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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Publications

Bridging May Increase the Risk of Symptomatic Intracranial Hemorrhage in Thrombectomy Patients With Low Alberta Stroke Program Early Computed Tomography Score.

PMID: 33504188
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 Mar;52(3):1098-1104. doi: 10.1161/STROKEAHA.120.030508. Epub 2021 Jan 28.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Schaafsma, Joanna, Gawlitza, Matthias, Friedrich, Benjamin, Benali, Amel, Hajdu, Steven D, Requena, Manuel, Kaesmacher, Johannes, Meinel, Thomas R, Nannoni, Stefania, Olive-Gadea, Marta et al.
DOI: 10.1161/STROKEAHA.120.030508

Response by Olive Gadea and Ribo to Letter Regarding Article, "Deep Learning Based Software to Identify Large Vessel Occlusion on Noncontrast Computed Tomography".

PMID: 33493060
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 Jan;52(2):e63. doi: 10.1161/STROKEAHA.120.033116. Epub 2021 Jan 25.
Impact factor: 7.914
Publication type: Letter or abstract
Authors: Olive Gadea, Marta, Ribo, Marc et al.
DOI: 10.1161/STROKEAHA.120.033116

Angiotensin II-induced cardiomyocyte hypertrophy: A complex response dependent on intertwined pathways.

PMID: 33478847
Journal: Revista Portuguesa de Cardiologia
Year: 2021
Reference: Rev Port Cardiol. 2021 Mar;40(3):201-203. doi: 10.1016/j.repc.2020.12.009. Epub 2021 Jan 18.
Impact factor: 1.374
Publication type: Letter or abstract
Authors: Consegal, Marta, Valls-Lacalle, Laura, Rodriguez-Sinovas, Antonio et al.
DOI: 10.1016/j.repc.2020.12.009

Levetiracetam as first-line monotherapy for Idiopathic Generalized Epilepsy in women.

PMID: 33452703
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2021
Reference: Acta Neurol Scand. 2021 Apr;143(4):407-412. doi: 10.1111/ane.13389. Epub 2021 Jan 15.
Impact factor: 3.209
Publication type: Paper in international publication
Authors: Salas-Puig, Javier, Quintana, Manuel, Campos, Daniel, Llaurado, Arnau, Raspall, Miquel, Fonseca, Elena, Abraira, Laura, Santamarina, Estevo, Toledo, Manuel, Ballve, Alejandro et al.
DOI: 10.1111/ane.13389

Computed Tomography Perfusion After Thrombectomy: An Immediate Surrogate Marker of Outcome After Recanalization in Acute Stroke.

PMID: 32404034
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1736-1742. doi: 10.1161/STROKEAHA.120.029212. Epub 2020 May 14.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Garcia-Tornel, Alvaro, Olive-Gadea, Marta, Campos, Daniel, Requena, Manuel, Vert, Carla, Pagola, Jorge, Rodriguez-Luna, David, Muchada, Marian, Boned, Sandra et al.
DOI: 10.1161/STROKEAHA.120.029212

Time Matters: Adjusted Analysis of the Influence of Direct Transfer to Angio-Suite Protocol in Functional Outcome.

PMID: 32390548
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1766-1771. doi: 10.1161/STROKEAHA.119.028586. Epub 2020 May 11.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Molina, Carlos A, Tomasello, Alejandro, Ribo, Marc, Hernandez, David, Rodriguez-Luna, David, Pagola, Jorge, Coscojuela, Pilar, Requena, Manuel, Olive, Marta et al.
DOI: 10.1161/STROKEAHA.119.028586

Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFbeta1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice.

PMID: 32340244
Journal: Biomolecules
Year: 2020
Reference: Biomolecules. 2020 Apr 23;10(4). pii: biom10040651. doi: 10.3390/biom10040651.
Impact factor: 4.082
Publication type: Paper in international publication
Authors: Ruiz-Meana, Marisol, Valls-Lacalle, Laura, Consegal, Marta, Barba, Ignasi, Ferreira-Gonzalez, Ignacio, Rodriguez-Sinovas, Antonio, Inserte, Javier, Benito, Begona et al.
DOI: 10.3390/biom10040651

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.

PMID: 32322099
Journal: Nature Reviews Neurology
Year: 2020
Reference: Nat Rev Neurol. 2020 May;16(5):247-264. doi: 10.1038/s41582-020-0350-6. Epub 2020 Apr 22.
Impact factor: 27
Publication type: Review in international publication
Authors: Tiedt, Steffen, Montaner, Joan, Ramiro, Laura, Simats, Alba, Debette, Stephanie, Sanchez, Jean-Charles, Bustamante, Alejandro, Jickling, Glen C, Makris, Konstantinos et al.
DOI: 10.1038/s41582-020-0350-6

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.