About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.
At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.
PMID: 39518917 Journal: Year: 2024 Reference: Int J Mol Sci. 2024 Oct 22;25(21):11364. doi: 10.3390/ijms252111364. Impact factor: Publication type: Paper in international publication Authors: Cortes-Hernandez, Josefina; Gabaldon, Alejandra; Joseph-Mullol, Blanca; Moline, Teresa; Royo, Maria; Sandoval, Sebastian; Sole, Cristina et al. DOI: 10.3390/ijms252111364
PMID: 39556831 Journal: JOURNAL OF MEDICAL INTERNET RESEARCH Year: 2024 Reference: J Med Internet Res. 2024 Nov 18;26:e58933. doi: 10.2196/58933. Impact factor: Publication type: Paper in international publication Authors: Berdun, Jesus; Bonet, Tara; Cano, Isaac; Cantenys-Saba, Roser; Carot-Sans, Gerard; de Pando Navarro, Thais; Fabregat-Fabregat, Pau; Fajardo, Joan Carles; Folguera-Profitos, Julia; Gomez Oliveros, Beatriz et al. DOI: 10.2196/58933
PMID: 39615810 Journal: JOURNAL OF PAIN Year: 2024 Reference: J Pain. 2024 Nov 28:104749. doi: 10.1016/j.jpain.2024.104749. Impact factor: Publication type: Paper in international publication Authors: Almirall, Miriam; Cano, Mireia; Chaler, Joaquim; Roman-Vinas, Blanca; Sanchez-Raya, Judith; Socorro-Cumplido, Jose Luis et al. DOI: 10.1016/j.jpain.2024.104749
PMID: 39719522 Journal: Internal and Emergency Medicine Year: 2024 Reference: Intern Emerg Med. 2024 Dec 24. doi: 10.1007/s11739-024-03850-x. Impact factor: Publication type: Paper in international publication Authors: Barra, Lillian; Fernandez-Codina, Andreu; Mirza, Kanza et al. DOI: 10.1007/s11739-024-03850-x
PMID: 37704212 Journal: Cancer Discovery Year: 2023 Reference: Cancer Discov. 2023 Sep 14:OF1-OF12. doi: 10.1158/2159-8290.CD-22-1340. Impact factor: Publication type: Paper in international publication Authors: Arenas, Enrique J; Arenas, Enrique J; Arevalo, Silvia; Arevalo, Silvia; Arribas, Joaquin; Balmana, Judith; Balmana, Judith; Bayo-Puxan, Neus; Bayo-Puxan, Neus; Carrasco, Estela et al. DOI: 10.1158/2159-8290.CD-22-1340
PMID: 37744357 Journal: Frontiers in Immunology Year: 2023 Reference: Front Immunol. 2023 Sep 7;14:1253121. doi: 10.3389/fimmu.2023.1253121. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Alegre-Martin, Jose; Alegre-Martin, Jose; Almirall, Miriam; Blanco-Suarez, Manuel; Caceres, Oscar; Castro-Marrero, Jesus; Domingo, Joan Carles; Gonzalez-Castro, Ana Maria; Gonzalez-Castro, Ana Maria; Jurek, Joanna et al. DOI: 10.3389/fimmu.2023.1253121
PMID: 37768647 Journal: Journal of Crohns & Colitis Year: 2023 Reference: J Crohns Colitis. 2023 Sep 28:jjad165. doi: 10.1093/ecco-jcc/jjad165. Impact factor: Publication type: Paper in international publication Authors: Almer, Sven; Bonfiglio, Ferdinando; Bresso, Francesca; Bujanda, Luis; Camargo Tavares, Leticia; Chen, Ye; Colombel, Jean-Frederic; D'Amato, Mauro; Escudero-Hernandez, Celia; Esteve, Maria et al. DOI: 10.1093/ecco-jcc/jjad165
PMID: 37801035 Journal: FASEB JOURNAL Year: 2023 Reference: FASEB J. 2023 Nov;37(11):e23220. doi: 10.1096/fj.202300077R. Impact factor: Publication type: Paper in international publication Authors: Albillos, Agustin; Alter, David N; Asselta, Rosanna; Banales, Jesus M; Brewer, Jo; Bujanda, Luis; Buti, Maria; Buti, Maria; Conway, Joseph; de Cid, Rafael et al. DOI: 10.1096/fj.202300077R
PMID: 35628558 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 May 20;23(10). pii: ijms23105748. doi: 10.3390/ijms23105748. Impact factor: Publication type: Paper in international publication Authors: Agustin, Juan Jose de; Corominas, Hector; Diaz-Torne, Cesar; Estrada, Paula; Mariscal, Anais; Moya, Patricia; Ortiz, M Angels; Reina, Delia; Vidal, Silvia; Zamora, Carlos et al. DOI: 10.3390/ijms23105748
PMID: 35105709 Journal: JOURNAL OF RHEUMATOLOGY Year: 2022 Reference: J Rheumatol. 2022 Apr;49(4):398-407. doi: 10.3899/jrheum.210563. Epub 2022 Feb 1. Impact factor: Publication type: Paper in international publication Authors: Anton, Jordi; Bagnasco, Francesca; Cederholm, Susanna; De Benedetti, Fabrizio; De Inocencio, Jaime; Franck-Larsson, Karin; Giancane, Gabriella; Glerup, Mia; Kamphuis, Sylvia; Kone-Paut, Isabelle et al. DOI: 10.3899/jrheum.210563
PMID: 34256936 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin (Barc). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcli.2021.05.013. Epub 2021 Jun 16. Impact factor: Publication type: Paper in national publication Authors: Arranz-Betegon, Maria; Canas-Ruano, Esperanza; Domingo-Baldrich, Eva; Fernandez-Codina, Andreu; Garcia-Vives, Eloi; Gil-Vila, Albert; Llaneras-Artigues, Jordi; Meza, Beatriz; Michelena, Xabier; Orozco-Galvez, Olimpia et al. DOI: 10.1016/j.medcli.2021.05.013
PMID: 35576644 Journal: EBioMedicine Year: 2022 Reference: EBioMedicine. 2022 Jun;80:104053. doi: 10.1016/j.ebiom.2022.104053. Epub 2022 May 13. Impact factor: Publication type: Paper in international publication Authors: Absher, Devin M; Alperi-Lopez, Mercedes; Blanco, Francisco; Diaz-Torne, Cesar; Erra, Alba; Fernandez-Cid, Carlos Marras; Fernandez-Nebro, Antonio; Gomez, Antonio; Julia, Antonio; Li, Tianlu et al. DOI: 10.1016/j.ebiom.2022.104053
PMID: 34290006 Journal: BMJ case reports Year: 2021 Reference: BMJ Case Rep. 2021 Jul 21;14(7). pii: 14/7/e241766. doi: 10.1136/bcr-2021-241766. Impact factor: Publication type: Letter or abstract Authors: Montoro, Bruno; Ros, Javier; Ros, Javier; Sanchez-Sancho, Pablo; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al. DOI: 10.1136/bcr-2021-241766
PMID: 34262032 Journal: Nature Communications Year: 2021 Reference: Nat Commun. 2021 Jul 14;12(1):4319. doi: 10.1038/s41467-021-24618-3. Impact factor: Publication type: Paper in international publication Authors: Alburquerque-Bejar, Juan J; Andrades, Alvaro; Farre, Lourdes; Gomez, Antonio; Llabata, Paula; Martin-Tejera, Juan F; Matias-Guiu, Xavier; Medina, Pedro P; Oaknin, Ana; Piulats, Josep M et al. DOI: 10.1038/s41467-021-24618-3
PMID: 33791744 Journal: Year: 2021 Reference: medRxiv. 2021 Mar 24. doi: 10.1101/2021.03.23.21254175. Impact factor: Publication type: Letter or abstract Authors: Bauer, Sandra; Castro-Marrero, Jesus; Cordeiro, Clara; Fonseca, Andre; Freitag, Helma; Grabowska, Anna D; Graca, Luis; Lacerda, Eliana M; Malato, Joao; Nacul, Luis et al. DOI: 10.1101/2021.03.23.21254175
PMID: 34201806 Journal: Antioxidants Year: 2021 Reference: Antioxidants (Basel). 2021 Jun 23;10(7). pii: antiox10071010. doi: 10.3390/antiox10071010. Impact factor: Publication type: Paper in international publication Authors: Alegre-Martin, Jose; Castro-Marrero, Jesus; Cordobilla, Begona; Domingo, Joan Carles; Galmes, Jose Luis; Lopez-Vilchez, Irene; Maurel, Sara; Zaragoza, Maria-Cleofe et al. DOI: 10.3390/antiox10071010
PMID: 32659758 Journal: DERMATOLOGY Year: 2020 Reference: Dermatology. 2020;236(5):467-476. doi: 10.1159/000508672. Epub 2020 Jul 13. Impact factor: Publication type: Review in international publication Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina et al. DOI: 10.1159/000508672
PMID: 32558485 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2020 Reference: N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17. Impact factor: Publication type: Paper in international publication Authors: Acosta-Herrera, Marialbert; Aghemo, Alessio; Albillos, Agustin; Albrecht, Wolfgang; Aliberti, Stefano; Aneli, Serena; Angelini, Claudio; Asselta, Rosanna; Aziz, Fatima; Badalamenti, Salvatore et al. DOI: 10.1056/NEJMoa2020283
PMID: 31033231 Journal: ARTHRITIS CARE & RESEARCH Year: 2020 Reference: Arthritis Care Res (Hoboken). 2020 Jun;72(6):822-828. doi: 10.1002/acr.23910. Epub 2020 May 14. Impact factor: Publication type: Paper in international publication Authors: Abasolo, Lydia; Alen, Jaime Calvo; Almagro, Raul Menor; Alonso, Elena Riera; Alvarez, Beatriz Gonzalez; Amirall, Miriam; Aparicio, Angel Maria Garcia; Arias, Miriam Garcia; Arija, Sara Manrique; Audera, Chesus Beltran et al. DOI: 10.1002/acr.23910
PMID: 32534273 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2020 Reference: Semin Arthritis Rheum. 2020 Aug;50(4):776-790. doi: 10.1016/j.semarthrit.2020.03.007. Epub 2020 Jun 1. Impact factor: Publication type: Paper in international publication Authors: Castellvi, I; Diaz Del Campo, P; Gono, T; Gonzalez-Gay, M A; Martinez-Becerra, M J; Pinal-Fernandez, I; Plana, M N; Rodriguez-Nieto, M J; Romero-Bueno, F; Ruiz-Rodriguez, J C et al. DOI: 10.1016/j.semarthrit.2020.03.007
PMID: 31308545 Journal: NATURE GENETICS Year: 2019 Reference: Nat Genet. 2019 Aug;51(8):1207-1214. doi: 10.1038/s41588-019-0439-2. Epub 2019 Jul 15. Impact factor: Publication type: Paper in international publication Authors: Adan, Roger A H; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A; Baker, Jessica H; Bergen, Andrew W; Berrettini, Wade H; Birgegard, Andreas; Boden, Joseph M; Boehm, Ilka et al. DOI: 10.1038/s41588-019-0439-2
PMID: 31312201 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Jul 2;10:1459. doi: 10.3389/fimmu.2019.01459. eCollection 2019. Impact factor: Publication type: Paper in international publication Authors: Alperi-Lopez, Mercedes; Aterido, Adria; Blanco, Francisco; Canete, Juan D; Corominas, Hector; Erra, Alba; Fernandez-Gutierrez, Benjamin; Fernandez-Nebro, Antonio; Gonzalez, Isidoro; Julia, Antonio et al. DOI: 10.3389/fimmu.2019.01459
PMID: 31253111 Journal: BMC PUBLIC HEALTH Year: 2019 Reference: BMC Public Health. 2019 Jun 28;19(1):840. doi: 10.1186/s12889-019-7225-z. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Aliste, Luisa; Castro-Marrero, Jesus; de Sevilla, Tomas Fernandez; Faro, Monica; Zaragoza, Maria Cleofe et al. DOI: 10.1186/s12889-019-7225-z
PMID: 31237427 Journal: Arthritis & Rheumatology Year: 2019 Reference: Arthritis Rheumatol. 2019 Dec;71(12):2081-2089. doi: 10.1002/art.41026. Epub 2019 Oct 21. Impact factor: Publication type: Paper in international publication Authors: Adan, Alfredo; Atanes-Sandoval, Antonio; Atienza-Mateo, Belen; Aurrecoechea, Elena; Beltran, Emma; Blanco, Ana; Blanco, Ricardo; Calvo-Rio, Vanesa; Caracuel-Ruiz, Miguel A; Carrasco-Cubero, Carmen et al. DOI: 10.1002/art.41026
PMID: 29696075 Journal: Journal of Extracellular Vesicles Year: 2018 Reference: J Extracell Vesicles. 2018 Mar 22;7(1):1453730. doi: 10.1080/20013078.2018.1453730. eCollection 2018. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Blanco-Lopez, Maria Del Carmen; Castro-Marrero, Jesus; Martinez-Martinez, Alba; Oliveira-Rodriguez, Myriam; Serrano-Pertierra, Esther; Zaragoza, Maria Cleofe et al. DOI: 10.1080/20013078.2018.1453730
PMID: 29635081 Journal: AUTOIMMUNITY REVIEWS Year: 2018 Reference: Autoimmun Rev. 2018 Jun;17(6):601-609. doi: 10.1016/j.autrev.2018.01.009. Epub 2018 Apr 7. Impact factor: Publication type: Review in national publication Authors: Blanco, Julia; Capelli, Enrica; Castro-Marrero, Jesus; Murovska, Modra; Scheibenbogen, Carmen; Sotzny, Franziska; Steiner, Sophie et al. DOI: 10.1016/j.autrev.2018.01.009
PMID: 29602447 Journal: REVISTA CLINICA ESPANOLA Year: 2018 Reference: Rev Clin Esp. 2018 Aug - Sep;218(6):298-304. doi: 10.1016/j.rce.2018.02.011. Epub 2018 Mar 27. Impact factor: Publication type: Review in national publication Authors: Fernandez-Codina, A; Fernandez-Fernandez, J; Fernandez-Pantiga, A et al. DOI: 10.1016/j.rce.2018.02.011
PMID: 29602570 Journal: OPHTHALMOLOGY Year: 2018 Reference: Ophthalmology. 2018 Sep;125(9):1444-1451. doi: 10.1016/j.ophtha.2018.02.020. Epub 2018 Mar 27. Impact factor: Publication type: Paper in international publication Authors: Adan, Alfredo; Atienza-Mateo, Belen; Aurrecoechea, Elena; Beltran, Emma; Blanco, Ana; Blanco, Ricardo; Callejas-Rubio, Jose-Luis; Calvo-Rio, Vanesa; Caracuel, Miguel A; Carrasco-Cubero, Carmen et al. DOI: 10.1016/j.ophtha.2018.02.020
PMID: 28052319 Journal: BRITISH JOURNAL OF PHARMACOLOGY Year: 2017 Reference: Br J Pharmacol. 2017 Mar;174(5):345-369. doi: 10.1111/bph.13702. Epub 2017 Feb 1. Impact factor: Publication type: Review in national publication Authors: Alegre, Jose; Castro-Marrero, Jesus; Saez-Francas, Naia; Santillo, Dafna et al. DOI: 10.1111/bph.13702
Funded by the European Union, this project coordinated by the Vall d'Hebron Research Institute (VHIR) seeks to develop more effective therapies by creating new combinations of existing drugs
The head of the Rheumatology Service at Vall d'Hebron University Hospital and of the Rheumatology research group at VHIR is a highly accomplished rheumatologist with a distinguished career in the field.
It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.
