.067
Publication type: Paper in international publication
Authors: Corona, Pablo S, Carbonell-Rosell, Carla, Vicente, Matias, Serracanta, Jordi, Tetsworth, Kevin, Glatt, Vaida et al.
DOI: 10.1007/s00402-021-04299-9

Trigger Digit Incidence After Carpal Tunnel Release: Reconstruction in Elongated Position Versus Traditional Carpal Tunnel Release.

PMID: 31847590
Journal: Hand (New York, N.Y.)
Year: 2021
Reference: Hand (N Y). 2021 Nov;16(6):741-745. doi: 10.1177/1558944719893055. Epub 2019 Dec 17.
Impact factor: 0
Publication type: Paper in international publication
Authors: Esteban-Feliu, Ignacio, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Nunez-Camarena, Jorge, Lluch-Bergada, Alex, Vidal-Tarrason, Nuria et al.
DOI: 10.1177/1558944719893055

Effect of allogeneic cell-based tissue engineered treatments in a sheep osteonecrosis model.

PMID: 32122263
Journal: Tissue Engineering Part A
Year: 2020
Reference: Tissue Eng Part A. 2020 Sep;26(17-18):993-1004. doi: 10.1089/ten.TEA.2019.0339. Epub 2020 Mar 27.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Barro, Victor; Ginebra, Maria-Pau; Lopez Fernandez, Alba; Manzanares-Cespedes, Maria Cristina; Ortiz-Hernandez, Monica; Velez, Roberto; Vivas, Daniel; Vives, Joaquim et al.
DOI: 10.1089/ten.TEA.2019.0339

Author Correction: Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study.

PMID: 32024916
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 6;10(1):2384. doi: 10.1038/s41598-020-59139-4.
Impact factor:
Publication type: Letter or abstract
Authors: Bago, Joan; Catala, Jordi; de Albert, Matias; Ramirez, Manuel; Rodriguez-Baeza, Alfonso; Sallent, Andrea; Velez, Roberto et al.
DOI: 10.1038/s41598-020-59139-4

Beyond chimerism analysis: methods for tracking a new generation of cell-based medicines.

PMID: 32024991
Journal: BONE MARROW TRANSPLANTATION
Year: 2020
Reference: Bone Marrow Transplant. 2020 Jul;55(7):1229-1239. doi: 10.1038/s41409-020-0822-8. Epub 2020 Feb 5.
Impact factor:
Publication type: Review in international publication
Authors: Casademont-Roca, Aina; Martorell, Lluis; Nogues, Nuria; Vives, Joaquim et al.
DOI: 10.1038/s41409-020-0822-8

Vancomycin-Gentamicin Prefabricated Spacers in 2-Stage Revision Arthroplasty for Chronic Hip and Knee Periprosthetic Joint Infection: Insights Into Reimplantation Microbiology and Outcomes.

PMID: 31530462
Journal: JOURNAL OF ARTHROPLASTY
Year: 2020
Reference: J Arthroplasty. 2020 Jan;35(1):247-254. doi: 10.1016/j.arth.2019.07.043. Epub 2019 Aug 19.
Impact factor:
Publication type: Paper in international publication
Authors: Corona, Pablo S; Corro, Sebastian; Lung, Mayli; Pigrau, Carles; Rodriguez-Pardo, Dolors; Vicente, Matias et al.
DOI: 10.1016/j.arth.2019.07.043

Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications.

PMID: 30845683
Journal: Nanomaterials
Year: 2019
Reference: Nanomaterials (Basel). 2019 Mar 6;9(3). pii: nano9030380. doi: 10.3390/nano9030380.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Aguirre, Marius; Andrade, Fernanda; Basas, Jana; Blanco, Alberto; Gavalda, Joan; Gomis, Xavier; Lopez-Fernandez, Alba; Martinez-Trucharte, Francesc; Palau, Marta et al.
DOI: 10.3390/nano9030380

Extracellular vesicles: squeezing every drop of regenerative potential of umbilical cord blood.

PMID: 30831143
Journal: METABOLISM-CLINICAL AND EXPERIMENTAL
Year: 2019
Reference: Metabolism. 2019 Jun;95:102-104. doi: 10.1016/j.metabol.2019.02.006. Epub 2019 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: Roura, Santiago; Vives, Joaquim et al.
DOI: 10.1016/j.metabol.2019.02.006

Causes and Frequencies of Reoperations After Endoprosthetic Reconstructions for Extremity Tumor Surgery: A Systematic Review.

PMID: 30801278
Journal: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Year: 2019
Reference: Clin Orthop Relat Res. 2019 Apr;477(4):894-902. doi: 10.1097/CORR.0000000000000630.
Impact factor:
Publication type: Review in international publication
Authors: Evaniew, Nathan; Ghert, Michelle; MacDonald, Austin; Thornley, Patrick; Velez, Roberto; Vicente, Matias et al.
DOI: 10.1097/CORR.0000000000000630

Outcomes of posterior cruciate ligament tibial avulsion treated with staple fixation: stress TELOS X-ray evaluation.

PMID: 30656430
Journal: European journal of orthopaedic surgery & trau
Year: 2019
Reference: Eur J Orthop Surg Traumatol. 2019 May;29(4):883-891. doi: 10.1007/s00590-019-02371-0. Epub 2019 Jan 17.
Impact factor:
Publication type: Paper in international publication
Authors: Castellet, E; Joshi, N; Minguell, J; Muneton, D; Nunez, J H; Reverte-Vinaixa, M M et al.
DOI: 10.1007/s00590-019-02371-0

Improving pain treatment with a smartphone app: study protocol for a randomized controlled trial.

PMID: 29482614
Journal: Trials
Year: 2018
Reference: Trials. 2018 Feb 27;19(1):145. doi: 10.1186/s13063-018-2539-1.
Impact factor:
Publication type: Paper in international publication
Authors: Castilla, Diana; Garcia-Palacios, Azucena; Marquez, Esther; Medel, Javier; Mesas, Angela; Server, Anna; Suso-Ribera, Carlos; Zaragoza, Irene et al.
DOI: 10.1186/s13063-018-2539-1

Long-term sustained effect of liver-targeted AAV gene therapy for MNGIE.

PMID: 29284302
Journal: HUMAN GENE THERAPY
Year: 2018
Reference: Hum Gene Ther. 2018 Jun;29(6):708-718. doi: 10.1089/hum.2017.133. Epub 2018 Feb 26.
Impact factor:
Publication type: Paper in international publication
Authors: Cabrera-Perez, Raquel; Camara, Yolanda; Hirano, Michio; Marti, Ramon; Torres-Torronteras, Javier; Vila-Julia, Ferran; Viscomi, Carlo; Zeviani, Massimo et al.
DOI: 10.1089/hum.2017.133

Peri-implant radial and ulnar shaft fractures after volar locking plate fixation of the distal radius.

PMID: 28552023
Journal: Journal of Hand Surgery-European Volume
Year: 2018
Reference: J Hand Surg Eur Vol. 2018 Feb;43(2):209-210. doi: 10.1177/1753193417709988. Epub 2017 May 27.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, S; Mir, X; Nunez, J H et al.
DOI: 10.1177/1753193417709988

Optimisation of a potency assay for the assessment of immunomodulative potential of clinical grade multipotent mesenchymal stromal cells.

PMID: 29322348
Journal: CYTOTECHNOLOGY
Year: 2018
Reference: Cytotechnology. 2018 Feb;70(1):31-44. doi: 10.1007/s10616-017-0186-0. Epub 2018 Jan 10.
Impact factor:
Publication type: Paper in international publication
Authors: Caminal, Marta; Grau-Vorster, Marta; Marin-Gallen, Silvia; Oliver-Vila, Irene; Ramirez-Moncayo, Carmen; Vives, Joaquim et al.
DOI: 10.1007/s10616-017-0186-0

A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies.

PMID: 27860364
Journal: Journal of Tissue Engineering and Regenerative Medicine
Year: 2017
Reference: J Tissue Eng Regen Med. 2017 Dec;11(12):3408-3416. doi: 10.1002/term.2254. Epub 2016 Nov 18.
Impact factor: 4.71
Publication type: Paper in international publication
Authors: Caminal, Marta, Rabanal, Rosa Maria, Vivas, Daniel, Batlle-Morera, Laura, Aguirre, Marius, Barquinero, Jordi, Garcia, Joan, Vives, Joaquim, Velez, Roberto et al.
DOI: 10.1002/term.2254

Toward the clinical use of circulating biomarkers predictive of bone union.

PMID: 29182015
Journal: Biomarkers in Medicine
Year: 2017
Reference: Biomark Med. 2017 Dec;11(12):1125-1133. doi: 10.2217/bmm-2017-0180. Epub 2017 Nov 28.
Impact factor: 2.02
Publication type: Editorail in international publication
Authors: Chaverri, Daniel, Vives, Joaquim et al.
DOI: 10.2217/bmm-2017-0180

Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?

PMID: 29078809
Journal: Stem Cell Research & Therapy
Year: 2017
Reference: Stem Cell Res Ther. 2017 Oct 27;8(1):238. doi: 10.1186/s13287-017-0695-y.
Impact factor: 4.211
Publication type: Review in national publication
Authors: Roura, Santiago, Galvez-Monton, Carolina, Mirabel, Clementine, Vives, Joaquim, Bayes-Genis, Antoni et al.
DOI: 10.1186/s13287-017-0695-y

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