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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Publications

Comparative analysis between 1-D, 2-D and 3-D carotid web quantification.

PMID: 35172982
Journal: Journal of NeuroInterventional Surgery
Year: 2022
Reference: J Neurointerv Surg. 2022 Feb 16. pii: neurintsurg-2021-018192. doi: 10.1136/neurintsurg-2021-018192.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Perry da Camara, Catarina, Nogueira, Raul G, Al-Bayati, Alhamza R, Pisani, Leonardo, Mohammaden, Mahmoud, Allen, Jason W, Nahab, Fadi, Olive Gadea, Marta, Frankel, Michael R, Haussen, Diogo C et al.
DOI: 10.1136/neurintsurg-2021-018192

Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke.

PMID: 34229512
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2022
Reference: J Cereb Blood Flow Metab. 2022 Feb;42(2):237-252. doi: 10.1177/0271678X211028816. Epub 2021 Jul 6.
Impact factor: 6.2
Publication type: Paper in international publication
Authors: Grayston, Alba, Zhang, Yajie, Garcia-Gabilondo, Miguel, Arrue, Mercedes, Martin, Abraham, Kopcansky, Peter, Timko, Milan, Kovac, Jozef, Strbak, Oliver, Castellote, Laura et al.
DOI: 10.1177/0271678X211028816

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion.

PMID: 34747975
Journal: JAMA Neurology
Year: 2022
Reference: JAMA Neurol. 2022 Jan 1;79(1):22-31. doi: 10.1001/jamaneurol.2021.4082.
Impact factor: 18.302
Publication type: Paper in international publication
Authors: Salazar-Marioni, Sergio, Kuhn, Anna L, Kaliaev, Artem, Farzin, Behzad, Boisseau, William, Masoud, Hesham E, Lopez, Carlos Ynigo, Rana, Ameena, Kareem, Samer Abdul, Sathya, Anvitha et al.
DOI: 10.1001/jamaneurol.2021.4082

New candidate blood biomarkers potentially associated with white matter hyperintensities progression.

PMID: 34253757
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Jul 12;11(1):14324. doi: 10.1038/s41598-021-93498-w.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Jimenez-Balado, Joan, Pizarro, Jesus, Riba-Llena, Iolanda, Penalba, Anna, Faura, Julia, Pala, Elena, Montaner, Joan, Hernandez-Guillamon, Mar, Delgado, Pilar et al.
DOI: 10.1038/s41598-021-93498-w

Angiogenin in the Neurogenic Subventricular Zone After Stroke.

PMID: 34234733
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Jun 21;12:662235. doi: 10.3389/fneur.2021.662235. eCollection 2021.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: Gabriel-Salazar, Marina, Lei, Ting, Grayston, Alba, Costa, Carme, Medina-Gutierrez, Esperanza, Comabella, Manuel, Montaner, Joan, Rosell, Anna et al.
DOI: 10.3389/fneur.2021.662235

Survival Bias and Crosstalk between Chronological and Behavioral Age: Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging.

PMID: 34199476
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Jun 2;9(6). pii: biomedicines9060636. doi: 10.3390/biomedicines9060636.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Hernandez-Guillamon, Mar, Marazuela, Paula, Marin-Pardo, Daniela, Gimenez-Llort, Lydia et al.
DOI: 10.3390/biomedicines9060636

Relationship between sleep quality and cognitive performance in patients with epilepsy.

PMID: 34147020
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Sep;122:108127. doi: 10.1016/j.yebeh.2021.108127. Epub 2021 Jun 17.
Impact factor: 2.937
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Seijo-Raposo, Ivan, Quintana, Manuel, Toledo, Manuel, Abraira, Laura, Falip, Merce, Mauri Llerda, Jose Angel, Fonseca, Elena, Campos Blanco, Dulce M, Castro Vilanova, Maria Dolores et al.
DOI: 10.1016/j.yebeh.2021.108127

Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.

PMID: 33173895
Journal:
Year: 2020
Reference: medRxiv. 2020 Nov 3:2020.10.29.20222257. doi: 10.1101/2020.10.29.20222257. Preprint.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Amini, Hajar; Ander, Bradley P; Arauz, Antonio; Arenillas, Juan Francisco; Arias-Rivas, Susana; Bang, Oh Young; Barboza, Miguel A; Bergmann, Kristy; Bradley, Joseph; Budde, John et al.
DOI: 10.1101/2020.10.29.20222257

Management of acute stroke. Specific nursing care and treatments in the stroke unit.

PMID: 33153769
Journal: NEUROLOGIA
Year: 2020
Reference: Neurologia. 2020 Nov 2. pii: S0213-4853(20)30291-7. doi: 10.1016/j.nrl.2020.07.025.
Impact factor: 2.283
Publication type: Review in national publication
Authors: Rodriguez-Luna, D, Sanjuan, E, Pancorbo, O, Santana, K, Minarro, O, Sala, V, Muchada, M, Boned, S, Juega, J M, Pagola, J et al.
DOI: 10.1016/j.nrl.2020.07.025

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.

PMID: 33146036
Journal: CEPHALALGIA
Year: 2020
Reference: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157.
Impact factor: 4.868
Publication type: Paper in international publication
Authors: Caronna, Edoardo, Ballve, Alejandro, Llaurado, Arnau, Gallardo, Victor Jose, Maria Ariton, Diana, Lallana, Sofia, Maza, Samuel Lopez, Gadea, Marta Olive, Quibus, Laura, Restrepo, Juan Luis et al.
DOI: 10.1177/0333102420965157

The mediating role of epileptic seizures, irritability, and depression on quality of life in people with epilepsy.

PMID: 33129044
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Dec;113:107511. doi: 10.1016/j.yebeh.2020.107511. Epub 2020 Oct 24.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Quintana, Manuel, Abraira, Laura, Seijo-Raposo, Ivan, Santamarina, Estevo, Toledo, Manuel, Fonseca, Elena, Campos-Fernandez, Daniel et al.
DOI: 10.1016/j.yebeh.2020.107511

Application of an Aptamer-Based Proteomics Assay (SOMAscan) in Rat Cerebrospinal Fluid.

PMID: 31432415
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2019
Reference: Methods Mol Biol. 2019;2044:221-231. doi: 10.1007/978-1-4939-9706-0_13.
Impact factor: 0
Publication type: Paper in international publication
Authors: Simats, Alba, Ramiro, Laura, Montaner, Joan, Garcia-Berrocoso, Teresa et al.
DOI: 10.1007/978-1-4939-9706-0_13

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.

PMID: 31366724
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Aug 27;93(9):e851-e863. doi: 10.1212/WNL.0000000000007997. Epub 2019 Jul 31.
Impact factor: 8.689
Publication type: Paper in international publication
Authors: Davalos, Antonio, Lopez-Cancio, Elena, Ribo, Marc, Molina, Carlos A, Giralt-Steinhauer, Eva, Soriano-Tarraga, Carolina, Mola-Caminal, Marina, Jimenez-Conde, Jordi, Roquer, Jaume, Vives-Bauza, Cristofol et al.
DOI: 10.1212/WNL.0000000000007997

Use of intravenous brivaracetam in status epilepticus: A multicenter registry.

PMID: 31260101
Journal: EPILEPSIA
Year: 2019
Reference: Epilepsia. 2019 Aug;60(8):1593-1601. doi: 10.1111/epi.16094. Epub 2019 Jul 1.
Impact factor: 5.562
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Parejo Carbonell, Beatriz, Sala, Jacint, Gutierrez-Viedma, Alvaro, Miro, Julia, Asensio, Montserrat, Abraira, Laura, Falip, Merce, Ojeda, Joaquin, Lopez-Gonzalez, Francisco Javier et al.
DOI: 10.1111/epi.16094

Comments on: "Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage".

PMID: 31256985
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2019
Reference: J Stroke Cerebrovasc Dis. 2019 Sep;28(9):2585-2586. doi: 10.1016/j.jstrokecerebrovasdis.2019.06.014. Epub 2019 Jun 28.
Impact factor: 1.646
Publication type: Letter or abstract
Authors: Ramiro, Laura, Simats, Alba, Penalba, Anna, Gill-Testa, Natalia, Bustamante, Alejandro, Montaner, Joan et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.014

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

PMID: 30049614
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Sep;17(9):760-772. doi: 10.1016/S1474-4422(18)30244-8. Epub 2018 Jul 23.
Impact factor: 27.138
Publication type: Paper in international publication
Authors: Munoz-Cabello, Beatriz, Armangue, Thais, Spatola, Marianna, Vlagea, Alexandru, Mattozzi, Simone, Carceles-Cordon, Marc, Martinez-Heras, Eloy, Llufriu, Sara, Muchart, Jordi, Erro, Maria Elena et al.
DOI: 10.1016/S1474-4422(18)30244-8

Prognosis of post-stroke status epilepticus: Effects of time difference between the two events.

PMID: 30015150
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Aug;60:172-177. doi: 10.1016/j.seizure.2018.07.006. Epub 2018 Jul 9.
Impact factor: 2.839
Publication type: Paper in international publication
Authors: Gonzalez-Cuevas, Montserrat, Quintana, Manuel, Maisterra, Olga, Sueiras, Maria, Guzman, Lorena, Salas-Puig, Javier, Sabin, Jose Alvarez, Toledo, Manuel, Abraira, Laura, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2018.07.006

Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia.

PMID: 30008694
Journal: Frontiers in Neurology
Year: 2018
Reference: Front Neurol. 2018 Jun 29;9:508. doi: 10.3389/fneur.2018.00508. eCollection 2018.
Impact factor: 3.508
Publication type: Paper in international publication
Authors: Montaner, Joan, Gabriel-Salazar, Marina, Morancho, Anna, Rodriguez, Susana, Buxó, Xavi, Garcia Rodriguez, Nicolas, Colell, Guillem, Fernandez, Albert, Giralt, Dolors, Bustamante, Alejandro et al.
DOI: 10.3389/fneur.2018.00508

[Social cognition and cognitive functions in patients with epilepsy treated with eslicarbazepine acetate].

PMID: 29790568
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Jun 1;66(11):361-367.
Impact factor: 0.601
Publication type: Paper in national publication
Authors: Abraira, L, Sanabria, A, Ortega, G, Santamarina, E, Salas-Puig, J, Toledo, M, Quintana, M et al.
DOI:

Assessment of enlarged perivascular spaces and their relation to target organ damage and mild cognitive impairment in patients with hypertension.

PMID: 26968973
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2016
Reference: Eur J Neurol. 2016 Jun;23(6):1044-50. doi: 10.1111/ene.12979. Epub 2016 Mar 10.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, J; Delgado, P; Domingo, M; Fernandez-Cortinas, I; Jarca, C I; Jimenez-Balado, J; Lopez-Rueda, A; Maisterra, O; Montaner, J; Mundet, X et al.
DOI: 10.1111/ene.12979

Increased von Willebrand factor, P-selectin and fibrin content in occlusive thrombus resistant to lytic therapy.

PMID: 26962963
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2016
Reference: Thromb Haemost. 2016 Jun 2;115(6):1129-37. doi: 10.1160/TH15-12-0985. Epub 2016 Mar 10.
Impact factor:
Publication type: Paper in international publication
Authors: Baneras, Jordi; Barrabes, Jose A; Figueras, Jaume; Francisco, Jaume; Garcia Del Blanco, Bruno; Garcia-Dorado, David; Montaner, Joan; Otaegui, Imanol; Rojas, Angeles; Ruiz-Meana, Marisol et al.
DOI: 10.1160/TH15-12-0985

Identification of Plasma Biomarkers of Human Intracerebral Hemorrhage Subtypes through Microarray Technology.

PMID: 26738811
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2016
Reference: J Stroke Cerebrovasc Dis. 2016 Mar;25(3):665-71. doi: 10.1016/j.jstrokecerebrovasdis.2015.11.032. Epub 2015 Dec 29.
Impact factor:
Publication type: Paper in international publication
Authors: Delgado, Pilar; Fernandez de Retana, Sofia; Fernandez-Cadenas, Israel; Hernandez-Guillamon, Mar; Merino-Zamorano, Cristina; Montaner, Joan; Rodriguez-Luna, David et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.032

ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy.

PMID: 26661731
Journal: NEUROMOLECULAR MEDICINE
Year: 2016
Reference: Neuromolecular Med. 2016 Mar;18(1):99-108. doi: 10.1007/s12017-015-8381-7. Epub 2015 Dec 14.
Impact factor:
Publication type: Paper in international publication
Authors: de Retana, Sofia Fernandez; Fernandez-Alvarez, Paula; Hernandez-Guillamon, Mar; Lopez-Rueda, Antonio; Malagelada, Ana; Merino-Zamorano, Cristina; Montaner, Joan; Montanola, Alex; Penalba, Anna; Pujadas, Francesc et al.
DOI: 10.1007/s12017-015-8381-7

Monitoring of Cortical Activity Postreperfusion. A Powerful Tool for Predicting Clinical Response Immediately After Recanalization.

PMID: 24641595
Journal: J NEUROIMAGING
Year: 2015
Reference: J Neuroimaging. 2015 Mar;25(2):257-62. doi: 10.1111/jon.12113. Epub 2014 Mar 19.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Flores, Alan; Gonzalez-Cuevas, Montserrat; Kallas, Julia; Meler, Pilar; Molina, Carlos A; Montaner, Joan; Muchada, Marian; Pagola, Jorge; Ribo, Marc et al.
DOI: 10.1111/jon.12113

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives.

PMID: 26597154
Journal: Journal of the American Heart Association
Year: 2015
Reference: J Am Heart Assoc. 2015 Nov 23;4(11). pii: JAHA.115.002669. doi: 10.1161/JAHA.115.002669.
Impact factor: 4.306
Publication type: Paper in international publication
Authors: Delgado, Pilar, Montaner, Joan, Libert, Claude, Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Vanhooren, Valerie, Dewaele, Sylviane, Penalba, Anna et al.
DOI: 10.1161/JAHA.115.002669

Small cortical infarcts: prevalence, determinants, and cognitive correlates in the general population.

PMID: 26043763
Journal: International Journal of Stroke
Year: 2015
Reference: Int J Stroke. 2015 Oct;10 Suppl A100:18-24. doi: 10.1111/ijs.12543. Epub 2015 Jun 4.
Impact factor: 3.833
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Koek, Marcel, Verhaaren, Benjamin F J, Vrooman, Henri A, van der Lugt, Aad, Hofman, Albert, Ikram, M Arfan, Vernooij, Meike W et al.
DOI: 10.1111/ijs.12543

B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis.

PMID: 25765726
Journal: STROKE
Year: 2015
Reference: Stroke. 2015 May;46(5):1187-95. doi: 10.1161/STROKEAHA.114.008311. Epub 2015 Mar 12.
Impact factor: 5.723
Publication type: Review in international publication
Authors: Etgen, Thorleif, Llombart, Victor, Antolin-Fontes, Albert, Bustamante, Alejandro, Giralt, Dolors, Rost, Natalia S, Furie, Karen, Shibazaki, Kensaku, Biteker, Murat, Castillo, Jose et al.
DOI: 10.1161/STROKEAHA.114.008311

Prevalence and associated factors of silent brain infarcts in a Mediterranean cohort of hypertensives.

PMID: 24958500
Journal: HYPERTENSION
Year: 2014
Reference: Hypertension. 2014 Sep;64(3):658-63. doi: 10.1161/HYPERTENSIONAHA.114.03563. Epub 2014 Jun 23.
Impact factor: 7.632
Publication type: Clinical Trials
Authors: Delgado, Pilar, Riba-Llena, Iolanda, Tovar, Jose L, Jarca, Carmen I, Mundet, Xavier, Lopez-Rueda, Antonio, Orfila, Francesc, Llussa, Judit, Manresa, Josep M, Alvarez-Sabin, Jose et al.
DOI: 10.1161/HYPERTENSIONAHA.114.03563

Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model.

PMID: 24661059
Journal: J NEUROCHEM
Year: 2014
Reference: J Neurochem. 2014 Jul;130(2):301-12. doi: 10.1111/jnc.12719. Epub 2014 Apr 30.
Impact factor: 4.244
Publication type: Paper in international publication
Authors: Campos-Martorell, Mireia, Salvador, Nelida, Monge, Marta, Canals, Francesc, Garcia-Bonilla, Lidia, Hernandez-Guillamon, Mar, Ayuso, Maria Irene, Chacon, Pilar, Rosell, Anna, Alcazar, Alberto et al.
DOI: 10.1111/jnc.12719

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.