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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

De la Torre Sanchez, Itsasne

De la Torre Sanchez, Itsasne

Research technician
Neurovascular Diseases
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Fernandez Resano, Laia

Fernandez Resano, Laia

Predoctoral researcher
Neurovascular Diseases
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Marta Kinga Klimczak

Marta Kinga Klimczak

Predoctoral researcher
Neurovascular Diseases
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Neus Salvadó Pérez

Neus Salvadó Pérez

Research technician
Neurovascular Diseases
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Ruiz Esteve, Fernando

Ruiz Esteve, Fernando

Research technician
Neurovascular Diseases
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Ana Rosa Olmo Muñoz

Ana Rosa Olmo Muñoz

Neurovascular Diseases
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De la Torre Sanchez, Itsasne

De la Torre Sanchez, Itsasne

Research technician
Neurovascular Diseases
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Fernandez Resano, Laia

Fernandez Resano, Laia

Predoctoral researcher
Neurovascular Diseases
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Marta Kinga Klimczak

Marta Kinga Klimczak

Predoctoral researcher
Neurovascular Diseases
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Neus Salvadó Pérez

Neus Salvadó Pérez

Research technician
Neurovascular Diseases
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Ruiz Esteve, Fernando

Ruiz Esteve, Fernando

Research technician
Neurovascular Diseases
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Ana Rosa Olmo Muñoz

Ana Rosa Olmo Muñoz

Neurovascular Diseases
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Research lines

L6 Stroke Prevention

Since cerebrovascular diseases and dementia are responsible for a huge economic burden, the early detection of patients at high risk for them, and the implementation of preventive measures as soon as possible, might be of great interest and profit.


The purposes of our research are:


- To promote awareness and knowledge of stroke in the general population and enhance collaboration between primary care services and hospital departments.


- To accurately predict those patients at high-risk for first stroke by the determination of novel risk factors or markers (neuroimaging or biological markers), and therefore to improve stroke risk stratification.


- To incorporate a standardized assessment of cognition in stroke research.


- To determine why interventions may be or not widely applied by means of cost-efficiency studies.


- To study quantitative predictors of preventive treatment compliance.



Future project: “Silent cerebral infarction detection and biomarkers associated with the risk of stroke in hypertensive spanish population”.


Silent cerebral infarctions (SCI) detected with neuroimaging techniques, particularly with brain MRI, are common in aged healthy population and even more frequent in selected patients at risk, such as hypertensive patients.  SCI constitute a preclinical stage of cerebrovascular disease and might precede both stroke and cognitive decline; therefore we think that their identification in hypertensive patients would be an adequate and cost-efficient tool, to avoid further strokes and dementia.


Our current project will include a estimated sample size of 1000 hypertensive patients, without known history of cerebrovascular disease or dementia. Silent Cerebral Infarctions (SCI) will be detected by MRI and the determination of several clinical and biological factors (plasma and genetic biomarkers) will be performed on baseline. The patients will be followed-up for at least 3 years, to assess the presence of incident strokes and/or cognitive impairment.

This study will allow us to determine the prevalence of silent cerebral infarctions in our setting, which is largely unknown.


Also, the identification of SCI will help us to better define the risk stratification in hypertensive patients. Patients at higher risk will be our target population for the development of new preventive strategies based on the results of randomized clinical trials.


Finally, this project will be carried out thanks to the collaboration between Neurovascular Research Laboratory, Primary Care Physicians Services and Nephrology Department of Vall d’Hebron, among others, and therefore, the improvement of the link between Primary Care Systems and the remaining hospitalary services, will favor in the future the preventive treatment and care of the patients.

IP: Maria Pilar Delgado Martínez

Projects

Aneurismas degenerativos de la aorta ascendente: ¿están relacionados los fenotipos de dilatación con su etiología, patofisiología y pronóstico?

IP: Jose Fernando Rodríguez Palomares
Collaborators: Guillem Casas Masnou, Ruperto Olivero Soldevila, Alicia Fresno González, Javier Limeres Freire, Lydia Dux-Santoy Hurtado, Laura Fruitós Montané, Raul Aguilar Lopez, Miguel García Gabilondo
Funding agency: Instituto de Salud Carlos III
Funding: 200000
Reference: PI23/01397
Duration: 01/01/2024 - 31/12/2026

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Kerrie Adrián Campbell, Jessica Camacho Soriano, Anas Chaachou Charradi, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 208750
Reference: PI23/00082
Duration: 01/01/2024 - 31/12/2026

Beca VHIR PhD

IP: Anna Rosell Novel
Collaborators: Beca VHIR PhD, Laia Perez Lasarte, Marta Kinga Klimczak , Marta Kinga Klimczak
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/MARTA_K
Duration: 15/05/2023 - 14/05/2026

Implication of proteins associated with vascular beta-amyloid in Cerebral Amyloid Angiopathy

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Laia Perez Lasarte
Funding agency: FUNDACIÓN JOSEP PALAU FRANCÀS
Funding: 68873.32
Reference: VHIRFRANCAS/PREDOC/2022
Duration: 01/02/2023 - 31/01/2026

Publications

Biomarkers to improve functional outcome prediction after ischemic stroke: Results from the SICFAIL, STRAWINSKI, and PREDICT studies.

PMID: 38711254
Journal: European Stroke Journal
Year: 2024
Reference: Eur Stroke J. 2024 May 6:23969873241250272. doi: 10.1177/23969873241250272.
Impact factor:
Publication type: Paper in international publication
Authors: Frantz, Stefan; Giralt, Marina; Haeusler, Karl Georg; Heuschmann, Peter U; Hotter, Benjamin; Kleinschnitz, Christoph; Mackenrodt, Daniel; Meisel, Andreas; Montaner, Joan; Montellano, Felipe A et al.
DOI: 10.1177/23969873241250272

SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.

PMID: 38738428
Journal: STROKE
Year: 2024
Reference: Stroke. 2024 May 13. doi: 10.1161/STROKEAHA.124.046736.
Impact factor:
Publication type: Paper in international publication
Authors: Deng, Wenjun; Garcia-Gabilondo, Miguel; Held, Aaron; Huang, Lena; Ji, Xunming; Li, Wenlu; Lo, Eng H; Ning, Mingming; Rosell, Anna; Shi, Jingfei et al.
DOI: 10.1161/STROKEAHA.124.046736

Apolipoprotein J protects cardiomyocytes from lipid-mediated inflammation and cytotoxicity induced by the epicardial adipose tissue of diabetic patients.

PMID: 38776681
Journal: BIOMEDICINE & PHARMACOTHERAPY
Year: 2024
Reference: Biomed Pharmacother. 2024 May 21;175:116779. doi: 10.1016/j.biopha.2024.116779.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez, Sonia; Bonaterra-Pastra, Anna; Gil-Millan, Pedro; Ginel, Antonino; Hernandez-Guillamon, Mar; Minambres, Inka; Perez, Antonio; Puig, Nuria; Rives, Jose; Sanchez-Quesada, Jose Luis et al.
DOI: 10.1016/j.biopha.2024.116779

Management of Pediatric Mild Traumatic Brain Injury Patients: S100b, Glial Fibrillary Acidic Protein, and Heart Fatty-Acid-Binding Protein Promising Biomarkers.

PMID: 39071980
Journal:
Year: 2024
Reference: Neurotrauma Rep. 2024 May 31;5(1):529-539. doi: 10.1089/neur.2024.0027. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso Cadenas, Jose Antonio; Carpio Linde, Maria Jose; Chiollaz, Anne-Cecile; Chocano, Elvira; de la Torre Sanchez, Paula; Gruaz, Lyssia; Habre, Celine; Korff, Christian; Lamana-Vallverdu, Marcel; Luaces-Cubells, Carlos et al.
DOI: 10.1089/neur.2024.0027

Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia.

PMID: 36594832
Journal: Journal of Extracellular Vesicles
Year: 2023
Reference: J Extracell Vesicles. 2023 Jan;12(1):e12297. doi: 10.1002/jev2.12297.
Impact factor:
Publication type: Paper in international publication
Authors: Batkova, Tereza; Bouvy-Liivrand, Maria; Cheng, Lesley; de Sande, Ana Hernandez; Eamen, Shaila; Giudice, Luca; Giugno, Rosalba; Gomez-Budia, Mireia; Heinaniemi, Merja; Hill, Andrew F et al.
DOI: 10.1002/jev2.12297

Compliance to Multidisciplinary Lifestyle Intervention Decreases Blood Pressure in Patients with Resistant Hypertension: A Cross-Sectional Pilot Study.

PMID: 36675608
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Jan 15;12(2):679. doi: 10.3390/jcm12020679.
Impact factor:
Publication type: Paper in international publication
Authors: Andurell, Laura; Andurell, Laura; Azancot, Maria Antonia; Azancot, Maria Antonia; Beneria, Anna; Caraben, Anna; Castane, Helena; Delgado, Pilar; Espinel, Eugenia; Gomez, Alba et al.
DOI: 10.3390/jcm12020679

Extracellular vesicles secreted by triple negative breast cancer stem cells trigger pre-metastatic niche remodeling and metastatic growth in the lungs.

PMID: 36705298
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2023
Reference: Int J Cancer. 2023 May 15;152(10):2153-2165. doi: 10.1002/ijc.34447. Epub 2023 Feb 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Albertazzi, Lorenzo; Arango, Diego; Camara-Sanchez, Patricia; Conti, Sefora; Diaz-Riascos, Zamira V; Garcia-Gabilondo, Miguel; Gener, Petra; Gonzalez-Callejo, Patricia; Gonzalez-Callejo, Patricia et al.
DOI: 10.1002/ijc.34447

Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia.

PMID: 36707762
Journal: BMC NEUROSCIENCE
Year: 2023
Reference: BMC Neurosci. 2023 Jan 27;24(1):7. doi: 10.1186/s12868-023-00775-7.
Impact factor:
Publication type: Paper in international publication
Authors: Canals, Francesc; Faura, Julia; Garcia-Rodriguez, Paula; Ma, Feifei; Martin, Luna; Martin, Luna; Montaner, Joan; Ramiro, Laura; Rosell, Anna; Simats, Alba et al.
DOI: 10.1186/s12868-023-00775-7

Association of blood-based biomarkers with radiologic markers and cognitive decline in atrial fibrillation patients.

PMID: 36309005
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2022
Reference: J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106833. doi: 10.1016/j.jstrokecerebrovasdis.2022.106833. Epub 2022 Oct 26.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Alejandro; Escudero-Martinez, Irene; Galvao-Carmona, Alejandro; Gomez-Herranz, Marta; Gonzalez, Alejandro; Lamana-Vallverdu, Marcel; Mancha, Fernando; Moniche, Francisco; Montaner, Joan; Ocete, Rafael F et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106833

Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.

PMID: 36180927
Journal: Clinical Epigenetics
Year: 2022
Reference: Clin Epigenetics. 2022 Sep 30;14(1):124. doi: 10.1186/s13148-022-01340-5.
Impact factor:
Publication type: Paper in international publication
Authors: Carcel-Marquez, Jara; Cullell, Natalia; de Moura, Manuel Castro; Delgado, Pilar; Esteller, Manel; Fernandez-Cadenas, Israel; Gallego-Fabrega, Cristina; Jimenez-Conde, Jordi; Krupinski, Jerzy; Lledos, Miquel et al.
DOI: 10.1186/s13148-022-01340-5

Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke.

PMID: 36158970
Journal: Frontiers in Neurology
Year: 2022
Reference: Front Neurol. 2022 Sep 8;13:940682. doi: 10.3389/fneur.2022.940682. eCollection 2022.
Impact factor:
Publication type: Review in international publication
Authors: Aramburu-Nunez, Marta; Castillo, Jose; Custodia, Antia; Ferreira, Lino; Hervella, Pablo; Ouro, Alberto; Pias-Peleteiro, Juan Manuel; Romaus-Sanjurjo, Daniel; Rosell, Anna; Sargento-Freitas, Joao et al.
DOI: 10.3389/fneur.2022.940682

Blood-biomarkers and devices for atrial fibrillation screening: Lessons learned from the AFRICAT (Atrial Fibrillation Research In CATalonia) study.

PMID: 35998199
Journal: PLoS One
Year: 2022
Reference: PLoS One. 2022 Aug 23;17(8):e0273571. doi: 10.1371/journal.pone.0273571. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Juan; Ballesta-Ors, Juan; Bustamante, Alejandro; Clua-Espuny, Josep Lluis; Gentille-Lorente, Delicia; Giralt, Marina; Gonzalez-Loyola, Felipe; Lechuga-Duran, Inigo; Montaner, Joan; Munoz, Miguel Angel et al.
DOI: 10.1371/journal.pone.0273571

MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy.

PMID: 34530925
Journal: Acta Neuropathologica Communications
Year: 2021
Reference: Acta Neuropathol Commun. 2021 Sep 16;9(1):154. doi: 10.1186/s40478-021-01257-9.
Impact factor:
Publication type: Paper in international publication
Authors: Bonaterra-Pastra, Anna; Camacho, Jessica; Castillo-Ribelles, Laura; de Kort, Anna M; Delgado, Pilar; Hernandez-Guillamon, Mar; Klijn, Catharina J M; Kuiperij, H Bea; Marazuela, Paula; Martinez-Saez, Elena et al.
DOI: 10.1186/s40478-021-01257-9

Predicting Atrial Fibrillation with High Risk of Embolization with Atrial Strain and NT-proBNP.

PMID: 33184686
Journal: Translational Stroke Research
Year: 2021
Reference: Transl Stroke Res. 2021 Oct;12(5):735-741. doi: 10.1007/s12975-020-00873-2. Epub 2020 Nov 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Arenillas, Juan F; Bustamante, Alejandro; Cabezas, Juan Antonio; De Lera-Alfonso, Mercedes; de Torres, Reyes; Francisco-Pascual, Jaume; Gonzalez-Alujas, Teresa; Juega, Jesus; Molina, Carlos A et al.
DOI: 10.1007/s12975-020-00873-2

Effect of late-onset epilepsy on cognitive functioning in patients with small vessel disease.

PMID: 34375799
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Oct;123:108238. doi: 10.1016/j.yebeh.2021.108238. Epub 2021 Aug 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abraira, Laura; Alvarez-Sabin, Jose; Delgado, Pilar; Fonseca, Elena; Jimenez-Balado, Joan; Maisterra, Olga; Quintana, Manuel; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2021.108238

RP11-362K2.2:RP11-767I20.1 Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis.

PMID: 34300314
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jul 16;10(14). pii: jcm10143137. doi: 10.3390/jcm10143137.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Arenillas, Juan F; Bustamante, Alejandro; Cabezas, Juan Antonio; Campos, Francisco; Camps-Renom, Pol; Carcel-Marquez, Jara; Carrera, Caty; Castellanos, Mar; Castillo, Jose et al.
DOI: 10.3390/jcm10143137

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.

PMID: 33146036
Journal: CEPHALALGIA
Year: 2020
Reference: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157.
Impact factor:
Publication type: Paper in international publication
Authors: Alpuente, Alicia; Alvarez-Sabin, Jose; Ballve, Alejandro; Borrell, Ricard Pujol; Caronna, Edoardo; Gadea, Marta Olive; Gallardo, Victor Jose; Gallo, Monica Martinez; Gonzalez, Manuel Hernandez; Lallana, Sofia et al.
DOI: 10.1177/0333102420965157

Non-invasive markers of vascular disease: An opportunity for early diagnosis of cognitive impairment.

PMID: 33051024
Journal: ATHEROSCLEROSIS
Year: 2020
Reference: Atherosclerosis. 2020 Nov;312:101-103. doi: 10.1016/j.atherosclerosis.2020.10.002. Epub 2020 Oct 6.
Impact factor:
Publication type: Editorail in international publication
Authors: Delgado, Pilar; Jimenez-Balado, Joan; Maisterra, Olga et al.
DOI: 10.1016/j.atherosclerosis.2020.10.002

The Role of Echocardiography Screening at the Stroke Unit.

PMID: 33013663
Journal: Frontiers in Neurology
Year: 2020
Reference: Front Neurol. 2020 Sep 11;11:1003. doi: 10.3389/fneur.2020.01003. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Gonzalez-Alujas, Teresa; Juega, Jesus; Molina, Carlos A; Pagola, Carlos; Pagola, Jorge et al.
DOI: 10.3389/fneur.2020.01003

Potential of Extracellular Vesicle-Associated TSG-6 from Adipose Mesenchymal Stromal Cells in Traumatic Brain Injury.

PMID: 32942629
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Sep 15;21(18). pii: ijms21186761. doi: 10.3390/ijms21186761.
Impact factor:
Publication type: Review in international publication
Authors: Borras, Francesc E; Clos-Sansalvador, Marta; Franquesa, Marcella; Monguio-Tortajada, Marta; Munizaga-Larroude, Micaela; Rosell, Anna; Roura, Santiago et al.
DOI: 10.3390/ijms21186761

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.

PMID: 31877821
Journal: Pharmaceutics
Year: 2019
Reference: Pharmaceutics. 2019 Dec 21;12(1). pii: pharmaceutics12010016. doi: 10.3390/pharmaceutics12010016.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Gabilondo, Miguel; Roig, Anna; Rosell, Anna; Zhang, Yajie et al.
DOI: 10.3390/pharmaceutics12010016

N-Terminal Pro B-Type Natriuretic Peptide's Usefulness for Paroxysmal Atrial Fibrillation Detection Among Populations Carrying Cardiovascular Risk Factors.

PMID: 31849809
Journal: Frontiers in Neurology
Year: 2019
Reference: Front Neurol. 2019 Nov 29;10:1226. doi: 10.3389/fneur.2019.01226. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Juan; Ballesta-Ors, Juan; Bustamante, Alejandro; Caballero, Andrea; Clua-Espuny, Josep Lluis; Gill, Natalia; Gonzalez-Loyola, Felipe; Montaner, Joan; Munoz, Miguel Angel; Pagola, Jorge et al.
DOI: 10.3389/fneur.2019.01226

Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration.

PMID: 31765261
Journal: CIRCULATION
Year: 2019
Reference: Circulation. 2019 Nov 26;140(22):1834-1850. doi: 10.1161/CIRCULATIONAHA.119.040267. Epub 2019 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Boriani, Giuseppe; Brachmann, Johannes; Brandes, Axel; Bustamante, Alejandro; Casadei, Barbara; Crijns, Harry J G M; Doehner, Wolfram; Engstrom, Gunnar; Fauchier, Laurent; Freedman, Ben et al.
DOI: 10.1161/CIRCULATIONAHA.119.040267

Genome-wide association meta-analysis of functional outcome after ischemic stroke.

PMID: 30796134
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Mar 19;92(12):e1271-e1283. doi: 10.1212/WNL.0000000000007138. Epub 2019 Feb 22.
Impact factor:
Publication type: Paper in international publication
Authors: Bevan, Steve; Cole, John W; Fernandez-Cadenas, Israel; Hankey, Graeme J; Jern, Christina; Jimenez-Conde, Jordi; Jood, Katarina; Lee, Jin-Moo; Lemmens, Robin; Levi, Christopher et al.
DOI: 10.1212/WNL.0000000000007138

Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review.

PMID: 30334955
Journal: MEDICINE
Year: 2018
Reference: Medicine (Baltimore). 2018 Oct;97(42):e12703. doi: 10.1097/MD.0000000000012703.
Impact factor:
Publication type: Paper in international publication
Authors: Cao, Junguo; Chen, Fan; Huang, Haiyan; Lei, Ting; Ma, Chengyuan; Zhang, Chaochao et al.
DOI: 10.1097/MD.0000000000012703

Reliability of the early syndromic diagnosis in adults with new-onset epileptic seizures: A retrospective study of 116 patients attended in the emergency room.

PMID: 30172139
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Oct;61:158-163. doi: 10.1016/j.seizure.2018.08.016. Epub 2018 Aug 18.
Impact factor:
Publication type: Clinical guide
Authors: Abraira Del Fresno, L; Alvarez Sabin, J; Fonseca Hernandez, E; Olive Gadea, M; Quintana, M; Requena Ruiz, M; Salas Puig, X; Santamarina Perez, E; Toledo, M et al.
DOI: 10.1016/j.seizure.2018.08.016

Revascularization and Endothelial Progenitor Cells in Stroke.

PMID: 30133323
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Year: 2018
Reference: Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C664-C674. doi: 10.1152/ajpcell.00200.2018. Epub 2018 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Esquiva, Gema; Grayston, Alba; Rosell, Anna et al.
DOI: 10.1152/ajpcell.00200.2018

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

PMID: 30120039
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Oct;17(10):885-894. doi: 10.1016/S1474-4422(18)30253-9. Epub 2018 Aug 14.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Shahi Salman, Rustam; Anderson, Craig S; Arima, Hisatomi; Aviv, Richard I; Ayres, Alison M; Bakhshayesh, Babak; Battey, Thomas W K; Broderick, Joseph; Brott, Thomas; Butcher, Kenneth S et al.
DOI: 10.1016/S1474-4422(18)30253-9

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

PMID: 27733675
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2017
Reference: J Cereb Blood Flow Metab. 2017 Dec;37(12):3671-3682. doi: 10.1177/0271678X16671964. Epub 2016 Oct 14.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Alejandro; Gohler, Jos; Hamilton, Frank; Harms, Hendrik; Hermans, Marcella; Heuschmann, Peter U; Hoffmann, Sarah; Jungehulsing, Gerhard J; Mackert, Bruno-Marcel; Malsch, Carolin et al.
DOI: 10.1177/0271678X16671964

Admission CT perfusion may overestimate initial infarct core: the ghost infarct core concept.

PMID: 27566491
Journal: Journal of NeuroInterventional Surgery
Year: 2017
Reference: J Neurointerv Surg. 2017 Jan;9(1):66-69. doi: 10.1136/neurintsurg-2016-012494. Epub 2016 Aug 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Boned, Sandra; Coscojuela, Pilar; Flores, Alan; Juega, Jesus; Molina, Carlos A; Muchada, Marian; Padroni, Marina; Pagola, Jorge; Ribo, Marc et al.
DOI: 10.1136/neurintsurg-2016-012494

The impact of post-stroke complications on in-hospital mortality depends on stroke severity.

PMID: 31008302
Journal: European stroke journal
Year: 2017
Reference: Eur Stroke J. 2017 Mar;2(1):54-63. doi: 10.1177/2396987316681872. Epub 2016 Nov 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Bustamante, Alejandro; Garcia-Berrocoso, Teresa; Giralt, Dolors; Molina, Carlos; Montaner, Joan; Rubiera, Marta; Serena, Joaquin et al.
DOI: 10.1177/2396987316681872

Myoclonic epilepsy in Down syndrome and Alzheimer disease.

PMID: 25661268
Journal: NEUROLOGIA
Year: 2017
Reference: Neurologia. 2017 Mar;32(2):69-73. doi: 10.1016/j.nrl.2014.12.008. Epub 2015 Feb 7.
Impact factor:
Publication type: Paper in national publication
Authors: Aller-Alvarez, J S; Alvarez-Sabin, J; Menendez-Gonzalez, M; Ribacoba-Montero, R; Salas-Puig, J; Salvado, M; Suarez-Moro, R; Sueiras, M; Toledo, M; Vega, V et al.
DOI: 10.1016/j.nrl.2014.12.008

Circulating cell-free DNA is a predictor of short-term neurological outcome in stroke patients treated with intravenous thrombolysis.

PMID: 28936264
Journal: Journal of circulating biomarkers
Year: 2016
Reference: J Circ Biomark. 2016 Sep 26;5:1849454416668791. doi: 10.1177/1849454416668791. eCollection 2016 Jan-Dec.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Alejandro; Garcia-Berrocoso, Teresa; Giralt, Dolors; Guerrero, Juan M; Macher, Hada C; Mancha, Fernando; Montaner, Joan; Ribo, Marc et al.
DOI: 10.1177/1849454416668791

Neuroinflammatory biomarkers: From stroke diagnosis and prognosis to therapy.

PMID: 26524637
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Year: 2016
Reference: Biochim Biophys Acta. 2016 Mar;1862(3):411-24. doi: 10.1016/j.bbadis.2015.10.025. Epub 2015 Oct 30.
Impact factor:
Publication type: Letter or abstract
Authors: Garcia-Berrocoso, Teresa; Montaner, Joan; Simats, Alba et al.
DOI: 10.1016/j.bbadis.2015.10.025

Plasmatic RBP4 and GFAP as biomarkers to differentiate ischemic stroke and intracerebral hemorrhage.

PMID: 26526443
Journal: JOURNAL OF NEUROCHEMISTRY
Year: 2016
Reference: J Neurochem. 2016 Jan;136(2):416-24. doi: 10.1111/jnc.13419. Epub 2015 Dec 17.
Impact factor:
Publication type: Paper in international publication
Authors: Boada, Cristina; Bustamante, Alejandro; Garcia-Berrocoso, Teresa; Giralt, Dolors; Hernandez-Guillamon, Mar; Llombart, Victor; Montaner, Joan; Muchada, Marian; Penalba, Anna; Rodriguez-Luna, David et al.
DOI: 10.1111/jnc.13419

Consensus statement for diagnosis of subcortical small vessel disease.

PMID: 26198175
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2016
Reference: J Cereb Blood Flow Metab. 2016 Jan;36(1):6-25. doi: 10.1038/jcbfm.2015.172.
Impact factor:
Publication type: Paper in international publication
Authors: Chui, Helena C; Dichgans, Martin; Duering, Marco; Grinberg, Lea T; Hachinski, Vladimir; Iadecola, Costantino; Joutel, Anne; Korczyn, Amos D; Markus, Hugh S; Montaner, Joan et al.
DOI: 10.1038/jcbfm.2015.172

Computed Tomography Perfusion in Acute Ischemic Stroke: Is It Ready for Prime Time?

PMID: 26159791
Journal: STROKE
Year: 2015
Reference: Stroke. 2015 Aug;46(8):2364-7. doi: 10.1161/STROKEAHA.115.009179. Epub 2015 Jul 9.
Impact factor:
Publication type: Review in international publication
Authors: Gonzalez, Ramon G; Lev, Michael H; Liebeskind, David S; Molina, Carlos A; Parsons, Mark W; Selim, Magdy; Wintermark, Max et al.
DOI: 10.1161/STROKEAHA.115.009179

Combined lysis of thrombus with ultrasound and systemic tissue plasminogen activator for emergent revascularization in acute ischemic stroke (CLOTBUST-ER): design and methodology of a multinational phase 3 trial.

PMID: 26120902
Journal: INT J STROKE
Year: 2015
Reference: Int J Stroke. 2015 Oct;10(7):1141-8. doi: 10.1111/ijs.12536. Epub 2015 Jun 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alexandrov, Andrei; Alexandrov, Andrei V; Alexandrov, Andrei V; Alexandrov, Anne W; Alleman, John; Barreto, Andrew; Barreto, Andrew; Barreto, Andrew D; Bornstein, Natan M; Bornstein, Natan M et al.
DOI: 10.1111/ijs.12536

Validation of the 9-Point and 24-Point Hematoma Expansion Prediction Scores and Derivation of the PREDICT A/B Scores.

PMID: 26463691
Journal: STROKE
Year: 2015
Reference: Stroke. 2015 Nov;46(11):3105-10. doi: 10.1161/STROKEAHA.115.009893. Epub 2015 Oct 13.
Impact factor:
Publication type: Paper in international publication
Authors: Aviv, Richard I; Bhatia, Rohit; Boulanger, Jean-Martin; Demchuk, Andrew M; Dowlatshahi, Dar; Dzialowski, Imanuel; Gladstone, David J; Gubitz, Gord; Hill, Michael D; Huynh, Thien J et al.
DOI: 10.1161/STROKEAHA.115.009893

Pittsburgh Response to Endovascular therapy (PRE) score: optimizing patient selection for endovascular therapy for large vessel occlusion strokes.

PMID: 25320054
Journal: J NEUROINTERV SURG
Year: 2015
Reference: J Neurointerv Surg. 2015 Nov;7(11):783-8. doi: 10.1136/neurintsurg-2014-011351. Epub 2014 Oct 15.
Impact factor:
Publication type: Paper in international publication
Authors: Aghaebrahim, Amin; Frankel, Michael; Gupta, Rishi; Jadhav, Ashutosh; Jovin, Tudor G; Muchada, Marion; Nogueira, Raul; Rangaraju, Srikant; Ribo, Marc; Streib, Christopher et al.
DOI: 10.1136/neurintsurg-2014-011351

Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment.

PMID: 23044408
Journal: NEUROLOGIA
Year: 2014
Reference: Neurologia. 2014 Jul-Aug;29(6):353-70. doi: 10.1016/j.nrl.2012.07.009. Epub 2012 Oct 6.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso de Lecinana, M; Alvarez-Sabin, J; Arenillas, J; Calleja, S; Casado, I; Castellanos, M; Castillo, J; Davalos, A; Diaz-Otero, F; Diez Tejedor, E et al.
DOI: 10.1016/j.nrl.2012.07.009

Guidelines for the treatment of acute ischaemic stroke.

PMID: 22152803
Journal: NEUROLOGIA
Year: 2014
Reference: Neurologia. 2014 Mar;29(2):102-22. doi: 10.1016/j.nrl.2011.09.012. Epub 2011 Dec 6.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.nrl.2011.09.012

Trevo versus Solitaire a Head-to-Head Comparison Between Two Heavy Weights of Clot Retrieval.

PMID: 22913726
Journal: JOURNAL OF NEUROIMAGING
Year: 2014
Reference: J Neuroimaging. 2014 Mar-Apr;24(2):167-70. doi: 10.1111/j.1552-6569.2012.00730.x. Epub 2012 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Cardona, Pere; Flores, Alan; Mendonca, Nuno; Miquel, M Angels De; Molina, Carlos; Mora, Paloma; Pagola, Jorge; Quesada, Helena; Ribo, Marc et al.
DOI: 10.1111/j.1552-6569.2012.00730.x

Age-adjusted infarct volume threshold for good outcome after endovascular treatment.

PMID: 23832414
Journal: Journal of NeuroInterventional Surgery
Year: 2014
Reference: J Neurointerv Surg. 2014 Jul;6(6):418-22. doi: 10.1136/neurintsurg-2013-010786. Epub 2013 Jul 6.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Coscojuela, Pilar; Flores, Alan; Mansilla, Eloy; Molina, Carlos A; Muchada, Marian; Pagola, Jorge; Ribo, Marc; Rodriguez-Luna, David; Rubiera, Marta et al.
DOI: 10.1136/neurintsurg-2013-010786

The costs of stroke in Spain by aetiology: the CONOCES study protocol.

PMID: 22995527
Journal: NEUROLOGIA
Year: 2013
Reference: Neurologia. 2013 Jul-Aug;28(6):332-9. doi: 10.1016/j.nrl.2012.07.004. Epub 2012 Sep 18.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Sabin, J; Arenillas, J F; Becerra, V; Casado, M A; Casado-Naranjo, I; Castillo, J; Escribano, B; Gallego, J; Gonzalez-Rodriguez, C; Gonzalez-Rojas, N et al.
DOI: 10.1016/j.nrl.2012.07.004

Clinical practice guidelines in intracerebral haemorrhage.

PMID: 21570742
Journal: NEUROLOGIA
Year: 2013
Reference: Neurologia. 2013 May;28(4):236-49. doi: 10.1016/j.nrl.2011.03.010. Epub 2011 May 13.
Impact factor:
Publication type: Review in national publication
Authors: Alonso de Lecinana, M; Alonso de Lecinana, Maria; Alvarez-Sabin, J; Alvarez-Sabin, Jose; Alvarez-Sabin, Jose; Antonio Egido, Jose; Arenillas, J; Arenillas, Juan; Calleja, S; Calleja, Sergio et al.
DOI: 10.1016/j.nrl.2011.03.010

Difficult catheter access to the occluded vessel during endovascular treatment of acute ischemic stroke is associated with worse clinical outcome.

PMID: 23117130
Journal: Journal of NeuroInterventional Surgery
Year: 2013
Reference: J Neurointerv Surg. 2013 May;5 Suppl 1:i70-3. doi: 10.1136/neurintsurg-2012-010438. Epub 2012 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Flores, Alan; Meler, Pilar; Mendonca, Nuno; Molina, Carlos A; Pagola, Jorge; Pineiro, Soco; Ribo, Marc; Rodriguez-Luna, David; Rubiera, Marta et al.
DOI: 10.1136/neurintsurg-2012-010438

Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design.

PMID: 24083440
Journal: BMC Neurology
Year: 2013
Reference: BMC Neurol. 2013 Oct 2;13:130. doi: 10.1186/1471-2377-13-130.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Castane, Xavier; Delgado, Pilar; Domingo, Mar; Fernandez, Jose L; Fernandez-Cortinas, Ines; Jarca, Carmen Ioana; Lopez-Rueda, Antonio; Maisterra, Olga; Montaner, Joan et al.
DOI: 10.1186/1471-2377-13-130

Impact of telemedicine on acute management of stroke patients undergoing endovascular procedures.

PMID: 23207552
Journal: CEREBROVASCULAR DISEASES
Year: 2012
Reference: Cerebrovasc Dis. 2012;34(5-6):436-42. doi: 10.1159/000345088. Epub 2012 Dec 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Brugues, Joan; Maisterra, Olga; Molina, Carlos; Pedragosa, Angels; Ribo, Marc; Rodriguez-Luna, David; Rubiera, Marta et al.
DOI: 10.1159/000345088

Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update.

PMID: 23052179
Journal: CEREBROVASCULAR DISEASES
Year: 2012
Reference: Cerebrovasc Dis. 2012;34(4):249-62. doi: 10.1159/000341686. Epub 2012 Oct 10.
Impact factor:
Publication type: Review in international publication
Authors: Florczak-Rzepka, M; Grond-Ginsbach, C; Montaner, J; Steiner, T et al.
DOI: 10.1159/000341686

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies.

PMID: 23041239
Journal: LANCET NEUROLOGY
Year: 2012
Reference: Lancet Neurol. 2012 Nov;11(11):951-62. doi: 10.1016/S1474-4422(12)70234-X. Epub 2012 Oct 5.
Impact factor:
Publication type: Paper in international publication
Authors: Abboud, Sherine; Achterberg, Sefanja; Algra, Ale; Benn, Marianne; Berger, Klaus; Bevan, Steve; Bis, Joshua C; Boncoraglio, Giorgio B; Carty, Cara; Chen, Wei-Min et al.
DOI: 10.1016/S1474-4422(12)70234-X

Blood glutathione S-transferase-pi as a time indicator of stroke onset.

PMID: 23028472
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(9):e43830. doi: 10.1371/journal.pone.0043830. Epub 2012 Sep 17.
Impact factor:
Publication type: Paper in international publication
Authors: Burkhard, Pierre R; Fouda, Catherine; Hainard, Alexandre; Hochstrasser, Denis F; Montaner, Joan; Robin, Xavier; Sanchez, Jean-Charles; Sztajzel, Roman; Turck, Natacha; Wagner, Ghislaine et al.
DOI: 10.1371/journal.pone.0043830

Ultraearly hematoma growth predicts poor outcome after acute intracerebral hemorrhage.

PMID: 21998314
Journal: NEUROLOGY
Year: 2011
Reference: Neurology. 2011 Oct 25;77(17):1599-604. Epub 2011 Oct 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1212/WNL.0b013e3182343387

Quantitative Evaluation of Striatal I-123-FP-CIT Uptake in Essential Tremor and Parkinsonism.

PMID: 21975386
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2011
Reference: Clin Nucl Med. 2011 Nov;36(11):991-6.
Impact factor:
Publication type: Paper in international publication
Authors: Aguade-Bruix, Santiago; Alvarez-Sabin, Jose; Castell-Conesa, Joan; Cuberas-Borros, Gemma; Hernandez-Vara, Jorge; Lorenzo-Bosquet, Carles; Miquel, Francesc; Pifarre-Montaner, Paloma et al.
DOI: 10.1097/RLU.0b013e3182291a7b

European Research Priorities for Intracerebral Haemorrhage.

PMID: 21986448
Journal: CEREBROVASCULAR DISEASES
Year: 2011
Reference: Cerebrovasc Dis. 2011;32(5):409-19. Epub 2011 Oct 8.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1159/000330653

Extending the Time Window for Endovascular Procedures According to Collateral Pial Circulation.

PMID: 21960574
Journal: STROKE
Year: 2011
Reference: Stroke. 2011 Dec;42(12):3465-9. Epub 2011 Sep 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1161/STROKEAHA.111.623827

A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population.

PMID: 21115960
Journal: NEUROLOGY
Year: 2010
Reference: Neurology. 2010 Nov 30;75(22):2033-5.
Impact factor:
Publication type: Editorail in international publication
Authors: Alvarez-Sabin, J; Del Rio-Espinola, A; Domingues-Montanari, S; Fernandez-Cadenas, I; Fernandez-Figueras, M T; Garcia-Patos, V; Mendioroz, M; Montaner, J; Rovira, A; Sastre-Garriga, J et al.
DOI: 10.1212/WNL.0b013e3181ff96ac

Variants at APOE influence risk of deep and lobar intracerebral hemorrhage.

PMID: 21061402
Journal: ANNALS OF NEUROLOGY
Year: 2010
Reference: Ann Neurol. 2010 Dec;68(6):934-43.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/ana.22134

[Pathophysiology of CADASIL disease]

PMID: 20036399
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Jul 10;135(5):222-30. Epub 2009 Dec 29.
Impact factor:
Publication type: Review in national publication
Authors: Del Rio Espinola, Alberto; Montaner, Joan; Sole, Esther et al.
DOI: 10.1016/j.medcli.2009.10.034

The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.

PMID: 20671249
Journal: STROKE
Year: 2010
Reference: Stroke. 2010 Sep;41(9):1850-7. Epub 2010 Jul 29.
Impact factor:
Publication type: Paper in international publication
Authors: Attia, John; Blomstrand, Christian; Buysschaert, Ian; Fernandez-Cadenas, Israel; Geelen, Veerle; Jern, Christina; Jood, Katarina; Lambrechts, Diether; Lemmens, Robin; Levi, Christopher et al.
DOI: 10.1161/STROKEAHA.110.587980

Evolution of lipid profile, liver function, and pattern of plasma fatty acids according to the type of lipid emulsion administered in parenteral nutrition in the early postoperative period after digestive surgery.

PMID: 19420283
Journal: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Year: 2009
Reference: JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):501-12.
Impact factor:
Publication type: Paper in international publication
Authors: Bou, R; Chacon, P; Planas, M; Puiggros, C; Rosello, J; Sabin, P; Sanchez, J et al.
DOI: 10.1177/0148607109333001

Inflammation markers and prediction of post-stroke vascular disease recurrence: the MITICO study.

PMID: 19252763
Journal: JOURNAL OF NEUROLOGY
Year: 2009
Reference: J Neurol. 2009 Feb;256(2):217-24.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, J; Castillo, J; Martinez-Vila, E; Montaner, J; Sobrino, T; Vivancos, J et al.
DOI: 10.1007/s00415-009-0058-4

Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro.

PMID: 19240740
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2009
Reference: J Cereb Blood Flow Metab. 2009 May;29(5):933-43.
Impact factor:
Publication type: Paper in international publication
Authors: Arai, Ken; Guo, Shuzhen; He, Tongrong; Katusic, Zvonimir S; Lo, Eng H; Lok, Josephine; Montaner, Joan; Navarro, Miriam; Rosell, Anna et al.
DOI: 10.1038/jcbfm.2009.17

Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia.

PMID: 18985055
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2009
Reference: J Cereb Blood Flow Metab. 2009 Feb;29(2):398-410.
Impact factor:
Publication type: Paper in international publication
Authors: Borrell-Pages, Maria; Cuadrado, Eloy; Garcia-Bonilla, Lidia; Hernandez-Guillamon, Mar; Montaner, Joan; Ortega-Aznar, Arantxa; Rosell, Anna et al.
DOI: 10.1038/jcbfm.2008.130

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.