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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Publications

Thumb-up sign: Characterization of an undescribed seizure semiologic sign.

PMID: 34015572
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2021
Reference: Seizure. 2021 Jul;89:62-64. doi: 10.1016/j.seizure.2021.04.029. Epub 2021 May 11.
Impact factor: 3.184
Publication type: Letter whit IF
Authors: Vilaseca, Andreu, Fonseca, Elena, Anciones Martin, Carla, Seijo-Raposo, Ivan, Abraira, Laura, Santamarina, Estevo, Quintana, Manuel, Alvarez-Sabin, Jose, Gil-Nagel, Antonio, Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2021.04.029

Status epilepticus without impairment of consciousness: Long-term outcomes according to duration.

PMID: 33992961
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Jul;120:108007. doi: 10.1016/j.yebeh.2021.108007. Epub 2021 May 13.
Impact factor: 2.937
Publication type: Paper in international publication
Authors: Santamarina, E, Parejo-Carbonell, B, Abraira, L, Gutierrez-Viedma, A, Fonseca, E, Seijo, I, Abarrategui, B, Salas-Puig, X, Quintana, M, Toledo, M et al.
DOI: 10.1016/j.yebeh.2021.108007

Implications of initiating antiseizure drugs prior to the performance of EEG in first epileptic seizures.

PMID: 33875301
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia (Engl Ed). 2021 Apr 16. pii: S0213-4853(21)00053-0. doi: 10.1016/j.nrl.2021.02.014.
Impact factor: 3.109
Publication type: Paper in national publication
Authors: Llaurado, A, Quintana, M, Fonseca, E, Abraira, L, Toledo, M, Requena, M, Olive, M, Ballve, A, Campos, D, Sueiras, M et al.
DOI: 10.1016/j.nrl.2021.02.014

COVID-19 Infection in Critically Ill Patients Carries a High Risk of Venous Thrombo-embolism.

PMID: 33583710
Journal: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
Year: 2021
Reference: Eur J Vasc Endovasc Surg. 2021 Apr;61(4):628-634. doi: 10.1016/j.ejvs.2020.12.015. Epub 2020 Dec 23.
Impact factor: 7.069
Publication type: Paper in international publication
Authors: Ferrer, Ricard, de Nadal, Miriam, Monreal, Manel, Llagostera, Secundino, Ruiz-Rodriguez, Juan Carlos, Gil, Miquel, Martinez-Carnovale, Lucia, Bellmunt-Montoya, Sergi, Riera, Claudia, Gil, Daniel et al.
DOI: 10.1016/j.ejvs.2020.12.015

(1)H NMR serum metabolomic profiling of patients at risk of cardiovascular diseases performing stress test.

PMID: 33082494
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Oct 20;10(1):17838. doi: 10.1038/s41598-020-74880-6.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Lema, Camila, Andres, Mireia, Aguade-Bruix, Santiago, Consegal, Marta, Rodriguez-Sinovas, Antonio, Benito, Begona, Ferreira-Gonzalez, Ignacio, Barba, Ignasi et al.
DOI: 10.1038/s41598-020-74880-6

COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center.

PMID: 33066917
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2020
Reference: J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105225. doi: 10.1016/j.jstrokecerebrovasdis.2020.105225. Epub 2020 Aug 5.
Impact factor: 1.787
Publication type: Paper in international publication
Authors: Ribo, Marc, Molina, Carlos A, Tomasello, Alejandro, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Garcia-Tornel, Alvaro, Deck, Matias, Juega, Jesus, Boned, Sandra et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105225

Discriminative value of glial fibrillar acidic protein (GFAP) as a diagnostic tool in acute stroke. Individual patient data meta-analysis.

PMID: 32907910
Journal: JOURNAL OF INVESTIGATIVE MEDICINE
Year: 2020
Reference: J Investig Med. 2020 Dec;68(8):1379-1385. doi: 10.1136/jim-2020-001432. Epub 2020 Sep 8.
Impact factor: 2.304
Publication type: Paper in international publication
Authors: Cabezas, Juan Antonio, Bustamante, Alejandro, Giannini, Nicola, Pecharroman, Emilio, Katsanos, Aristeidis H, Tsivgoulis, Georgios, Rozanski, Michal, Audebert, Heinrich, Mondello, Stefania, Llombart, Victor et al.
DOI: 10.1136/jim-2020-001432

A mouse brain-based multi-omics integrative approach reveals potential blood biomarkers for ischemic stroke.

PMID: 32868372
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2020
Reference: Mol Cell Proteomics. 2020 Dec;19(12):1921-1935. doi: 10.1074/mcp.RA120.002283. Epub 2020 Aug 31.
Impact factor: 4.87
Publication type: Paper in international publication
Authors: Montaner, Joan, Bustamante, Alejandro, Simats, Alba, Ramiro, Laura, Garcia-Berrocoso, Teresa, Brianso, Ferran, Gonzalo, Ricardo, Martin, Luna, Sabe, Anna, Gill, Natalia et al.
DOI: 10.1074/mcp.RA120.002283

When to Stop.

PMID: 31177974
Journal: STROKE
Year: 2019
Reference: Stroke. 2019 Jul;50(7):1781-1788. doi: 10.1161/STROKEAHA.119.025088. Epub 2019 Jun 10.
Impact factor: 6.046
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Garcia-Tornel, Alvaro, Requena, Manuel, Rubiera, Marta, Muchada, Marian, Pagola, Jorge, Rodriguez-Luna, David, Deck, Matias, Juega, Jesus, Rodriguez-Villatoro, Noelia et al.
DOI: 10.1161/STROKEAHA.119.025088

Matrix metalloproteinases and ADAMs in stroke.

PMID: 31165904
Journal: CELLULAR AND MOLECULAR LIFE SCIENCES
Year: 2019
Reference: Cell Mol Life Sci. 2019 Aug;76(16):3117-3140. doi: 10.1007/s00018-019-03175-5. Epub 2019 Jun 5.
Impact factor: 7.014
Publication type: Review in international publication
Authors: Montaner, Joan, Ramiro, Laura, Simats, Alba, Hernandez-Guillamon, Mar, Delgado, Pilar, Bustamante, Alejandro, Rosell, Anna et al.
DOI: 10.1007/s00018-019-03175-5

Effect of brivaracetam on the anger levels of epilepsy patients. A prospective open-labelled controlled study.

PMID: 31079028
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Jul;69:198-203. doi: 10.1016/j.seizure.2019.04.021. Epub 2019 May 1.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Toledo, Manuel, Abraira, Laura, Mazuela, Gonzalo, Quintana, Manuel, Cazorla, Sonia, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2019.04.021

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice.

PMID: 31077261
Journal: Alzheimers Research & Therapy
Year: 2019
Reference: Alzheimers Res Ther. 2019 May 10;11(1):42. doi: 10.1186/s13195-019-0498-8.
Impact factor: 6.142
Publication type: Paper in international publication
Authors: Bonaterra, Anna, Sanchez-Quesada, Jose Luis, Montaner, Joan, Maspoch, Daniel, Cano-Sarabia, Mary, Hernandez-Guillamon, Mar, Colell, Guillem, Sole, Montse, Marazuela, Paula, de Retana, Sofia Fernandez et al.
DOI: 10.1186/s13195-019-0498-8

Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.

PMID: 29784938
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 May 21;8(1):7899. doi: 10.1038/s41598-018-26237-3.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Simats, Alba, Garcia-Berrocoso, Teresa, Ramiro, Laura, Giralt, Dolors, Gill, Natalia, Penalba, Anna, Bustamante, Alejandro, Rosell, Anna, Montaner, Joan et al.
DOI: 10.1038/s41598-018-26237-3

Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load.

PMID: 29669870
Journal: STROKE
Year: 2018
Reference: Stroke. 2018 May;49(5):1279-1281. doi: 10.1161/STROKEAHA.118.020163. Epub 2018 Apr 18.
Impact factor: 6.239
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Jimenez-Balado, Joan, Castane, Xavier, Girona, Anna, Lopez-Rueda, Antonio, Mundet, Xavier, Jarca, Carmen I, Alvarez-Sabin, Jose, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/STROKEAHA.118.020163

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

PMID: 29531354
Journal: NATURE GENETICS
Year: 2018
Reference: Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12.
Impact factor: 27.125
Publication type: Paper in international publication
Authors: Haessler, Jeffrey, Brown, Robert D Jr, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana et al.
DOI: 10.1038/s41588-018-0058-3

Obstructive sleep apnea and silent cerebral infarction in hypertensive individuals.

PMID: 28631309
Journal: JOURNAL OF SLEEP RESEARCH
Year: 2018
Reference: J Sleep Res. 2018 Apr;27(2):232-239. doi: 10.1111/jsr.12571. Epub 2017 Jun 20.
Impact factor: 3.433
Publication type: Paper in international publication
Authors: Montaner, Joan, Alvarez-Sabin, Jose, Romero, Odile, Delgado, Pilar, Quintana, Manuel, Santamarina, Estevo, Ferre, Alex, Maisterra, Olga, Riba-Llena, Iolanda, Sampol, Gabriel et al.
DOI: 10.1111/jsr.12571

Characterization of secretomes from a human blood brain barrier endothelial cells in-vitro model after ischemia by stable isotope labeling with aminoacids in cell culture (SILAC).

PMID: 26718731
Journal: Journal of Proteomics
Year: 2016
Reference: J Proteomics. 2016 Feb 5;133:100-12. doi: 10.1016/j.jprot.2015.12.011. Epub 2015 Dec 21.
Impact factor:
Publication type: Paper in international publication
Authors: Bech-Serra, Joan Josep; Bustamante, Alejandro; Canals, Francesc; Garcia-Berrocoso, Teresa; Giralt, Dolors; Hernandez-Guillamon, Mar; Llombart, Victor; Montaner, Joan; Reverter-Branchat, Gemma; Simats, Alba et al.
DOI: 10.1016/j.jprot.2015.12.011

Semi-automatic measuring of arteriovenous relation as a possible silent brain infarction risk index in hypertensive patients.

PMID: 27311989
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2016
Reference: Arch Soc Esp Oftalmol. 2016 Nov;91(11):513-519. doi: 10.1016/j.oftal.2016.05.001. Epub 2016 Jun 13.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vazquez Dorrego, X M, Manresa Dominguez, J M, Heras Tebar, A, Fores, R, Girona Marce, A, Alzamora Sas, M T, Delgado Martinez, P, Riba-Llena, I, Ugarte Anduaga, J, Beristain Iraola, A et al.
DOI: 10.1016/j.oftal.2016.05.001

High daytime and nighttime ambulatory pulse pressure predict poor cognitive function and mild cognitive impairment in hypertensive individuals.

PMID: 25966945
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2016
Reference: J Cereb Blood Flow Metab. 2016 Jan;36(1):253-63. doi: 10.1038/jcbfm.2015.90.
Impact factor: 5.407
Publication type: Paper in international publication
Authors: Montaner, Joan, Riba-Llena, Iolanda, Nafria, Cristina, Filomena, Josefina, Tovar, Jose L, Vinyoles, Ernest, Mundet, Xavier, Jarca, Carmen I, Vilar-Bergua, Andrea, Delgado, Pilar et al.
DOI: 10.1038/jcbfm.2015.90

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: involved pathways and clinical applicability.

PMID: 25899297
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2016
Reference: J Cereb Blood Flow Metab. 2016 Jan;36(1):55-71. doi: 10.1038/jcbfm.2015.68.
Impact factor: 5.407
Publication type: Paper in international publication
Authors: Vilar-Bergua, A, Riba-Llena, I, Nafria, C, Bustamante, A, Llombart, V, Delgado, P, Montaner, J et al.
DOI: 10.1038/jcbfm.2015.68

Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension.

PMID: 26101344
Journal: HYPERTENSION
Year: 2015
Reference: Hypertension. 2015 Sep;66(3):634-40; discussion 445. doi: 10.1161/HYPERTENSIONAHA.115.05440. Epub 2015 Jun 22.
Impact factor: 6.48
Publication type: Paper in international publication
Authors: Filomena, Josefina, Tovar, Jose L, Mundet, Xavier, Castane, Xavier, Vilar, Andrea, Lopez-Rueda, Antonio, Jimenez-Balado, Joan, Cartanya, Anna, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/HYPERTENSIONAHA.115.05440

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.