About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.
Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.
Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.
Since cerebrovascular diseases and dementia are responsible for a huge economic burden, the early detection of patients at high risk for them, and the implementation of preventive measures as soon as possible, might be of great interest and profit.
The purposes of our research are:
- To promote awareness and knowledge of stroke in the general population and enhance collaboration between primary care services and hospital departments.
- To accurately predict those patients at high-risk for first stroke by the determination of novel risk factors or markers (neuroimaging or biological markers), and therefore to improve stroke risk stratification.
- To incorporate a standardized assessment of cognition in stroke research.
- To determine why interventions may be or not widely applied by means of cost-efficiency studies.
- To study quantitative predictors of preventive treatment compliance.
Future project: “Silent cerebral infarction detection and biomarkers associated with the risk of stroke in hypertensive spanish population”.
Silent cerebral infarctions (SCI) detected with neuroimaging techniques, particularly with brain MRI, are common in aged healthy population and even more frequent in selected patients at risk, such as hypertensive patients. SCI constitute a preclinical stage of cerebrovascular disease and might precede both stroke and cognitive decline; therefore we think that their identification in hypertensive patients would be an adequate and cost-efficient tool, to avoid further strokes and dementia.
Our current project will include a estimated sample size of 1000 hypertensive patients, without known history of cerebrovascular disease or dementia. Silent Cerebral Infarctions (SCI) will be detected by MRI and the determination of several clinical and biological factors (plasma and genetic biomarkers) will be performed on baseline. The patients will be followed-up for at least 3 years, to assess the presence of incident strokes and/or cognitive impairment.
This study will allow us to determine the prevalence of silent cerebral infarctions in our setting, which is largely unknown.
Also, the identification of SCI will help us to better define the risk stratification in hypertensive patients. Patients at higher risk will be our target population for the development of new preventive strategies based on the results of randomized clinical trials.
Finally, this project will be carried out thanks to the collaboration between Neurovascular Research Laboratory, Primary Care Physicians Services and Nephrology Department of Vall d’Hebron, among others, and therefore, the improvement of the link between Primary Care Systems and the remaining hospitalary services, will favor in the future the preventive treatment and care of the patients.
IP: Maria Pilar Delgado Martínez, Yolanda Riba Llena
IP: Maria Mar Hernandez Guillamon Collaborators: Berta Paez Montserrat, Laia Perez Lasarte Funding agency: FUNDACIÓN JOSEP PALAU FRANCÀS Funding: 68873.32 Reference: VHIRFRANCAS/PREDOC/2022 Duration: 01/02/2023 - 31/01/2026
IP: LAURA ABRAIRA DEL FRESNO Collaborators: Anna Penalba Morenilla, Manuel Toledo Argany, Anna Sánchez Corral, Elena Fonseca Hernandez, Daniel Campos Fernández, Sofia Lallana Serrano, Estevo Santamarina Pérez, Manuel Quintana Luque Funding agency: Fundación Eugenio Rodríguez Pascual Funding: 24990 Reference: FERP-2022-FERP-2022-1 Duration: 01/01/2023 - 31/12/2024
IP: Anna Rosell Novel Collaborators: Mercedes Arrue Gonzalo, Joan Montaner Villalonga, Marcel Lamana Vallverdu, Anna Penalba Morenilla, Anna Bonaterra Pastra, Maria Mar Hernandez Guillamon, Olga Maisterra Santos, Maria Pilar Delgado Martínez, Antonio Palasi Franco, Jesús Pizarro Gonzálvez, Paula Garcia Rodriguez, Miguel García Gabilondo, Nicolas Garcia Rodriguez Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00656 Duration: 01/01/2022 - 30/06/2025
IP: Maria Mar Hernandez Guillamon Collaborators: Judit Álvarez González Funding agency: Instituto de Salud Carlos III Funding: 65000 Reference: CM22/00226 Duration: 01/01/2023 - 31/12/2024
PMID: 37430546 Journal: SENSORS Year: 2023 Reference: Sensors (Basel). 2023 May 10;23(10):4632. doi: 10.3390/s23104632. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Sabin, Jose; Bashir, Saima; Duran, Laura; Francisco, Jaume; Juega, Jesus; Meza, Claudia; Molina, Carlos; Pagola, Jorge; Rodriguez, Maite; Santos, Alba et al. DOI: 10.3390/s23104632
PMID: 37686257 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2023 Reference: Int J Mol Sci. 2023 Aug 30;24(17):13452. doi: 10.3390/ijms241713452. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Simon, Ana; Bernardo, David; Carcel-Marquez, Jara; Cordioli, Mattia; Cullell, Natalia; Darcis, Gilles; de Felipe Mimbrera, Alicia; DeDiego, Marta L; Delgado, Pilar; Delgado, Pilar et al. DOI: 10.3390/ijms241713452
PMID: 37721534 Journal: Brain and Behavior Year: 2023 Reference: Brain Behav. 2023 Sep 18:e3230. doi: 10.1002/brb3.3230. Impact factor: Publication type: Paper in international publication Authors: Bustamante, Alejandro; Bustamante, Alejandro; Garcia-Berrocoso, Teresa; Kallmunzer, Bernd; Lamana-Vallverdu, Marcel; Meisel, Andreas; Meisel, Christian; Montaner, Joan; Montaner, Joan; Pala, Elena et al. DOI: 10.1002/brb3.3230
PMID: 37069360 Journal: NATURE MEDICINE Year: 2023 Reference: Nat Med. 2023 Apr 17. doi: 10.1038/s41591-023-02268-w. Impact factor: Publication type: Paper in international publication Authors: Adams, Hieab H H; Armstrong, Nicola J; Bastin, Mark E; Beiser, Alexa; Bordes, Constance; Bourgey, Mathieu; Bourque, Guillaume; Boutinaud, Philippe; Brodaty, Henry; Bulow, Robin et al. DOI: 10.1038/s41591-023-02268-w
PMID: 35137910 Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION Year: 2022 Reference: Nephrol Dial Transplant. 2022 May 25;37(6):1199. doi: 10.1093/ndt/gfab339. Impact factor: 5.992 Publication type: Letter or abstract Authors: Kurganaite, Justina; Pepin, Marion; Ferreira, Ana Carina; Arici, Mustafa; Bachmann, Maie; Barbieri, Michelangela; Bumblyte, Inga Arune; Carriazo, Sol; Delgado, Pilar; Garneata, Liliana et al. DOI: 10.1093/ndt/gfab339
PMID: 35152335 Journal: JOURNAL OF NEUROLOGY Year: 2022 Reference: J Neurol. 2022 Jul;269(7):3761-3769. doi: 10.1007/s00415-022-11005-1. Epub 2022 Feb 13. Impact factor: 4.849 Publication type: Paper in international publication Authors: Coscojuela, P; Fonseca, E; Quintana, M; Sarria-Estrada, S; Santamarina, E; Abraira, L; Sueiras, M; Thonon, V; Alvarez-Sabin, J; Toledo, M et al. DOI: 10.1007/s00415-022-11005-1
PMID: 35717949 Journal: THROMBOSIS AND HAEMOSTASIS Year: 2022 Reference: Thromb Haemost. 2022 Jun 19. doi: 10.1055/s-0042-1749328. Impact factor: 5.723 Publication type: Paper in international publication Authors: Cullell, Natalia; Soriano-Tarraga, Carolina; Gallego-Fabrega, Cristina; Carcel-Marquez, Jara; Torres-Aguila, Nuria P; Muino, Elena; Lledos, Miquel; Llucia-Carol, Laia; Esteller, Manel; Castro de Moura, Manuel et al. DOI: 10.1055/s-0042-1749328
PMID: 35599458 Journal: ANNALS OF NEUROLOGY Year: 2022 Reference: Ann Neurol. 2022 May 22. doi: 10.1002/ana.26418. Impact factor: 10.422 Publication type: Paper in international publication Authors: Sarraj, Amrou, Albers, Gregory W, Blasco, Jordi, Arenillas, Juan F, Ribo, Marc, Hassan, Ameer E, Perez de la Ossa, Natalia, Wu, Teddy Yuan-Hao, Cardona Portela, Pere, Abraham, Michael G et al. DOI: 10.1002/ana.26418
PMID: 34781064 Journal: EPILEPSY & BEHAVIOR Year: 2021 Reference: Epilepsy Behav. 2021 Dec;125:108395. doi: 10.1016/j.yebeh.2021.108395. Epub 2021 Nov 12. Impact factor: 2.937 Publication type: Paper in international publication Authors: Quintana, Manuel, Fonseca, Elena, Sanchez-Lopez, Javier, Mazuela, Gonzalo, Santamarina, Estevo, Abraira, Laura, Alvarez-Sabin, Jose, Toledo, Manuel et al. DOI: 10.1016/j.yebeh.2021.108395
PMID: 34455823 Journal: STROKE Year: 2021 Reference: Stroke. 2021 Dec;52(12):3908-3917. doi: 10.1161/STROKEAHA.121.034883. Epub 2021 Aug 30. Impact factor: 7.914 Publication type: Paper in international publication Authors: Martinez-Domeno, Alejandro, Prats-Sanchez, Luis, Guasch-Jimenez, Marina, Cardona, Pere, Nunez-Guillen, Ana, Requena, Manuel, Rubiera, Marta, Olive, Marta, Bustamante, Alejandro, Gomis, Meritxell et al. DOI: 10.1161/STROKEAHA.121.034883
PMID: 34375799 Journal: EPILEPSY & BEHAVIOR Year: 2021 Reference: Epilepsy Behav. 2021 Oct;123:108238. doi: 10.1016/j.yebeh.2021.108238. Epub 2021 Aug 7. Impact factor: 2.937 Publication type: Paper in international publication Authors: Turon, Marc, Jimenez-Balado, Joan, Abraira, Laura, Fonseca, Elena, Toledo, Manuel, Delgado, Pilar, Maisterra, Olga, Salas-Puig, Xavier, Alvarez-Sabin, Jose, Santamarina, Estevo et al. DOI: 10.1016/j.yebeh.2021.108238
PMID: 34338742 Journal: JAMA Neurology Year: 2021 Reference: JAMA Neurol. 2021 Sep 1;78(9):1099-1107. doi: 10.1001/jamaneurol.2021.2385. Impact factor: 18.302 Publication type: Paper in international publication Authors: Requena, Manuel, Olive-Gadea, Marta, Muchada, Marian, Hernandez, David, Rubiera, Marta, Boned, Sandra, Pinana, Carlos, Deck, Matias, Garcia-Tornel, Alvaro, Diaz-Silva, Humberto et al. DOI: 10.1001/jamaneurol.2021.2385
PMID: 33082494 Journal: Scientific Reports Year: 2020 Reference: Sci Rep. 2020 Oct 20;10(1):17838. doi: 10.1038/s41598-020-74880-6. Impact factor: 3.998 Publication type: Paper in international publication Authors: Lema, Camila, Andres, Mireia, Aguade-Bruix, Santiago, Consegal, Marta, Rodriguez-Sinovas, Antonio, Benito, Begona, Ferreira-Gonzalez, Ignacio, Barba, Ignasi et al. DOI: 10.1038/s41598-020-74880-6
PMID: 33066917 Journal: Journal of Stroke & Cerebrovascular Diseases Year: 2020 Reference: J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105225. doi: 10.1016/j.jstrokecerebrovasdis.2020.105225. Epub 2020 Aug 5. Impact factor: 1.787 Publication type: Paper in international publication Authors: Ribo, Marc, Molina, Carlos A, Tomasello, Alejandro, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Garcia-Tornel, Alvaro, Deck, Matias, Juega, Jesus, Boned, Sandra et al. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105225
PMID: 32907910 Journal: JOURNAL OF INVESTIGATIVE MEDICINE Year: 2020 Reference: J Investig Med. 2020 Dec;68(8):1379-1385. doi: 10.1136/jim-2020-001432. Epub 2020 Sep 8. Impact factor: 2.304 Publication type: Paper in international publication Authors: Cabezas, Juan Antonio, Bustamante, Alejandro, Giannini, Nicola, Pecharroman, Emilio, Katsanos, Aristeidis H, Tsivgoulis, Georgios, Rozanski, Michal, Audebert, Heinrich, Mondello, Stefania, Llombart, Victor et al. DOI: 10.1136/jim-2020-001432
PMID: 32868372 Journal: MOLECULAR & CELLULAR PROTEOMICS Year: 2020 Reference: Mol Cell Proteomics. 2020 Dec;19(12):1921-1935. doi: 10.1074/mcp.RA120.002283. Epub 2020 Aug 31. Impact factor: 4.87 Publication type: Paper in international publication Authors: Montaner, Joan, Bustamante, Alejandro, Simats, Alba, Ramiro, Laura, Garcia-Berrocoso, Teresa, Brianso, Ferran, Gonzalo, Ricardo, Martin, Luna, Sabe, Anna, Gill, Natalia et al. DOI: 10.1074/mcp.RA120.002283
PMID: 30582445 Journal: CIRCULATION RESEARCH Year: 2019 Reference: Circ Res. 2019 Jan 4;124(1):114-120. doi: 10.1161/CIRCRESAHA.118.313533. Impact factor: 15.862 Publication type: Paper in international publication Authors: Torres-Aguila, Nuria P, Mola-Caminal, Marina, Carrera, Caty, Soriano-Tarraga, Carolina, Giralt Steinhauer, Eva, Diaz-Navarro, Rosa M, Tur, Silvia, Jimenez, Carmen, Medina-Dols, Aina, Cullell, Natalia et al. DOI: 10.1161/CIRCRESAHA.118.313533
PMID: 31652649 Journal: Cells Year: 2019 Reference: Cells. 2019 Oct 22;8(10). pii: cells8101299. doi: 10.3390/cells8101299. Impact factor: 5.656 Publication type: Paper in international publication Authors: Valls-Lacalle, Laura, Negre-Pujol, Corall, Rodriguez, Cristina, Varona, Saray, Valera-Canellas, Antoni, Consegal, Marta, Martinez-Gonzalez, Jose, Rodriguez-Sinovas, Antonio et al. DOI: 10.3390/cells8101299
PMID: 31590472 Journal: Journal of Stroke Year: 2019 Reference: J Stroke. 2019 Sep;21(3):276-289. doi: 10.5853/jos.2019.01522. Epub 2019 Sep 30. Impact factor: 5.571 Publication type: Review in international publication Authors: Gallego-Fabrega, Cristina, Torres-Aguila, Nuria P, Carrera, Caty, Muino, Elena, Cullell, Natalia, Carcel-Marquez, Jara, Delgado, Pilar, Ibanez, Laura, Heitsch, Laura, Krupinski, Jerzy et al. DOI: 10.5853/jos.2019.01522
PMID: 31059794 Journal: Nanomedicine-Nanotechnology Biology and Medicine Year: 2019 Reference: Nanomedicine. 2019 Aug;20:101986. doi: 10.1016/j.nano.2019.03.008. Epub 2019 May 3. Impact factor: 5.57 Publication type: Paper in international publication Authors: Crich, Simonetta Geninatti, Alberti, Diego, Protti, Nicoletta, Comella, Joan X, Teixidor, Francesc, Rosell, Anna, Vinas, Clara, Grayston, Alba, Galenkamp, Koen M O, Morancho, Anna et al. DOI: 10.1016/j.nano.2019.03.008
PMID: 30133323 Journal: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY Year: 2018 Reference: Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C664-C674. doi: 10.1152/ajpcell.00200.2018. Epub 2018 Aug 22. Impact factor: 3.454 Publication type: Paper in international publication Authors: Esquiva, Gema, Grayston, Alba, Rosell, Anna et al. DOI: 10.1152/ajpcell.00200.2018
PMID: 30118928 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2018 Reference: Seizure. 2018 Oct;61:78-82. doi: 10.1016/j.seizure.2018.08.007. Epub 2018 Aug 11. Impact factor: 2.839 Publication type: Paper in international publication Authors: Toledo, Manuel, Fonseca, Elena, Olive, Marta, Requena, Manuel, Quintana, Manuel, Abraira-Del-Fresno, Laura, Salas-Puig, Xavier, Santamarina, Estevo et al. DOI: 10.1016/j.seizure.2018.08.007
PMID: 30093920 Journal: Therapeutic Advances in Neurological Disorders Year: 2018 Reference: Ther Adv Neurol Disord. 2018 Aug 6;11:1756286418789340. doi: 10.1177/1756286418789340. eCollection 2018. Impact factor: 4.75 Publication type: Review in international publication Authors: Ramiro, Laura, Simats, Alba, Garcia-Berrocoso, Teresa, Montaner, Joan et al. DOI: 10.1177/1756286418789340
PMID: 30049614 Journal: LANCET NEUROLOGY Year: 2018 Reference: Lancet Neurol. 2018 Sep;17(9):760-772. doi: 10.1016/S1474-4422(18)30244-8. Epub 2018 Jul 23. Impact factor: 27.138 Publication type: Paper in international publication Authors: Munoz-Cabello, Beatriz, Armangue, Thais, Spatola, Marianna, Vlagea, Alexandru, Mattozzi, Simone, Carceles-Cordon, Marc, Martinez-Heras, Eloy, Llufriu, Sara, Muchart, Jordi, Erro, Maria Elena et al. DOI: 10.1016/S1474-4422(18)30244-8
PMID: 27940648 Journal: NEUROLOGY Year: 2017 Reference: Neurology. 2017 Jan 17;88(3):245-251. doi: 10.1212/WNL.0000000000003517. Epub 2016 Dec 9. Impact factor: 8.32 Publication type: Clinical Trials Authors: Lopez-Cancio, Elena, Jovin, Tudor G, Cobo, Erik, Cerda, Neus, Jimenez, Marta, Gomis, Meritxell, Hernandez-Perez, Maria, Caceres, Cynthia, Cardona, Pere, Lara, Blanca et al. DOI: 10.1212/WNL.0000000000003517
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PMID: 27168059 Journal: CLINICAL NEUROPSYCHOLOGIST Year: 2016 Reference: Clin Neuropsychol. 2016 Jan-Dec;30(sup1):1443-1456. Epub 2016 May 11. Impact factor: 1.556 Publication type: Paper in international publication Authors: Riba-Llena, Iolanda, Nafria, Cristina, Giralt, Dolors, Fernandez-Cortinas, Ines, Jarca, Carmen Ioana, Mundet, Xavier, Tovar, Jose Luis, Orfila, Francesc, Castane, Xavier, Alvarez-Sabin, Jose et al. DOI: 10.1080/13854046.2016.1174307
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The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.
The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.
La recerca és fonamental per contrarestar els efectes de la pol·lució, que segons l’AEMPS, va ser la causa de més de 300.000 morts prematures a la UE el 2020.
