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The science produced by our scientists is very important. In 2022, 1,629 papers were published in scientific journals with a global impact factor of over 15,000 points.

Phaeohyphomycosis caused by Medicopsis romeroi in solid organ transplant recipients: report of two cases and comprehensive review of the literature.

PMID: 30865352
Journal: Transplant Infectious Disease
Year: 2019
Reference: Transpl Infect Dis. 2019 Jun;21(3):e13072. doi: 10.1111/tid.13072. Epub 2019 Mar 27.
Impact factor: 2.112
Publication type: Review in international publication
Authors: Los-Arcos, Ibai, Royuela, Meritxell, Martin-Gomez, Maria Teresa, Alastruey-Izquierdo, Ana, Sellares, Joana, Perello, Manel, Castells, Lluis, Dopazo, Cristina, Gavalda, Joan, Len, Oscar et al.
DOI: 10.1111/tid.13072

Pharmacokinetic and exposure-response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer.

PMID: 31183514
Journal: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Year: 2019
Reference: Cancer Chemother Pharmacol. 2019 Sep;84(3):539-550. doi: 10.1007/s00280-019-03871-w. Epub 2019 Jun 10.
Impact factor: 3.008
Publication type: Paper in international publication
Authors: Wang, Bei, Kirschbrown, Whitney P, Hoff, Paulo M, Shah, Manish A, Shen, Lin, Kang, Yoon-Koo, Alsina, Maria, Girish, Sandhya, Garg, Amit, Ohtsu, Atsushi et al.
DOI: 10.1007/s00280-019-03871-w

Pharmacokinetics of Micafungin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis With High Cutoff Membranes.

PMID: 30633087
Journal: THERAPEUTIC DRUG MONITORING
Year: 2019
Reference: Ther Drug Monit. 2019 Jun;41(3):376-382. doi: 10.1097/FTD.0000000000000595.
Impact factor:
Publication type: Paper in international publication
Authors: Fortun, Jesus; Grau, Santiago; Liano, Fernando; Luque, Sonia; Roberts, Jason A; Tenorio-Canamas, Teresa et al.
DOI: 10.1097/FTD.0000000000000595

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma.

PMID: 29954928
Journal: HAEMATOLOGICA
Year: 2019
Reference: Haematologica. 2019 Apr;104(4):778-788. doi: 10.3324/haematol.2017.180505. Epub 2018 Jun 28.
Impact factor: 7.57
Publication type: Paper in international publication
Authors: Guerrero-Hernandez, Martina, Rodriguez, Vanina, Soldini, Davide, Valera, Alexandra, Moros, Alexandra, Climent, Fina, Gonzalez-Barca, Eva, Mercadal, Santiago, Arenillas, Leonor, Calvo, Xavier et al.
DOI: 10.3324/haematol.2017.180505

Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical Applications.

PMID: 31581671
Journal: Cancers
Year: 2019
Reference: Cancers (Basel). 2019 Oct 2;11(10). pii: cancers11101483. doi: 10.3390/cancers11101483.
Impact factor: 6.162
Publication type: Review in international publication
Authors: Reyes-Garau, Diana, Ribeiro, Marcelo L, Roue, Gael et al.
DOI: 10.3390/cancers11101483

Phase 2 Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes.

PMID: 31481511
Journal: CLINICAL CANCER RESEARCH
Year: 2019
Reference: Clin Cancer Res. 2019 Dec 1;25(23):6976-6985. doi: 10.1158/1078-0432.CCR-19-1338. Epub 2019 Sep 3.
Impact factor: 8.911
Publication type: Paper in international publication
Authors: Cleverly, Ann, Lahn, Michael M, Janssen, Jan, Zhao, Yumin, Chiang, Alan, Giagounidis, Aristoteles, Guba, Susan C, Sridharan, Ashwin, Gueorguieva, Ivelina, Girvan, Alicia et al.
DOI: 10.1158/1078-0432.CCR-19-1338

Phase 3 multicenter, open-label, randomized study of infigratinib versus gemcitabine plus cisplatin in the first-line treatment of patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: the PROOF trial.

PMID: 32085233
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jul;30 Suppl 4:iv62. doi: 10.1093/annonc/mdz155.224. Epub 2019 Dec 4.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Macarulla, T, Javle, M, Borbath, I, Clarke, S, Hitre, E, Louvet, C, Valle, J, Weiss, K, Berman, C, Howland, M et al.
DOI: 10.1093/annonc/mdz155.224

Phase I dose-escalation of trifluridine/tipiracil in combination with oxaliplatin in patients with metastatic colorectal cancer.

PMID: 30889492
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2019
Reference: Eur J Cancer. 2019 May;112:12-19. doi: 10.1016/j.ejca.2019.01.101. Epub 2019 Mar 16.
Impact factor: 6.68
Publication type: Paper in international publication
Authors: Hollebecque, Antoine, Calvo, Aitana, Dahan, Laetitia, Cervantes, Andres, Leger, Catherine, Amellal, Nadia, Fougeray, Ronan, Tabernero, Josep, Andre, Thierry, Argiles, Guillem et al.
DOI: 10.1016/j.ejca.2019.01.101

Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory Small Cell Lung Cancer.

PMID: 31260835
Journal: Journal of Thoracic Oncology
Year: 2019
Reference: J Thorac Oncol. 2019 Oct;14(10):1828-1838. doi: 10.1016/j.jtho.2019.06.021. Epub 2019 Jun 28.
Impact factor: 12.46
Publication type: Paper in international publication
Authors: Dhar, Arindam, Govindan, Ramaswamy, Ballas, Marc S, Mohammad, Helai P, Collingwood, Therese, Bauer, Todd M, Besse, Benjamin, Martinez-Marti, Alex, Trigo, Jose Manuel, Moreno, Victor et al.
DOI: 10.1016/j.jtho.2019.06.021

Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors.

PMID: 30624604
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jun 1;30(6):1020. doi: 10.1093/annonc/mdy532.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Andreis, D De, Ropert, S, Lopez, E, Catteau, A, James, J, Marier, J-F, Beliveau, M, Martell, R E, Baselga, J, Armand, J-P et al.
DOI: 10.1093/annonc/mdy532

Phase I study of rapid alternation of sunitinib and regorafenib for the treatment of tyrosine-kinase inhibitor refractory gastrointestinal stromal tumors.

PMID: 31471313
Journal: CLINICAL CANCER RESEARCH
Year: 2019
Reference: Clin Cancer Res. 2019 Dec 15;25(24):7287-7293. doi: 10.1158/1078-0432.CCR-19-2150. Epub 2019 Aug 30.
Impact factor: 8.911
Publication type: Paper in international publication
Authors: Barysauskas, Constance M, Phallen, Jillian, Triplett, Olivia, Marino-Enriquez, Adrian, Wagner, Andrew J, Demetri, George D, Velculescu, Victor E, Paweletz, Cloud P, Fletcher, Jonathan A, George, Suzanne et al.
DOI: 10.1158/1078-0432.CCR-19-2150

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors.

PMID: 30770348
Journal: CLINICAL CANCER RESEARCH
Year: 2019
Reference: Clin Cancer Res. 2019 Jun 1;25(11):3220-3228. doi: 10.1158/1078-0432.CCR-18-2740. Epub 2019 Feb 15.
Impact factor: 8.911
Publication type: Paper in international publication
Authors: Jung, Kyung Hae, LoRusso, Patricia M, Burris, Howard A, Gordon, Michael S, Bang, Yung-Jue, Hellmann, Matthew D, Cervantes, Andres, Ochoa de Olza, Maria, Marabelle, Aurelien, Hodi, F Stephen et al.
DOI: 10.1158/1078-0432.CCR-18-2740

Phase II, Multicenter, Single-arm Trial of Eribulin as First-line Therapy for Patients With Aggressive Taxane-pretreated HER2-Negative Metastatic Breast Cancer: The MERIBEL Study.

PMID: 30679100
Journal: Clinical Breast Cancer
Year: 2019
Reference: Clin Breast Cancer. 2019 Apr;19(2):105-112. doi: 10.1016/j.clbc.2018.12.012. Epub 2018 Dec 20.
Impact factor: 2.762
Publication type: Paper in international publication
Authors: Ortega, Vanesa, Anton, Antonio, Garau, Isabel, Afonso, Noemia, Calvo, Lourdes, Fernandez, Yolanda, Martinez-Garcia, Maria, Blanco, Esperanza, Zamora, Pilar, Garcia, Mirta et al.
DOI: 10.1016/j.clbc.2018.12.012

Phase II randomized study of radiotherapy and three-year androgen deprivation with or without concurrent weekly docetaxel in high-risk localized prostate cancer patients.

PMID: 30321689
Journal: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Year: 2019
Reference: Int J Radiat Oncol Biol Phys. 2019 Feb 1;103(2):344-352. doi: 10.1016/j.ijrobp.2018.10.005. Epub 2018 Oct 12.
Impact factor: 6.203
Publication type: Paper in international publication
Authors: Mendez, Ma Jose, Maroto, Pablo, Luque, Raquel, de Portugal, Teresa, Aldabo, Ramon, Bonfill, Teresa, Morales-Barrera, Rafael, Garcia, Jose, Macia, Sonia, Maldonado, Xavier et al.
DOI: 10.1016/j.ijrobp.2018.10.005

Phase II Study of Everolimus and Octreotide LAR in Patients with Nonfunctioning Gastrointestinal Neuroendocrine Tumors: The GETNE1003_EVERLAR study.

PMID: 29794066
Journal: ONCOLOGIST
Year: 2019
Reference: Oncologist. 2019 Jan;24(1):38-46. doi: 10.1634/theoncologist.2017-0622. Epub 2018 May 23.
Impact factor: 5.252
Publication type: Paper in international publication
Authors: Capdevila, Jaume, Teule, Alexandre, Barriuso, Jorge, Castellano, Daniel, Lopez, Carlos, Manzano, Jose Luis, Alonso, Vicente, Garcia-Carbonero, Rocio, Dotor, Emma, Matos, Ignacio et al.
DOI: 10.1634/theoncologist.2017-0622

Phase II study of high-sensitivity genotyping of KRAS, NRAS, BRAF and PIK3CA to ultra-select metastatic colorectal cancer patients for panitumumab plus FOLFIRI: the ULTRA trial.

PMID: 30840064
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 May 1;30(5):796-803. doi: 10.1093/annonc/mdz082.
Impact factor: 14.196
Publication type: Paper in international publication
Authors: Robles-Diaz, L, Garcia-Alfonso, P, Buges, C, Duran, G, Salud, A, Navarro, V, Capella, G, Salazar, R, Aranda, E, Valladares, M et al.
DOI: 10.1093/annonc/mdz082

Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide.

PMID: 30523748
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2019
Reference: J Clin Oncol. 2019 Feb 10;37(5):367-374. doi: 10.1200/JCO.18.00053. Epub 2018 Dec 4.
Impact factor: 28.245
Publication type: Paper in international publication
Authors: Wease, Stephen, Blackwell, Beth, Valcarcel, David, Frassoni, Francesco, Boelens, Jaap Jan, Nierkens, Stefan, Jagasia, Madan, Wagner, John E, Kuball, Jurgen, Koh, Liang Piu et al.
DOI: 10.1200/JCO.18.00053

Phase III trial of nonpegylated liposomal doxorubicin in combination with trastuzumab and paclitaxel in HER2-positive metastatic breast cancer.

PMID: 30624616
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jun 1;30(6):1017. doi: 10.1093/annonc/mdy529.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Baselga, J, Manikhas, A, Cortes, J, Roman, L, Semiglazov, V F, Byakhov, M, Lokanatha, D, Forenza, S, Goldfarb, R H, Matera, J et al.
DOI: 10.1093/annonc/mdy529

Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer.

PMID: 30817251
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2019
Reference: J Clin Oncol. 2019 May 1;37(13):1051-1061. doi: 10.1200/JCO.18.02031. Epub 2019 Feb 28.
Impact factor: 28.245
Publication type: Paper in international publication
Authors: Heery, Christopher R, Gulley, James L, Borre, Michael, Vogelzang, Nicholas J, Ng, Siobhan, Agarwal, Neeraj, Parker, Chris C, Pook, David W, Rathenborg, Per, Flaig, Thomas W et al.
DOI: 10.1200/JCO.18.02031

Phase I/II Trial to Evaluate the Efficacy and Safety of Nanoparticle Albumin-Bound Paclitaxel in Combination With Gemcitabine in Patients With Pancreatic Cancer and an ECOG Performance Status of 2.

PMID: 30523758
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2019
Reference: J Clin Oncol. 2019 Jan 20;37(3):230-238. doi: 10.1200/JCO.18.00089. Epub 2018 Dec 4.
Impact factor: 28.245
Publication type: Paper in international publication
Authors: Macarulla, Teresa, Pazo-Cid, Roberto, Guillen-Ponce, Carmen, Lopez, Rafael, Vera, Ruth, Reboredo, Margarita, Munoz Martin, Andres, Rivera, Fernando, Diaz Beveridge, Roberto, La Casta, Adelaida et al.
DOI: 10.1200/JCO.18.00089

Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: Data from the E-HOD registry.

PMID: 30773687
Journal: JOURNAL OF INHERITED METABOLIC DISEASE
Year: 2019
Reference: J Inherit Metab Dis. 2019 Mar;42(2):333-352. doi: 10.1002/jimd.12041. Epub 2019 Feb 17.
Impact factor: 4.287
Publication type: Paper in international publication
Authors: Boy, Nikolas, Huemer, Martina, Diodato, Daria, Martinelli, Diego, Olivieri, Giorgia, Blom, Henk, Gleich, Florian, Kolker, Stefan, Kozich, Viktor, Morris, Andrew A et al.
DOI: 10.1002/jimd.12041

PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors.

PMID: 31488723
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Year: 2019
Reference: Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19464-19473. doi: 10.1073/pnas.1903188116. Epub 2019 Sep 5.
Impact factor: 9.58
Publication type: Paper in international publication
Authors: Navarro, Claudia, Pappa, Stella, Padilla, Natalia, Iacobucci, Simona, Vicioso, Marta, Alvarez de la Campa, Elena, Martinez-Balbas, Marian A, de la Cruz, Xavier, Marcos, Elia et al.
DOI: 10.1073/pnas.1903188116

Physical Activity Is Associated with Attenuated Disease Progression in COPD.

PMID: 30531289
Journal: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
Year: 2019
Reference: Med Sci Sports Exerc. 2019 May;51(5):833-840. doi: 10.1249/MSS.0000000000001859.
Impact factor: 4.478
Publication type: Paper in international publication
Authors: Serra, Ignasi, Guerra, Stefano, Farrero, Eva, Rodriguez, Esther, Ferrer, Jaume, Sauleda, Jaume, Monso, Eduard, Gea, Joaquim, Rodriguez-Roisin, Robert, Agusti, Alvar et al.
DOI: 10.1249/MSS.0000000000001859

Physicochemical and microbiological stability of two news oral liquid formulations of clonidine hydrochloride for pediatric patients.

PMID: 30124097
Journal: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Year: 2019
Reference: Pharm Dev Technol. 2019 Apr;24(4):465-478. doi: 10.1080/10837450.2018.1514520. Epub 2018 Nov 19.
Impact factor: 2.347
Publication type: Paper in international publication
Authors: Rodriguez-Marrodan, B, Merino-Bohorquez, V, Delgado-Valverde, M, Garcia-Palomo, M, Davila-Pousa, M C, Canete, C, Villaronga, M, Camean, M, Lopez-Rojas, R et al.
DOI: 10.1080/10837450.2018.1514520