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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

Silvia Ruiz Álvarez

Silvia Ruiz Álvarez

Administration and Management
Neurovascular Diseases
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Silvia Ruiz Álvarez

Silvia Ruiz Álvarez

Administration and Management
Neurovascular Diseases
Read more

Publications

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion.

PMID: 34747975
Journal: JAMA Neurology
Year: 2022
Reference: JAMA Neurol. 2022 Jan 1;79(1):22-31. doi: 10.1001/jamaneurol.2021.4082.
Impact factor: 18.302
Publication type: Paper in international publication
Authors: Salazar-Marioni, Sergio, Kuhn, Anna L, Kaliaev, Artem, Farzin, Behzad, Boisseau, William, Masoud, Hesham E, Lopez, Carlos Ynigo, Rana, Ameena, Kareem, Samer Abdul, Sathya, Anvitha et al.
DOI: 10.1001/jamaneurol.2021.4082

Ischemic Core Overestimation on Computed Tomography Perfusion.

PMID: 33682453
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 May;52(5):1751-1760. doi: 10.1161/STROKEAHA.120.031800. Epub 2021 Mar 8.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Campos, Daniel, Rubiera, Marta, Boned, Sandra, Olive-Gadea, Marta, Requena, Manuel, Ciolli, Ludovico, Muchada, Marian, Pagola, Jorge, Deck, Matias et al.
DOI: 10.1161/STROKEAHA.120.031800

Blood Biomarkers to Differentiate Ischemic and Hemorrhagic Strokes Might Allow Prehospital Thrombolysis.

PMID: 33674361
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Apr 13;96(15):e1928-e1939. doi: 10.1212/WNL.0000000000011742. Epub 2021 Mar 5.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Sanchez, Jean Charles, Montaner, Joan, Vivien, Denis, Ribo, Marc, Pecharroman, Emili, Bustamante, Alejandro, Penalba, Anna, Orset, Cyrille, Azurmendi, Leire, Llombart, Victor et al.
DOI: 10.1212/WNL.0000000000011742

Factors associated with resistance to benzodiazepines in status epilepticus.

PMID: 33652289
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2021
Reference: J Neurol Sci. 2021 Apr 15;423:117368. doi: 10.1016/j.jns.2021.117368. Epub 2021 Feb 23.
Impact factor: 3.181
Publication type: Paper in international publication
Authors: Llaurado, Arnau, Quintana, Manuel, Ballve, Alejandro, Campos, Daniel, Fonseca, Elena, Abraira, Laura, Santamarina, Estevo, Toledo, Manuel et al.
DOI: 10.1016/j.jns.2021.117368

Blood Biomarker Panels for the Early Prediction of Stroke-Associated Complications.

PMID: 33634708
Journal: Journal of the American Heart Association
Year: 2021
Reference: J Am Heart Assoc. 2021 Feb;10(5):e018946. doi: 10.1161/JAHA.120.018946. Epub 2021 Feb 26.
Impact factor: 5.501
Publication type: Paper in international publication
Authors: Faura, Julia, Bustamante, Alejandro, Reverte, Silvia, Garcia-Berrocoso, Teresa, Millan, Monica, Castellanos, Mar, Lara-Rodriguez, Blanca, Zaragoza, Josep, Ventura, Oriol, Hernandez-Perez, Maria et al.
DOI: 10.1161/JAHA.120.018946

Computed Tomography Perfusion After Thrombectomy: An Immediate Surrogate Marker of Outcome After Recanalization in Acute Stroke.

PMID: 32404034
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1736-1742. doi: 10.1161/STROKEAHA.120.029212. Epub 2020 May 14.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Garcia-Tornel, Alvaro, Olive-Gadea, Marta, Campos, Daniel, Requena, Manuel, Vert, Carla, Pagola, Jorge, Rodriguez-Luna, David, Muchada, Marian, Boned, Sandra et al.
DOI: 10.1161/STROKEAHA.120.029212

Time Matters: Adjusted Analysis of the Influence of Direct Transfer to Angio-Suite Protocol in Functional Outcome.

PMID: 32390548
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Jun;51(6):1766-1771. doi: 10.1161/STROKEAHA.119.028586. Epub 2020 May 11.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Rubiera, Marta, Molina, Carlos A, Tomasello, Alejandro, Ribo, Marc, Hernandez, David, Rodriguez-Luna, David, Pagola, Jorge, Coscojuela, Pilar, Requena, Manuel, Olive, Marta et al.
DOI: 10.1161/STROKEAHA.119.028586

Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFbeta1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice.

PMID: 32340244
Journal: Biomolecules
Year: 2020
Reference: Biomolecules. 2020 Apr 23;10(4). pii: biom10040651. doi: 10.3390/biom10040651.
Impact factor: 4.082
Publication type: Paper in international publication
Authors: Ruiz-Meana, Marisol, Valls-Lacalle, Laura, Consegal, Marta, Barba, Ignasi, Ferreira-Gonzalez, Ignacio, Rodriguez-Sinovas, Antonio, Inserte, Javier, Benito, Begona et al.
DOI: 10.3390/biom10040651

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.

PMID: 32322099
Journal: Nature Reviews Neurology
Year: 2020
Reference: Nat Rev Neurol. 2020 May;16(5):247-264. doi: 10.1038/s41582-020-0350-6. Epub 2020 Apr 22.
Impact factor: 27
Publication type: Review in international publication
Authors: Tiedt, Steffen, Montaner, Joan, Ramiro, Laura, Simats, Alba, Debette, Stephanie, Sanchez, Jean-Charles, Bustamante, Alejandro, Jickling, Glen C, Makris, Konstantinos et al.
DOI: 10.1038/s41582-020-0350-6

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

PMID: 30776698
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Mar;66:31-35. doi: 10.1016/j.seizure.2019.02.004. Epub 2019 Feb 8.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Toledo, Manuel, Sarria, Silvana, Abraira, Laura, Gramegna, Laura Ludovica, Quintana, Manuel, Santamarina, Estevo, Salas-Puig, Javier, Rovira, Alex et al.
DOI: 10.1016/j.seizure.2019.02.004

Etiology, seizure type, and prognosis of epileptic seizures in the emergency department.

PMID: 30763767
Journal: EPILEPSY & BEHAVIOR
Year: 2019
Reference: Epilepsy Behav. 2019 Mar;92:327-331. doi: 10.1016/j.yebeh.2018.12.008. Epub 2019 Feb 11.
Impact factor: 2.378
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Requena, Manuel, Fonseca Hernandez, Elena, Quintana, Manuel, Santamarina, Estevo, Abraira Del Fresno, Laura, Alvarez-Sabin, Jose, Salas-Puig, Xavier, Toledo, Manuel et al.
DOI: 10.1016/j.yebeh.2018.12.008

[Progressive multifocal leukoencephalopathy and non-specific immune dysfunction].

PMID: 30687923
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 Feb 1;68(3):132-133.
Impact factor: 0.485
Publication type: Letter whit IF
Authors: Llaurado-Gayete, A, Campos-Fernandez, D, Olive-Gadea, M, Ballve-Martin, A, Rio, J, Rovira, A, Santamarina, E et al.
DOI: 10.33588/rn.6803.2018377

Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study).

PMID: 30658321
Journal: EPILEPSY & BEHAVIOR
Year: 2019
Reference: Epilepsy Behav. 2019 Mar;92:135-139. doi: 10.1016/j.yebeh.2018.10.043. Epub 2019 Jan 15.
Impact factor: 2.378
Publication type: Paper in international publication
Authors: Puig, Josep, Abraira, Laura, Iniesta, Marc, Salas-Puig, Xavier et al.
DOI: 10.1016/j.yebeh.2018.10.043

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.