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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

Nora Guasch Capella

Nora Guasch Capella

Research technician
Neurovascular Diseases
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Ruiz Esteve, Fernando

Ruiz Esteve, Fernando

Research technician
Neurovascular Diseases
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Ana Rosa Olmo Muñoz

Ana Rosa Olmo Muñoz

Neurovascular Diseases
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Anna Penalba  Morenilla

Anna Penalba Morenilla

Main researcher
Neurovascular Diseases
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Anna Suades Juncadella

Anna Suades Juncadella

Research technician
Neurovascular Diseases
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Carlos Ernesto Marrero Eligio de la Puente

Carlos Ernesto Marrero Eligio de la Puente

Administration and Management
Neurovascular Diseases
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Nora Guasch Capella

Nora Guasch Capella

Research technician
Neurovascular Diseases
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Ruiz Esteve, Fernando

Ruiz Esteve, Fernando

Research technician
Neurovascular Diseases
Read more
Ana Rosa Olmo Muñoz

Ana Rosa Olmo Muñoz

Neurovascular Diseases
Read more
Anna Penalba  Morenilla

Anna Penalba Morenilla

Main researcher
Neurovascular Diseases
Read more
Anna Suades Juncadella

Anna Suades Juncadella

Research technician
Neurovascular Diseases
Read more
Carlos Ernesto Marrero Eligio de la Puente

Carlos Ernesto Marrero Eligio de la Puente

Administration and Management
Neurovascular Diseases
Read more

Projects

Tratamientos endovasculares de neuroprotección y neuroreparación en la recuperación del ictus.

IP: Anna Rosell Novel
Collaborators: Anna Penalba Morenilla, Paula Garcia Rodriguez, Miguel García Gabilondo
Funding agency: Instituto de Salud Carlos III
Funding: 141570
Reference: PI22/01055
Duration: 01/01/2023 - 31/12/2025

Alt risc de Fibril.lació Auricular, Ictus Silent i trastorn COgnitiu: estudi multicéntric, prospectiu i aleatori (PREFA-TE)

IP: -
Collaborators: Maria Pilar Delgado Martínez
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 27950.35
Reference: SLT021/21/000027
Duration: 01/04/2022 - 31/12/2024

RICORS-ICTUS

IP: Anna Rosell Novel
Collaborators: Marcel Lamana Vallverdu, Anna Penalba Morenilla, Anna Bonaterra Pastra, Maria Mar Hernandez Guillamon, Olga Maisterra Santos, Maria Pilar Delgado Martínez, Jesús Pizarro Gonzálvez
Funding agency: Instituto de Salud Carlos III
Funding: 250214.8
Reference: RD21/0006/0007
Duration: 01/01/2022 - 31/12/2024

PRESTIGE-AF: PREvention of STroke in Intracerebral hemorrhaGE survivors with Atrial Fibrillation

IP: Joan Montaner Villalonga
Collaborators: Anna Penalba Morenilla, Tamara Del Rio Higueras, Ariadna Martín Balcells, Olalla Pancorbo Rosal, Olga Sánchez- Maroto Carrizo, Amaia Latasa Arrazubi, Silvia Morata Perez, Daisy Guamán Pilco
Funding agency: EUROPEAN COMMISSION
Funding: 481723
Reference: PRESTIGE-AF_H2020SC12017
Duration: 01/12/2017 - 30/11/2024

Publications

Common and specific proteins and pathways in heart and cerebral ischemia.

PMID: 37944280
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2023
Reference: J Stroke Cerebrovasc Dis. 2023 Nov 7;33(1):107467. doi: 10.1016/j.jstrokecerebrovasdis.2023.107467.
Impact factor:
Publication type: Paper in international publication
Authors: Agudelo, Victor Hugo; Alonso, Javier Robles; Alvarez, Maria Eugenia Vazquez; Amat-Santos, Ignacio J; Andraka, Leire; Anton, Salvador Alvarez; Aquino, Rosa Sanchez; Arellano, Manuel Vizcaino; Arroyo, Jose Ramon Ruiz; Arzamendi, Dabit et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2023.107467

Minimally invasive surgery of the abdominal wall.

PMID: 37951468
Journal: Cirugia espanola
Year: 2023
Reference: Cir Esp (Engl Ed). 2023 Nov 9:S2173-5077(23)00193-X. doi: 10.1016/j.cireng.2023.01.009.
Impact factor:
Publication type: Paper in international publication
Authors: Bustamante, Alejandro; Delgado, Pilar; Escudero-Martinez, Irene; Garcia-Rodriguez, Paula; Guaman-Pilco, Daisy R; Jimenez-Balado, Joan; Lamana-Vallverdu, Marcel; Lopez Cano, Manuel; Montaner, Joan; Pala, Elena et al.
DOI: 10.1016/j.cireng.2023.01.009

Diesel exhaust particles exposure exacerbates pro-thrombogenic plasma features ex-vivo after cerebral ischemia and accelerates tPA-induced clot-lysis in hypertensive subjects.

PMID: 37974302
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2023
Reference: J Cereb Blood Flow Metab. 2023 Nov 16:271678X231214826. doi: 10.1177/0271678X231214826.
Impact factor:
Publication type: Paper in international publication
Authors: Arrue, Mercedes; Buxo, Xavier; Cacho Lavin, Diego; Cano, Juana Maria; Carmona-Bayonas, Alberto; Cerda, Paula; Cruz, Maria-Jesus; Custodio, Ana; de Homdedeu, Miquel; Delgado, Pilar et al.
DOI: 10.1177/0271678X231214826

Neonatal and Infant Lung Disorders: Glossary, Practical Approach, and Diagnoses.

PMID: 37982525
Journal: JOURNAL OF THORACIC IMAGING
Year: 2023
Reference: J Thorac Imaging. 2023 Nov 3. doi: 10.1097/RTI.0000000000000758.
Impact factor:
Publication type: Paper in international publication
Authors: Arrue, Mercedes; Buxo, Xavier; Chu, Winnie C; Concepcion, Nathan David P; Cruz, Maria-Jesus; Daltro, Pedro; de Homdedeu, Miquel; Delgado, Pilar; DiPrete, Olivia; Elicegui, Amaia et al.
DOI: 10.1097/RTI.0000000000000758

Endovascular Therapy versus No Endovascular Therapy in Patients receiving Best Medical Management for Acute Isolated Occlusion of the Posterior Cerebral Artery: Systematic Review and Meta-Analysis.

PMID: 35587104
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 May 19. doi: 10.1111/ene.15410.
Impact factor: 6.089
Publication type: Review in international publication
Authors: Berberich, Anne, Finitsis, Stephanos, Strambo, Davide, Michel, Patrik, Herweh, Christian, Meyer, Lukas, Hanning, Uta, Strbian, Daniel, Abdalkader, Mohamad, Nogueira, Raul G et al.
DOI: 10.1111/ene.15410

Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral beta-Amyloidosis: A Neuropathological Study.

PMID: 35563362
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Apr 29;23(9). pii: ijms23094972. doi: 10.3390/ijms23094972.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Marazuela, Paula, Paez-Montserrat, Berta, Bonaterra-Pastra, Anna, Sole, Montse, Hernandez-Guillamon, Mar et al.
DOI: 10.3390/ijms23094972

Patient-reported outcome measures after thrombectomy in patients with acute stroke: fine-tuning the modified Rankin Scale.

PMID: 35508380
Journal: Journal of NeuroInterventional Surgery
Year: 2022
Reference: J Neurointerv Surg. 2022 May 4. pii: neurintsurg-2022-018840. doi: 10.1136/neurintsurg-2022-018840.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Cano, David, Montiel, Estefania, Baladas, Maria, Sanchez-Gavilan, Esther, Paredes, Carolina, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Olive Gadea, Marta, Garcia-Tornel, Alvaro et al.
DOI: 10.1136/neurintsurg-2022-018840

Combined technique as first approach in mechanical thrombectomy: Efficacy and safety of REACT catheter combined with stent retriever.

PMID: 35491662
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2022
Reference: Interv Neuroradiol. 2022 May 2:15910199221095798. doi: 10.1177/15910199221095798.
Impact factor: 1.61
Publication type: Paper in international publication
Authors: Requena, Manuel, Pinana, Carlos, Olive-Gadea, Marta, Hernandez, David, Boned, Sandra, De Dios, Marta, Rodrigo, Marc, Rivera, Eila, Muchada, Marian, Cuevas, Jose Luis et al.
DOI: 10.1177/15910199221095798

New candidate blood biomarkers potentially associated with white matter hyperintensities progression.

PMID: 34253757
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Jul 12;11(1):14324. doi: 10.1038/s41598-021-93498-w.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Jimenez-Balado, Joan, Pizarro, Jesus, Riba-Llena, Iolanda, Penalba, Anna, Faura, Julia, Pala, Elena, Montaner, Joan, Hernandez-Guillamon, Mar, Delgado, Pilar et al.
DOI: 10.1038/s41598-021-93498-w

Angiogenin in the Neurogenic Subventricular Zone After Stroke.

PMID: 34234733
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Jun 21;12:662235. doi: 10.3389/fneur.2021.662235. eCollection 2021.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: Gabriel-Salazar, Marina, Lei, Ting, Grayston, Alba, Costa, Carme, Medina-Gutierrez, Esperanza, Comabella, Manuel, Montaner, Joan, Rosell, Anna et al.
DOI: 10.3389/fneur.2021.662235

Survival Bias and Crosstalk between Chronological and Behavioral Age: Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging.

PMID: 34199476
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Jun 2;9(6). pii: biomedicines9060636. doi: 10.3390/biomedicines9060636.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Hernandez-Guillamon, Mar, Marazuela, Paula, Marin-Pardo, Daniela, Gimenez-Llort, Lydia et al.
DOI: 10.3390/biomedicines9060636

Relationship between sleep quality and cognitive performance in patients with epilepsy.

PMID: 34147020
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Sep;122:108127. doi: 10.1016/j.yebeh.2021.108127. Epub 2021 Jun 17.
Impact factor: 2.937
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Seijo-Raposo, Ivan, Quintana, Manuel, Toledo, Manuel, Abraira, Laura, Falip, Merce, Mauri Llerda, Jose Angel, Fonseca, Elena, Campos Blanco, Dulce M, Castro Vilanova, Maria Dolores et al.
DOI: 10.1016/j.yebeh.2021.108127

Blood biomarkers predictive of epilepsy after an acute stroke event.

PMID: 32857458
Journal: EPILEPSIA
Year: 2020
Reference: Epilepsia. 2020 Oct;61(10):2244-2253. doi: 10.1111/epi.16648. Epub 2020 Aug 28.
Impact factor: 6.04
Publication type: Paper in international publication
Authors: Terceno, Mikel, Zaragoza, Josep, Canovas, David, Gasull, Teresa, Ustrell, Xavier, Rubiera, Marta, Castellanos, Mar, Montaner, Joan, Alvarez-Sabin, Jose, Cardona, Pere et al.
DOI: 10.1111/epi.16648

Deep Learning Based Software to Identify Large Vessel Occlusion on Noncontrast Computed Tomography.

PMID: 32842922
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Oct;51(10):3133-3137. doi: 10.1161/STROKEAHA.120.030326. Epub 2020 Aug 26.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Crespo, Carlos, Granes, Cristina, Hernandez-Perez, Maria, Perez de la Ossa, Natalia, Laredo, Carlos, Urra, Xabier, Carlos Soler, Juan, Puyalto, Paloma, Cuadras, Patricia et al.
DOI: 10.1161/STROKEAHA.120.030326

Association of initial imaging modality and futile recanalization after thrombectomy.

PMID: 32847948
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Oct 27;95(17):e2331-e2342. doi: 10.1212/WNL.0000000000010614. Epub 2020 Aug 26.
Impact factor: 8.77
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Meinel, Thomas Raphael, Kaesmacher, Johannes, Mosimann, Pascal John, Seiffge, David, Jung, Simon, Mordasini, Pasquale, Arnold, Marcel, Goeldlin, Martina, Hajdu, Steven D et al.
DOI: 10.1212/WNL.0000000000010614

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

PMID: 32807790
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Aug 17;11(1):4110. doi: 10.1038/s41467-020-17901-2.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Pitrez, Patricia R, Colell, Guillem, Vazao, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire, Egesipe, Anne-Laure, Carvalho, Tania, Dos Santos, Rodrigo L et al.
DOI: 10.1038/s41467-020-17901-2

Application of an Aptamer-Based Proteomics Assay (SOMAscan) in Rat Cerebrospinal Fluid.

PMID: 31432415
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2019
Reference: Methods Mol Biol. 2019;2044:221-231. doi: 10.1007/978-1-4939-9706-0_13.
Impact factor: 0
Publication type: Paper in international publication
Authors: Simats, Alba, Ramiro, Laura, Montaner, Joan, Garcia-Berrocoso, Teresa et al.
DOI: 10.1007/978-1-4939-9706-0_13

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.

PMID: 31366724
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Aug 27;93(9):e851-e863. doi: 10.1212/WNL.0000000000007997. Epub 2019 Jul 31.
Impact factor: 8.689
Publication type: Paper in international publication
Authors: Davalos, Antonio, Lopez-Cancio, Elena, Ribo, Marc, Molina, Carlos A, Giralt-Steinhauer, Eva, Soriano-Tarraga, Carolina, Mola-Caminal, Marina, Jimenez-Conde, Jordi, Roquer, Jaume, Vives-Bauza, Cristofol et al.
DOI: 10.1212/WNL.0000000000007997

Use of intravenous brivaracetam in status epilepticus: A multicenter registry.

PMID: 31260101
Journal: EPILEPSIA
Year: 2019
Reference: Epilepsia. 2019 Aug;60(8):1593-1601. doi: 10.1111/epi.16094. Epub 2019 Jul 1.
Impact factor: 5.562
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Parejo Carbonell, Beatriz, Sala, Jacint, Gutierrez-Viedma, Alvaro, Miro, Julia, Asensio, Montserrat, Abraira, Laura, Falip, Merce, Ojeda, Joaquin, Lopez-Gonzalez, Francisco Javier et al.
DOI: 10.1111/epi.16094

Comments on: "Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage".

PMID: 31256985
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2019
Reference: J Stroke Cerebrovasc Dis. 2019 Sep;28(9):2585-2586. doi: 10.1016/j.jstrokecerebrovasdis.2019.06.014. Epub 2019 Jun 28.
Impact factor: 1.646
Publication type: Letter or abstract
Authors: Ramiro, Laura, Simats, Alba, Penalba, Anna, Gill-Testa, Natalia, Bustamante, Alejandro, Montaner, Joan et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.014

Prognosis of post-stroke status epilepticus: Effects of time difference between the two events.

PMID: 30015150
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Aug;60:172-177. doi: 10.1016/j.seizure.2018.07.006. Epub 2018 Jul 9.
Impact factor: 2.839
Publication type: Paper in international publication
Authors: Gonzalez-Cuevas, Montserrat, Quintana, Manuel, Maisterra, Olga, Sueiras, Maria, Guzman, Lorena, Salas-Puig, Javier, Sabin, Jose Alvarez, Toledo, Manuel, Abraira, Laura, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2018.07.006

Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia.

PMID: 30008694
Journal: Frontiers in Neurology
Year: 2018
Reference: Front Neurol. 2018 Jun 29;9:508. doi: 10.3389/fneur.2018.00508. eCollection 2018.
Impact factor: 3.508
Publication type: Paper in international publication
Authors: Montaner, Joan, Gabriel-Salazar, Marina, Morancho, Anna, Rodriguez, Susana, Buxó, Xavi, Garcia Rodriguez, Nicolas, Colell, Guillem, Fernandez, Albert, Giralt, Dolors, Bustamante, Alejandro et al.
DOI: 10.3389/fneur.2018.00508

[Social cognition and cognitive functions in patients with epilepsy treated with eslicarbazepine acetate].

PMID: 29790568
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Jun 1;66(11):361-367.
Impact factor: 0.601
Publication type: Paper in national publication
Authors: Abraira, L, Sanabria, A, Ortega, G, Santamarina, E, Salas-Puig, J, Toledo, M, Quintana, M et al.
DOI:

Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.

PMID: 29784938
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 May 21;8(1):7899. doi: 10.1038/s41598-018-26237-3.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Simats, Alba, Garcia-Berrocoso, Teresa, Ramiro, Laura, Giralt, Dolors, Gill, Natalia, Penalba, Anna, Bustamante, Alejandro, Rosell, Anna, Montaner, Joan et al.
DOI: 10.1038/s41598-018-26237-3

Assessment of enlarged perivascular spaces and their relation to target organ damage and mild cognitive impairment in patients with hypertension.

PMID: 26968973
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2016
Reference: Eur J Neurol. 2016 Jun;23(6):1044-50. doi: 10.1111/ene.12979. Epub 2016 Mar 10.
Impact factor: 3.956
Publication type: Paper in international publication
Authors: Delgado, P, Riba-Llena, I, Nafria, C, Mundet, X, Lopez-Rueda, A, Fernandez-Cortinas, I, Jarca, C I, Jimenez-Balado, J, Domingo, M, Tovar, J L et al.
DOI: 10.1111/ene.12979

Blog

News

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.

La recerca és fonamental per contrarestar els efectes de la pol·lució, que segons l’AEMPS, va ser la causa de més de 300.000 morts prematures a la UE el 2020.

The international study has identified 89 genes involved in the risk of developing a stroke, 61 of which had not been previously described.

Job offers

Research Technician
Start date:
12/06/2023
End date:
26/06/2023
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Statistician Neurovascular
Start date:
09/06/2023
End date:
23/06/2023
Document: Download
Research technician- Neurovascular Research Laboratory
Start date:
09/04/2023
End date:
23/04/2023
Document: Download