About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 37216904 Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Year: 2023 Reference: J Clin Endocrinol Metab. 2023 May 22:dgad280. doi: 10.1210/clinem/dgad280. Impact factor: Publication type: Paper in international publication Authors: Antolin, Maria; Baz-Redon, Noelia; Caimari, Maria; Camats-Tarruella, Nuria; Campos, Ariadna; Clemente, Maria; Cobo, Patricia; Fernandez-Cancio, Monica; Garcia-Arumi, Elena; Masas, Miriam et al. DOI: 10.1210/clinem/dgad280
PMID: 37121854 Journal: MEDICINA CLINICA Year: 2023 Reference: Med Clin (Barc). 2023 Apr 28:S0025-7753(23)00180-X. doi: 10.1016/j.medcli.2023.03.030. Impact factor: Publication type: Letter or abstract Authors: Aguilar, Anna; Monforte, Arnau; Silva, Tulio Mateo et al. DOI: 10.1016/j.medcli.2023.03.030
PMID: 37114390 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2023 Reference: Rev Esp Enferm Dig. 2023 Apr 28;115:223-224. doi: 10.17235/reed.2023.9692/2023. Impact factor: Publication type: Paper in international publication Authors: Albillos Martinez, Agustin; Bejarano Garcia, Ana; Casado Martin, Marta; Ceballos Santos, Daniel; Fernandez Vazquez, Inmaculada; Gomez Rodriguez, Rafael Angel; Iglesias Garcia, Julio; Malagelada Prats, Carolina; Orive Calzada, Aitor et al. DOI: 10.17235/reed.2023.9692/2023
PMID: 37081523 Journal: Genome Medicine Year: 2023 Reference: Genome Med. 2023 Apr 20;15(1):27. doi: 10.1186/s13073-023-01171-w. Impact factor: Publication type: Paper in international publication Authors: Alonso, Carolina; Arenillas, Carlota; Black, James R M; Feliu, Jaime; Garcia-Carbonero, Rocio; Guillen, Carmen; Hidalgo, Manuel; Huebner, Ariana; Juez, Ignacio; Macarulla, Teresa et al. DOI: 10.1186/s13073-023-01171-w
PMID: 35086339 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2022 Reference: Rev Esp Enferm Dig. 2022 Jan 28. doi: 10.17235/reed.2022.8388/2021. Impact factor: 2.086 Publication type: Paper in international publication Authors: Alcala-Gonzalez, Luis, Cortina, Vicente, Jimenez, Alba, Cerda, Maria, Johansson, Erik, Olivera, Pavel, Santamaria, Amparo, Alonso-Cotoner, Carmen, Jimenez, Cesar et al. DOI: 10.17235/reed.2022.8388/2021
PMID: 32993305 Journal: Nutricion Hospitalaria Year: 2021 Reference: Nutr Hosp. 2021 Jan 13;37(Spec No2):34-37. doi: 10.20960/nh.03354. Impact factor: 1.057 Publication type: Letter or abstract Authors: Guarner, Francisco et al. DOI: 10.20960/nh.03354
PMID: 32409590 Journal: GUT Year: 2021 Reference: Gut. 2021 Feb;70(2):319-329. doi: 10.1136/gutjnl-2019-319990. Epub 2020 May 14. Impact factor: 23.059 Publication type: Paper in international publication Authors: Tardon, Adonina, Molina-Montes, Esther, Coscia, Claudia, Gomez-Rubio, Paulina, Fernandez, Alba, Boenink, Rianne, Rava, Marta, Marquez, Mirari, Molero, Xavier, Lohr, Matthias et al. DOI: 10.1136/gutjnl-2019-319990
PMID: 33411965 Journal: INTERNATIONAL JOURNAL OF CANCER Year: 2021 Reference: Int J Cancer. 2021 Apr 15;148(8):2048-2058. doi: 10.1002/ijc.33464. Epub 2021 Jan 15. Impact factor: 7.396 Publication type: Paper in international publication Authors: Nilsson, Magnus, Evangelina Lopez de Maturana, Maria, Estudillo Garcia, Lidia, Renz, Harald, Carrato, Alfredo, Molero, Xavier, Real, Francisco X, Malats, Nuria, Ye, Weimin, Lohr, Matthias et al. DOI: 10.1002/ijc.33464
PMID: 32051190 Journal: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION Year: 2020 Reference: Cancer Epidemiol Biomarkers Prev. 2020 May;29(5):1009-1018. doi: 10.1158/1055-9965.EPI-19-1027. Epub 2020 Feb 12. Impact factor: 4.344 Publication type: Paper in international publication Authors: Barbera, Victor M, Molina-Montes, Esther, Van Hoogstraten, Lisa, Gomez-Rubio, Paulina, Lohr, Matthias, Sharp, Linda, Molero, Xavier, Marquez, Mirari, Michalski, Christoph W, Farre, Antoni et al. DOI: 10.1158/1055-9965.EPI-19-1027
PMID: 31211875 Journal: HEPATOLOGY Year: 2020 Reference: Hepatology. 2020 Feb;71(2):658-669. doi: 10.1002/hep.30817. Epub 2019 Aug 19. Impact factor: 14.679 Publication type: Paper in international publication Authors: Tellez, Luis, Martinez, Javier, Alvarez-Navascues, Carmen, Fraile, Miguel, Procopet, Bogdan, Piscaglia, Fabio, de Koning, Barbara, Llop, Elba, Romero Cristobal, Mario, Tjwa, Eric et al. DOI: 10.1002/hep.30817
PMID: 31756783 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2020 Reference: Neurogastroenterol Motil. 2020 Feb;32(2):e13762. doi: 10.1111/nmo.13762. Epub 2019 Nov 22. Impact factor: 2.946 Publication type: Review in international publication Authors: Mendive, Juan-Manuel, Pfeifer, Johann, Rogler, Gerhard, Scott, S Mark, Simren, Magnus, Whorwell, Peter, Layer, Peter, Hungin, A Pali S, Gourcerol, Guillaume, Ducrotte, Philippe et al. DOI: 10.1111/nmo.13762
PMID: 31991794 Journal: Nutrients Year: 2020 Reference: Nutrients. 2020 Jan 25;12(2). pii: nu12020320. doi: 10.3390/nu12020320. Impact factor: 4.546 Publication type: Paper in international publication Authors: Cotillard, Aurelie, Barba, Elizabeth, Mego, Marianela, Nieto Ruiz, Adoracion, Hernandez-Palet, Laura, Dornic, Quentin, Faurie, Jean-Michel, Butler, John, Merino, Xavi, Lobo, Beatriz et al. DOI: 10.3390/nu12020320
PMID: 29158237 Journal: GUT Year: 2019 Reference: Gut. 2019 Jan;68(1):130-139. doi: 10.1136/gutjnl-2017-314828. Epub 2017 Nov 20. Impact factor: 17.943 Publication type: Paper in international publication Authors: Molina-Montes, Esther, Babaei, Masoud, van der Geest, Lydia, Lemmens, Valery, Van Eycken, Liesbet, De Schutter, Harlinde, Johannesen, Tom B, Fristrup, Claus W, Mortensen, Michael B, Primic-Zakelj, Maja et al. DOI: 10.1136/gutjnl-2017-314828
PMID: 28834270 Journal: LIVER INTERNATIONAL Year: 2018 Reference: Liver Int. 2018 Feb;38(2):295-302. doi: 10.1111/liv.13551. Epub 2017 Sep 13. Impact factor: 4.5 Publication type: Paper in international publication Authors: Gomez-Hurtado, Isabel, Gimenez, Paula, Garcia, Irma, Zapater, Pedro, Frances, Ruben, Gonzalez-Navajas, Jose Manuel, Manichahn, Chaysavanh, Ramos, Jose Manuel, Bellot, Pablo, Guarner, Francisco et al. DOI: 10.1111/liv.13551
PMID: 28836716 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2018 Reference: Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13197. Epub 2017 Aug 24. Impact factor: 3.842 Publication type: Paper in international publication Authors: Azpiroz, F, Pribic, T, Vilaseca, H, Nieto, A, Hernandez, L, Malagelada, C, Accarino, A, Roca, J et al. DOI: 10.1111/nmo.13197
PMID: 29105893 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2018 Reference: Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13248. Epub 2017 Nov 6. Impact factor: 3.842 Publication type: Paper in international publication Authors: Nieto, A, Malagelada, C, Accarino, A, Azpiroz, F, Hernandez, L, Pribic, T et al. DOI: 10.1111/nmo.13248
PMID: 29330618 Journal: Annals of Intensive Care Year: 2018 Reference: Ann Intensive Care. 2018 Jan 9;8(1):1. doi: 10.1186/s13613-017-0346-6. Impact factor: 3.771 Publication type: Paper in international publication Authors: de-Madaria, Enrique, Molero, Xavier, Bonjoch, Laia, Casas, Josefina, Cardenas-Jaen, Karina, Montenegro, Andrea, Closa, Daniel et al. DOI: 10.1186/s13613-017-0346-6
PMID: 28179361 Journal: GUT Year: 2017 Reference: Gut. 2017 May;66(5):813-822. doi: 10.1136/gutjnl-2016-313235. Epub 2017 Feb 7. Impact factor: 16.658 Publication type: Paper in international publication Authors: Machiels, Kathleen, Vermeire, Severine, Sokol, Harry, Guarner, Francisco, Manichanh, Chaysavanh, Sarrabayrouse, Guillaume, Varela, Encarna, Santiago, Alba, Pascal, Victoria, Pozuelo, Marta et al. DOI: 10.1136/gutjnl-2016-313235
PMID: 28175097 Journal: Journal of Crohns & Colitis Year: 2017 Reference: J Crohns Colitis. 2017 Feb 1;11(suppl_1):S291-S292. doi: 10.1093/ecco-jcc/jjx002.548. Impact factor: 5.813 Publication type: Letter or abstract Authors: Casellas, F, Barreiro-de Acosta, M, Esteve, M, Castro-Laria, L, Vicente, R, Ceballos, D, Echarri, A, Martin-Arranz, M D, Busquets, D, Llaomicron, J et al. DOI: 10.1093/ecco-jcc/jjx002.548
PMID: 28104319 Journal: Revista de gastroenterologia de Mexico Year: 2017 Reference: Rev Gastroenterol Mex. 2017 Apr - Jun;82(2):156-178. doi: 10.1016/j.rgmx.2016.08.004. Epub 2017 Jan 16. Impact factor: 0 Publication type: Paper in national publication Authors: Murata, C, Valdovinos, M A, Montijo, E, Abreu, A T, Heller, S, Gonzalez-Garay, A, Bacarreza, D, Bielsa-Fernandez, M, Bojorquez-Ramos, M C, Bosques-Padilla, F et al. DOI: 10.1016/j.rgmx.2016.08.004
PMID: 28090679 Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Year: 2017 Reference: J Gastroenterol Hepatol. 2017 Aug;32(8):1457-1462. doi: 10.1111/jgh.13733. Impact factor: 3.452 Publication type: Paper in international publication Authors: Nieto, Adoracion, Malagelada, Carolina, Santos, Javier, Malagelada, Juan-R, Azpiroz, Fernando, Accarino, Anna, Mendez, Sara et al. DOI: 10.1111/jgh.13733
PMID: 27185077 Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Year: 2016 Reference: Am J Gastroenterol. 2016 Jul;111(7):1007-13. doi: 10.1038/ajg.2016.197. Epub 2016 May 17. Impact factor: 10.383 Publication type: Paper in international publication Authors: Barba, Elizabeth, Accarino, Anna, Soldevilla, Alfredo, Malagelada, Juan-R, Azpiroz, Fernando et al. DOI: 10.1038/ajg.2016.197
PMID: 27144619 Journal: GASTROENTEROLOGY Year: 2016 Reference: Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00221-3. doi: 10.1053/j.gastro.2016.02.030. Impact factor: 18.187 Publication type: Paper in international publication Authors: Boeckxstaens, Guy, Camilleri, Michael, Sifrim, Daniel, Houghton, Lesley A, Elsenbruch, Sigrid, Lindberg, Greger, Azpiroz, Fernando, Parkman, Henry P et al. DOI: 10.1053/j.gastro.2016.02.030
PMID: 27112233 Journal: Scientific Reports Year: 2016 Reference: Sci Rep. 2016 Apr 26;6:25001. doi: 10.1038/srep25001. Impact factor: 5.228 Publication type: Paper in international publication Authors: Gely, Cristina, Santiago, Alba, Pozuelo, Marta, Poca, Maria, Roman, Eva, Campos, David, Sarrabayrouse, Guillaume, Vidal, Silvia, Alvarado-Tapias, Edilmar, Guarner, Francisco et al. DOI: 10.1038/srep25001
PMID: 27077120 Journal: EBioMedicine Year: 2016 Reference: EBioMedicine. 2016 Jan 28;5:135-46. doi: 10.1016/j.ebiom.2016.01.032. eCollection 2016 Mar. Impact factor: 0 Publication type: Paper in international publication Authors: Noguera-Julian, Marc, Rocafort, Muntsa, Guillen, Yolanda, Rivera, Javier, Casadella, Maria, Nowak, Piotr, Hildebrand, Falk, Zeller, Georg, Parera, Mariona, Bellido, Rocio et al. DOI: 10.1016/j.ebiom.2016.01.032
PMID: 26264513 Journal: BRAIN Year: 2015 Reference: Brain. 2015 Oct;138(Pt 10):2847-58. doi: 10.1093/brain/awv226. Epub 2015 Aug 10. Impact factor: 9.196 Publication type: Paper in international publication Authors: Accarino, Anna, Ferra, Christelle, Illa, Isabel, Beguin, Yves, Bakker, Jaap A, Boelens, Jaap J, de Coo, Irenaeus F M, Fay, Keith, Sue, Carolyn M, Nachbaur, David et al. DOI: 10.1093/brain/awv226
PMID: 25037190 Journal: GUT Year: 2015 Reference: Gut. 2015 Jun;64(6):937-47. doi: 10.1136/gutjnl-2013-306068. Epub 2014 Jul 18. Impact factor: 14.66 Publication type: Paper in international publication Authors: Cendrowski, Jaroslaw, Lobo, Victor J Sanchez-Arevalo, Sendler, Matthias, Salas, Antonio, Kuhn, Jens-Peter, Molero, Xavier, Fukunaga, Rikiro, Mayerle, Julia, Lerch, Markus M, Real, Francisco X et al. DOI: 10.1136/gutjnl-2013-306068
PMID: 25537677 Journal: Journal of Neurogastroenterology and Motility Year: 2015 Reference: J Neurogastroenterol Motil. 2015 Jan 1;21(1):33-50. doi: 10.5056/jnm14084. Impact factor: 2.296 Publication type: Paper in international publication Authors: Santos, Javier, Rodino-Janeiro, Bruno K, Alonso-Cotoner, Carmen, Pigrau, Marc, Lobo, Beatriz, Vicario, Maria et al. DOI: 10.5056/jnm14084
PMID: 25458544 Journal: Gastroenterologia y Hepatologia Year: 2015 Reference: Gastroenterol Hepatol. 2015 Feb;38(2):82-96. doi: 10.1016/j.gastrohep.2014.09.006. Epub 2014 Nov 6. Impact factor: 0.838 Publication type: Paper in national publication Authors: Gines, Angels, Gornals, Joan, Gruartmoner, Guillem, Ilzarbe, Lucas, Merino, Xavier, Oms, Lluis, Puig, Ignasi, Puig-Divi, Valenti, Vaquero, Eva, Vida, Francesc et al. DOI: 10.1016/j.gastrohep.2014.09.006
PMID: 23360536 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2013 Reference: Neurogastroenterol Motil. 2013 Apr;25(4):339-e253. doi: 10.1111/nmo.12068. Epub 2013 Jan 29. Impact factor: 2.935 Publication type: Paper in international publication Authors: Burri, E, Cisternas, D, Villoria, A, Accarino, A, Soldevilla, A, Malagelada, J-R, Azpiroz, F et al. DOI: 10.1111/nmo.12068
PMID: 23334821 Journal: NATURE IMMUNOLOGY Year: 2013 Reference: Nat Immunol. 2013 Feb;14(2):101-5. doi: 10.1038/ni.2512. Impact factor: 26.199 Publication type: Paper in international publication Authors: Guarner, Francisco, Hooper, Lora V, Nunez, Gabriel et al. DOI: 10.1038/ni.2512
PMID: 23296252 Journal: Nature Reviews Gastroenterology & Hepatology Year: 2013 Reference: Nat Rev Gastroenterol Hepatol. 2013 Mar;10(3):150-7. doi: 10.1038/nrgastro.2012.246. Epub 2013 Jan 8. Impact factor: 10.426 Publication type: Review in international publication Authors: Feinle-Bisset, Christine, Azpiroz, Fernando et al. DOI: 10.1038/nrgastro.2012.246
PMID: 23279728 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2013 Reference: Neurogastroenterol Motil. 2013 Jan;25(1):4-15. doi: 10.1111/nmo.12046. Impact factor: 2.935 Publication type: Review in international publication Authors: Aziz, Q, Dore, J, Emmanuel, A, Guarner, F, Quigley, E M M et al. DOI: 10.1111/nmo.12046
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.
