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Pharmacokinetic Nanoparticles

The group of design and pharmacodynamics of nanoparticles at the Vall d’Hebron Research Institute focuses on the synthesis, characterization, and applications of engineered inorganic nanoparticles in the field of medicine. By mastering the inorganic core (size, structure, and shape) and understanding and controlling the linking of molecules to the nanoparticle surface, we engineer nanoparticles that can interact with biological systems in a specific way. We also put particular emphasis on safety, feasibility, scale-up, applicability, and other aspects of nanoparticle design.

Our group is led by Prof. Víctor Puntes, who holds an ICREA Research Professorship. Since a great part of our work demands highly multidisciplinary expertise, we maintain several strong collaborations with biologists, immunologists, oncologists, physicists, environmentalists, and more, from all over Europe, China and the US. The work of the group has resulted in several patents and the creation of several spin-offs such as Nanotargeting and Applied nanoparticles.

Publications

The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective.

PMID: 34835755
Journal: Nanomaterials
Year: 2021
Reference: Nanomaterials (Basel). 2021 Nov 6;11(11). pii: nano11112991. doi: 10.3390/nano11112991.
Impact factor: 5.076
Publication type: Review in international publication
Authors: Ernst, Lena M, Casals, Eudald, Italiani, Paola, Boraschi, Diana, Puntes, Victor et al.
DOI: 10.3390/nano11112991

Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells.

PMID: 34394703
Journal: Nano Today
Year: 2021
Reference: Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101056. Epub 2020 Dec 20.
Impact factor: 20.722
Publication type: Paper in international publication
Authors: Buzon, Maria J, Puntes, Victor, Genesca, Meritxell, Astorga-Gamaza, Antonio, Vitali, Michele, Borrajo, Mireya L, Jaime, Carlos, Bastus, Neus, Serra-Peinado, Carla, Luque-Ballesteros, Laura et al.
DOI: 10.1016/j.nantod.2020.101056

Conserved effects and altered trafficking of Cetuximab antibodies conjugated to gold nanoparticles with precise control of their number and orientation.

PMID: 28447703
Journal: Nanoscale
Year: 2017
Reference: Nanoscale. 2017 May 11;9(18):6111-6121. doi: 10.1039/c7nr00947j.
Impact factor:
Publication type: Paper in international publication
Authors: Brust, Mathias; Casals, Eudald; Garcia-Fernandez, Lorena; Garcia-Pardo, Javier; Lorenzo, Julia; Prior, Ian; Puntes, Victor F; Tort, Olivia et al.
DOI: 10.1039/c7nr00947j

Diverse Applications of Nanomedicine.

PMID: 28290206
Journal: ACS Nano
Year: 2017
Reference: ACS Nano. 2017 Mar 28;11(3):2313-2381. doi: 10.1021/acsnano.6b06040. Epub 2017 Mar 14.
Impact factor:
Publication type: Review in international publication
Authors: Alexiou, Christoph; Alvarez-Puebla, Ramon A; Alves, Frauke; Andrews, Anne M; Ashraf, Sumaira; Ballerini, Laura; Balogh, Lajos P; Bestetti, Alessandra; Bosi, Susanna; Brendel, Cornelia et al.
DOI: 10.1021/acsnano.6b06040