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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Team

Delphine Kervella

Delphine Kervella

Postdoctoral researcher
Nephrology and kidney transplantation
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Elena Isabel Crespo Gimeno

Elena Isabel Crespo Gimeno

Main researcher
Nephrology and kidney transplantation
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Emma Pardo De los Santos

Emma Pardo De los Santos

Research technician
Nephrology and kidney transplantation
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Irene Martinez Diaz

Irene Martinez Diaz

Predoctoral researcher
Nephrology and kidney transplantation
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Jordi Guiteras Vila

Jordi Guiteras Vila

Predoctoral researcher
Nephrology and kidney transplantation
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Juan  León  Román

Juan León Román

Predoctoral researcher
Nephrology and kidney transplantation
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Delphine Kervella

Delphine Kervella

Postdoctoral researcher
Nephrology and kidney transplantation
Read more
Elena Isabel Crespo Gimeno

Elena Isabel Crespo Gimeno

Main researcher
Nephrology and kidney transplantation
Read more
Emma Pardo De los Santos

Emma Pardo De los Santos

Research technician
Nephrology and kidney transplantation
Read more
Irene Martinez Diaz

Irene Martinez Diaz

Predoctoral researcher
Nephrology and kidney transplantation
Read more
Jordi Guiteras Vila

Jordi Guiteras Vila

Predoctoral researcher
Nephrology and kidney transplantation
Read more
Juan  León  Román

Juan León Román

Predoctoral researcher
Nephrology and kidney transplantation
Read more

Projects

Mecanismos y dianas terapéuticas de la respuesta Inmunológica Humoral de Memoria facilitando el rechazo del injerto en el trasplante renal

IP: Oriol Bestard Matamoros
Collaborators: Nuria Bolaños Peruga
Funding agency: Instituto de Salud Carlos III
Funding: 158886.66
Reference: PI19/01710
Duration: 01/04/2021 - 30/06/2024

Deciphering the Mechanisms of PLA2R-specific B-cell Autoimmunity in Primary Membranous Nephropathy (PMN)(BCELL-MEM)

IP: Maria Jose Soler Romeo
Collaborators: Laura Donadeu Casassas
Funding agency: Fundació La Marató de TV3
Funding: 199935.54
Reference: 202037-31
Duration: 01/06/2021 - 31/12/2024

The interplay between ACE2 and AXL systems to predict COVID-19 disease severity and outcomes

IP: Maria Jose Soler Romeo
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 154125
Reference: 202133-30
Duration: 23/09/2021 - 22/09/2024

The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

IP: Oriol Bestard Matamoros
Collaborators: Alba Torija Recasens, Elena Isabel Crespo Gimeno, Delphine Kervella, Nuria Bolaños Peruga
Funding agency: EUROPEAN COMMISSION
Funding: 835583.76
Reference: EUTRAIN_H2020-SC12017
Duration: 01/01/2018 - 30/06/2024

Publications

Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100.

PMID: 37862791
Journal: Gynecologic Oncology
Year: 2023
Reference: Gynecol Oncol. 2023 Oct 18;178:119-129. doi: 10.1016/j.ygyno.2023.09.012.
Impact factor:
Publication type: Paper in international publication
Authors: Birrer, Michael; Boixadera, A; Castany-Aregall, M; Colombo, Nicoletta; Cristescu, Razvan; Distefano, L; Edmondson, Mackenzie; Garcia-Arumi, J; Garrell-Salat, X; Gonzalez-Martin, Antonio et al.
DOI: 10.1016/j.ygyno.2023.09.012

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Primary results from the phase 3 MARIPOSA-2 study.

PMID: 37879444
Journal: ANNALS OF ONCOLOGY
Year: 2023
Reference: Ann Oncol. 2023 Oct 17:S0923-7534(23)04281-3. doi: 10.1016/j.annonc.2023.10.117.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Azuma, K; Baneras, Jordi; Barala, P; Bauml, J M; Bearz, A; Boixadera, Anna; Bourla, A B; Califano, R; Campelo, R G et al.
DOI: 10.1016/j.annonc.2023.10.117

Mutual modulation of gut microbiota and the immune system in type 1 diabetes models.

PMID: 38012160
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Nov 27;14(1):7770. doi: 10.1038/s41467-023-43652-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Arpa, Berta; Aunon, Pilar; Corral-Pujol, Marta; Cosovanu, Catalina; Egia-Mendikute, Leire; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo; Manichanh, Chaysavanh et al.
DOI: 10.1038/s41467-023-43652-x

Cytomegalovirus Cell-Mediated Immunity: Ready for Routine Use?

PMID: 38020746
Journal: TRANSPLANT INTERNATIONAL
Year: 2023
Reference: Transpl Int. 2023 Nov 7;36:11963. doi: 10.3389/ti.2023.11963. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Couzi, Lionel; Del Carmen, Amin; Fernandez-Ruiz, Mario; Garnacho-Castano, Manuel V; Kaminski, Hannah; Manuel, Oriol; Miravitlles, Marc; Moreno, Eva; Pleguezuelos, Eulogio et al.
DOI: 10.3389/ti.2023.11963

Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study.

PMID: 35629041
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 May 21;11(10). pii: jcm11102915. doi: 10.3390/jcm11102915.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Blasco, Miquel, Quintana, Luis F, Shabaka, Amir, Rabasco, Cristina, Draibe, Juliana, Merino, Ana, Melero, Maria Rosa, Alonso, Fabiola, Buxeda, Anna, Batalha, Paula et al.
DOI: 10.3390/jcm11102915

Anti-myeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in anti-neutrophil cytoplasmic antibody-associated vasculitis.

PMID: 33533909
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Mar 25;37(4):697-704. doi: 10.1093/ndt/gfab020.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Rodriguez, Eva, Latzke, Belen, Sierra, Milagros, Romera, Ana Maria, Siedel, Diego, Agraz, Irene, Soler, Maria Jose, Garcia-Carro, Clara, Draibe, Juliana, de la Prada, Francisco Jose et al.
DOI: 10.1093/ndt/gfab020

Usefulness of urinary biomarkers to estimate the interstitial fibrosis surface in diabetic nephropathy with normal kidney function.

PMID: 35583251
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 May 18. pii: 6588052. doi: 10.1093/ndt/gfac185.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Segarra, Alfons, Garcia, Alicia, Abo, Anabel, Gonzalez, Jorge, Jatem, Elias, Roig, Jordi, Valtierra, Naiara, Ostos, Elena, Santacana, Maria et al.
DOI: 10.1093/ndt/gfac185

Humoral Response to Third Dose of SARS-CoV-2 Vaccines in the CKD Spectrum.

PMID: 35551070
Journal: Clinical Journal of the American Society of Nephro
Year: 2022
Reference: Clin J Am Soc Nephrol. 2022 Jun;17(6):872-876. doi: 10.2215/CJN.01770222. Epub 2022 May 12.
Impact factor: 8.237
Publication type: Letter whit IF
Authors: Puerta Carretero, Marta, Jaldo Rodriguez, Maria Teresa, Carnerero Di Riso, Manuel Antonio, Martinez, Shaira, Gonzalez, Carmen Calderon, Cervienka, Michal, Macias Carmona, Nicolas, Arroyo, David, Perez Del Valle, Katia M, de Arriba, Gabriel et al.
DOI: 10.2215/CJN.01770222

SARS CoV-2 vaccination in patients receiving kidney replacement therapies: where are we now with the protective immune response?

PMID: 34289072
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Sep 27;36(10):1950-1954. doi: 10.1093/ndt/gfab227.
Impact factor: 5.992
Publication type: Letter whit IF
Authors: Soler, Maria Jose, Toapanta, Nestor, Bestard, Oriol et al.
DOI: 10.1093/ndt/gfab227

Use and safety of remdesivir in kidney transplant recipients with COVID-19.

PMID: 34250317
Journal: Kidney International Reports
Year: 2021
Reference: Kidney Int Rep. 2021 Sep;6(9):2305-2315. doi: 10.1016/j.ekir.2021.06.023. Epub 2021 Jul 6.
Impact factor: 4.164
Publication type: Paper in international publication
Authors: Lopez, Veronica, Buxeda, Anna, Arias-Cabrales, Carlos, Perez-Saez, Maria Jose, Cacho, Judit, Pelegrin, Sheila Cabello, Melilli, Edoardo, Aladren, Maria Jose, Galeano, Cristina, Lorenzo, Inmaculada et al.
DOI: 10.1016/j.ekir.2021.06.023

[Malignant hypertension and pheochromocytoma: a case report].

PMID: 34238673
Journal: Hipertension y riesgo vascular
Year: 2021
Reference: Hipertens Riesgo Vasc. 2021 Oct-Dec;38(4):201-205. doi: 10.1016/j.hipert.2021.05.003. Epub 2021 Jul 6.
Impact factor: 0
Publication type: Letter or abstract
Authors: Bury, R, Leon Roman, J, Casteras, A, Vergara, A, Biagetti, B, Garcia-Carro, C, Cordero-Vazquez, E, Hernandez Hernandez, I, Agraz, I, Soler, M J et al.
DOI: 10.1016/j.hipert.2021.05.003

COVID-19 in Solid Organ Transplant Recipients in Spain Throughout 2020: Catching the Wave?

PMID: 34241988
Journal: TRANSPLANTATION
Year: 2021
Reference: Transplantation. 2021 Oct 1;105(10):2146-2155. doi: 10.1097/TP.0000000000003873.
Impact factor: 4.939
Publication type: Paper in international publication
Authors: Molina, Maria, Vazquez-Sanchez, Teresa, Crespo, Marta, Facundo, Carme, Rodriguez-Ferrero, M feminine Luisa, Ruiz Fuentes, M feminine Carmen, Loinaz, Carmelo, Bernal, Gabriel, Melilli, Edoardo, Bravo, Carlos et al.
DOI: 10.1097/TP.0000000000003873

ADAM17 inhibition may exert a protective effect on COVID-19.

PMID: 32291449
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2020
Reference: Nephrol Dial Transplant. 2020 Jun 1;35(6):1071-1072. doi: 10.1093/ndt/gfaa093.
Impact factor: 4.531
Publication type: Letter whit IF
Authors: Palau, Vanesa, Riera, Marta, Soler, Maria Jose et al.
DOI: 10.1093/ndt/gfaa093

Paving the way towards gender equality: how are we faring in nephrology?

PMID: 31407783
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2020
Reference: Nephrol Dial Transplant. 2020 Apr 1;35(4):552-554. doi: 10.1093/ndt/gfz165.
Impact factor: 4.531
Publication type: Editorail in international publication
Authors: Stevens, Kate I, Bruchfeld, Annette, Mallamaci, Francesca, Soler, Maria J et al.
DOI: 10.1093/ndt/gfz165

Is There Decreasing Public Interest in Renal Transplantation? A Google Trends(TM) Analysis.

PMID: 32272783
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Apr 7;9(4). pii: jcm9041048. doi: 10.3390/jcm9041048.
Impact factor: 3.303
Publication type: Paper in international publication
Authors: Kronbichler, Andreas, Effenberger, Maria, Shin, Jae Il, Denicolo, Sara, Rudnicki, Michael, Neuwirt, Hannes, Soler, Maria Jose, Stevens, Kate, Bruchfeld, Annette, Tilg, Herbert et al.
DOI: 10.3390/jcm9041048

GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists.

PMID: 32235471
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Mar 30;9(4). pii: jcm9040947. doi: 10.3390/jcm9040947.
Impact factor: 3.303
Publication type: Review in international publication
Authors: Navarro-Gonzalez, Juan F, Gorriz, Jose Luis, Soler, Maria Jose, D'Marco, Luis, Martinez Castelao, Alberto, Fernandez-Fernandez, Beatriz, Ortiz, Alberto, Gorriz-Zambrano, Carmen, Navarro-Perez, Jorge, Gorgojo-Martinez, Juan Jose et al.
DOI: 10.3390/jcm9040947

Will the new molecules be effective in renal and cardiovascular protection in diabetes mellitus and diabetic kidney disease?

PMID: 30290959
Journal: NEFROLOGIA
Year: 2019
Reference: Nefrologia. 2019 Jan - Feb;39(1):3-10. doi: 10.1016/j.nefro.2018.05.011. Epub 2018 Oct 2.
Impact factor: 1.439
Publication type: Paper in national publication
Authors: Navarro-Gonzalez, Juan F, Gorriz, Jose Luis, Soler, M Jose, Martinez Martinez-Castelao, Alberto et al.
DOI: 10.1016/j.nefro.2018.05.011

Lancet Countdown paper: what does it mean for nephrology?

PMID: 30496519
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Jan 1;34(1):4-6. doi: 10.1093/ndt/gfy369.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Fouque, Denis, Blankestijn, Peter J, Bruchfeld, Annette, Capasso, Giovambattista, Fliser, Danilo, Rychlik, Ivan, Soler, Maria Jose, Spasovski, Goce, Stevens, Kate, Wanner, Christoph et al.
DOI: 10.1093/ndt/gfy369

Sex hormones and their influence on chronic kidney disease.

PMID: 30320621
Journal: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Year: 2019
Reference: Curr Opin Nephrol Hypertens. 2019 Jan;28(1):1-9. doi: 10.1097/MNH.0000000000000463.
Impact factor: 3.013
Publication type: Paper in international publication
Authors: Soler, Maria Jose, Valdivielso, Jose Manuel, Jacobs-Cacha, Conxita et al.
DOI: 10.1097/MNH.0000000000000463

Is antibody-mediated rejection in kidney transplant recipients a risk factor for developing cytomegalovirus or BK virus infection? Results from a case-control study.

PMID: 30537648
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2019
Reference: J Clin Virol. 2019 Jan;110:45-50. doi: 10.1016/j.jcv.2018.11.010. Epub 2018 Dec 1.
Impact factor: 3.02
Publication type: Paper in international publication
Authors: Len, Oscar, Perello, Manel, Torres, Irina B, Codina, Gemma, Esperalba, Juliana, Sellares, Joana, Moreso, Francesc, Seron, Daniel, Gavalda, Joan, Los-Arcos, Ibai et al.
DOI: 10.1016/j.jcv.2018.11.010

A randomized controlled study of CPAP effect on plasma aldosterone concentration in patients with resistant hypertension and obstructive sleep apnea.

PMID: 24879492
Journal: J HYPERTENS
Year: 2014
Reference: J Hypertens. 2014 Aug;32(8):1650-7. doi: 10.1097/HJH.0000000000000238.
Impact factor: 4.222
Publication type: Paper in international publication
Authors: Martinez-Garcia, Miguel-Angel, Tovar, Jose-Luis, Ferrer, Roser, Romero, Odile, Segarra, Alfons, Lloberes, Patricia, Sampol, Gabriel, Espinel, Eugenia, Ramon, Maria-Antonia et al.
DOI: 10.1097/HJH.0000000000000238

The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors.

PMID: 24284518
Journal: KIDNEY INT
Year: 2014
Reference: Kidney Int. 2014 May;85(5):1161-8. doi: 10.1038/ki.2013.461. Epub 2013 Nov 27.
Impact factor: 8.52
Publication type: Paper in international publication
Authors: Trilla, Enric, Sellares, Joana, Morote, Joan, Seron, Daniel, Montero, Angeles, Torres, Irina B, Perello, Manel, Cantarell, Carme, Antonieta Azancot, M, Moreso, Francesc et al.
DOI: 10.1038/ki.2013.461

Native ureteropyelostomy in the treatment of obstructive uropathy in adult renal transplant.

PMID: 24636074
Journal: ACTAS UROL ESP
Year: 2014
Reference: Actas Urol Esp. 2014 Oct;38(8):552-6. doi: 10.1016/j.acuro.2014.02.004. Epub 2014 Mar 11.
Impact factor: 1.148
Publication type: Paper in national publication
Authors: Celma, A, Cantarell, C, Moreso, F, Seron, D, Morote, J, Placer, J, Planas, J, Salvador, C, Lorente, D, Trilla, E et al.
DOI: 10.1016/j.acuro.2014.02.004

[Health related quality of life and kidney transplantation: A comparison with population values at 6 months post-transplant.]

PMID: 24480289
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 May 6;142(9):393-6. doi: 10.1016/j.medcli.2013.09.044. Epub 2014 Jan 28.
Impact factor: 1.252
Publication type: Paper in national publication
Authors: Costa-Requena, Gema, Cantarell Aixendri, M Carmen, Rodriguez Urrutia, Amanda, Seron Micas, Daniel et al.
DOI: 10.1016/j.medcli.2013.09.044

Blog

News

An international study involving the Hospital del Mar Research Institute and VHIR shows that there are substantial differences between men and women in the energy metabolism of of renal tubular cells.

Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.

Job offers

Research Nurse Neurovascular diseases group
Start date:
29/12/2022
End date:
15/01/2023
Document: Download
Computational Bioinformatician - Nephrology and Transplantation Group
Start date:
21/12/2022
End date:
04/01/2023
Document: Download
LABORATORY TECHNICIAN - Nephrology Research Group
Start date:
30/09/2022
End date:
14/10/2022
Document: Download