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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Team

Paul Gerard Buck Espel

Paul Gerard Buck Espel

Predoctoral researcher
Ophtalmology
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Sandra  Banderas García

Sandra Banderas García

Ophtalmology
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Xavier Garrell Salat

Xavier Garrell Salat

Predoctoral researcher
Ophtalmology
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Paul Gerard Buck Espel

Paul Gerard Buck Espel

Predoctoral researcher
Ophtalmology
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Sandra  Banderas García

Sandra Banderas García

Ophtalmology
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Xavier Garrell Salat

Xavier Garrell Salat

Predoctoral researcher
Ophtalmology
Read more

Publications

[Iris prolapse in Terrien's marginal degeneration].

PMID: 33388189
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2021
Reference: J Fr Ophtalmol. 2021 Apr;44(4):618-619. doi: 10.1016/j.jfo.2020.07.006. Epub 2020 Dec 30.
Impact factor: 0.818
Publication type: Letter or abstract
Authors: Azarfane, B, Puig, J, Jurado, E, Kirkegaard, E, Berges, M et al.
DOI: 10.1016/j.jfo.2020.07.006

Angioid streaks and obstructive sleep apnea syndrome: are they related?

PMID: 32301031
Journal: Sleep and Breathing
Year: 2021
Reference: Sleep Breath. 2021 Mar;25(1):163-169. doi: 10.1007/s11325-020-02019-y. Epub 2020 Apr 16.
Impact factor: 2.816
Publication type: Paper in international publication
Authors: Catala-Mora, Jaume, Anton, Alfonso, Perez-Hoyos, Santiago, Carceller, Amadeu, Aparicio, Gloria, Castany-Aregall, Marta, Grau, Nuria et al.
DOI: 10.1007/s11325-020-02019-y

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration.

PMID: 33738324
Journal: Molecular Therapy-Methods & Clinical Development
Year: 2021
Reference: Mol Ther Methods Clin Dev. 2021 Feb 10;20:688-702. doi: 10.1016/j.omtm.2021.02.006. eCollection 2021 Mar 12.
Impact factor: 6.698
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Veiga, Anna, Zapata, Miguel Angel, Salas, Anna, Duarri, Anna, Fontrodona, Laura, Ramirez, Diana Mora, Badia, Anna, Isla-Magrane, Helena, Ferreira-de-Souza, Barbara et al.
DOI: 10.1016/j.omtm.2021.02.006

Role of intraretinal and subretinal fluid on clinical and anatomical outcomes in patients with neovascular age-related macular degeneration treated with bimonthly, treat-and-extend and as-needed ranibizumab in the In-Eye study.

PMID: 33720541
Journal: ACTA OPHTHALMOLOGICA
Year: 2021
Reference: Acta Ophthalmol. 2021 Dec;99(8):861-870. doi: 10.1111/aos.14786. Epub 2021 Mar 15.
Impact factor: 3.761
Publication type: Paper in international publication
Authors: Galvez, Maria Isabel Lopez, Saenz-de-Viteri, Manuel, Recalde, Sergio, Fernandez-Robredo, Patricia, Lopez Galvez, Maria Isabel, Arias Barquet, Lluis, Figueroa, Marta S, Garcia-Arumi, Jose, Garcia-Layana, Alfredo, Figueroa, Marta S et al.
DOI: 10.1111/aos.14786

The Usefulness of Serum Biomarkers in the Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial.

PMID: 32344735
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Apr 24;9(4). pii: jcm9041233. doi: 10.3390/jcm9041233.
Impact factor: 3.303
Publication type: Paper in international publication
Authors: Egan, Catherine, Hernandez, Cristina, Porta, Massimo, Bandello, Francesco, Grauslund, Jakob, Harding, Simon P, Aldington, Stephen J, Gibson, Jonathan, Lang, Gabriele E, Lattanzio, Rosangela et al.
DOI: 10.3390/jcm9041233

Untitled Reply

PMID: 32349099
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2020
Reference: Retina. 2020 Aug;40(8):e38-e39. doi: 10.1097/IAE.0000000000002832.
Impact factor: 3.649
Publication type: Letter or abstract
Authors: Copete, Sergio, Pastor-Idoate, Salvador, Garcia-Arumi, Josep, Zapata, Miguel A et al.
DOI: 10.1097/IAE.0000000000002832

Bimonthly, treat-and-extend and as-needed ranibizumab in naive neovascular age-related macular degeneration patients: 12-month outcomes of a randomized study.

PMID: 32190990
Journal: ACTA OPHTHALMOLOGICA
Year: 2020
Reference: Acta Ophthalmol. 2020 Nov;98(7):e820-e829. doi: 10.1111/aos.14399. Epub 2020 Mar 19.
Impact factor: 3.362
Publication type: Paper in international publication
Authors: S Figueroa, Marta, Garcia-Layana, Alfredo, Ruiz Moreno, Jose M, Fernandez Rodriguez, Maribel, Garcia Arumi, Josep, Amat Peral, Pedro, Ascaso Puyuelo, Javier, Armada Maresca, Felix, Cervera Taulet, Enrique, Torres Imaz, Ramon et al.
DOI: 10.1111/aos.14399

ANATOMICAL AND VISUAL OUTCOMES OF INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE VERSUS INTERNAL LIMITING MEMBRANE PEELING IN MYOPIC MACULAR HOLE WITHOUT RETINAL DETACHMENT: A Preliminary Retrospective Study.

PMID: 31972792
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2020
Reference: Retina. 2020 Feb;40(2):233-240. doi: 10.1097/IAE.0000000000002368.
Impact factor: 3.649
Publication type: Paper in international publication
Authors: Bove Alvarez, Maria, Sabate, Sergi, Gomez-Resa, Maria, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000002368

Management of diabetic macular edema patients in clinical practice in Spain.

PMID: 30295076
Journal: EUROPEAN JOURNAL OF OPHTHALMOLOGY
Year: 2019
Reference: Eur J Ophthalmol. 2019 Nov;29(6):664-672. doi: 10.1177/1120672118804079. Epub 2018 Oct 7.
Impact factor: 1.716
Publication type: Paper in international publication
Authors: , Abreu-Gonzalez, Rodrigo, Gallego-Pinazo, Roberto, Abraldes, Maximino, Pinilla, Isabel, Lopez-Galvez, Maria I, , , , Boixadera Espax, Ana et al.
DOI: 10.1177/1120672118804079

PREOPERATIVE VITREORETINAL INTERFACE ABNORMALITIES ON SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AS RISK FACTOR FOR PSEUDOPHAKIC CYSTOID MACULAR EDEMA AFTER PHACOEMULSIFICATION.

PMID: 30157113
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2019
Reference: Retina. 2019 Nov;39(11):2225-2232. doi: 10.1097/IAE.0000000000002298.
Impact factor: 3.815
Publication type: Paper in international publication
Authors: Marti-Rodrigo, Pablo, Copete, Sergio, Rigo, Jaume, Figueroa, Marta S, Garcia-Arumi, Jose, Zapata, Miguel A, Pastor-Idoate, Salvador, Muniz-Vidal, Romina et al.
DOI: 10.1097/IAE.0000000000002298

Disc-foveal angle and ocular counterrolling as a key in its interpretation.

PMID: 31582183
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2019
Reference: Arch Soc Esp Oftalmol. 2019 Dec;94(12):585-590. doi: 10.1016/j.oftal.2019.05.019. Epub 2019 Oct 1.
Impact factor: 0
Publication type: Paper in national publication
Authors: Martin Begue, N, Puig Galy, J, Velazquez Villoria, D, Arcos Algaba, G, Mora Ramirez, D, Garcia-Arumi, J, Lagreze, W A, Galan Terraza, A, Velez Escola, L et al.
DOI: 10.1016/j.oftal.2019.05.019

Predictive capacity of baseline hyperreflective dots on the intravitreal dexamethasone implant (Ozurdex(R)) outcomes in diabetic macular edema: a multicenter study.

PMID: 31451909
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2019
Reference: Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2381-2390. doi: 10.1007/s00417-019-04446-4. Epub 2019 Aug 26.
Impact factor: 2.25
Publication type: Paper in international publication
Authors: Fonollosa, Alejandro, Zarranz-Ventura, Javier, Valverde, Alicia, Becerra, Erika, Bernal-Morales, Carolina, Pastor-Idoate, Salvador, Zapata, Miguel Angel et al.
DOI: 10.1007/s00417-019-04446-4

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.