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Pharmacokinetic Nanoparticles

The group of design and pharmacodynamics of nanoparticles at the Vall d’Hebron Research Institute focuses on the synthesis, characterization, and applications of engineered inorganic nanoparticles in the field of medicine. By mastering the inorganic core (size, structure, and shape) and understanding and controlling the linking of molecules to the nanoparticle surface, we engineer nanoparticles that can interact with biological systems in a specific way. We also put particular emphasis on safety, feasibility, scale-up, applicability, and other aspects of nanoparticle design.

Our group is led by Prof. Víctor Puntes, who holds an ICREA Research Professorship. Since a great part of our work demands highly multidisciplinary expertise, we maintain several strong collaborations with biologists, immunologists, oncologists, physicists, environmentalists, and more, from all over Europe, China and the US. The work of the group has resulted in several patents and the creation of several spin-offs such as Nanotargeting and Applied nanoparticles.

Publications

Sustained effect of zero-valent iron nanoparticles under semi-continuous anaerobic digestion of sewage sludge: Evolution of nanoparticles and microbial community dynamics.

PMID: 33676214
Journal: SCIENCE OF THE TOTAL ENVIRONMENT
Year: 2021
Reference: Sci Total Environ. 2021 Jul 10;777:145969. doi: 10.1016/j.scitotenv.2021.145969. Epub 2021 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Baranska, Maja; Barrena, Raquel; Capell, Georgina; Font, Xavier; Moral-Vico, Javier; Puntes, Victor; Sanchez, Antoni; Vargas-Garcia, Maria Del Carmen et al.
DOI: 10.1016/j.scitotenv.2021.145969

Introducing visible-light sensitivity into photocatalytic CeO2 nanoparticles by hybrid particle preparation exploiting plasmonic properties of gold: enhanced photoelectrocatalysis exemplified for hydrogen peroxide sensing.

PMID: 33367345
Journal: Nanoscale
Year: 2021
Reference: Nanoscale. 2021 Jan 14;13(2):980-990. doi: 10.1039/d0nr06356h. Epub 2020 Dec 24.
Impact factor:
Publication type: Paper in international publication
Authors: Bastus, Neus; Lisdat, Fred; Parak, Wolfgang J; Patarroyo, Javier; Puntes, Victor; Riedel, Marc; Yue, Zhao; Zhao, Shuang et al.
DOI: 10.1039/d0nr06356h

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening.

PMID: 33458959
Journal: Small
Year: 2021
Reference: Small. 2021 Apr;17(15):e2006012. doi: 10.1002/smll.202006012. Epub 2021 Jan 18.
Impact factor:
Publication type: Paper in international publication
Authors: Bastus, Neus G; Biehl, Margit; Dubaj, Tibor; Dusinska, Maria; Elje, Elisabeth; Gabelova, Alena; Hesler, Michelle; Kapur, Nikil; Knoll, Thorsten; Kohl, Yvonne et al.
DOI: 10.1002/smll.202006012

Gold nanoparticles coated with polyvinylpyrrolidone and sea urchin extracellular molecules induce transient immune activation.

PMID: 33254802
Journal: JOURNAL OF HAZARDOUS MATERIALS
Year: 2021
Reference: J Hazard Mater. 2021 Jan 15;402:123793. doi: 10.1016/j.jhazmat.2020.123793. Epub 2020 Aug 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alijagic, Andi; Barbero, Francesco; Bastus, Neus G; Benada, Oldrich; Gaglio, Daniela; Kofronova, Olga; Napodano, Elisabetta; Pinsino, Annalisa; Puntes, Victor F et al.
DOI: 10.1016/j.jhazmat.2020.123793

Domain Formation and Conformational Changes in Gold Nanoparticle Conjugates Studied Using DPD Simulations.

PMID: 29199832
Journal: LANGMUIR
Year: 2017
Reference: Langmuir. 2017 Dec 19;33(50):14502-14512. doi: 10.1021/acs.langmuir.7b03318. Epub 2017 Dec 4.
Impact factor:
Publication type: Paper in international publication
Authors: Jaime, Carlos; Puntes, Victor F; Raman, Asli et al.
DOI: 10.1021/acs.langmuir.7b03318

Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles.

PMID: 29104700
Journal: Cancer nanotechnology
Year: 2017
Reference: Cancer Nanotechnol. 2017;8(1):7. doi: 10.1186/s12645-017-0030-4. Epub 2017 Oct 26.
Impact factor:
Publication type: Review in national publication
Authors: Casals, Eudald; Cobaleda-Siles, Macarena; Garcia-Sanz, Ana; Gusta, Muriel F; Puntes, Victor F et al.
DOI: 10.1186/s12645-017-0030-4

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System.

PMID: 29066063
Journal: SEMINARS IN IMMUNOLOGY
Year: 2017
Reference: Semin Immunol. 2017 Dec;34:52-60. doi: 10.1016/j.smim.2017.10.001. Epub 2017 Oct 21.
Impact factor:
Publication type: Review in national publication
Authors: Barbero, Francesco; Bastus, Neus G; Borrajo, Mireya L; Busquets-Fite, Marti; Casals, Eudald; Grandori, Rita; Piella, Jordi; Puntes, Victor; Russo, Lorenzo; Salvo, Ignacio et al.
DOI: 10.1016/j.smim.2017.10.001

Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide.

PMID: 28855907
Journal: Frontiers in Immunology
Year: 2017
Reference: Front Immunol. 2017 Aug 14;8:970. doi: 10.3389/fimmu.2017.00970. eCollection 2017.
Impact factor:
Publication type: Review in national publication
Authors: Casals, Eudald; Casals, Gregori; Gusta, Muriel F; Jimenez, Wladimiro; Piella, Jordi; Puntes, Victor et al.
DOI: 10.3389/fimmu.2017.00970

Enhanced reactivity of high-index surface platinum hollow nanocrystals

PMID: NOPMID3
Journal: Journal of Materials Chemistry A
Year: 2016
Reference: J. Mater. Chem. A, 2016,4, 200-208
Impact factor:
Publication type: Paper in international publication
Authors: Edgar Gonzalez; Florind Merkoçi; Joan Esteve; Jordi Arbiol; Neus G Bastus; Raul Arenal; Victor Puntes et al.
DOI: 10.1039/C5TA07504A

Design and pharmacokinetical aspects for the use of inorganic nanoparticles in radiomedicine.

PMID: 26495872
Journal: BRITISH JOURNAL OF RADIOLOGY
Year: 2016
Reference: Br J Radiol. 2016;89(1057):20150210. doi: 10.1259/bjr.20150210. Epub 2015 Oct 23.
Impact factor:
Publication type: Paper in international publication
Authors: Puntes, Victor et al.
DOI: 10.1259/bjr.20150210