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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Team

Fernando Trejo Velasco

Fernando Trejo Velasco

Predoctoral researcher
Ophtalmology
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Ferran Casals Riera

Ferran Casals Riera

Research technician
Ophtalmology
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Helena Isla Magrané

Helena Isla Magrané

Postdoctoral researcher
Ophtalmology
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Laura Sánchez Vela

Laura Sánchez Vela

Ophtalmology
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Marta Garrido Marin

Marta Garrido Marin

Predoctoral researcher
Ophtalmology
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Mireia Campius Piñas

Mireia Campius Piñas

Maintenance staff and general services
Ophtalmology
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Fernando Trejo Velasco

Fernando Trejo Velasco

Predoctoral researcher
Ophtalmology
Read more
Ferran Casals Riera

Ferran Casals Riera

Research technician
Ophtalmology
Read more
Helena Isla Magrané

Helena Isla Magrané

Postdoctoral researcher
Ophtalmology
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Laura Sánchez Vela

Laura Sánchez Vela

Ophtalmology
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Marta Garrido Marin

Marta Garrido Marin

Predoctoral researcher
Ophtalmology
Read more
Mireia Campius Piñas

Mireia Campius Piñas

Maintenance staff and general services
Ophtalmology
Read more

Publications

Iridocorneal endothelial syndrome: Descemet's membrane-endothelium complex assessed by high-resolution anterior segment optical coherence tomography.

PMID: 35078646
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2022
Reference: J Fr Ophtalmol. 2022 Jun;45(6):e280-e283. doi: 10.1016/j.jfo.2021.09.015. Epub 2022 Jan 22.
Impact factor: 0.818
Publication type: Letter or abstract
Authors: Bisbe, L, Castany, M, Sanchez-Vela, L, Berges, M, Kirkegaard, E, Azarfane, B, Oliveres, J, Andrade, A et al.
DOI: 10.1016/j.jfo.2021.09.015

Persistent reduction of retinal microvascular vessel density in patients with moderate and severe COVID-19 disease.

PMID: 35039796
Journal: BMJ open ophthalmology
Year: 2022
Reference: BMJ Open Ophthalmol. 2022 Jan 11;7(1):e000867. doi: 10.1136/bmjophth-2021-000867. eCollection 2022.
Impact factor: 0
Publication type: Paper in international publication
Authors: Banderas Garcia, Sandra, Aragon, David, Azarfane, Brahim, Trejo, Fernando, Garrell-Salat, Xavier, Sanchez-Montalva, Adrian, Garcia-Arumi, Jose, Zapata, Miguel Angel, Otero-Romero, Susana et al.
DOI: 10.1136/bmjophth-2021-000867

Interobserver and Intertest Agreement in Telemedicine Glaucoma Screening with Optic Disk Photos and Optical Coherence Tomography.

PMID: 34362120
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jul 28;10(15). pii: jcm10153337. doi: 10.3390/jcm10153337.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Anton, Alfonso, Nolivos, Karen, Pazos, Marta, Fatti, Gianluca, Herranz, Alejandra, Ayala-Fuentes, Miriam Eleonora, Martinez-Prats, Elena, Peral, Oscar, Vega-Lopez, Zaida, Monleon-Getino, Antoni et al.
DOI: 10.3390/jcm10153337

Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation.

PMID: 34332373
Journal: BIOMATERIALS
Year: 2021
Reference: Biomaterials. 2021 Sep;276:121049. doi: 10.1016/j.biomaterials.2021.121049. Epub 2021 Jul 24.
Impact factor: 12.479
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Veiga, Anna, Duarri, Anna, Mosquera, Jose Luis, Maqueda, Maria et al.
DOI: 10.1016/j.biomaterials.2021.121049

Visual impairment induced by prosthetic cobaltism.

PMID: 34092285
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2021
Reference: Arch Soc Esp Oftalmol (Engl Ed). 2021 Jun;96(6):316-320. doi: 10.1016/j.oftale.2020.06.025. Epub 2020 Dec 22.
Impact factor: 0
Publication type: Letter whit IF
Authors: Sanchez-Dalmau, B F, Spencer, F, Sanchez-Vela, L, Camos-Carreras, A, Fernandez-Valencia, J A, Nogue Xarau, S et al.
DOI: 10.1016/j.oftale.2020.06.025

Fundus flavimaculatus-like in myotonic dystrophy: a case report.

PMID: 34051736
Journal: BMC Ophthalmology
Year: 2021
Reference: BMC Ophthalmol. 2021 May 29;21(1):240. doi: 10.1186/s12886-021-02002-5.
Impact factor: 2.209
Publication type: Letter or abstract
Authors: Kirkegaard-Biosca, Eric, Berges-Marti, Monica, Azarfane, Brahim, Cilveti, Esther, Distefano, Laura, Garcia-Arumi, Jose et al.
DOI: 10.1186/s12886-021-02002-5

Surgical Options for Optic Disc Pit Maculopathy: Perspectives and Controversies.

PMID: 32606575
Journal: Clinical ophthalmology (Auckland, N.Z.)
Year: 2020
Reference: Clin Ophthalmol. 2020 Jun 16;14:1601-1608. doi: 10.2147/OPTH.S250921. eCollection 2020.
Impact factor: 0
Publication type: Paper in international publication
Authors: Pastor-Idoate, Salvador, Garcia-Arumi Fuste, Claudia, Garcia-Onrubia, Luis, Copete, Sergio, Garcia-Arumi, Jose et al.
DOI: 10.2147/OPTH.S250921

EFFICACY AND SAFETY OF A TREAT-AND-EXTEND REGIMEN WITH AFLIBERCEPT IN TREATMENT-NAIVE PATIENTS WITH TYPE 3 NEOVASCULARIZATION: A 52-Week, Single-Arm, Multicenter Trial.

PMID: 31259813
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2020
Reference: Retina. 2020 Jul;40(7):1234-1244. doi: 10.1097/IAE.0000000000002582.
Impact factor: 3.649
Publication type: Paper in international publication
Authors: Cervera, Enrique, Vilimelis, Jaume Crespi, Escobar, Jose Juan, Escobar, Antonio Gomez, Zapata, Miguel Angel, Arias, Luis et al.
DOI: 10.1097/IAE.0000000000002582

Inter-Ocular Asymmetry in Anterior Corneal Aberrations Using Placido Disk-Based Topography.

PMID: 32546953
Journal: Clinical ophthalmology (Auckland, N.Z.)
Year: 2020
Reference: Clin Ophthalmol. 2020 May 27;14:1451-1457. doi: 10.2147/OPTH.S255086. eCollection 2020.
Impact factor: 0
Publication type: Paper in international publication
Authors: Alzaben, Zeyad, Gammoh, Yazan, Freixas, Marta, Zaben, Ahmad, Zapata, Miguel A, Koff, Dana N et al.
DOI: 10.2147/OPTH.S255086

Retinal Vasculitis Secondary to Durvalumab.

PMID: 32508622
Journal: Case reports in ophthalmology
Year: 2020
Reference: Case Rep Ophthalmol. 2020 May 5;11(2):161-166. doi: 10.1159/000507609. eCollection 2020 May-Aug.
Impact factor: 0
Publication type: Letter or abstract
Authors: R Andrade, Antonio, Moll-Udina, Aina, Cilveti, Esther, Subira, Olaia, Disfetano, Laura, Garcia-Arumi, Jose, Martin, Ruth et al.
DOI: 10.1159/000507609

Possible Intraluminal Obstruction of the XEN45 Gel Stent Observed With Anterior Segment Optical Coherence Tomography.

PMID: 31453896
Journal: JOURNAL OF GLAUCOMA
Year: 2019
Reference: J Glaucoma. 2019 Dec;28(12):1095-1101. doi: 10.1097/IJG.0000000000001351.
Impact factor: 1.661
Publication type: Paper in international publication
Authors: Rigo, Jaume, Castany, Marta, Banderas, Sandra, Pujol, Olivia, Amilburu, Manuel, Dou, Antoni et al.
DOI: 10.1097/IJG.0000000000001351

Editors' note: Novel ocular toxicity associated with fibroblast growth factor receptor (FGFR) inhibitors in cancer treatment: observational case series.

PMID: 29217514
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2019
Reference: Br J Ophthalmol. 2019 Aug;103(8):1200. doi: 10.1136/bjophthalmol-2017-311282. Epub 2017 Dec 7.
Impact factor: 3.615
Publication type: Letter or abstract
Authors: Velazquez-Villoria, Daniel, Azaro, Analia, Rodon, Jordi, Hierro, Cinta, Kyriakou, Danai, Garcia-Arumi, Jose, Zapata, Miguel Angel et al.
DOI: 10.1136/bjophthalmol-2017-311282

SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CHORIORETINAL CHANGES IN HYPERTENSIVE CHOROIDOPATHY RELATED TO HELLP SYNDROME.

PMID: 28067720
Journal: Retinal cases & brief reports
Year: 2019
Reference: Retin Cases Brief Rep. 2019 Winter;13(1):30-33. doi: 10.1097/ICB.0000000000000524.
Impact factor: 0
Publication type: Paper in international publication
Authors: Velazquez-Villoria, Daniel, Marti Rodrigo, Pablo, DeNicola, Maria L, Zapata Vitori, Miguel A, Segura Garcia, Antonio, Garcia-Arumi, Jose et al.
DOI: 10.1097/ICB.0000000000000524

Management of Wet Age-Related Macular Degeneration in Spain: Challenges for Treat and Extend Implementation in Routine Clinical Practice.

PMID: 31662900
Journal: Journal of Ophthalmology
Year: 2019
Reference: J Ophthalmol. 2019 Sep 30;2019:9821509. doi: 10.1155/2019/9821509. eCollection 2019.
Impact factor: 1.58
Publication type: Paper in international publication
Authors: Garcia-Layana, A, Garcia-Arumi, J, Figueroa, M S, Arias Barquet, L, The Spanish Amd Multicenter Group, Monclus-Arbona, L, Ruiz-Moreno, J M et al.
DOI: 10.1155/2019/9821509

Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables.

PMID: 25075124
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2015
Reference: Br J Ophthalmol. 2015 Jan;99(1):41-8. doi: 10.1136/bjophthalmol-2014-305263. Epub 2014 Jul 29.
Impact factor: 2.976
Publication type: Paper in international publication
Authors: Navea, Amparo, Rocha-Sousa, Amandio, Brion, Maria, Carracedo, Angel, Alfaiate, Mario, Boixadera, Anna, Coco, Rosa Maria, de la Fuente, Miguel A, Desco, Carmen, Diaz-Llopis, Manuel et al.
DOI: 10.1136/bjophthalmol-2014-305263

Effect of Intravitreal Injection of Dexamethasone 0.7 mg (Ozurdex(R)) on Intraocular Pressure in Patients with Macular Edema.

PMID: 26394206
Journal: OPHTHALMIC RESEARCH
Year: 2015
Reference: Ophthalmic Res. 2015;54(3):143-9. doi: 10.1159/000438759. Epub 2015 Sep 23.
Impact factor: 1.422
Publication type: Paper in international publication
Authors: Mazzarella, Stefania, Mateo, Carlos, Freixes, Silvia, Bures-Jelstrup, Anniken, Rios, Jose, Navarro, Rafael, Garcia-Arumi, Jose, Corcostegui, Borja, Arrondo, Elena et al.
DOI: 10.1159/000438759

Management of Vision-Threatening Complications of Vasoproliferative Tumors of the Retina.

PMID: 26065358
Journal: OPHTHALMIC RESEARCH
Year: 2015
Reference: Ophthalmic Res. 2015;54(1):34-40. doi: 10.1159/000430955. Epub 2015 Jun 6.
Impact factor: 1.422
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Distefano, Laura N, Fonollosa, Alex, Quijano, Claudia, Corcostegui, Borja et al.
DOI: 10.1159/000430955

RETINAL SENSITIVITY AND CHOROIDAL THICKNESS IN HIGH MYOPIA.

PMID: 25478863
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2015
Reference: Retina. 2015 Mar;35(3):398-406. doi: 10.1097/IAE.0000000000000367.
Impact factor: 3.243
Publication type: Paper in international publication
Authors: Zaben, Ahmad, Zapata, Miguel A, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000000367

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.