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The science produced by our scientists is very important. In 2022, 1,629 papers were published in scientific journals with a global impact factor of over 15,000 points.

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial.

PMID: 31296491
Journal: LANCET ONCOLOGY
Year: 2019
Reference: Lancet Oncol. 2019 Aug;20(8):1148-1159. doi: 10.1016/S1470-2045(19)30326-2. Epub 2019 Jul 8.
Impact factor: 35.386
Publication type: Paper in international publication
Authors: Wardelmann, Eva, Mangel, Laszlo, Sy-Ortin, Teresa, Hohenberger, Peter, de Baere, Thierry, Le Cesne, Axel, Helfre, Sylvie, Saada-Bouzid, Esma, Borkowska, Aneta, Anghel, Rodica et al.
DOI: 10.1016/S1470-2045(19)30326-2

Negative autoimmunity in a Spanish pediatric cohort suspected of type 1 diabetes, could it be monogenic diabetes?

PMID: 31365591
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Jul 31;14(7):e0220634. doi: 10.1371/journal.pone.0220634. eCollection 2019.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Urrutia, Ines, Martinez, Rosa, Rica, Itxaso, Martinez de LaPiscina, Idoia, Garcia-Castano, Alejandro, Aguayo, Anibal, Calvo, Begona, Castano, Luis, Campos Martorell, Ariadna, Clemente Leon, Maria et al.
DOI: 10.1371/journal.pone.0220634

Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

PMID: 31402321
Journal: LANCET ONCOLOGY
Year: 2019
Reference: Lancet Oncol. 2019 Sep;20(9):1226-1238. doi: 10.1016/S1470-2045(19)30334-1. Epub 2019 Aug 8.
Impact factor: 35.386
Publication type: Paper in international publication
Authors: Saura, Cristina, Hlauschek, Dominik, Oliveira, Mafalda, Zardavas, Dimitrios, Jallitsch-Halper, Anita, de la Pena, Lorena, Nuciforo, Paolo, Ballestrero, Alberto, Dubsky, Peter, Lombard, Janine M et al.
DOI: 10.1016/S1470-2045(19)30334-1

Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement.

PMID: 30710068
Journal: ONCOLOGIST
Year: 2019
Reference: Oncologist. 2019 May;24(5):603-611. doi: 10.1634/theoncologist.2018-0228. Epub 2019 Feb 1.
Impact factor: 5.252
Publication type: Paper in international publication
Authors: Colomer, Ramon, Saura, Cristina, Sanchez-Rovira, Pedro, Pascual, Tomas, Rubio, Isabel T, Burgues, Octavio, Marcos, Lourdes, Rodriguez, Cesar A, Martin, Miguel, Lluch, Ana et al.
DOI: 10.1634/theoncologist.2018-0228

Neoadjuvant Metformin Added to Systemic Therapy Decreases the Proliferative Capacity of Residual Breast Cancer.

PMID: 31835708
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Dec 11;8(12). pii: jcm8122180. doi: 10.3390/jcm8122180.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Lopez-Bonet, Eugeni, Buxo, Maria, Cuyas, Elisabet, Pernas, Sonia, Dorca, Joan, Alvarez, Isabel, Martinez, Susana, Perez-Garcia, Jose Manuel, Batista-Lopez, Norberto, Rodriguez-Sanchez, Cesar A et al.
DOI: 10.3390/jcm8122180

[Neonatal haemochromatosis: 10 years into a paradigm shift].

PMID: 30292726
Journal: ANALES DE PEDIATRIA
Year: 2019
Reference: An Pediatr (Barc). 2019 Aug;91(2):124-126. doi: 10.1016/j.anpedi.2018.06.016. Epub 2018 Oct 3.
Impact factor: 1.166
Publication type: Review in national publication
Authors: Garcia Victori, Elena, Manas, Raquel, Castilla Fernandez, Yolanda, Ruiz Campillo, Cesar W, Castillo Salinas, Felix et al.
DOI: 10.1016/j.anpedi.2018.06.016

Nephrology and Public Policy Committee propositions to stimulate research collaboration in adults and children in Europe.

PMID: 31197325
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Sep 1;34(9):1469-1480. doi: 10.1093/ndt/gfz089.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Sever, Mehmet Sukru, Massy, Ziad A, Caskey, Fergus J, Finne, Patrik, Harambat, Jerome, Jager, Kitty J, Nagler, Evi, Stengel, Benedicte, Bruchfeld, Annette, Capasso, Giovambattista et al.
DOI: 10.1093/ndt/gfz089

Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes.

PMID: 31360307
Journal: Oncotarget
Year: 2019
Reference: Oncotarget. 2019 Jul 16;10(44):4598-4608. doi: 10.18632/oncotarget.27078. eCollection 2019 Jul 16.
Impact factor: 0
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Carbonell-Socias, Melchor, Bradbury, Melissa, Garcia, Angel, Verges, Ramona, Puig, Oriol Puig, Sanchez-Iglesias, Jose Luis, Cabrera-Diaz, Silvia, de la Torre, Javier, Gomez-Hidalgo, Natalia R et al.
DOI: 10.18632/oncotarget.27078

Neurofilament as a potential biomarker for spinal muscular atrophy.

PMID: 31139691
Journal: Annals of Clinical and Translational Neurology
Year: 2019
Reference: Ann Clin Transl Neurol. 2019 Apr 17;6(5):932-944. doi: 10.1002/acn3.779. eCollection 2019 May.
Impact factor: 4.656
Publication type: Paper in international publication
Authors: Darras, Basil T, Crawford, Thomas O, Finkel, Richard S, Mercuri, Eugenio, De Vivo, Darryl C, Oskoui, Maryam, Tizzano, Eduardo F, Ryan, Monique M, Muntoni, Francesco, Zhao, Guolin et al.
DOI: 10.1002/acn3.779

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease.

PMID: 31251435
Journal: MOVEMENT DISORDERS
Year: 2019
Reference: Mov Disord. 2019 Oct;34(10):1440-1451. doi: 10.1002/mds.27776. Epub 2019 Jun 28.
Impact factor: 8.061
Publication type: Paper in international publication
Authors: Vila, Miquel et al.
DOI: 10.1002/mds.27776

New and expanding ventricular hemorrhage predicts poor outcome in acute intracerebral hemorrhage.

PMID: 31371565
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Aug 27;93(9):e879-e888. doi: 10.1212/WNL.0000000000008007. Epub 2019 Aug 1.
Impact factor: 8.689
Publication type: Paper in international publication
Authors: Demchuk, Andrew M, Aviv, Richard I, Rodriguez-Luna, David, Molina, Carlos A, Silva, Yolanda, Dzialowski, Imanuel, Kobayashi, Adam, Boulanger, Jean-Martin, Lum, Cheemun, Gubitz, Gord et al.
DOI: 10.1212/WNL.0000000000008007

New clinical trial designs in the era of Precision Medicine.

PMID: 30698321
Journal: Molecular Oncology
Year: 2019
Reference: Mol Oncol. 2019 Mar;13(3):549-557. doi: 10.1002/1878-0261.12465. Epub 2019 Feb 22.
Impact factor: 5.962
Publication type: Review in national publication
Authors: Garralda, Elena, Dienstmann, Rodrigo, Piris, Alex, Brana, Irene, Rodon, Jordi, Tabernero, Josep et al.
DOI: 10.1002/1878-0261.12465

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

PMID: 30804560
Journal: NATURE GENETICS
Year: 2019
Reference: Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7. Epub 2019 Feb 25.
Impact factor: 25.455
Publication type: Paper in international publication
Authors: Wilson, James F, Zhou, Jian, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E, Marten, Jonathan, Enroth, Stefan, Kerr, Shona M, Surakka, Ida et al.
DOI: 10.1038/s41588-018-0321-7

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy.

PMID: 30862093
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Mar 11;8(3). pii: jcm8030339. doi: 10.3390/jcm8030339.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Sampedro, Joel, Bogdanov, Patricia, Ramos, Hugo, Sola-Adell, Cristina, Turch, Mireia, Valeri, Marta, Simo-Servat, Olga, Lagunas, Carmen, Simo, Rafael, Hernandez, Cristina et al.
DOI: 10.3390/jcm8030339

New perspectives on screening and early detection of endometrial cancer.

PMID: 31199503
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2019
Reference: Int J Cancer. 2019 Dec 15;145(12):3194-3206. doi: 10.1002/ijc.32514. Epub 2019 Jun 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alemany, Laia; Aytes, Alvaro; Barahona, Marc; Benavente, Yolanda; Bianchi, Ilaria; Bosch, Francesc X; Brunet, Joan; Canet, Julia; Capella, Gabriel; Climent, Maite et al.
DOI: 10.1002/ijc.32514

Newly Diagnosed and Growing Subependymal Giant Cell Astrocytoma in Adults With Tuberous Sclerosis Complex: Results From the International TOSCA Study.

PMID: 31428037
Journal: Frontiers in Neurology
Year: 2019
Reference: Front Neurol. 2019 Aug 2;10:821. doi: 10.3389/fneur.2019.00821. eCollection 2019.
Impact factor: 2.635
Publication type: Paper in international publication
Authors: Jansen, Anna C, Belousova, Elena, Benedik, Mirjana P, Carter, Tom, Cottin, Vincent, Curatolo, Paolo, D'Amato, Lisa, Beaure d'Augeres, Guillaume, de Vries, Petrus J, Ferreira, Jose C et al.
DOI: 10.3389/fneur.2019.00821

Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA.

PMID: 30609936
Journal: Genome Medicine
Year: 2019
Reference: Genome Med. 2019 Jan 4;11(1):1. doi: 10.1186/s13073-018-0611-9.
Impact factor: 10.886
Publication type: Paper in international publication
Authors: Caldas, Carlos, Gao, Meiling, Callari, Maurizio, Beddowes, Emma, Sammut, Stephen-John, Grzelak, Marta, Biggs, Heather, Jones, Linda, Boumertit, Abdelhamid, Linn, Sabine C et al.
DOI: 10.1186/s13073-018-0611-9

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.

PMID: 31516692
Journal: Clinical and Translational Allergy
Year: 2019
Reference: Clin Transl Allergy. 2019 Sep 9;9:44. doi: 10.1186/s13601-019-0279-2. eCollection 2019.
Impact factor: 4.232
Publication type: Review in international publication
Authors: Dokic, Dejand, Fonseca, Joao A, Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L T T, Larenas-Linnemann, Desiree et al.
DOI: 10.1186/s13601-019-0279-2

Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 1).

PMID: 31559071
Journal: Journal of Thoracic Disease
Year: 2019
Reference: J Thorac Dis. 2019 Aug;11(8):3633-3642. doi: 10.21037/jtd.2019.08.64.
Impact factor: 2.027
Publication type: Paper in international publication
Authors: Tsiligianni, Ioanna, Bousquet, Jean, Pham-Thi, Nhan, Bedbrook, Anna, Agache, Ioana, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep M, Bachert, Claus, Benveniste, Samuel et al.
DOI: 10.21037/jtd.2019.08.64

Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 2).

PMID: 31656683
Journal: Journal of Thoracic Disease
Year: 2019
Reference: J Thorac Dis. 2019 Sep;11(9):4072-4084. doi: 10.21037/jtd.2019.09.38.
Impact factor: 2.027
Publication type: Review in international publication
Authors: Williams, Sian, Pham-Thi, Nhan, Bedbrook, Anna, Agache, Ioana, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep M, Bachert, Claus, Benveniste, Samuel, Bewick, Mike et al.
DOI: 10.21037/jtd.2019.09.38

Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial.

PMID: 31103412
Journal: Lancet Respiratory Medicine
Year: 2019
Reference: Lancet Respir Med. 2019 Jul;7(7):569-580. doi: 10.1016/S2213-2600(19)30139-0. Epub 2019 May 15.
Impact factor: 22.992
Publication type: Paper in international publication
Authors: Nowak, Anna K, Scagliotti, Giorgio V, Gaafar, Rabab, Popat, Sanjay, Vogelzang, Nicholas J, Grosso, Federica, Aboelhassan, Rasha, Jakopovic, Marko, Ceresoli, Giovanni L, Taylor, Paul et al.
DOI: 10.1016/S2213-2600(19)30139-0

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases.

PMID: 31566307
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2019
Reference: N Engl J Med. 2019 Oct 31;381(18):1718-1727. doi: 10.1056/NEJMoa1908681. Epub 2019 Sep 29.
Impact factor: 70.67
Publication type: Paper in international publication
Authors: Abe, S, Flaherty, Kevin R, Wells, Athol U, Cottin, Vincent, Devaraj, Anand, Walsh, Simon L F, Inoue, Yoshikazu, Richeldi, Luca, Kolb, Martin, Tetzlaff, Kay et al.
DOI: 10.1056/NEJMoa1908681

Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial.

PMID: 31173551
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2019
Reference: J Clin Oncol. 2019 Nov 10;37(32):2968-2973. doi: 10.1200/JCO.18.02238. Epub 2019 Jun 7.
Impact factor: 28.245
Publication type: Paper in international publication
Authors: Del Campo, Josep M, Matulonis, Ursula A, Malander, Susanne, Provencher, Diane, Mahner, Sven, Follana, Philippe, Waters, Justin, Berek, Jonathan S, Woie, Kathrine, Oza, Amit M et al.
DOI: 10.1200/JCO.18.02238

Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer.

PMID: 31357748
Journal: Cancers
Year: 2019
Reference: Cancers (Basel). 2019 Jul 28;11(8). pii: cancers11081068. doi: 10.3390/cancers11081068.
Impact factor: 6.162
Publication type: Paper in international publication
Authors: Blanc, Jean-Frederic, Mirakhur, Beloo, Jong, Floris A de, Belanger, Bruce, Bekaii-Saab, Tanios, Siveke, Jens T, Macarulla, Teresa, Chen, Li-Tzong et al.
DOI: 10.3390/cancers11081068