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Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Research lines

Orthopaedic oncology - 3D planification / printing

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.

Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.

Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.

Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.


Current research:

1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).

A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.

Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.

3. 3D Planification / Printing

3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.

IP: Roberto Vélez Villa

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