About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.
At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.
PMID: 39742894 Journal: BRAIN BEHAVIOR AND IMMUNITY Year: 2024 Reference: Brain Behav Immun. 2024 Dec 30:S0889-1591(24)00878-X. doi: 10.1016/j.bbi.2024.12.149. Impact factor: Publication type: Paper in international publication Authors: Almirall, Miriam; Auer, William; Borras, Xavier; Feliu-Soler, Albert; Ferres, Sonia; Lizama-Lefno, Andrea; Luciano, Juan V; Maes, Michael; Nijs, Jo; Royuela-Colomer, Estibaliz et al. DOI: 10.1016/j.bbi.2024.12.149
PMID: 38203745 Journal: Year: 2024 Reference: Int J Mol Sci. 2024 Jan 1;25(1):574. doi: 10.3390/ijms25010574. Impact factor: Publication type: Paper in international publication Authors: Castro-Marrero, Jesus; Domingo, Joan Carles; Hargreaves, Iain Parry; Mantle, David et al. DOI: 10.3390/ijms25010574
PMID: 37802746 Journal: CLINICAL THERAPEUTICS Year: 2023 Reference: Clin Ther. 2023 Oct 4:S0149-2918(23)00352-1. doi: 10.1016/j.clinthera.2023.09.007. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Alegre, Jose; Casas-Roma, Jordi; Lacasa, Marcos; Launois, Patricia; Launois, Patricia; Prados, Ferran et al. DOI: 10.1016/j.clinthera.2023.09.007
PMID: 37805255 Journal: Reumatologia clinica Year: 2023 Reference: Reumatol Clin (Engl Ed). 2023 Oct;19(8):423-429. doi: 10.1016/j.reumae.2023.03.007. Impact factor: Publication type: Paper in international publication Authors: Almirall, Miriam; Borruel, Natalia; Borruel, Natalia; Ginard, Daniel; Gonzalez-Lama, Yago; Gratacos, Jordi; Juanola, Xavier; Loza, Estibaliz; Sanz, Jesus; Urruticoechea-Arana, Ana et al. DOI: 10.1016/j.reumae.2023.03.007
PMID: 37184889 Journal: RHEUMATOLOGY Year: 2023 Reference: Rheumatology (Oxford). 2023 May 15:kead225. doi: 10.1093/rheumatology/kead225. Impact factor: Publication type: Paper in international publication Authors: Almirall, Miriam; Collantes, Eduardo; Font-Ugalde, Pilar; Juanola, Xavier; Lopez-Medina, Clementina; Marco-Pascual, Carla; Marzo-Ortega, Helena; Michelena, Xabier; Morgan, Ann W; Rodriguez, Jesus et al. DOI: 10.1093/rheumatology/kead225
PMID: 37841754 Journal: HemaSphere Year: 2023 Reference: Hemasphere. 2023 Oct 11;7(10):e961. doi: 10.1097/HS9.0000000000000961. eCollection 2023 Oct. Impact factor: Publication type: Paper in international publication Authors: Beltran Catalan, Emma; Benlloch, Luis E; Blanco, Ricardo; Brito Garcia, Noe; Carcel, Paula; Cedena Romero, Maria Teresa; Crucitti, Davide; De Miguel Sanchez, Carlos; Del Orbe Barreto, Rafael Andres; Diaz Valle, David et al. DOI: 10.1097/HS9.0000000000000961
PMID: 34538611 Journal: Reumatologia clinica Year: 2022 Reference: Reumatol Clin. 2022 May;18(5):260-265. doi: 10.1016/j.reumae.2021.01.005. Epub 2021 Sep 15. Impact factor: Publication type: Paper in national publication Authors: Alegre de Miquel, Cayetano; Almirall Bernabe, Miriam; Brito Garcia, Noe; Casanueva Fernandez, Benigno; Castillo Ojeda, Cristina; Collado Cruz, Antonio; Diaz Del Campo Fontecha, Petra; Merino Argumanez, Carol; Monteso-Curto, Pilar; Palao Tarrero, Angela et al. DOI: 10.1016/j.reuma.2021.01.006
PMID: 35536413 Journal: CLINICAL RHEUMATOLOGY Year: 2022 Reference: Clin Rheumatol. 2022 Aug;41(8):2361-2373. doi: 10.1007/s10067-022-06176-1. Epub 2022 May 10. Impact factor: Publication type: Paper in international publication Authors: Alten, Rieke; Bannert, Bettina; Buch, Maya H; Caporali, Roberto; Chartier, Melanie; Connolly, Sean E; Flipo, Rene-Marc; Griffiths, Hedley; Lozenski, Karissa; Mariette, Xavier et al. DOI: 10.1007/s10067-022-06176-1
PMID: 35486339 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2022 Reference: J Clin Immunol. 2022 Jul;42(5):1071-1082. doi: 10.1007/s10875-022-01257-x. Epub 2022 Apr 29. Impact factor: Publication type: Paper in international publication Authors: Abu Jamra, Soraya Regina; Alsina, Laia; Blanco Lobo, Pilar; Bloomfield, Marketa; Deya-Martinez, Angela; Esteve-Sole, Ana; Garcia-Garcia, Ana; Guisado Hernandez, Paloma; Kanderova, Veronika; Lopez-Corbeto, Mireia et al. DOI: 10.1007/s10875-022-01257-x
PMID: 35460231 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Oct 6;61(10):3887-3888. doi: 10.1093/rheumatology/keac252. Impact factor: Publication type: Paper in international publication Authors: Sanz-Martinez, Maria Teresa; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al. DOI: 10.1093/rheumatology/keac252
PMID: 32167877 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):13-19. Epub 2020 Mar 13. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Calvo, Natalia; Castro-Marrero, Jesus; Maurel, Sara; Saez-Francas, Naia et al. DOI:
PMID: 34161227 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):170-173. Epub 2021 Jun 21. Impact factor: Publication type: Paper in international publication Authors: Alegre, Cayetano; Almirall, Miriam; Alperi-Lopez, Mercedes; Arias, Anna; Arranz, Laura I; Blanco, Francisco; Calandre, Elena P; Canete, Juan D; Carrillo, Maria D; Collado, Antonio et al. DOI:
PMID: 34071326 Journal: SENSORS Year: 2021 Reference: Sensors (Basel). 2021 May 28;21(11). pii: s21113746. doi: 10.3390/s21113746. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Capdevila, Lluis; Castro-Marrero, Jesus; Escorihuela, Rosa M; Ramos-Castro, Juan et al. DOI: 10.3390/s21113746
PMID: 34069603 Journal: Medicina-Lithuania Year: 2021 Reference: Medicina (Kaunas). 2021 May 19;57(5). pii: medicina57050510. doi: 10.3390/medicina57050510. Impact factor: Publication type: Paper in international publication Authors: Authier, Francois Jerome; Behrends, Uta; Bergquist, Jonas; Brundsdlund, Ivan; Capelli, Enrica; Castro-Marrero, Jesus; Cullinan, John; Estevez-Lopez, Fernando; Grabowski, Patricia; Helland, Ingrid Bergliot et al. DOI: 10.3390/medicina57050510
PMID: 32508154 Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Year: 2020 Reference: Am J Physiol Gastrointest Liver Physiol. 2020 Aug 1;319(2):G109-G120. doi: 10.1152/ajpgi.00027.2020. Epub 2020 Jun 8. Impact factor: Publication type: Paper in international publication Authors: Aterido, Adria; Cabre, Eduard; Domenech, Eugeni; Ferreiro, Miriam; Garcia-Jaraquemada, Arce; Julia, Antonio; Loren, Violeta; Lozano, Juan Jose; Manosa, Miriam; Manye, Josep et al. DOI: 10.1152/ajpgi.00027.2020
PMID: 32482595 Journal: European Journal of Internal Medicine Year: 2020 Reference: Eur J Intern Med. 2020 Sep;79:43-50. doi: 10.1016/j.ejim.2020.05.012. Epub 2020 May 29. Impact factor: Publication type: Paper in international publication Authors: Becattini, Cecilia; Cerda, Pau; Corbella, Xavier; Hernandez, Josefina Cortes; Iriarte, Adriana; Riera-Mestre, Antoni et al. DOI: 10.1016/j.ejim.2020.05.012
PMID: 31171347 Journal: MEDICINA CLINICA Year: 2020 Reference: Med Clin (Barc). 2020 Jun 12;154(11):468-469. doi: 10.1016/j.medcli.2019.04.011. Epub 2019 Jun 4. Impact factor: Publication type: Letter or abstract Authors: Fernandez-Codina, Andreu; Pope, Janet E; Silverman, Michael et al. DOI: 10.1016/j.medcli.2019.04.011
PMID: 32455633 Journal: Journal of Clinical Medicine Year: 2020 Reference: J Clin Med. 2020 May 21;9(5). pii: jcm9051557. doi: 10.3390/jcm9051557. Impact factor: Publication type: Review in international publication Authors: Alegre, Jose; Bakken, Inger Johanne; Capelli, Enrica; Castro-Marrero, Jesus; Estevez-Lopez, Fernando; Ivanovs, Andrejs; Lacerda, Eliana; Lorusso, Lorenzo; Mudie, Kathleen; Murovska, Modra et al. DOI: 10.3390/jcm9051557
PMID: 31229481 Journal: ANNALS OF THORACIC SURGERY Year: 2019 Reference: Ann Thorac Surg. 2019 Oct;108(4):1052-1058. doi: 10.1016/j.athoracsur.2019.04.096. Epub 2019 Jun 21. Impact factor: Publication type: Paper in international publication Authors: Alvarez, Antonio; Berastegui, Cristina; Culebras, Mario; de Gracia, Javier; Loor, Karina; Loor, Karina; Sansano, Irene et al. DOI: 10.1016/j.athoracsur.2019.04.096
PMID: 31113593 Journal: Annals of Hepatology Year: 2019 Reference: Ann Hepatol. 2019 Jan - Feb;18(1):215-219. doi: 10.5604/01.3001.0012.7916. Impact factor: Publication type: Paper in international publication Authors: Buti, Maria; Esteban, Rafael; Fernandez-Codina, Andreu; Martinez-Valle, Fernando; Merino-Casabiel, Xavier; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa; Torres, Ines de et al. DOI: 10.5604/01.3001.0012.7916
PMID: 30911161 Journal: NATURE GENETICS Year: 2019 Reference: Nat Genet. 2019 Apr;51(4):659-674. doi: 10.1038/s41588-019-0364-4. Epub 2019 Mar 25. Impact factor: Publication type: Paper in international publication Authors: Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Als, Thomas D; Als, Thomas D; Amin, Farooq; Andreassen, Ole A et al. DOI: 10.1038/s41588-019-0364-4
PMID: 31086353 Journal: NATURE GENETICS Year: 2019 Reference: Nat Genet. 2019 Jun;51(6):1068. doi: 10.1038/s41588-019-0435-6. Impact factor: Publication type: Letter or abstract Authors: Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Als, Thomas D; Als, Thomas D; Amin, Farooq; Andreassen, Ole A et al. DOI: 10.1038/s41588-019-0435-6
PMID: 29473763 Journal: Expert Review of Clinical Immunology Year: 2018 Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23. Impact factor: Publication type: Paper in international publication Authors: Alvarado-Cardenas, Marcelo; Grau-Junyent, Josep Maria; Juarez, Candido; Labrador-Horrillo, Moises; Marin, Ana; Martinez, Maria Angeles; Milisenda, Jose Cesar; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al. DOI: 10.1080/1744666X.2018.1440206
PMID: 29452298 Journal: JOINT BONE SPINE Year: 2018 Reference: Joint Bone Spine. 2018 Dec;85(6):721-726. doi: 10.1016/j.jbspin.2018.01.014. Epub 2018 Feb 13. Impact factor: Publication type: Paper in international publication Authors: Brito-Zeron, Pilar; Carballo, Iago; Cid, Maria Cinta; Feijoo-Masso, Carlos; Fernandez-Codina, Andreu; Fonseca-Aizpuru, Eva; Fraile-Rodriguez, Guadalupe; Lopez, Cristina; Lopez-Dupla, Miguel; Martinez-Valle, Fernando et al. DOI: 10.1016/j.jbspin.2018.01.014
PMID: 29422324 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2018 Reference: Semin Arthritis Rheum. 2018 Aug;48(1):22-27. doi: 10.1016/j.semarthrit.2017.12.012. Epub 2018 Jan 6. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Cros, Clara; Alvarez-Rodriguez, Belen; Arboleya, Luis; Bernal, Jose A; Blanco, Ricardo; Blanco-Madrigal, Juan; Bonilla, Gema; Carreira, Patricia E; Castaneda, Santos; Cervantes-Perez, Evelin C et al. DOI: 10.1016/j.semarthrit.2017.12.012
PMID: 29149307 Journal: RHEUMATOLOGY Year: 2018 Reference: Rheumatology (Oxford). 2018 Feb 1;57(2):388-396. doi: 10.1093/rheumatology/kex413. Impact factor: Publication type: Paper in international publication Authors: Aparicio-Espanol, Gloria; Balada, Eva; Ferrer-Fabregas, Berta; Garcia-Patos, Vicente; Grau-Junyent, Josep M; Labrador-Horrillo, Moises; Martinez, Maria Angeles; Milisenda, Jose Cesar; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert et al. DOI: 10.1093/rheumatology/kex413
Funded by the European Union, this project coordinated by the Vall d'Hebron Research Institute (VHIR) seeks to develop more effective therapies by creating new combinations of existing drugs
The head of the Rheumatology Service at Vall d'Hebron University Hospital and of the Rheumatology research group at VHIR is a highly accomplished rheumatologist with a distinguished career in the field.
It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.
