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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Publications

Uveitic macular edema response to intravitreal dexamethasone implant is independent of optical coherence tomography findings.

PMID: 33184677
Journal: INTERNATIONAL OPHTHALMOLOGY
Year: 2021
Reference: Int Ophthalmol. 2021 Mar;41(3):787-796. doi: 10.1007/s10792-020-01631-x. Epub 2020 Nov 12.
Impact factor: 2.031
Publication type: Paper in international publication
Authors: Moll-Udina, Aina, Figueras-Roca, Marc, Oliveres, Joan, Sala-Puigdollers, Anna, Esquinas, Cristina, Alba-Linero, Carmen, Llorenc, Victor, Adan, Alfredo et al.
DOI: 10.1007/s10792-020-01631-x

Prevalence of age-related macular degeneration among optometric telemedicine users in Spain: a retrospective nationwide population-based study.

PMID: 33576860
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2021
Reference: Graefes Arch Clin Exp Ophthalmol. 2021 Jul;259(7):1993-2003. doi: 10.1007/s00417-021-05093-4. Epub 2021 Feb 12.
Impact factor: 3.117
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Bures, Anniken, Gallego-Pinazo, Roberto, Gutierrez-Sanchez, Estanislao, Olenik, Andrea, Pastor, Salvador, Ruiz-Medrano, Jorge, Salinas, Cecilia, Otero-Romero, Susana, Abraldes, Maximino et al.
DOI: 10.1007/s00417-021-05093-4

Guidelines for the Management of Retinal Vein Occlusion by the European Society of Retina Specialists (EURETINA).

PMID: 31412332
Journal: OPHTHALMOLOGICA
Year: 2019
Reference: Ophthalmologica. 2019;242(3):123-162. doi: 10.1159/000502041. Epub 2019 Aug 14.
Impact factor: 1.781
Publication type: Paper in international publication
Authors: Schmidt-Erfurth, Ursula, Garcia-Arumi, Jose, Gerendas, Bianca S, Midena, Edoardo, Sivaprasad, Sobha, Tadayoni, Ramin, Wolf, Sebastian, Loewenstein, Anat et al.
DOI: 10.1159/000502041

Comparative study of penetrating keratoplasty and vitreoretinal surgery with Eckardt temporary keratoprosthesis in ocular trauma versus non-trauma patients.

PMID: 31363832
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2019
Reference: Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2547-2558. doi: 10.1007/s00417-019-04420-0. Epub 2019 Jul 30.
Impact factor: 2.25
Publication type: Paper in international publication
Authors: Bove Alvarez, Maria, Arumi, Claudia Garcia, Distefano, Laura, Guell, Jose Luis, Gris, Oscar, Mateo, Carlos, Corcostegui, Borja, Garcia-Arumi, Jose et al.
DOI: 10.1007/s00417-019-04420-0

Comparison of Anatomical and Visual Outcomes between Idiopathic and Myopic Macular Holes Using the Internal Limiting Membrane or Inverted Internal Limiting Membrane Flap Technique.

PMID: 31205783
Journal: Journal of Ophthalmology
Year: 2019
Reference: J Ophthalmol. 2019 May 7;2019:6723824. doi: 10.1155/2019/6723824. eCollection 2019.
Impact factor: 1.58
Publication type: Paper in international publication
Authors: Peralta Iturburu, Federico, Garcia-Arumi, Claudia, Bove Alvarez, Maria, Garcia-Arumi, Jose et al.
DOI: 10.1155/2019/6723824

The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.

PMID: 30931966
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Apr 1;9(1):5392. doi: 10.1038/s41598-019-41524-3.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Gasull, Xavier, Castany, Marta, Castellanos, Aida, Rezola, Mikel, Andres-Bilbe, Alba, Canut, Maria Isabel, Estevez, Raul, Borras, Teresa, Comes, Nuria et al.
DOI: 10.1038/s41598-019-41524-3

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.