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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Publications

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

PMID: 33801197
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 2;10(5). pii: jcm10050989. doi: 10.3390/jcm10050989.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Marazuela, Paula, Bonaterra-Pastra, Anna, Faura, Julia, Penalba, Anna, Pizarro, Jesus, Pancorbo, Olalla, Rodriguez-Luna, David, Vert, Carla, Rovira, Alex, Pujadas, Francesc et al.
DOI: 10.3390/jcm10050989

SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.

PMID: 33805974
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Mar 25;22(7). pii: ijms22073365. doi: 10.3390/ijms22073365.
Impact factor: 5.924
Publication type: Review in international publication
Authors: Unzeta, Mercedes, Hernandez-Guillamon, Mar, Sun, Ping, Sole, Montse et al.
DOI: 10.3390/ijms22073365

Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders.

PMID: 33738082
Journal: Journal of Extracellular Vesicles
Year: 2021
Reference: J Extracell Vesicles. 2021 Mar;10(5):e12058. doi: 10.1002/jev2.12058. Epub 2021 Mar 12.
Impact factor: 25.841
Publication type: Paper in international publication
Authors: Seras-Franzoso, Joaquin, Diaz-Riascos, Zamira V, Corchero, Jose Luis, Gonzalez, Patricia, Garcia-Aranda, Natalia, Mandana, Monica, Riera, Roger, Boullosa, Ana, Mancilla, Sandra, Grayston, Alba et al.
DOI: 10.1002/jev2.12058

[Quality of life in adult patients with idiopathic generalised epilepsy. The EPILAK study].

PMID: 33710609
Journal: REVISTA DE NEUROLOGIA
Year: 2021
Reference: Rev Neurol. 2021 Mar 16;72(6):195-202. doi: 10.33588/rn.7206.2020518.
Impact factor: 0.87
Publication type: Paper in national publication
Authors: Salas-Puig, J, Sopelana, D, Quintana, M, Seijo-Raposo, I, Abraira, L, Fonseca, E, Santamarina, E, Toledo, M et al.
DOI: 10.33588/rn.7206.2020518

Blood biomarkers predictive of epilepsy after an acute stroke event.

PMID: 32857458
Journal: EPILEPSIA
Year: 2020
Reference: Epilepsia. 2020 Oct;61(10):2244-2253. doi: 10.1111/epi.16648. Epub 2020 Aug 28.
Impact factor: 6.04
Publication type: Paper in international publication
Authors: Terceno, Mikel, Zaragoza, Josep, Canovas, David, Gasull, Teresa, Ustrell, Xavier, Rubiera, Marta, Castellanos, Mar, Montaner, Joan, Alvarez-Sabin, Jose, Cardona, Pere et al.
DOI: 10.1111/epi.16648

Deep Learning Based Software to Identify Large Vessel Occlusion on Noncontrast Computed Tomography.

PMID: 32842922
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Oct;51(10):3133-3137. doi: 10.1161/STROKEAHA.120.030326. Epub 2020 Aug 26.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Crespo, Carlos, Granes, Cristina, Hernandez-Perez, Maria, Perez de la Ossa, Natalia, Laredo, Carlos, Urra, Xabier, Carlos Soler, Juan, Puyalto, Paloma, Cuadras, Patricia et al.
DOI: 10.1161/STROKEAHA.120.030326

Association of initial imaging modality and futile recanalization after thrombectomy.

PMID: 32847948
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Oct 27;95(17):e2331-e2342. doi: 10.1212/WNL.0000000000010614. Epub 2020 Aug 26.
Impact factor: 8.77
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Meinel, Thomas Raphael, Kaesmacher, Johannes, Mosimann, Pascal John, Seiffge, David, Jung, Simon, Mordasini, Pasquale, Arnold, Marcel, Goeldlin, Martina, Hajdu, Steven D et al.
DOI: 10.1212/WNL.0000000000010614

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

PMID: 32807790
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Aug 17;11(1):4110. doi: 10.1038/s41467-020-17901-2.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Pitrez, Patricia R, Colell, Guillem, Vazao, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire, Egesipe, Anne-Laure, Carvalho, Tania, Dos Santos, Rodrigo L et al.
DOI: 10.1038/s41467-020-17901-2

Long-term epilepsy after early post-stroke status epilepticus.

PMID: 31077960
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Jul;69:193-197. doi: 10.1016/j.seizure.2019.04.022. Epub 2019 May 1.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Abraira, Laura, Toledo, Manuel, Guzman, Lorena, Sueiras, Maria, Quintana, Manuel, Fonseca, Elena, Salas-Puig, Javier, Alvarez-Sabin, Jose, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2019.04.022

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy.

PMID: 30918495
Journal: Frontiers in Neurology
Year: 2019
Reference: Front Neurol. 2019 Mar 13;10:187. doi: 10.3389/fneur.2019.00187. eCollection 2019.
Impact factor: 2.635
Publication type: Paper in international publication
Authors: Camacho, Jessica, Moline, Teresa, Bonaterra-Pastra, Anna, Ramon Y Cajal, Santiago, Martinez-Saez, Elena, Hernandez-Guillamon, Mar et al.
DOI: 10.3389/fneur.2019.00187

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.

PMID: 30834194
Journal: Epilepsy & behavior case reports
Year: 2019
Reference: Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019.
Impact factor: 0
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Alpuente, Alicia, Maisterra, Olga, Sueiras, Maria, Sarria, Silvana, Guzman, Lorena, Abraira, Laura, Salas-Puig, Javier, Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2019.01.008

Update in status epilepticus.

PMID: 30803796
Journal: MEDICINA CLINICA
Year: 2019
Reference: Med Clin (Barc). 2019 Jul 19;153(2):70-77. doi: 10.1016/j.medcli.2019.01.013. Epub 2019 Feb 23.
Impact factor: 1.277
Publication type: Review in national publication
Authors: Santamarina, Estevo, Abraira, Laura, Toledo, Manuel et al.
DOI: 10.1016/j.medcli.2019.01.013

CCL23: A new CC chemokine involved in human brain damage.

PMID: 29415332
Journal: JOURNAL OF INTERNAL MEDICINE
Year: 2018
Reference: J Intern Med. 2018 May;283(5):461-475. doi: 10.1111/joim.12738. Epub 2018 Mar 5.
Impact factor: 6.754
Publication type: Paper in international publication
Authors: Simats, Alba, Garcia-Berrocoso, Teresa, Penalba, Anna, Giralt, Dolors, Llovera, Gemma, Jiang, Yinghua, Ramiro, Laura, Bustamante, Alejandro, Martinez-Saez, Elena, Canals, Francesc et al.
DOI: 10.1111/joim.12738

Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function.

PMID: 29326289
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2018
Reference: J Neurol Neurosurg Psychiatry. 2018 Jun;89(6):651-656. doi: 10.1136/jnnp-2017-316724. Epub 2018 Jan 11.
Impact factor: 7.144
Publication type: Paper in international publication
Authors: Jimenez-Balado, Joan, Riba-Llena, Iolanda, Garde, Edurne, Valor, Marta, Gutierrez, Belen, Pujadas, Francesc, Delgado, Pilar et al.
DOI: 10.1136/jnnp-2017-316724

Single Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia.

PMID: 29133510
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2018
Reference: Mol Cell Proteomics. 2018 Jan;17(1):175-189. doi: 10.1074/mcp.RA117.000419. Epub 2017 Nov 13.
Impact factor: 5.232
Publication type: Paper in international publication
Authors: Garcia-Berrocoso, Teresa, Llombart, Victor, Colas-Campas, Laura, Hainard, Alexandre, Licker, Virginie, Penalba, Anna, Ramiro, Laura, Simats, Alba, Martinez-Saez, Elena, Canals, Francesc et al.
DOI: 10.1074/mcp.RA117.000419

N-terminal pro-brain natriuretic peptide and subclinical brain small vessel disease.

PMID: 27956564
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Dec 13;87(24):2533-2539. Epub 2016 Nov 9.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Penalba, Anna, Jimenez-Balado, Joan, Montaner, Joan, Delgado, Pilar, Cruz, Luz Maria et al.
DOI: 10.1212/WNL.0000000000003423

Plasma matrix metalloproteinases in stroke patients during intensive rehabilitation therapy.

PMID: 27373742
Journal: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
Year: 2016
Reference: Arch Phys Med Rehabil. 2016 Nov;97(11):1832-1840. doi: 10.1016/j.apmr.2016.06.007. Epub 2016 Jul 1.
Impact factor: 3.045
Publication type: Paper in international publication
Authors: Ma, Feifei, Rodriguez, Susana, Buxo, Xavi, Morancho, Anna, Riba-Llena, Iolanda, Carrera, Ana, Bustamante, Alejandro, Giralt, Dolors, Montaner, Joan, Martinez, Carmen et al.
DOI: 10.1016/j.apmr.2016.06.007

Dementia Rating Scale-2 normative data for middle-and older-aged Castilian speaking Spaniards.

PMID: 27168059
Journal: CLINICAL NEUROPSYCHOLOGIST
Year: 2016
Reference: Clin Neuropsychol. 2016 Jan-Dec;30(sup1):1443-1456. Epub 2016 May 11.
Impact factor: 1.556
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Nafria, Cristina, Giralt, Dolors, Fernandez-Cortinas, Ines, Jarca, Carmen Ioana, Mundet, Xavier, Tovar, Jose Luis, Orfila, Francesc, Castane, Xavier, Alvarez-Sabin, Jose et al.
DOI: 10.1080/13854046.2016.1174307

Clinical and psychopathological factors associated with impulse control disorders in Parkinson's disease.

PMID: 26096669
Journal: NEUROLOGIA
Year: 2016
Reference: Neurologia. 2016 May;31(4):231-238. doi: 10.1016/j.nrl.2015.05.002. Epub 2015 Jun 19.
Impact factor: 1.79
Publication type: Paper in international publication
Authors: Saez-Francas, N, Marti Andres, G, Ramirez, N, de Fabregues, O, Alvarez-Sabin, J, Hernandez-Vara, J, Casas, M et al.
DOI: 10.1016/j.nrl.2015.05.002

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.